Cov tshuaj "Aminazine": xyuas cov kws kho mob, cov lus qhia rau kev siv, muaj pes tsawg thiab piav qhia

Cov tshuaj tiv thaiv kev noj qab haus huv yog cov tshuaj psychotropic uas tsim los kho cov kev puas siab puas ntsws. Nws yuav tsum tau qhia tshwj xeeb uas tau muab sau tias cov npe tshuaj rau cov tshuaj no yog neuroleptics. Cov tshuaj yuav zoo feem xyuam rau txoj cov tsos mob xws li delusions, illusions, hallucinations, xav tias tsis meej, psychotic ntxhov siab, kev coj cwj pwm tsis meej , thiab thiaj li nyob. D. Muab cov tshuaj tsuas tau ntsib tus kws kho mob.

Cov tshuaj tiv thaiv kab mob siab tshaj plaws yog cov tshuaj "Aminazine." Cov lus qhia txog kev siv, nqe, kev txheeb xyuas, cov yeeb yaj kiab, cov kev tiv thaiv thiab cov yeeb yam ntawm cov tshuaj muaj npe hauv qab no.

Cov cwj pwm, cov lus piav qhia, daim ntawv

Dab tsi yog qhov tsim nyog nyob rau hauv yeeb tshuaj "Aminazine"? Kev qhia, tshuaj xyuas daim ntawv qhia tias cov tshuaj no mus rau ntawm kev muag khoom nyob rau hauv daim ntawv ntawm ib tug drowne xim kasfes, nrog rau kev kho rau cov tshuaj intravenous thiab intramuscular. Cov khoom nquag ntawm cov kabmob no yog chlorpromazine hydrochloride. Tsis tas li ntawd, nyob ntawm daim ntawv tso tawm, lawv cov lus muaj xws li ntau yam kev pabcuam.

Pharmacological nta

Dab tsi yog qhov zoo tshaj plaws txog yeeb tshuaj "Aminazine"? Cov lus qhia siv, kev txheeb xyuas tau hais tias qhov no yog ib tug neeg mob hlwb, uas nyob rau hauv nws cov tshuaj pharmacological yog hais txog neuroleptics. Nws muaj antihypertensive, antiemist thiab antihistamine nkaus.

Cov khoom xyaw ntawm cov tshuaj no yog ib qho phenotiazine derivative. Ntxiv nrog rau cov khoom no, cov tshuaj no muaj kev sib daj sib, tsis muaj zog hypothermic, antipsychotic, zos irritant, vasodilating thiab mob M-cholinoblocking.

Antipsychotic nyhuv ntawm lub cuab tam yog tiav los thaiv cov hlab dopamine D ₂ receptors thiab mesolimbic tshuab Mesocortical. Ua tsaug rau cov khoom zoo li no, cov tshuaj hauv cov lus nug yuav tshem tawm cov kev xav, kev ntxias thiab lwm yam kev mob tshwm sim ntawm kev xav.

Nws tseem yuav tsum tau sau tseg tias "Aminazin", cov kev txheeb xyuas uas muaj npe nyob rau hauv qab, suppresses ntau yam ntawm psychomotor ntxhov siab, txo txoj kev hnyav ntawm aggression thiab psychotic ntshai.

Cov tshuaj tua kabmob ntawm cov tshuaj no yog tiav los ntawm blockade ntawm adrenoreceptors ntawm reticular lub tsev muag tshuaj uas nyob hauv lub hlwb.

Cov khoom ntawm cov tshuaj

Dab tsi yog cov khoom ntawm cov tshuaj "Aminazine"? Cov kev txheeb xyuas qhia tias cov tshuaj no muaj kev nyuab siab rau kev ua haujlwm zoo, ua rau cov nqaij pob txha tawm, ua kom tsis muaj zog ntawm lub cev, ua rau cov neeg ua haujlwm tsis muaj zog thiab tsis muaj zog. Kev siv ntau cov tshuaj ntawm cov tshuaj no ua rau muaj kev qaug zog heev.

Blockade ntawm lub vagus paj nyob rau hauv lub mob huam thiab dopamine _D2 receptors nyob rau hauv lub emetic txhais cheeb tsam thiab qhov chaw muab cov antiemetic nyhuv ntawm cov tshuaj. Nws kuj tseem yuav tsum tau sau tseg tias tus neeg sawv cev no muaj qhov tsis zoo ntawm M-cholinergic receptors. Tsis tas li ntawd, nws cov nyhuv qhia tau hais tias yog rau alpha-adrenergic receptors.

Kev noj tshuaj

Yuav siv tshuaj yeeb "Aminazine" li cas? Kev txheeb xyuas hais tias qhov cuab yeej no muaj peev xwm tshem tawm cov teebmeem uas tau tshwm sim los ntawm epinephrine. Nws cov nyhuv hypothermic yog vim lub blockade ntawm dopamine receptors uas nyob hauv lub hypothalamus.

Cov tshuaj no txo cov ntshav siab, nce lub plawv dhia, muaj cov nyhuv ua haujlwm tsis zoo thiab cov cataleptogenic cov nyhuv, thiab kuj txo cov kab ntawm cov phab ntsa capillary.

