Cov tsos mob thiab kev kho mob ntawm serotonin syndrome

Tus ntse nce nyob rau hauv cov theem ntawm serotonin - ib tug es loj mob, uas yog nrog los ntawm loj ua txhaum nyob rau hauv lub chaw ua hauj lwm ntawm tag nrho cov kab mob. Feem ntau, cov kev hloov no yog cov kev tshwm sim ntawm kev noj tej yam tshuaj los yog overdose los ntawm ntau yam tshuaj. Nyob rau hauv lub qhaj ntawv ntawm raws sij hawm kev kho mob qhov teeb meem no yog fraught nrog kev txaus ntshai, tej zaum irreversible txim. Nws yog yog li ntawd tsim nyog yuav tau xav txog cov lus qhia txog dab tsi yog qhov ua rau thiab cov tsos mob ntawm serotonin syndrome. Yuav ua li cas kho mob yuav muab niaj hnub tshuaj thiab qhov ntau fraught nrog tsis muaj kev kho mob?

Serotonin syndrome: yog dab tsi?

Nyob rau hauv qhov tseeb, cov thawj cov lus qhia txog lub xeev no nyob tsis yog li ntawd ntev dhau los. Nyob rau hauv 1960 nyob rau hauv lub tebchaws United States thawj cov kev tshawb fawb tau luam tawm ntawm cov ntawv no. Lub fact tias cov ua rau ntawm lub syndrome, uas, nyob rau hauv qhov tseeb, nrog los ntawm ib tug ntse nce nyob rau hauv lub kom muaj nuj nqis ntawm cov tshuaj yeeb dej caw nyob rau hauv lub paj hlwb, nyob rau hauv cov zaubmov, yog txuam nrog rau antidepressants.

Nws yog lub npe hu hais tias serotonin deficiency syndrome ua rau txoj kev loj hlob ntawm kev nyuaj siab. Thiab nyob rau hauv lub xyoo pua xeem nws yog invented ib tug kho rau xws ua txhaum, tam sim no lub npe hu ua "antidepressants". Cov tshuaj pab rau kom cov theem ntawm serotonin, paub ncha li cov "kev zoo siab lawm". Nyob rau hauv lawv cov cawv, mob nkees thiab apathy maj ploj, thiab cov neeg maj mam rov qab mus rau li qub lub neej. Txawm li cas los, ib yam nkaus thiab loj qhov ntau ntawm serotonin ua raws li ib tug taug, nyhuv dejnum rau paj hlwb, ua rau ib tug luj tsis meej nyob rau hauv tus kab mob. Ib tug zoo xws li cov syndrome tej zaum yuav raws li ib tug tshwm sim ntawm antidepressants, thiab ib tug ua ke ntawm antidepressants thiab lwm yam tshuaj (e.g., ib txhia ntawm hnoos syrups thiab thiaj li nyob. D.).

Nyob rau hauv qhov tseeb, nyob rau hauv lub ntiaj teb no, tus neeg mob ntawm serotonin syndrome yog kaw tsis yog li ntawd feem ntau. Tab sis, raws li cov kws kho mob thiab soj ntsuam ntawm, nws tshwm sim xwb vim hais tias cov teeb meem disguised raws li ib tug loj imperceptible cov tsos mob, uas feem ntau yog blamed rau paj lim los yog qaug zog. Nws yog yog li ntawd tsim nyog paub txog yog vim li cas serotonin syndrome zaum yuav tshwm sim, dab tsi yog nws thiab yog dab tsi tej yam tshwm sim raws li.

Lub ntsiab functions ntawm serotonin

Nws yog ib nqi kom paub cov mechanism ntawm qhov kev txiav txim ntawm "kev zoo siab lawm", ua ntej koj xaiv lo lus nug ntawm yuav ua li cas thiab vim li cas loj hlob serotonin syndrome. Yuav ua li cas yog khoom no? Lub ntsiab muaj nuj nqi yog cov kev cai ntawm serotonin zog nyob rau hauv tej yam neurons nyob rau hauv lub hlwb. Dhau los ntawm lub synaptic cleft los ntawm ib tug neuron, qhov no tshuaj reacts nrog kev receptors nyob rau hauv daim nyias nyias ntawm lub nyob ib sab paj ntawm tes, activating nws thiab firing paj lam ua.

