Triptans rau migraine. Triptans tshuaj nqi

Migraine - ib qho teeb meem rau ntau cov neeg mob. Yuav luag txhua leej txhua tus tsawg kawg ib zaug nyob rau hauv ib tug lub neej yaam puab paub mob nyob rau hauv lub taub hau. Raws li ib tug txoj cai, lawv yuav nrog kiv taub hau, xeev siab, ntuav, raws li zoo raws li xws li loog loog, tingling thiab tsis muaj zog nyob rau hauv lub extremities, photo- thiab phonophobia. Tom qab ib tug nres, cov neeg mob tsis txaus siab qaug zog, nkees thiab nkees nkees. Tej zaum kuj muaj mob thaum muaj tus kab mob yog li ntawd khiav, uas muaj peev xwm tsuas pab tus neeg mob triptans mob taub hau. Nws yuav tsum tau muab sau tseg hais tias migraine - ib tug kab mob ntawm cov poj niam, raws li lawv muaj ntau susceptible mus xws pathology, dua li cov txiv neej. Kwv yees li 10-18% ntawm cov neeg laus mob migraine.

Qhov teeb meem ntawm mob taub hau paub rau txhua tus neeg

Feem ntau cov neeg tsis nrhiav kev pab los ntawm ib tug tsim nyog kho mob thiab yuav tiv nrog tus kab mob no, thaum noj analgesics. Needless hais, xws li ib mus kom ze tsis tau kev pab, tiam sis tsuas yog exacerbates tus kab mob no. Lub uncontrolled siv analgesics yuav ua rau txoj kev loj hlob ntawm cov tshuaj vim mob mob taub hau. Yog li ntawd, nws tsis yog li ntawd muaj yog ib tug loj loj tus naj npawb ntawm cov lus nug txog dab tsi zoo ntawm mob taub hau tshuaj - qhov zoo tshaj.

Tshab plaws kho migraine yog tsis yooj yim sua, tab sis los txhim kho qhov zoo ntawm lub neej yog tau nrog tshwj xeeb khoom, uas yog tsa los ntawm ib tug neurologist. Muaj tam sim no lub npe hu ib tug lossis loj npaum li cas ntawm migraine uas yog sufficiently zoo ob thaum lub sij hawm ib tug nres, thiab nyob rau hauv lub interictal lub sij hawm. Tom ntej no, ib tug los ze zog saib cov tshuaj rau migraine: ib daim ntawv teev cov kev pab thiab cov mob nres-free txoj kev kho. Nws yog muaj pov thawj hais tias triptans - qhov zoo tshaj tshuaj los mus tshem tawm cov mob taub hau. Nrog prophylactic tshuaj raug cov nram qab no pawg:

• β-blockers;
• antidepressants;
• antiemetic;
• dej-soluble vitamin B;
• calcium blockers;
• anticonvulsants.

Txais ntawm tag nrho cov saum toj no ranked li pharmaceuticals yuav tsum appoint ib tug uas tsim nyog tus neeg.

Yog vim li cas muaj ib tug mob taub hau?

Ua ntej koj yuav to taub yuav ua li cas ua triptans los ntawm mob taub hau, tus nqi uas nyob rau ntawm lub chaw tsim tshuaj paus, nws yog tsim nyog los nkag siab txog cov mechanism ntawm lub pathology. Mob taub hau muaj vim stimulation ntawm receptors ntawm lub meninges thiab cerebral hlab ntsha. Thaum ntev nro thiab yog tag nrho ntawm cov hlab ntsha, tshwj xeeb yog cov leeg, nyob rau hauv ib tug hypotonic lub xeev muaj mob heev, uas yuav tsum tau tshem tawm tsuas yog txhais tau tias ntawm tshwj xeeb pharmaceuticals. Muaj ntau soj ntsuam ntawm leej twg ntsia rau ib ntev lub sij hawm, npaj rau cov kev kho mob ntawm migraine, tau xaus lus tias triptans - qhov zoo tshaj plaws txhais tau tias nyob rau qhov no pathology.