Nrog rau kev txhaj tshuaj hauv lub cev, cov tshuaj no ua rau cov tshuaj siv li ¼ teev, thiab nrog lub qhov ncauj khiav dej num - tom qab 120 nas this. Kev ua siab ntev ntawm tus neeg mob mus rau kev sib daj sib deev thiab hypotensive tshwm sim tom qab ib lub lim tiam.

Thaum noj cov tshuaj no hauv nws qhov kev puas hlwb los ua rau lawv tus kheej muaj kev xav rau hnub 4 lossis 7 hnub. Txoj kev kho mob ntawm cov tshuaj no kav li 2-6 lub hlis.

Pharmacokinetics ntawm cov tshuaj

Yog "Aminazine" sucked? Cov kev txheeb xyuas hais tias thaum noj cov lus hais, chlorpromazine yog sai sai, tab sis tsis yog tag nrho absorbed los ntawm digestive system. Nws ncov siab concentration nyob rau hauv cov ntshav yog mus txog tom qab 4 xuab moos.

Qhov yeeb tshuaj no muaj mob thawj zaug los ntawm nplooj siab. Yog li, nws cov concentration hauv cov ntshav tom qab nqos tau yog tsawg dua cov concentration tom qab txhaj tshuaj tiv thaiv kab mob.

Cov tshuaj no yog metabolized nyob rau hauv daim siab nrog tsim kom muaj kev phom sij thiab tsis ua haujlwm.

Chlorpromazine muaj kev sib cog khov siab nrog plasma proteins. Nws yog dav faib nyob rau hauv tus neeg mob lub cev, tob tob los ntawm BBB.

Ib nrab ntawm lub neej ntawm cov khoom nyhuv ntawm cov tshuaj no yog kwv yees li 30 feeb. Nyob rau tib lub sij hawm, tshem tawm ntawm nws cov kev ua ub no yuav ua rau ntev dua.

Cov tshuaj nyob rau hauv kev saib xyuas yog excreted ua ke nrog zis thiab bile.

Cov tshuaj "Aminazine": qhia txog kev siv

Cov kev txheeb xyuas tau hais tias cov tshuaj no yog nquag siv hauv kev siv hlwb kho mob. Nws tau hais rau txoj kev kho ntawm psychomotor ntxhov siab nyob rau hauv ib tug neeg uas muaj tus mob schizophrenia. Tsis tas li ntawd, qhov no tshuaj yog siv nyob rau hauv mob psychosis, mob delusional lub xeev, hypomanic excitement, insomnia, psychopathy, kev puas hlwb, kev ntxhov siab vim, kev ntshai thiab ntxhov siab vim.

Ntxiv rau cov mob no, cov kev qhia txog kev siv cov tshuaj no yog: pheej tsis muaj mob, tsis muaj kev ntxhov siab, ntuav thiab tsis xeev siab. Thaum muaj mob qhov hnyuv, qhov tshuaj no ua rau qhov kev txiav txim siab ntawm qhov muag.

Nws kuj tseem yuav tsum tau sau tseg tias tus neeg sawv cev ntawm qhov lus nug tau muab teev rau cov kab mob uas muaj zog los ntawm cov nqaij mob siab, tetanus (ua ke nrog kev sib tham nrog kev sib txuas lus) thiab tom qab ua txhaum cai hauv cov paj hlwb.

Tsis li ntawd, ntev dhau los, cov tshuaj no yog siv rau cov dag hypothermia muaj lytic mixtures. Hauv kev mob anesthesiology, cov tshuaj no feem ntau tau hais rau kev yug kabmob thiab kev ua haujlwm ntawm cov tshuaj loog.

Hauv kev xyaum dermatological, "Aminazine" (kev txheeb xyuas ntawm cov neeg mob txog cov tshuaj no feem ntau zoo) yog siv rau khaus dermatoses. Tsis tas li ntawd, nws yuav siv tau nyob rau hauv kev kho mob ntawm mob porphyria.

Contraindications

Nyob rau hauv cov ntaub ntawv twg yog qhov tshuaj tiv thaiv kev puas hlwb "Aminazine" tsis sau ntawv? Cov kws kho mob cov lus hais tias qhov kev kho no tsis yog siv rau hauv cov neeg mob hauv lub cev, thiab nrog rau kev ua siab loj ntawm cov leeg hlwb, kev mob plawv, thiab kev mob siab, mob hnyuv tws ntawm lub hlwb thiab tus txha nqaj qaum ntawm lub cev tsis muaj zog, lub cev nqaij daim tawv thiab thaum lub sijhawm Pub Noj.

Pom tau tias muaj kev pheej hmoo siab ntawm kev tsim muaj kab mob siab hepatotoxic, qhov tshuaj no tau sau nrog kev ceev faj txog kev quav dej caw. Tib yam siv rau kev mob qog nqaij hlav cancer mis, kev hloov ntawm cov ntshav, hyperplasia ntawm lub caj pas prostate, lub qhov mob kaw glaucoma, Parkinson's kab mob, qaug dab peg, myxedema, ntuav, cachexia, Reye's syndrome thiab cov laus.