Muaj ntau ntau systems uas yuav tswj tus nqi ntawm cov serotonin nyob rau hauv lub cev. Nyob rau hauv kev, qhov no reuptake, nyob rau lub molecule rov mus ua tus thawj neuron (incidentally, feem ntau antidepressants yog inhibitors ntawm serotonin reuptake) thiab enzymatic kev cai, nyob rau hauv uas tshwj xeeb active tshuaj muab siab npuab lawm molecule.

Serotonin regulates ntau dab nyob rau hauv lub cev, xws li:

• lub sij hawm ntawm pw tsaug zog thiab wakefulness;
• qab los noj mov;
• txoj kev loj hlob los yog disappearance ntawm cov kev xav ntawm xeev siab;
• kev sib deev tus cwj pwm;
• thermoregulatory mechanisms;
• lub xaav ntawm kev mob;
• kev pab txhawb nqa ntawm nqaij laus;
• kom ntawm cov hnyuv;
• cov kev cai ntawm vascular laus;
• Nws muaj pov thawj hais tias serotonin yog muab kev koom tes nyob rau hauv lub mechanisms ntawm migraine.

Raws li yuav pom, "zoo siab cov tshuaj hormones" muab tib neeg lub cev tsis yog tsuas yog ib tug kev xav ntawm kev zoo siab. Tom qab kev kawm cov kev ua ntawm no yeeb tshuaj, nws yog tau xav txog tej yam ib co tsos mob ntawm serotonin syndrome. Los ntawm txoj kev, lub siab tshaj plaws cai concentration ntawm cov hormone nyob rau hauv lub hlwb qia thiab reticular tsim.

Serotonin syndrome: biochemistry. Yuav ua li cas yuav ua rau ib tug ua txhaum?

Raws li twb tau hais, qhov no ua txhaum, rau qhov cov tsim thaum noj tej yam tshuaj, los yog ib tug ua ke ntawd. Yog li ntawd yog dab tsi tshuaj yuav ua rau txoj kev loj hlob ntawm txaus ntshai kab mob xws li serotonin syndrome?

• "Tsipraleks" thiab lwm yam khoom cua serotonin reuptake inhibitors thiab monoamine oxidase.
• Tib mus kho mob nrog monoamine oxidase inhibitors thiab thyroid hormones, "clomipramine", "carbamazepine", "imipramine" thiab "Amitriptyline".
• Mao inhibitors thiab ib tug ua ke ntawm ib co tshuaj siv rau poob, nyob rau hauv particular "Dezopimona", "fepranona".
• Lub ua ke ntawm ib tug SSRI los yog Mao contact lenses nrog npaj muaj L-tryptophan, St. John lub wort extract thiab ecstasy.
• Lub ua ke ntawm lithium nrog antidepressant tshuaj, nyob rau hauv kev lub "Kontemnola" thiab "Kviloniuma".
• Tib mus txais tos ntawm inhibitors thiab dextromethorphan (ib yam khoom uas yog nyob rau hauv ntau hnoos syrups, xws li "Kaffetin Khaub thuas", "Glikodin", "Tussin Plus" thiab ib txhia lwm leej lwm tus.
• Lub ua ke ntawm serotonin reuptake inhibitors nrog tshuaj xws li "dihydroergotamine", "sumatriptan" (migraine yeeb siv tshuaj), "Levodopa" (siv nyob rau hauv Parkinson tus kab mob).
• Muaj pov thawj hais tias serotonin syndrome yuav tshwm sim nrog rau kev siv cov dej cawv nyob rau hauv lub keeb kwm yav dhau ntawm antidepressant txoj kev kho.

Tam sim ntawd nws yog tsim nyog hais tias hais tias kwv yees seb puas yuav tsim lub syndrome nyob rau tom qab ntawm ib tug kws kho mob lub sij hawm teem tseg txoj kev kho, yog zoo tsis yooj yim sua. Nws tag nrho cov nyob rau hauv lub koob tshuaj, tus neeg yam ntxwv ntawm tus neeg mob, nws muaj hnub nyoog thiab muaj ntau yam lwm yam. Txawm li cas los, Yog hais tias koj cov kws kho antidepressants, kom paub tseeb tias koj qhia koj tus kws kho mob txog txhua yam tshuaj uas koj noj thiab nco ntsoov mus sab laj nyob rau hauv cov kev taw qhia ntawm cov tshiab tswvyim ntawm txoj kev kho, seb nws yog txawm ib txwm hnoos phoov.

