"Nebilong": cov lus qhia rau kev siv. "Nebilong": xyuas thiab analogues

"Nebilong" yog ib qho zoo tshuaj rau cov kev kho mob ntawm cov kab mob txuam nrog impaired lub plawv muaj nuj nqi. Cov kev txhim kho li cas tom qab siv nws rau ib lub hlis. Tom qab daim ntawv thov "Nebilonga" normalized mem tes thiab ntshav siab, vascular so yog mus txog, lub myocardium nkag txaus oxygen. Nyob rau hauv yuav luag txhua tus neeg mob yog ib tug zoo tshwm sim ntawm txoj kev kho yog muab khaws cia tseg rau ib ntev lub sij hawm.

Muaj pes tsawg leeg, Muaj pes tsawg leeg

Cov tshuaj no muaj nyob rau cov ntsiav tshuaj. Txhua ntsiav tshuaj yuav muaj 2.5, 5 los yog 10 mg ntawm active ingredient. Cov tshuaj no yog ua rau lub hauv paus ntawm nebivolol hydrochloride. Ntawm cam tam sim no nyob rau hauv nyob tus yeees ntawm povidone, lactose, magnesium stearate. Muaj pes tsawg leeg supplemented nrog talc, microcrystalline cellulose, sodium dioctyl sulfate, colloidal silicon dioxide, croscarmellose sodium, Beta-cyclodextrin.

pharmacological los

"Nebilong" phau ntawv qhia no qhia raws li ib tug txhais tau tias muaj nyob rau hauv nws cov qauv ob enantiomers (L- thiab D-nebivolol). D-nebivolol - heev xim, kev sib tw β1-adrenoceptor blocker, L-nebivolol maj rau cov hlab ntsha, expands lawv, uas yog vim muaj ib tug txheej txheem nyob rau hauv lub vascular endothelium (tso vasodilating tes taws los piav tau).

Nebivolol thiaj li ntshav siab thiab lub plawv dhia, qhov tshwm sim yog muab tsis tau tsuas yog nyob rau hauv lub quiescent lub xeev tab sis kuj nyob rau hauv load. Tom qab noj cov tshuaj puag ncig thiab end-diastolic sab laug ventricular pressures yog txo, muaj yog ib tug zoo feem nyob rau hauv ib tug ntawm lub zog ua los ntawm lub siab - diastolic. Vim hais tias daim ntawv thov ntawm lub "Nebilonga" ncaws feem nce, cov neeg uas muaj IBS cim antianginal nyhuv.

Hypotensive kev txiav txim ntsiav tshuaj "Nebilong" phau ntawv piav txog cov poob nyob rau hauv kev ua si nyob rau hauv lub renin-angiotensin system. Antiarrhythmic txiav txim no yog tiav los ntawm kev txo qhov AV-conduction thiab suppressing txawv txav automaticity lub plawv. Cas hypotensive nyhuv tshwm sim nyob rau 7-14 hnub ntawm kev kho mob, feem ntau - nyob rau hauv ib lub hlis. Ruaj tshwm sim los ntawm kev noj cov ntsiav tshuaj cai tom qab ib mus rau ob lub hlis ntawm kev kho mob.

tshuaj

Cov tshuaj noj, absorbed zoo, cov txheej txheem yog Attendance zoo hais txog ntawm cov mov noj. Metabolism hauv nyob rau hauv lub siab thiab ua tiav lub tsim ntawm active gidroksimetabolitov. Qhov nruab nrab bioavailability tom qab daim ntawv thov ntawm cov internal medicament tug neeg uas muaj ib tug sai metabolism ntawm 12%, qhov no daim duab yog ntau tshaj li nrog qeeb metabolism. Txij li thaum lub metabolism ntawm cov neeg mob yuav tshwm sim nyob rau txawv cov nqi, "Nebilong" phau ntawv pom zoo rau cov neeg tus yam ntxwv ntawm tus neeg mob lub cev. Nrog ib tug qeeb metabolism yog siv tsawg koob tshuaj ntawm cov tshuaj. Nyob rau hauv kev kawm nrog lub ceev ceev pauv tshuaj yuav siv sij hawm qhov chaw ib nrab-lub neej ntawm kwv yees li 10 teev, nyob rau hauv cov neeg mob uas muaj ib tug qeeb metabolism, ib nrab-lub neej nce los ntawm 3-5 lub sij hawm. Tom qab xya hnub ntawm txoj kev kho, hais txog 38% tau txais cov tshuaj tas los ntawm ob lub raum, hais txog 48% "Nebilonga" yog tam sim no nyob rau hauv cov quav. Muaj pes tsawg leeg ntawm cov zis yog ib tug me me npaum li cas ntawm cov tshuaj unchanged - txog li 0.5%.

zaj lus tim khawv

Nyob rau hauv daim ntawv thov ntawm "Nebilong" qhia yuav siv tau rau tawg, rau qhov kev siv ntawm cov tshuaj tiv thaiv kev ntsuas nyob rau hauv cov neeg mob uas CAD (bouts ntawm angina) thiab rau qhov kev siv ntawm lub complex txoj kev kho ntawm lub plawv tsis ua hauj lwm ntawm tus mob daim ntawv.

