Cov kev thiab cov lus qhia rau kev siv "Loraksona". Analogs thiab xyuas

Yuav ua li cas yog xws li ib tug yeeb tshuaj raws li "Lorakson 500"? Cov lus qhia rau kev siv, tus yam ntxwv ntawm lub cuab tam, raws li zoo raws li nws cov hais, zoo lawm, muaj pes tsawg leeg thiab analogs yuav sib tham txog hauv qab no.

Ntim, zoo lawm, muaj pes tsawg leeg ntawm cov tshuaj

Yuav ua li cas zoo yog cov yam ntxwv rau qhov suav hais tias cov tshuaj? Yuav ua li cas no nqi hais tias phau ntawv qhia? "Lorakson" yog ib tug crystalline hmoov ntawm dawb los yog me ntsis yellowish, npaj rau qhov kev npaj ntawm tso dej los yog intramuscular tshuaj. Muaj pes tsawg leeg ntawm lub medicament muaj xws li cov active ingredient xws li ceftriaxone. Nws yog nyob rau hauv daim ntawv ntawm nws cov sodium ntsev.

Tsis tas li ntawd, cov tshuaj "Lorakson" phau ntawv qhia uas yog muaj nyob rau hauv ib pawg ntawm cov duab los qhia muaj xws li ib tug hnyav li dej cov kev txhaj tshuaj.

Cov kev kawm npaj ua nyob rau hauv lub khob vials ntawm 10 ml uas yog muab tso rau hauv daim ntawv thawv (tej zaum yuav muab muag los yog tsis muaj ib tug hnyav).

Pharmaceuticals Kws khoom

Yuav ua li cas yog lub aforementioned tshuaj? Cov ntaub ntawv muaj cov lus qhia rau kev siv? "Lorakson" - ib tug tshuaj tua kab mob (cephalosporin) peb tiam, npaj rau parenteral thawj coj. Nws muaj bactericidal kev txiav txim.

Muaj peev xwm inhibit qhov kev synthesis ntawm cell daim nyias nyias ntawm cov tshuaj cheeb qhov uas cov kev loj hlob ntawm feem ntau Gram-tsis zoo thiab Gram-zoo microorganisms.

Raws li cov kws txawj, ceftriaxone qhia tau hais tias kev ruaj ntseg tiv thaiv beta-lactamase (penicillinase, cephalosporinase), uas yog ua los ntawm feem ntau cov kab mob.

Kinetics ntawm cov tshuaj

Yuav ua li cas kho cov khoom kis rau tib neeg lub cev? Yuav ua li cas no hais tias lub nrog cov lus qhia rau kev siv? "Lorakson" rau parenteral thawj coj yog zoo mus rau hauv yuav luag tag nrho cov ntaub so ntswg thiab lub cev.

Nrog tso dej Txoj kev lis ntshav ntawm ceftriaxone zoo nkauj sai sai diffuses mus rau hauv lub interstitial kua, qhov chaw uas nws antibacterial thaj chaw khaws cia thoob plaws hauv lub hnub.

Nws yuav tsum tau muab sau tseg kuj hais tias tus active feem ntawm cov neeg saib xyuas reversibly ua txhua yam rau albumin. Vim hais tias ntawm cov me me ntsiab lus ntawm lub yav tas rau hauv lub interstitial kua, lub concentration ntawm cov tshuaj nyob rau hauv nws ib tug me ntsis ntau tshaj li nyob rau hauv lub ntshiab.

Nyob rau hauv dab tsi cov ntsiab lus uas cov tshuaj yog muab los ntawm ib tug neeg mob? Yuav ua li cas nws hais tias nyob rau cov lus qhia rau kev siv? "Lorakson» uas nws muaj pes tsawg leeg tau los sib tham saum toj no, yog tso tawm rau 8 teev (nrog rau cov kua tsib thiab zis). Nws yuav tsum tau muab sau tseg tias nyob rau hauv tus ntawm lub plab hnyuv muaj ntawm ib qho active keeb ntawm cov cuab tam yog hloov mus rau ib qho tsaug zog metabolite.

Nyob rau hauv tus me nyuam mos cov me nyuam mos, ib nrab-lub neej yog suav hais tias yog tshuaj ntawm 8 hnub, thiab nyob rau hauv cov neeg laus (tshaj 70 xyoo), lub sij hawm no yog 2 lub sij hawm ntau.

Lub kinetics ntawm cov tshuaj nyob rau hauv tshwj xeeb mob

Thaum malfunctions raum system thiab nyob rau hauv pathologies ntawm lub siab nyob rau hauv neeg laus tib neeg lub tshuaj ntawm ceftriaxone yog suab unchanged, ib tug ib nrab-lub neej lub sij hawm yog lengthened tsis tseem ceeb.

Thaum lub raum muaj nuj nqi yog nyom ho, lub tshem tawm ntawm cov tshuaj yuav siv sij hawm qhov chaw mas nrog cov kua tsib, tab sis yog puas siab, lub ceftriaxone muab mas ntawm ob lub raum.