Lub ntsiab yam ntxwv ntawm tus soj ntsuam daim duab

Yuav ua li cas yog lub serotonin syndrome? Tej yam tshwm sim ntawm ib nrab ntawm cov neeg mob yuav tshwm sim tom qab 2-4 xuab moos tom qab haus. Tab sis cov thawj cov tsos mob tej zaum yuav tshwm sim thiab ib hnub twg. Nyob rau hauv kev twb kev txuas nrog lub ntsiab zog ntawm serotonin, tag nrho cov tau ua txhaum cai raug muab faib mus rau hauv peb lub ntsiab pawg:

• puas siab puas ntsws;
• los ntawm nqaij muaj teeb meem thiab peripheral tshee systems;
• autonomic ntshawv siab.

Tag nrho cov tau cov tsos mob yuav piav hauv qab no, tab sis ua ntej nws yuav tsum tau hais tias ntau yam infringements tsis yog ib tug nyias muaj nyias ib lub hauv paus rau lub formulation ntawm xws li ib tug mob. Tsuas yog ib tug ua kom tiav lub cev kev xeem, kuaj kev tshawb fawb, thiab lawv muaj nyob rau hauv tej yam cov tsos mob thiab tau muaj tej yam ua rau nws tau mus tshawb nrhiav qhov tshaj serotonin nyob rau hauv lub paj ntaub so ntswg.

Puas siab puas ntsws rau lub hauv paus ntawm lub syndrome

Yuav ua li cas kom paub txog serotonin syndrome? Cov tsos mob feem ntau yog pib muaj kev puas hlwb kev ntshawv siab, xws li:

• lub siab lub ntsws arousal;
• qhia, causeless ntshai thiab ntxhov siab vim, tej zaum mus rau lub point ntawm ntshai tsam;
• tej zaum kuj yog lwm daim duab - tus neeg pom tau tias ib tug txiav txim zoo ntawm kev zoo siab, mob siab heev kev xyiv fab, muaj lub siab yuav tsiv mus nyob, hais lus incessantly thiab ua ib yam dab tsi txog nws;
• tau puas nco qab;
• Nyob rau hauv ntau mob loj, muaj cov tsos ntawm delusions thiab hallucinations.

Nws yog ib nqi sau cia hais tias cov tsos mob thiab cov neeg kawm ntawv ntawm hnyav yog ncaj qha nyob rau hauv lub heev ntawm cov tshuaj lom los. Piv txwv li, tej zaum tsuas yog ib lub me ntsis excitation yog cai. Nyob rau hauv lwm tus neeg mob muaj yog ib tug ntsuas cov tsos mob ntawm tus lwm kab mob (e.g., kev nyuaj siab), vim uas cov tshuaj txuas ntxiv. Nyob rau hauv lub feem ntau loj heev zaum, tus neeg mob suffers los ntawm tsis meej pem, tsis meej pem nyob rau hauv lub ntiaj teb no thiab nws tus kheej, kev txom nyem los ntawm delusions thiab hallucinations sib txawv.

Lub ntsiab vegetative cov tsos mob

Muaj mob lwm yam uas nrog serotonin syndrome. Puas tsuaj los ntawm ib tug ntse sawv nyob rau hauv cov theem ntawm no substance yuav saib rau lwm txoj kev. Nyob rau hauv kev, lub cai thiab autonomic mob, nrog rau cov nram qab no:

• dilated cov menyuam kawm ntawv, thiab muaj zog lacrimation;
• kom nyob rau hauv lub plawv dhia, tachycardia;
• nce nyob rau pa nqi;
• tej zaum kuj yog kub ib ce (feem ntau, nws yog me me, tab sis kaw ua npaws kub 42 degrees nyob rau hauv ib co neeg mob);
• ib tug ntse nce nyob rau hauv cov ntshav siab nrog concomitant cov tsos mob kom txog thaum tsis nco qab;
• cov tsos ntawm dryness nyob rau hauv lub qhov ncauj thiab nyob rau ib co lwm yam txheej week;
• accelerating hnyuv kom, uas nyob rau hauv lem yuav ua rau mob xws li mob raws plab, mob xeev siab thiab ntuav, flatulence, tsam plab thiab mob plab ntawm qhov ntau heev;
• xav lub ntsawj txias;
• Mob taub hau, tej zaum yastes yastaw.

Raws li koj tau pom, cov tsos mob ntawm tus kab mob no yog tsis heev tej, vim hais tias cov tib tsos mob tej zaum yuav nrog los ntawm ib tug kaum os cov lwm yam kab mob.