Kev kho mob nrog rau cov tshuaj "Nebilong"

tawg

Tus neeg laus cov neeg mob muab 5 mg "Nebilonga", uas sib raug rau ib ntsiav tshuaj formulation yog lub hnub koob tshuaj. Cov tshuaj yog pom zoo kom siv txhua txhua hnub nyob rau tib lub sij hawm. Ib tug me me nyhuv yog hnov tom qab ib mus rau ob lub lim piam ntawm txoj kev kho, feem ntau cov lus hais, nws yog ib lub hlis thaum lub sij hawm uas cov kev kho mob yog ua. Ntsiav tshuaj haum rau kev siv monotherapy thiab rau kev kho mob raws li cov kev siv ntawm cov tshuaj, uas tseem muaj hypotensive los. Cov neeg uas coj "Nebilong AM", cov kev qhia ntawv pom zoo nyob rau hauv thiaj li yuav tau ib tug ntxiv cov nyhuv rau thov "Hydrochlorothiazide" ntawm 12.5-25 mg. Tej chav kho mob yuav txhim khu qhov kev txiav txim ntawm "Nebilonga", tab sis nws yuav ua tau tsuas yog tom qab tau txais lub tswv yim ntawm cov kws kho mob.

Lub plawv tsis ua hauj lwm yog ib tug mob daim ntawv

Thawj ib tug me me koob tshuaj ntawm medicament, tus kws kho mob maj nce, muab cov yam ntxwv ntawm tus neeg mob. Rau cov kev kho mob ntawm mob ntaub ntawv ntawm "Nebilong" yog tsis tsim nyog, nyob rau hauv xws li mob, lwm yam tshuaj muaj tau siv. Feem ntau thawj tua tau 1.25 mg ntawm yeeb tshuaj rau ib hnub ib zaug siv, tom qab 1-2 lub lis piam lub koob yuav tau nce mus 5 mg, thiab tom qab ntawd - mus txog rau 10 mg. Lub hnub koob tshuaj yuav tsum tsis txhob ntau tshaj 10 mg medicament "Nebilong". Cov lus qhia rau kev siv qhia tau hais tias hais tias thaum lub thawj zaug rau theem ntawm txoj kev kho cov neeg mob tseem tshuav nyob rau hauv kev soj rau ob teev tom qab haus ntawm cov ntsiav tshuaj, thiaj li ua rau txhua ua koob txhais tau tias. Nce koob tshuaj yuav txo tau dua yog hais tias qhov yuav tsum tau tshwm sim.

Yog hais tias lub plawv tsis ua hauj lwm cov tsos mob nyob ntau pronounced los yog tus neeg mob intolerance mus rau yeeb tshuaj Cheebtsam twb pom, tau cov tshuaj ntawm cov tshuaj los yog ua nws abolition. Feem ntau, lub plawv tsis ua hauj lwm, mob hauv daim ntawv ntawm "Nebilongom" kho sai sai. Thaum txoj kev kho aimed ntawm xa xws tej yam kev mob, lub abolition ntawm cov tshuaj los maj mam, koj yuav tsis tau ua qhov kev txiav txim sharply, vim hais tias cov teeb meem no tej zaum yuav exacerbated. Yog hais tias koj rho cov tshuaj txhua lub lim tiam tej zaum yuav txo tau cov tshuaj los ntawm ib nrab. Rau kev noj cov tshuaj "Nebilong AM" phau ntawv qhia muab rau tej yam kev txwv.

txwv:

• Raum insufficiency. Ua ntej, rau txoj kev kho siv 2.5 mg ntawm cov tshuaj ib hnub twg, cov tshuaj yuav tau nce tom qab, tab sis nws yuav tsum tsis txhob ntau tshaj 5 mg.
• Laus lub hnub nyoog. Cov thawj zaug koob tshuaj tej zaum yuav tsis ntau tshaj 2.5 mg yog tias tsim nyog, nws yog tsa mus rau 5 mg. Tom qab 65 xyoo, yuav tsum tau kev soj ntsuam ntawm ob lub raum (ib txhua txhua plaub mus rau tsib lub hlis).
• Cev xeeb tub. Ib tug me nyuam mos yuav tsim ib co kab mob, no muaj xws li ua pa tuag tes tuag taw, hypoglycemia, hypotension, bradycardia, li ntawd, cev xeeb tub cov poj niam cov tshuaj yog tshuaj heev tsis tshua muaj. Yog hais tias ib tug cev xeeb tub poj niam siv "Nebilong" nws tshem tawm yog yuav tsum tau rau 48-72 xuab moos ua ntej tus me nyuam. Yog hais tias qhov no yog tsis tau, tus me nyuam mos yuav tsum tau cai rau 48-72 teev.