Nyob rau hauv cov me nyuam mos thiab cov me nyuam nrog ib tus mob o ntawm lub meninges no medicament yuav txeem mus rau hauv lub hlwb txha nqaj qaum kua. Nyob rau hauv cov laus uas meningitis tom qab 5-25 teev tom qab thawj coj ntawm ib tug ntau npaum ntawm ceftriaxone 50 mg / kg lub cev hnyav ob peb lub sij hawm nws concentration tshaj lub MIC, uas yog yuav tsum tau rau kev tsuj ntawm cov kab mob uas ua rau tus kab mob.

zaj lus tim khawv

Thaum yuav tsum ua li cas nrog rau cov tshuaj txhaj "Lorakson 500"? Cov lus qhia rau kev siv (tshuaj yuav tsum tau muab tsuas yog ib tug kws kho mob) hais tias cov tshuaj no yog tsim los kho kab mob thiab inflammatory kab mob tshwm sim los ntawm cov kab mob rhiab mus rau yeeb tshuaj. Yog li, nws yog koom siv nyob rau hauv:

• meningitis;
• kab mob ntawm Upper pa ib ntsuj av tau;
• sepsis;
• mob txeeb zig thiab raum;
• kab mob nyob rau hauv lub tsev me nyuam system (xws li gonorrhea);
• mob plab kab mob (xws li inflammatory kab mob ntawm txoj hnyuv, peritonitis, biliary ib ntsuj av tau tus kab mob);
• kab mob ntawm daim tawv nqaij;
• kab mob ntawm cov pa ib ntsuj av tau (xws li mob ntsws muaj dej);
• kab mob, ob leeg thiab pob txha ntaub so ntswg;
• kab mob nyob rau hauv cov neeg uas muaj nws txo qis kev tiv thaiv.

Tsis tas li ntawd, txhais tau tias tej zaum yuav muab suav hais tias qhia rau kev tiv thaiv ntawm cov kab txhab nyob rau hauv lub postoperative lub sij hawm.

Bans lub sij hawm

Puas muaj tej contraindications aforementioned tshuaj? Yuav ua li cas nws hais tias lub nrog cov lus qhia rau kev siv? "Lorakson" indications uas tau raug teev tseg saum toj no, yuav tsum tsis txhob muab nyob rau hauv cov nram no mob:

• neeg mob nrog npau taws me ntsis rau penicillins thiab cephalosporins;
• nyob rau hauv thawj peb lub hlis uas cev xeeb tub.

Nrog ib tug ceev faj cov tshuaj no yog pom zoo rau cov neeg uas muaj lub siab tus kab mob, mob plab thiab enteritis. Tsis tas li ntawd, ceev faj yuav tsum tau siv thaum NUC, hyperbilirubinemia nyob rau hauv tus me nyuam mos cov me nyuam mos nyob rau hauv lub ob lub trimesters uas cev xeeb tub, ntxov ntxov cov me nyuam mos thiab pub niam mis.

Cov lus qhia rau kev siv

"Lorakson" los siv rau cov neeg mob intravenously los yog intramuscularly. Qhov nruab nrab txhua hnub ntau npaum ntawm cov tshuaj rau cov neeg laus thiab cov me nyuam los ntawm 12 xyoo ntawm lub hnub nyoog yog li 1-2 g ib hnub ib zaug (txhua txhua 24 xuaj moos).

Nyob rau hauv loj heev zaum, raws li zoo raws li kab mob uas tshwm sim los ntawm pathogens mob pesnrab rhiab, ib tug txhua txhua hnub koob tshuaj no neeg sawv cev yuav tau nce mus rau 4 g

Tshiab khiv yug me nyuam nyob rau hauv txoj kev saib xyuas cov tshuaj 1 lub sij hawm ib hnub twg yog pom zoo cov nram qab no ntau npaum: 20-50 mg / kg (mus txog 2 lub lim piam ntawm lub hnub nyoog).

Tus me nyuam cov me nyuam thiab cov me nyuam mus txog 12 xyoo, lub koob tshuaj ib hnub twg yuav tsum tau 20-75 mg / kg. Cov me nyuam hluas nrog lub cev hnyav ntawm 50 kg medicament noj tshuaj npaum cas muab nyob rau hauv cov neeg laus.

Lub caij ntawm kev kho mob los ntawm qhov no txhais tau tias nyob rau tus kab mob no.

Cov ntsiab lus uas npaj kev daws teeb meem

Yuav ua li cas npaj ib tug yeeb tshuaj tov? Yuav ua li cas no nqi hais tias phau ntawv qhia? "Lorakson" tso tawm daim ntawv uas tau raug nthuav saum toj no, rau intramuscular txhaj yuav tsum tau diluted (1 g) nyob rau hauv 3.5 ml ntawm 1% - tov ntawm lidocaine, thiab ces nkag mus tob lawm hauv cov gluteal nqaij.

