"Glibenclamide": cov lus qhia rau kev siv, qhov kev tso tawm daim ntawv no, yees duab, analogs

Yuav ua li cas yog tus kho "glibenclamide"? Cov lus qhia rau kev siv, tso tawm daim ntawv no, analogues thiab indications rau lub koom haum saib xyuas ntawm cov tshuaj no muaj nyob hauv qab no.

Muaj pes tsawg leeg, ntim, daim ntawv tso cai cov neeg ua hauj

Nyob rau hauv dab tsi daim ntawv no yog ua los tshuaj "glibenclamide"? Phau Ntawv Qhia hais tias lub cuab tam yog ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj uas yog muab tso rau hauv hnab yas ntim (tus qauv npaj ntawm lub cell) thiab lub box ua los ntawm cov duab los qhia, ntsig txog.

Muaj pes tsawg leeg ntawm cov tshuaj nyob rau hauv kev saib xyuas muaj xws li 5 mg glibenclamide thiab koom haum pab khoom xyaw xws li qos starch, lactose monohydrate, magnesium stearate, sodium croscarmellose, indigo carmine E 132 colloidal silicon dioxide 25, thiab povidone.

Tshuaj txiav txim

Yuav ua li cas yog cov tshuaj "glibenclamide"? Cov lus qhia rau Siv hais tias qhov no txhais tau tias seeb hypoglycemic nyhuv noj qab nyob zoo neeg thiab cov neeg mob uas mob ntshav qab zib hom II.

Cov hauj lwm zoo cov tshuaj no vim nws muaj peev xwm yuav ua tau kom insulin secretion ntawm pancreatic beta hlwb vim lawv stimulation. Raws li cov kws txawj, qhov no nyhuv uas cov tshuaj no yog kho kom zoo nyob rau hauv tus ntawm qabzib.

Kev tig tau nta ib lub qhov ncauj formulation

Yuav ua li cas nta yog cov yam ntxwv ntawm pharmacokinetic tshuaj "glibenclamide"? Cov lus qhia rau kev siv siv hais tias tom qab qhov ncauj dosing ntawm cov ntsiav tshuaj ntawm lub active tshuaj yog sai thiab yuav luag tag absorbed los ntawm lub digestive ib ntsuj av.

Tib mus noj kom tsawg yuav ua rau ib tug txo ntawm lub glibenclamide concentration nyob rau hauv ntshav (piv nrog ib qho kev npliag plab). Cov kev twb kev txuas ntawm no tivthaiv nrog lub albumin tshaj 98%.

Tus neeg mob lub siab glibenclamide yog hloov dua siab tshiab rau hauv cov nram no metabolites: 3-cis-hydroxy-glibenclamide thiab 4-trans-hydroxy-glyburide. Lawv yog cov tso zis rau tus tib neeg los ntawm ob lub raum thiab, ua ke nrog rau cov quav.

Qhov mean tshem tawm ib nrab-lub neej ntawm cov tshuaj yog 2-3.5 teev. Nyob rau hauv cov neeg uas muaj impaired siab muaj nuj nqi, qhov no xam yog significantly txo.

Indications rau kev siv ntawm cov tshuaj

Nyob rau hauv tej rooj plaub, ib tug neeg mob tshuaj "glibenclamide" yuav raug muab tso? Qhov no txhais tau tias pom zoo kom noj cov neeg mob uas mob ntshav qab zib hom II, thaum tsis muaj tau pab kom txawm peem hyperglycemia nruj kev noj haus thiab kev qoj ib ce, los yog yuag poob.

Bans kev siv cov

Puas muaj tej contraindications nyob rau hauv lub tshuaj "glibenclamide"? Cov lus qhia rau Siv hais tias lub tsev no yuav tsum tsis txhob siv rau cov neeg mob uas muaj:

• uas nws kim heev kev kub nyhiab;
• Npau taws me ntsis rau lub active tivthaiv, thiab cov thiazide diuretic los yog sulfonamides;
• ketoacidosis;
• ntshav qab zib coma thiab prekomatosnoe lub xeev;
• txoj kev loj hlob ntawm hypoglycemia;
• kev phais thiab lwm yam kev poob plig;
• gastroparesis thiab plab hnyuv rhuav txhua;
• cev xeeb tub;
• mob ntshav qab zib thawj hom;
• pub niam mis.

Medicament "glibenclamide": cov lus qhia rau kev siv

Xam tias yog cov tshuaj yuav tsum tau muab nkaus xwb los ntawm ib tug kws kho mob. Qhov no tshuaj yuav tsum yeej ib txwm yuav ua ke nrog ib tug nruj kev noj haus. Tsuas yog nyob rau hauv cov ntaub ntawv no nws yuav pab tau zoo. nws ntau npaum nyob rau tus neeg mob kuaj tau (cov ntshav qab zib ntau ntau, ntsuas los ntawm cov zis, etc.).

Yog li ntawd yuav ua li cas coj cov tshuaj "glibenclamide"? Txoj kev kho uas txhais tau tias pib muaj tsawg heev koob tshuaj. Qhov no yog tshwj xeeb tshaj yog muaj tseeb ntawm cov neeg uas muaj ib tug ib txwm mus hypoglycemia thiab lub cev hnyav tsawg tshaj li 50 kg.