zog triptans

Cov tshuaj tswj narrowing dilated cov hlab ntsha ntawm lub paj hlwb. Triptans - ib tug tshuaj uas ua rau lub nucleus thiab cov receptors ntawm lub trigeminal paj, uas nyob rau hauv lem thiaj li rhiab heev ntawm tus mob pib. Triptans - niaj hnub antimigraine tshuaj, uas muaj ib tug es siab selectivity rau hauv cov hlab ntsha ntawm lub Dura mater (Dura mater encephali) thiab kuj me thiab peripheral thiab coronary hlab ntsha.

Nthuav tshuaj yog zoo nyob rau hauv txo cov kev mob nyob rau theem ntawm cov leeg nrob nucleus ntawm lub trigeminal paj. Nyob rau hauv tas li ntawd rau tag nrho cov saum toj no triptans - tshuaj uas yuav tsis tau tsuas yog txo cov xwm txheej ntawm tus kab mob relapse, tab sis kuj tshem tawm cov kab kev soj ntsuam ces nws (xws li, xeev siab, ntuav, photophobia, thiab lub suab).

Lub ntsiab zoo ntawm triptans

Cov pharmacological thaj chaw ntawm cov kev kub ceev siv lub txiaj ntsim. Cia nyob rau hauv ib nrab ib teev muaj cov cim qhia ntawm zoo los ntawm cov tshuaj nyob rau hauv tus neeg mob lub cev. Tus kho nyhuv yog khaws cia thoob plaws hauv lub migraine nres. Feem coob ntawm cov neeg mob mob taub hau tsis recur.

Hnub no, zaum tau muaj pov thawj hais tias cov nrhiav kom tau ntawm precursors nres yuav tsum tam sim ntawd muab triptans rau migraine. Nyuam qhuav pib muaj lub hom phiaj uas migraine tawm tsam yuav tsum tau kho nyob rau hauv ua sawv, pib nrog lub txais tos ntawm tej yam yooj yim tshuaj.

Tshuaj rau migraine: ib daim ntawv teev cov feem ntau nrov tshuaj

Nyob rau hauv lub triptan pab pawg neeg ntawm cov tshuaj muaj xws li cov nram qab no:

• 'Zomig'.
• "Amigrenin".
• "Sumatriptan".
• "Imigran".
• "Relpaks".
• "Trimigren".
• "Sumamigren".
• "Rapimed".
• "Almotriptan".
• "Naramig".
• "Naratriptan."
• "Frovatriptan."
• "Zolmitriptan."

Cov tshuaj rau txhua tus neeg mob tej zaum yuav nruj me ntsis ib tug neeg, li ntawd, nyob rau hauv thiaj li yuav kom cov hauj lwm zoo ntawm no los yog lwm yam tshuaj, kws kho mob pom zoo kom mus sim noj nws rau peb migraine tawm tsam. Tryptamine pab pawg neeg ntawm cov tshuaj yog yus muaj los ntawm siab bioavailability, lawv yog ib qho yooj yim kuj mus kov yeej lub ntshav-hlwb barrier, yog zoo nyob rau hauv txo migraine xawv, txawm nyob rau hauv lub mob theem. Cov tshuaj no tsim nyog rau muab rau cov neeg mob muaj mob loj tsawv mus rau mob hnyav kab mob heev.

Daim ntawv thov ntawv

Heev feem ntau peb tau hnov tib lo lus nug: yog dab tsi mob taub hau tshuaj yog zoo dua? Seb cov kev tshawb fawb tau qhia tias qhov zoo tshaj txhais tau tias kom tshem tawm cov tsos mob ntawm migraine yog triptans. Nws yog qhov zoo tshaj plaws coj triptans rau migraine thaum nws detects cov thawj cov cim qhia ntawm nres. Qhov siab tshaj plaws analgesic nyhuv tau tau cai rau ob teev tom qab noj cov tshuaj. Ua ntej yuav noj ib tug yeeb tshuaj, ua tib zoo nyeem cov lus qhia thiab tham ib tug kws kho mob. Nws yog ib qho tseem ceeb heev los mus tiv thaiv yeeb tshuaj overdose. Triptans rau migraine yog tsis pom zoo kom siv ua ke nrog tshuaj tua kab mob, noj, antiviral agents, raws li zoo raws li nrog antidepressants.