Yuav kom npaj ib tug formulation tso dej raws leeg txhaj tshuaj, 1 g ntawm hmoov yuav tsum tau diluted nyob rau hauv 10 ml distilled dej (muaj menyuam tsis taus). Qhov kawg cov tshuaj yuav tsum tau maj mam nkag mus rau hauv cov hlab ntsha (rau 4 feeb).

Tso dej raws leeg Txoj kev lis ntshav ntawm 2 g ntawm cov tshuaj yuav tsum tau kom yaj nyob rau hauv 40 ml ntawm ib tug tov (e.g., sodium tshuaj dawb, dextrose los yog fructose), pub dawb los ntawm calcium. Qhov no Txoj kev lis ntshav yuav tsum tau nqa tawm tsawg kawg yog ib nrab ib teev.

Tshwm sim los ntawm-cim

Puas muaj cov tsis zoo tshua cov tshuaj tov "Lorakson"? Cov lus qhia rau kev siv (tshuaj yuav tsum tau ua xwb nyob rau hauv lub tsev kho mob) cav tias nyob rau hauv lub ntsiab lus teb ntawm kev siv cov tshuaj no rau tus neeg mob tej zaum yuav tsim:

• xeev siab, leukopenia thiab ntuav, granulocytopenia, raws plab, hypocoagulation, cem quav, hemolytic anemia, flatulence, lymphopenia;
• mob plab, phlebitis, saj ntxaug, mob raws leeg, stomatitis, urticaria, glossitis, neutropenia;
• pseudomembranous enterocolitis, infiltration thiab rhiab ntawm qhov chaw ntawm intramuscular cov thawj coj, impaired siab muaj nuj nqi;
• raum tsis ua haujlwm, goiter, thrombocytosis, glycosuria, thrombocytopenia, oliguria, tawm pob, azotemia, bronchospasm;
• nce ntawm urea nyob rau hauv cov ntshav, eosinophilia, hypercreatininemia, polymorphic erythema, cylinduria, epistaxis, hematuria, superinfection, anuria;
• kub taub hau, ntshiab kev mob kev nkeeg, kub taub hau, angioedema, pruritus, kiv taub hau, anaphylactic poob siab, Candidiasis, mob taub hau.

Kev koom tes thiab mob ntawm overdose

Overdose ntawm cov nyiaj yog manifested kiv taub hau, mob taub hau, paresthesia, convulsions, encephalopathy thiab coma. Yuav kom tshem tawm cov phenomena thov symptomatic kev kho mob, thiab txhawb qhov tseem ceeb heev functions ntawm lub cev.

Tib mus kho mob nrog ceftriaxone nrog aminoglycosides tsub kom lawv antibacterial kev ua si. Nyob rau hauv thiaj li yuav tiv thaiv tau cov tshuaj lom nyhuv ntawm cov ua hauj lawm yog xeem nyob rau txawv sij hawm thiab nyob rau hauv qhov chaw sib txawv.

Siv nyob rau hauv thaum uas tig mus "Loraksona" platelet aggregation inhibitors thiab narcotics yuav muab yog ib tug yuav muaj los ntshav.

Thaum koj tau txais ib tug "voj" diuretics, muaj yog ib tug zoo kev pheej hmoo ntawm nephrotoxicity.

Saib cov tshuaj incompatible nrog ethanol, raws li no thaum lawv tseem ua mob loj heev xeev siab, chua nyob rau hauv lub epigastric cheeb tsam, ntuav, kais, yuav txo tau ntawm cov ntshav siab thiab tachycardia.

Nws yog nruj me ntsis txwv tsis pub ntaus nyob rau hauv ib tug koob txhaj ceftriaxone thiab lwm yam tshuaj tua kab mob.

Zoo ib yam li cov tshuaj thiab cov tswv yim nyob rau hauv cov tshuaj

Tam sim no koj paub tias dab tsi yog ib tug "Lorakson". Cov lus qhia rau kev siv, txhais tau tias analogs yog tham nyob rau hauv no tsab xov xwm.

Yuav ua li cas yuav hloov tau cov tshuaj? Rau zoo xws li cov tshuaj kws txawj xav txog cov nram qab no: "Ceftriaxone-Promed" "Ceftriaxone-Elf," "Tsefogram", "Tsefson" "Ceftriaxone-Protekh" "Ceftriaxone-Dzhodas", "Tseftriabol", "Tsefatrin".

Raws li cov lus teb ntawm cov neeg mob, feem ntau tseem ua hauj lwm nrog cov txhais tau tias lawv tau siv los kho Upper pa kab mob thiab ua pa ib ntsuj av tau kab mob. Cais lawv cov lus, peb yuav xyuam xim xaus nws ceev ceev txiav txim thiab high efficiency. Nws yuav tsum tau muab sau tseg tias thaum uas siv cov tshuaj no nyob rau hauv ib co neeg mob muaj me sab los hais tias tsis tau yuav tsum tau discontinuation ntawm txoj kev kho.