Feem ntau, thawj koob tshuaj ntawm cov medicament yog 0,5-1 ntsiav tshuaj ib hnub twg. Qhov no sau raws nkaus Ii 2.5-5 mg active ingredient. Thaum inefficient tshuaj txiav txim teev xov tooj yuav tsum maj mam nce mus rau peb cov ntsiav tshuaj ib hnub twg, coj mus rau 15 mg ntawm active ingredient. Qhov no yuav tsum tau ua nyob rau cov Team sib ntawm ib tug ob peb hnub mus rau ib lub lim tiam, txog thaum lub Desired tshwm sim yog tiav.

Yuav ua li cas mus rau cov hloov tus neeg mob mus rau lwm lub tshuaj nyob rau hauv cov tshuaj "glibenclamide"? Kev siv cov tshuaj nyob rau hauv cov ntaub ntawv no yuav tsum tau nqa tawm nrog huab ceev faj. Thawj, tus neeg mob yog cov tshuaj ntsiav tshuaj nyob rau hauv 0.5 teev, thiab ces maj mam nce lub koob tshuaj yuav tsum tau zoo tshaj plaws.

Cov laus thiab debilitated cov neeg mob los yog cov neeg mob uas noj tsis txaus thiab impaired siab los yog raum ua hauj lwm txhawb los yog cov thawj zaug ntau npaum cov tshuaj yog qhov kev kawm kom txo tau cov ntxim yuav zoo siv ntawm kev loj hlob ntawm hypoglycemia. Tsis tas li ntawd txiav txim siab nyob rau hauv qhov tseeb koob tshuaj ntawm cov tshuaj yuav tsum tau nrog zuj zus lawm lub cev hnyav los yog thaum hloov nws txoj kev cai ntawm lub neej.

Ib tug qauv rau kev tau txais hypoglycemic ntsiav tshuaj

Yuav ua li cas siv cov tshuaj "glibenclamide"? Cov lus qhia rau kev siv (yees duab ntawm cov tshuaj no yog hais nyob rau hauv no tsab xov xwm) hais tias saib cov ntsiav tshuaj yuav tsum tau noj ua ntej noj mov nrog ib tug iav ntawm dej thiab tsis muaj kev zom khoom.

Thaum ib tug txhua txhua hnub ntau npaum ntawm 2 ntsiav tshuaj, nws yog pom zoo kom faib lub medicament nyob rau hauv 2 faib koob tshuaj (thaum sawv ntxov thiab yav tsaus ntuj) nyob rau hauv ib qho ratio ntawm 2: 1.

Nws yog tsis tshua muaj ib qho tseem ceeb rau siv yam tshuaj no nyob rau tib lub sij hawm. Twg tus txais tos cov ntsiav tshuaj formulation txwv tsis pub noj ua ke nrog rau cov nram qab no.

Lub caij ntawm txoj kev kho nrog no neeg sawv cev nyob rau tus kab mob no. Thoob plaws hauv lub chav kawm ntawm kev kho mob yuav tsum tau nqa tawm tas mus li xyuas ntawm tus neeg mob lub xeev ntawm cov kev pauv tshuaj.

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Lub medicament "Glibenclamide" analogs uas muaj li nram no, yuav ua rau txoj kev loj hlob ntawm pliaj tshua rau lub paj hlwb, endocrine, peripheral thiab digestive systems thiab hematopoietic. Nyob rau hauv no hais txog, tus neeg mob tej zaum yuav tshwm sim cov nyom cov tsos mob xws li xeev siab, hypoglycemia ntawm qhov ntau heev, hepatic kawg, raws plab, mob taub hau, cholestasis, tsis muaj zog, kiv taub hau thiab nkees heev.

Nws yuav tsum tau muab sau tseg tias kom tsawg ntawm lub cuab tam tsis cais cov tsos ntawm dermatological thiab kev tsis haum tshuaj raws li photosensitivity, khaus, daim tawv nqaij ua pob liab vog thiab lwm yam unpleasant cov tsos mob.

Overdose mob hypoglycemic cov neeg ua hauj

Yuav ua li cas cov tsos mob tshwm sim thaum ntau dua koob tshuaj noj tshuaj "glibenclamide"? Phau ntawv hais tias ib tug overdose, tus neeg mob tej zaum yuav tsim hypoglycemia, tejzaum nws nrog tsis muaj zog, cov kev xav ntawm kev tshaib kev nqhis, mob taub hau, ntxhov siab vim, tawm fws, kiv taub hau, mob nqaij pob co, palpitations, o ntawm lub paj hlwb, lub zeem muag thiab hais lus ntshawv siab.

Kev kho mob ntawm xws tej yam kev mob yuav tsum tau ceev nkag glucose-digestible khoom noj khoom haus. Piv txwv li, txiv hmab txiv ntoo kua txiv, qab zib, pob kws phoov, qab zib kub tshuaj yej los yog zib mu.