Neuromuscular mob nyob rau tom qab ntawm lub syndrome

Raws li twb tau hais, serotonin regulates lub kis tau tus mob ntawm cov hlab impulses. Uas yog vim li cas qhov kev hloov nyob rau hauv lub theem ntawm no substance muaj feem xyuam rau cov neuromuscular kev ua si. Ntawm no yog ib daim ntawv teev uas tau mob:

• nce kev siv ntawm txog leeg reflexes (tshwj xeeb tshaj yog cov lus hais yog qis povtseg reflexes);
• kev txhim kho ntawm nqaij laus thiab tej thaum mus txog rau npag rigidity;
• ceev ceev thiab tsis tuaj yeem spasmodic contraction ntawm ib tug neeg cov nqaij (tej zaum txawm tag nrho cov pab pawg ntawm cov leeg);
• trembling ntawm lub nqua;
• tsis tuaj yeem taw ntawm lub ceev ceev (rau lub hom phiaj no nyob rau hauv cov tshuaj rau hauv lub sij hawm "nystagmus" yog siv);
• tej zaum kuj yog ib tug thiaj li hu ua lub qhov muag spasm, uas yog nrog los ntawm cov tsis tuaj yeem dov ntawm lub eyeballs nce los yog;
• puav kaw qaug dab peg;
• tsis muaj kev sib koom tes;
• teeb meem nrog hais lus, nws qhov muag plooj thiab inaccuracy uas tshwm sim vim cov tsis tuaj yeem contraction ntawm cov nqaij ntshiv ntawm articulation apparatus.

Nws yog to taub hais tias tag nrho cov saum toj no cov tsos mob ntawm serotonin syndrome tshwm sim tsis tshua. Nyob rau hauv feem ntau tus neeg mob, cov neeg mob raug kev txom nyem tsuas yog los ntawm ib co ntawm cov kev ua txhaum, thiab yog li ntawd mob ntawm tus kab mob yog ib tug heev cumbersome txheej txheem.

Lub degree ntawm tus kab mob heev

Nyob rau hauv niaj hnub tshuaj yog muab faib ua peb degrees ntawm heev ntawm lub syndrome, xws li:

• Me me kab mob no yog nrog, raws li ib tug txoj cai, nce tawm hws, tsis muaj zog co nyob rau hauv lub ob txhais tes thiab hauv caug, tsis dhau pronounced nce nyob rau hauv lub plawv dhia. Reflexes kuj los ua ib tug me ntsis loj heev, txawm hais tias lub cev kub tsis sawv. Tej zaum tus neeg mob tej zaum yuav pom tus menyuam kawm ntawv dilation. Nws yog tsuas ntuj hais tias cov neeg zoo li no cov tsos mob tsis tshua mus rau tus kws kho mob, thiab mus txuas ntxiv muab tshuaj, vim hais tias nws yog tus saum toj no cov tsos mob yuav tshwm sim los ntawm kev nyuaj siab los yog overexertion.
• Nyob rau hauv loj tsawv soj ntsuam daim duab ntawm tus kab mob yog xav paub ntau pronounced. Cov neeg mob sau tseg ib tug ntse nce nyob rau hauv lub cev kub (tej thaum mus txog rau 40 degrees), thiab cov ntshav siab, pheej dilation ntawm cov tub kawm ntawv, cov yuav txo tau ntawm cov leeg, lub cev muaj zog thiab kev puas hlwb kev zoo siab. Feem ntau, cov tsos mob no ua rau ib tug neeg mus nrhiav kev pab, tab sis hmoov tsis, muab tso rau qhov tseeb mob yog tsis ib txwm tau.
• Loj serotonin syndrome yog tsis tshua muaj txaus ntshai, raws li nws yuav ua tau kom mob. Nyob rau hauv daim ntawv no ntawm pathology cai ib tug muaj zog tachycardia, nce ntshav siab, kub taub hau, mob nqaij pob chua kom txog thaum tus nruj, lub paj hlwb kev ntshawv siab, tsis meej pem. Cov neeg mob feem ntau yog muaj kev heev tiag tiag li hallucinations. Nyob rau hauv lub qhaj ntawv ntawm raws sij hawm kev pab tej zaum yuav puas nqaij, daim siab thiab lub raum. Feem ntau, cov neeg mob poob rau hauv ib tug coma. Qee zaus tsim ntau yam khoom hauv nrog cev tsis ua hauj lwm, uas feem ntau yog xaus rau hauv txoj kev tuag.