Cov tshuaj "Aminazine": cov lus qhia siv

Cov ntsiav tshuaj, cov kev ntsuam xyuas uas tau nthuav tawm hauv qab no, yog siv rau kev kho kev puas siab puas ntsws nyob rau hauv thawj hnub noj pes tsawg rau 25-100 mg. Cov nyiaj no muab faib ua 1-4 nkag. Txij lub sij hawm, cov koob tshuaj tau nce txhua plaub hnub los ntawm 25 los sis 50 mg kom txog rau thaum cov kev xav tau ua tiav.

Nyob rau hauv cov ntaub ntawv ntawm kev ntxhov siab, qhov no npaj yog haus 2-3 teev ua ntej lub lag luam.

Qhov ntau tshaj ib koob ntawm tus neeg sawv cev no yog 300 mg, thiab cov tshuaj txhua hnub yog 1.5 g.

Raws li kev daws teeb meem, nws yog tus siv intravenously los yog intramuscularly. Thawj cov tshuaj ntawm cov tshuaj no yog 25-50 mg.

Ua ntej qhia txog ntawm cov tshuaj, dilute nws nrog 2-5 ml ntawm ib tug daws ntawm sodium chloride los yog ib tug daws ntawm procaine. Cov kev txhaj tshuaj ua tiav hlo.

Qhov ntau tshaj ib koob ntawm tus neeg sawv cev no yog 150 mg, thiab cov koob tshuaj txhua hnub yog 1 g. Raws li kev tso dej tshuaj, cov kev ntseeg no sib raug 100 thiab 250 mg.

Undesirable teebmeem

Puas muaj kev phiv los ntawm "Aminazine" (ntsiav tshuaj)? Cov kev txheeb xyuas cov ntaub ntawv qhia tias thaum lub sijhawm thawj zaug ntawm kev kho mob tshuaj no yuav ua rau lub qhov ncauj qhuav, qhov paug ntawm qhov chaw, kev txhaws qa, hnyav nce, cem quav, kev pw tsaug zog, kiv taub hau, mob anorexia, tachycardia, orthostatic hypotension, retraction, txo hwj chim, Ntshav siab.

Cov kev kho mob ntev no ua rau qaug tshuaj ntawm lub caj dab thiab cov nplaig nqaij, kev nyuab siab rau lub hlwb, kev nyuab siab rau lub cev, kev mob hlwb, kev mob hlwb, kev ua kom tsis muaj zog, kev kho siab, kev ntuav, kev hloov hlwb, lub plawv dhia ceev nrig, tawv pigmentation, oppression ntawm pob txha marrow hematopoiesis , gynecomastia, cholestatic daj ntseg, galactorrhea, giperplolaktinemiyu, oliguria, raws plab, thiab neuroleptic phem syndrome. Nrog cov kab mob tua kab mob hauv lub cev, phlebitis daim ntawv, thiab kab mob hauv nruab nrog.

Cov Lus Qhia Tshwj Xeeb

Txoj kev kho nrog cov tshuaj no yuav tsum ceev faj soj ntsuam ntshav siab, mem tes, raum thiab lub siab ua haujlwm.

Cov tshuaj no tuaj yeem ua rau cov tshuaj pleev xim, thiab vim li no nws yog qhov pom zoo kom tsis txhob muaj kev ywj pheej thaum lub sijhawm saib xyuas.

Analogues thiab cov nqi

Tus nqi ntawm cov tshuaj no nyob ntawm nws daim ntawv tso tawm. Ib pob ntawm 10 ampoules yuav tau muas rau 60 rubles, thiab ib tug zoo li tus naj npawb ntawm cov ntsiav tshuaj cov nqi txog 150 RUB.

Analogs ntawm cov tshuaj no muaj xws li "Chlorpromazine Hydrochloride" thiab "Tizerzin."

Xyuas

Raws li cov kws kho mob tshwj xeeb, cov tshuaj no muaj cov tshuaj tua kab mob loj heev, tshem tawm tag nrho cov paib ntawm txoj kev xav ntawm psychomotor. Txawm li cas los xij, nws yuav tsum tau sau tseg tias cov kev txheeb xyuas txog qhov cuab yeej no yog qhov sib txawv.

Qee cov neeg mob tau hais tias cov tshuaj no siv tau hauv Alzheimer's tus kab mob, schizophrenia, psychosis, qaug dab peg, thiab kuj ua rau muaj ntxhov siab thiab ntxhov siab. Lwm cov neeg tau txais kev ntseeg ntseeg hais tias qhov tshuaj no ua rau muaj kev txhawj xeeb ntawm kev qaug dab peg, tshee txhais tes, ntau tus neeg muaj kev ntxhov siab thiab ib lub xeev uas muaj kev ntshai.

Nyob rau hauv txhua rooj plaub, qhov kev kho no yuav tsum raug siv rau lub hom phiaj intended thiab tsuas yog kev saib xyuas ntawm tus kws kho mob.