Nyob rau hauv ntau mob loj, tus neeg mob yog muab ib tug 50% zib tov, "Dextrose" "Glucagon" los yog "Diazoxide". Nws kuj yuav tsum tau tshwj xeeb kev tswj ntawm glycemia, creatinine, urea nitrogen, electrolytes thiab txiav txim pH.

Sis nrog rau lwm cov kev kho mob txhais tau hais tias

Lub ua ke ntawm qhov suav hais tias cov tshuaj nrog anti-mauj tshuaj, tetracyclines, fluoroquinolones, chloramphenicol, Mao inhibitors, thiab ACE, H2-blockers, "clofibrate" beta-blockers, probenecid, bezafibrate, "paracetamol", anabolic steroids, ethionamide, allopurinol, pentoxifylline, cyclophosphamide "reserpine", insulin thiab sulfonamides yog tau potentiate hypoglycemia.

Tib daim ntawv thov ntawm cov tshuaj nrog phenothiazines, thyroid thiab glucocorticoid cov tshuaj hormones, barbiturates, estrogens, diazoxide, progestins, glucagon, lithium ntsev, Adrenomimeticalkie txhais tau tias saluretikami nicotinic acid thiab derivatives yuav tsis muaj zog nws hypoglycemic nyhuv.

Tej formulations yog acidified zis (xws li ammonium tshuaj dawb, poov hlau tshuaj dawb, ascorbic acid), yuav txhim khu qhov kev txiav txim ntawm lub xam tau tias yog medicament.

Txoj kev siv "glibenclamide" nrog "rifamycins" accelerates inactivation thiab txo cov hauj lwm zoo ntawm cov qub.

tej ntaub ntawv

Hypoglycemic neeg sawv cev yuav tsum raug xam tias yog nrog ceev faj rau cov neeg mob kev txom nyem los ntawm lub raum tsis ua hauj lwm thiab lub siab, raws li tau zoo raws li pathological cov thyroid thiab adrenal qog, febrile tej yam kev mob thiab mob alcoholism.

Mus nqa tawm lub qub kho mob yuav tsum xyuas ntawm cov ntshav piam thaj ntau ntawm tus neeg mob, raws li tau zoo raws li nws cov feem.

Yog hais tias qhov tsawg ntawm cov tshuaj tus neeg mob muaj hypoglycemia, lub qab zib taw sab hauv (nyob rau hauv rooj plaub yog tias tus neeg ntawd yog meej pem). Yog tsis nco lawm, qabzib yog xeem intravenously, thiab glucagon - subcutaneously, intramuscularly los yog intravenously. Tom qab tus neeg mob tsim thaum, nws yuav tam sim ntawd muab khoom noj khoom haus, nplua nuj nyob rau hauv carbohydrates, nyob rau hauv kev txiav txim kom tsis txhob muaj ib tug tsis tshua mob heev ntawm hypoglycemia.

Nqi thiab analogues (txhais) txhais tau tias

Xaiv cov analogs ntawm cov tshuaj no yuav tsum tsuas muaj ib txog tej kev. Rau cov kws kho mob li tshuaj muaj xws li cov nram qab no: "Manin", "Manin", "Maniglid", "Betanaz" thiab "Antibet".

Nws yuav tsum tau muab sau tseg tias nyob rau hauv cov chaw muag tshuaj feem ntau muag txhais ntawm no lub cuab tam. Cov feem ntau siv lawv, "Glidanil", "Glibeks", "Glibamid", "Gilemal", "Glibomet", "glibenclamide". Cov tshuaj ntawm cov nyiaj no yog xaiv ib lub zuj zus.

Raws li rau tus nqi "glibenclamide" yeeb tshuaj, nws mas nws txawv nyob rau hauv ntau 280-360 rubles.

Xyuas ntawm cov tshuaj

Tam sim no koj paub tias yog ib tug yeeb tshuaj "glibenclamide". Cov lus qhia rau kev siv, thiab rau hauv daim ntawv ntawm analogues ntawm cov txhais tau tias piav saum toj no.

Yuav ua li cas lawv hais txog cov tshuaj no cov neeg siv? Raws li ib tug txoj cai, tag nrho cov lus hais txog nws yog txo mus rau ib tug kev sib tham ntawm cov neeg los yog lwm yam tshuaj kiag hais tias yog pom zoo rau cov neeg uas muaj mob ntshav qab zib.

Tau txais kev pab hais tias feem ntau feem ntau "glibenclamide" raug siv tau raws li ib tug monotherapy. Txawm hais tias muaj cov neeg mob uas cov kws kho cov tshuaj nyob rau hauv ua ke nrog nrog rau lwm cov hypoglycemic tshuaj.

Raws li cov kws kho mob, lub sij hawm ntawm cov tshuaj nyob rau hauv saib xyuas yuav tsum tau ib tug neeg mus kom ze. Nyob rau hauv cov ntaub ntawv no, cov kws muaj txuj yuav tsum paub txog tag nrho cov kev tshwm sim ntawm analyses, thiab lwm yam kev tshawb fawb. Siv "glibenclamide" cov neeg mob nyob rau ntawm lawv kev txiav txim yog tsis tshua muaj txaus ntshai rau kev noj qab nyob thiab lub neej.