Uas yog vim li cas nyob rau hauv txhua rooj plaub yuav tsum tsis txhob las mees cov tsos mob vim hais tias nws muaj peev xwm masquerade raws li ib tug qub serotonin syndrome overwork. Yuav ua li cas kom tau tawm ntawm lub xeev no, thiab seb puas muaj cov zoo kev kho mob?

Thawj pab nyob rau hauv lub xeev no

Yuav ua li cas yog tias ib tug neeg yog xav tias serotonin syndrome? Thaum muaj xwm ceev kho mob feem ntau yog ib tug tam sim ntawd cessation ntawm cov tshuaj, uas txhais mob no. Lawm, koj yuav tsum tau twv yuav raug hu tau tus neeg mob mus rau lub tsev kho mob.

Nws thawj pais plab lavage, ua tau mus ntxuav lub cev ntawm ib tug tshuaj uas muaj tseem tsis tau muaj lub sij hawm yuav absorbed. Nrog rau tib lub hom phiaj, cov neeg mob tshuaj tshuaj thiab lwm yam sorbents deducing toxins los ntawm lub cev. Nyob rau hauv me me mob ntawm tej txheej xwm no yog txaus kom cov neeg zoo. Cov tsos mob yog sau tom qab 6-12 teev.

Yuav ua li cas yog cov kev kho mob ntawm cov syndrome?

Tu siab, tshuaj ntsoos ntsoos thiab ntxuav lub cev los ntawm cov khib nyiab yog tsis ib txwm txaus. Yog li ntawd yog dab tsi kho yuav tsum tau serotonin syndrome? Kev kho mob, ntawm chav kawm, nyob rau cov theem thiab heev. Feem ntau, ib tug neeg mob taw serotonin receptor antagonists, xws li "methysergide" thiab "Cyproheptadine". Tsis tas li ntawd, ua symptomatic txoj kev kho, uas yog nyob rau hauv lub xub ntiag ntawm tej yam mob.

• Piv txwv li, nyob rau hauv epileptic qaug dab peg thiab nqaij rigidity muab benzodiazepines, xws li "lorazepam" thiab "Sibazon".
• Nyob rau hauv lub xub ntiag ntawm kub cev yog nqa tawm txias rubdown thiab ib co lwm cov kev. Qhov tseeb hais tias tus sawv nyob rau hauv kub thaum serotonin syndrome yog tsis txuam nrog o, thiab nrog ntau zog nqaij contractility, thiab vim hais tias cov pa antipyretic thiab nonsteroidal anti-inflammatory siv tshuaj muaj tsis ntxim. Lub tsuas kos yog paracetamol, tab sis nws yuav tsum tau siv kom zoo zoo.
• Thaum lub kub nce mus rau 40 thiab ntau nqaij hnaiv yog muab rau ib tug neeg mob. Cov tshuaj pab los so kom txaus rau cov nqaij ntshiv, tshem tawm kub taub hau, los mus tiv thaiv cov kev loj hlob ntawm ntau yam mob, xws li cov teeb meem nrog cov ntshav txhaws.
• Tsis tas li ntawd tso dej Txoj kev lis ntshav ua raws li ntev li tawm hws, raws plab, mob nro thiab ua rau lub cev qhuav dej.
• Tsis tas li ntawd, nws yog tsim nyog los saib xyuas cov ntshav siab thiab lub plawv dhia ntawm tus neeg mob, yog tias tsim nyog normaliziruya cov nuj nqis nrog rau cov kev pab los ntawm cov tshuaj.

Nyob rau hauv feem ntau tus neeg mob, kom ua txoj kev kho yuav sai txhim kho cov mob ntawm tus neeg mob thiab kom tsis txhob muaj lub txim. Tu siab, nyob rau hauv uas tsis tshua muaj mob, tshwj xeeb tshaj yog yog hais tias tus neeg mob twb tsis tau muab raws sij hawm kev kho mob, serotonin syndrome tej zaum yuav ua rau disintegration ntawm cov nqaij cov ntaub so ntswg, lub siab thiab lub raum puas tsuaj, paj txoj, thiab nws thiaj li tuag. Uas yog vim li cas nyob rau hauv txhua rooj plaub yuav tsum tsis txhob maj mam coj antidepressants thiab lwm yam tshuaj.