Contraindications

"Nebilong H" phau ntawv qhia txwv tsis pub siv nyob rau hauv cov nram no mob:

• hnub nyoog tsawg tshaj 18 xyoo;
• npau taws me ntsis mus rau yeeb tshuaj Cheebtsam;
• bronchospasm, mob hawb pob (keeb kwm);
• pheochromocytoma, uas tsis tau kho ua ntej;
• metabolic acidosis;
• nyuaj tshwm sim daim siab mob, lub siab tsis ua hauj lwm;
• hypotension nyob rau hauv cov tib neeg uas nws systolic siab ntawm 90 mm hg los yog tsawg dua. Tsab xov xwm.;
• AV-thaiv (qib kuv, III), bradycardia, uas yog nrog los ntawm lub plawv dhia coj mus rau 60 BPM. ib feeb;
• thaum lub sij hawm nyuam, pub niam mis;
• mob lub plawv tsis ua hauj lwm zoo lawm;
• teeb meem nrog peripheral kev, nrog tiag tiag li expressiveness;
• cardiogenic poob siab, ib tug mob nyob rau hauv uas nws yog tsim nyog los siv isotropic tshuaj;
• syndrome, mob qhov ntswg nrog.

ceev faj yuav tsum tau thaum appointing cov tshuaj rau cov neeg mob nrog tej yam kev mob:

• mob ntshav qab zib;
• psoriasis (keeb kwm);
• Prinzmetal angina.

phiv

Nyob rau hauv cov kev kho mob txhais tau hais tias "Nebilong" phau ntawv qhia, xyuas hais txog qhov yuav tshwm ntawm tshwm sim ntawm tej yam kev phiv, uas yog manifested nyob rau hauv lub chaw ua hauj lwm ntawm cov hlab plawv, digestive thiab tshee systems. Cov lwm ua txhaum - bronchoconstriction cov tshuaj tiv thaiv rau ntawm daim tawv nqaij mob.

ceev faj

"Nebilong" tej zaum yuav ua ntu rhiab heev rau allergens, uas threatens lub kev loj hlob ntawm kev mob loj anaphylactic cov tshuaj tiv thaiv.

Tshuaj kho mob tsis cuam tshuam rau theem ntawm qab zib nyob rau hauv lub cev nyob rau hauv lub xub ntiag ntawm cov ntshav qab zib, tab sis cov neeg mob nyob rau hauv pab pawg neeg no yuav tau thov cov tshuaj nrog ceev faj. Raws li nyob rau hauv cov ntshav qab zib thiab nyob rau hauv hyperthyroidism tshuaj tej zaum yuav npog cov tsos mob ntawm tachycardia, nws yog ntau pronounced vim lub ceev tshem ntawm cov ntsiav tshuaj.

Yog hais tias cov neeg mob uas muaj teeb meem nyob rau hauv lub pa system yog siv "Nebilong" phau ntawv qhia qhia txog qhov tshwm sim rau koj qhov nce constriction ntawm cov hlab cua nyob rau hauv COPD. Cov tau ntawm combining cov tshuaj noj lwm yam tshuaj yuav tsum tau soj ntsuam nrog koj tus kws kho mob.

"Nebilong" muaj feem xyuam rau cov muaj peev xwm tsav tsheb, yuav ua tau kom qaug zog thiab kiv taub hau.

analogs

Nws yog ua tau los hloov cov tshuaj uas tsis pub siv cov tshuaj "Nebilong" phau ntawv qhia. Drug analogues muaj xws li "Nebilet", "Binelol". By hloov kuj muaj xws li "Nebikor" thiab "Nebivator".

Xyuas

Raws li cov kev txheeb xyuas, cov tshuaj yog zoo thaum siv kom yog yog. Nws yog ib qho tseem ceeb rau siv cov tshuaj thiab ua raws li tag nrho cov kws kho mob lub tswv yim pom zoo. Lub medicament yog muab nrog cov contraindications thiab cov yam ntxwv ntawm tus neeg mob, uas ua nyob rau hauv ib tug zoo ntxim. Hais tias kev kho mob tsis ua rau txoj kev loj hlob ntawm sab los, koj yuav tsum lossi saib xyuas qhov mob ntawm tus neeg mob.