Mus cuag tej yam tshwm sim, cov neeg mob yuav tsum tau ua raws li cov nram qab no raws li kev cai hais txog kev txais triptans:

• nrog me me mus rau mob loj tsawv mob taub hau noj 1 ntsiav tshuaj (los yog ib koob tshuaj tsuag);
• txhaj koob thib ob yog coj tsis ntxov tshaj li 2 chasa;
• thaum lub sij hawm hnub tsis noj ntau tshaj li ob koob tshuaj;
• triptans yog tsis pom zoo kom coj ntau tshaj li ob hnub ib lub lim tiam.

Thaum lub sij hawm kev kho mob ntawm koj noj cov zaub mov yuav tsum tsis tiraminsoderzhaschie khoom:

• cocoa;
• chocolate;
• taum;
• qe;
• kav;
• citrus;
• kev pab noj haus;
• cheese;
• txiv lws suav;
• ceev;
• haus dej haus cawv.

Ib tug yuav tsum kuj tsis noj cov zaub mov txias.

Thaum tshwm sim ntawm migraine triptane, tus nqi ntawm uas yuav tsum tau qhia rau hauv qab no, kuj yuav siv tau nrog rau lwm cov tshuaj, xws li metoclopramide los yog domperidone.

phiv

Thaum ib tug yeeb tshuaj overdose, cov neeg mob lub ntsej muag hauv qab no txoj kev sib tw:

• kiv taub hau;
• anaphylactic poob siab;
• ceev ceev;
• xeev siab;
• kev xav ntawm warmth;
• infarction ntawm tus po, cov hnyuv;
• ntuav;
• qhov ncauj qhuav;
• myalgia;
• mob plab;
• nkees nkees;
• hlawv nov ntawm nqaij tawv ntawm daim tawv nqaij;
• Angioedema;
• tachycardia;
• ua xua;
• polyuria;
• leeg tsis muaj zog;
• tsis xim;
• piav thoob hlo teeb;
• haemorrhagic raws plab;
• nquag tso zis;
• coronary vasospasm.

Txawm tias tag nrho cov no, triptans rau migraine - ib tug ceev ceev-kuj noj tshuaj. Subject ntau npaum thiab zaus ntawm kev noj cov tshuaj uas yuav muaj tshwm sim tsis zoo yog tsawg heev. Nyob rau hauv Feem ntau, tag nrho cov triptans zam los ntawm lub cev feem ntau. Sab los, yog hais tias lawv tshwm sim, ces qhia me me thiab daws nthawv tsis kho mob kev pab. Lub ntsiab drawback ntawm triptans - qhov no yog lawv cov nqi. Tu siab, tsis yog txhua txhua tus neeg mob yuav them taus xws li ib tug yeeb tshuaj.

Contraindications

Triptans rau migraine tsis pom zoo rau siv nyob rau hauv cov nram no mob:

• stroke;
• angiospastic angina;
• cev xeeb tub;
• cerebrovascular kev huam yuaj;
• thaum lub sij hawm lub mis-pub ib tug me nyuam;
• coagulopathy (ntshav);
• tiav hluas;
• cov kab mob ntawm cov hlab plawv system;
• npau taws me ntsis rau bioactive tshuaj ntawm lub formulation;
• uncontrolled tawg;
• arrhythmia;
• daim siab thiab lub raum kab mob;
• atherosclerosis.

