Antidepressant 'Azafen', cov lus qhia rau kev siv, phiv

Tshuaj "Azafen" yog hais txog cov pab pawg neeg ntawm cov tricyclic antidepressants. Nws muaj ib tug high sedative, anxiolytic thiab antiaggressive los. Qhov no tshuaj yog dav siv rau cov kev kho mob ntawm lub ntsws thiab theem nrab depressions, xws li:

- endogenous;

- astenodepressiya;

- exogenous;

- dej;

- tswb;

- lub xeev thaum lub sij hawm Somatic tej yam kev mob ntawm ib tug mob xwm.

Lub active ingredient ntawm cov tshuaj "Azafen" piav qhia hais txog pipofezine. Lub mechanism ntawm qhov kev txiav txim ntawm ib yam khoom raws li inhibition ntawm neuronal uptake ntawm norepinephrine thiab serotonin. Qhov no ua rau ib qho kev nce rau hauv lub concentration ntawm pipofezine nyob rau hauv lub Cns thiab depressive cov tsos mob cropped.

Muaj yog ib tug zoo dua tshaj zoo xws li cov tshuaj ntawm antidepressant tshuaj kev txiav txim "Azafen" cov lus qhia rau kev siv hais txog qhov uas tsis muaj nws cardiotoxic los. Nws yog muab sau raws li ib tug yam ntxwv zoo txhais tau tias "Azafen" rau affective mob, weakening lub Somatic, psychic thiab autonomic mob txuam nrog kev nyuaj siab. High miv nyuas siv zug "Azafen" phau ntawv qhia sij tiv thaiv asthenia, teeb meem tshwm sim vim Somatic tib neeg psyche. Thaum lub sij hawm cov thawj coj ntawm cov tshuaj nyob rau hauv cov neeg mob disappears ntxhov siab vim, kev nyuaj siab. Zoo puab nyob rau hauv cov neeg mob uas anorexia nervosa, ib txwm pw tsaug zog thiab tsaug zog disappears thaum lub sij hawm ib hnub.

Tshuaj "Azafen", raws li lawv pharmacokinetic zog muaj zoo digestibility, nws yog zoo yaim los ntawm lub digestive ib ntsuj av tau, muaj siab bioavailability (80%), nyiaj pab ntau tshaj cov ntshav concentration nce mus txog twb tsis pub dhau 2 lub sij hawm. Nyob rau hauv lub siab tshwm sim los ntawm biotransformation pipofezine rau tsaug zog metabolites uas tso tawm kom pom nyob rau hauv lub ob lub raum. Tag nrho cov kev tso cai ntawm cov tshuaj los ntawm lub cev tshwm sim nyob rau 16 teev.

Kev kho mob ntawm kev nyuaj siab los ntawm ntau yam keeb kwm yog ib tug yuav tsum muaj hais rau cov kev siv ntawm cov tshuaj "Azafen" phau ntawv qhia qhia lub xeev, qhia tag nrho cov hom depressioy, raug cov tshuaj.

Muaj ntau ntau contraindications rau tau txais kev nyuaj siab "Azafen" cov lus qhia rau kev siv los qhia nram qab no xeev yog tsis muaj raws li cov tshuaj kho mob:

- mob ntshav qab zib;

- sib koom nrog Mao inhibitors ;

- myocardial infarction, lub plawv tsis ua hauj lwm, coronary artery kab mob;

- hepatic los yog lub raum tsis ua hauj lwm;

- kab mob, mob;

- lub xeev tom qab loj cerebrovascular xwm txheej (stroke);

- Cev xeeb tub, lactation.

Nws yuav tsum tiv thaiv tau tshwm sim ntawm sab los thaum lub sij hawm kev kho mob, lawv yuav qhia los ntawm kiv taub hau thiab mob taub hau, kev tsis haum tshuaj, ntuav thiab xeev siab. Tu siab, muaj yog tsis muaj cov lus qhia txog cov kev kho mob nyob rau hauv cov ntaub ntawv ntawm cov tshuaj overdose, nyob rau hauv xws li mob, nws yuav siv sij hawm symptomatic. Nyob rau hauv qhov teeb meem ntawm contraindications yuav tsum tau ntxiv rau qhov teeb meem qub ntawm "Azafen" thiab dej caw. Cov no yog ob tag nrog kom lub tswv yim thaum lub sij hawm kev kho mob yuav tsum tau txiav los ntawm haus dej cawv thiab cov simultaneous txais tos ntawm cov kev npaj muaj ethanol.

Lub "azafen" tsis pom anticholinergic zog, yog li ntawd tsis muab tsis tau li tshuaj kho mob rau cov neeg mob nrog glaucoma. Tsis tas li ntawd incompatible nrog haus dej haus cawv, muaj yog ib tug uas yuav ntawm simultaneous daim ntawv thov ntawm cov tshuaj nrog anticoagulants, antihistamines thiab tag nrho cov tshuaj, Cns depressants. Thov tsum paub hais tias simultaneous txais tos ntawm "azafen" nrog antiepileptic tshuaj txo cov hauj lwm zoo ntawm lub yav tas.

Tso tawm "Azafen" nruj me ntsis raws li hauv daim ntawv qhia, lub siab tshaj plaws txee lub neej yog 5 xyoo, nws yuav tsum tau muab cia rau hauv tmax 25.