Ua ntej muab tshuaj tej triptans, lub tus kws kho mob yuav tsum qhia hais tias muaj tej yam atherosclerosis. Tej yam zoo xws li nram qab no:

• mob ntshav qab zib;
• post-menopausal poj niam;
• haus luam yeeb;
• tawg;
• rog;
• ib theem siab ntawm kev txawv txav ntshav cholesterol;
• muaj hnub nyoog tshaj 40 xyoo rau cov txiv neej;
• kev tshuaj ntsuam genetic predisposition mus rau ib tug plawv nres.

Ib txhia neeg uas muaj feem yuav tsum tau txais lawv cov thawj koob tshuaj ntawm tryptamine nyob rau hauv lub saib xyuas ntawm ib tug kws thiab nyob rau hauv ECG tswj.

Scheme kho migraine

Muaj dav dav ntawm tshuaj kev kho mob ntawm cov kab mob uas tau kev txaus cai nyob rau hauv feem ntau tus neeg mob:

• tsim nyog los pib kev kho mob nrog analgesics los yog ob peb ua ke ntawd (xws li nonsteroidal anti-inflammatory siv tshuaj);
• Yog hais tias analgesic siv tsis muab ib tug zoo tshwm sim, ces tom qab 45 feeb yuav tsum coj ib tug triptan;
• Yog hais tias ib tug triptan tau tawg paj txi txiv, cov tom ntej no nres yuav tsum tau siv lwm cov tshuaj los ntawm triptanovoy pab pawg neeg;
• nrog atypical mob taub hau yog tsim nyog los siv uas tsis yog-tshuaj anti-inflammatory siv tshuaj.

Cov kev siv uas niaj hnub cuab yeej rau cov kev kho mob ntawm migraine, tsim nyob rau hauv lub hauv paus ntawm triptans, pab mus ua lub neej yooj yim dua rau tus neeg. Tsis txhob hnov qab tias noj cov tshuaj no muaj peev xwm yuav kho los ntawm ib tus kws kho mob, thiab tsuas yog thaum tus mob. Muaj tej yam teeb meem thaum triptans thiab lwm yam nonspecific analgesics tsis muab cov kev kawm tshwm sim thiab tsis tshem tawm qhov mob. Nyob rau hauv cov ntaub ntawv no, cov kws kho mob feem ntau yog muab ib tug complex kho nrog anticonvulsant tshuaj, thiab beta-blockers. Cov tshuaj xws li cov nram qab no tshuaj:

• "Penbutolol".
• "Nadolol."
• "Betaxolol."
• "Topiramate".
• "Neurontin."
• "Phenobarbital".
• "Timolol".
• "Propranolol".
• "Labetanol".
• "Bellataminal".
• "Metoprolol".
• "Topamax".
• "Acebutolol".

Yuav ua li cas los txo cov xwm txheej ntawm cov tawm tsam?

Yuav kom txo tau lub zaus ntawm migraine cov neeg mob yuav tsum ua raws li cov cai nram qab no:

• noj tsis tu ncua;
• cais los ntawm koj cov zaub mov khoom noj thiab dej haus uas ua tawm tsam (npias, qhob noom xim kasfes, cheese, champagne, citrus txiv hmab txiv ntoo, liab wine);
• txiav luam yeeb haus luam yeeb;
• raws li nws yog tau mus yuav nraum zoov lawm;
• tsis txhob nyuaj siab;
• Ce (zoo tagnrho - ua luam dej);
• tsis txhob ntev journeys los ntawm chaw tos tsheb loj, nkoj, tsheb.

Triptans yog ib tug mob taub hau: tus nqi

Triptans yog ua nyob rau hauv txawv ntau npaum cov ntaub ntawv: txhaj dlaws, qhov ntswg tshuaj tsuag, ntsiav tshuaj, qhov quav suppositories. Nyob rau tus nqi ntawm cov tshuaj muaj feem xyuam rau qhov kev tso tawm daim ntawv no, ntau npaum, tus naj npawb ntawm cov tshuaj nyob rau hauv ib lub pob. Raws li ib tug tshwm sim, tus nqi ntawm cov tshuaj mas nws txawv nyob rau hauv ib tug ntau yam - 150-1500 rubles ib pob.