Cov tshuaj "Mikosist": xyuas, analogues, nqe. Tshuaj "Mikosist": cov lus qhia rau kev siv

Tshuaj "Mikosist" phau ntawv qhia txhais ua ib qho kev noj neeg sawv cev. Lub active ingredient ntawm cov tshuaj fluconazole ua - ib tug xim inhibitor ntawm sterol synthesis nyob rau hauv lub fungal hlwb. Nws suppresses nyob rau hauv tus tib neeg lub cytochrome system P450 tsis muaj androgenic kev ua si, nws yog zoo nrog rau kev hwm mus pathogens ntawm mycosis.

tshuaj

Tom qab qhov ncauj los yog tso dej raws leeg medicament "Mikosist" (neeg siv indicates no) zoo rau hauv lub cev kua thiab ntaub so ntswg. Nyob rau hauv cov hnoos, peritoneal kua thiab articular, cov qaub ncaug, niam cov kua mis tshuaj concentration zoo li ntawd tiav nyob rau hauv cov ntshav ntshav. Cov ntsiab lus ntawm fluconazole nyob rau hauv lub hlwb txha nqaj qaum kua nyob rau hauv cov neeg mob uas fungal meningitis yog yim caum feem pua ntawm cov concentration nyob rau hauv ntshav uas, nyob rau hauv lem, yog ncaj qha xwm yeem mus rau koob tshuaj. Thaum ib zaug-txhua hnub daim ntawv thov mus rau lub plaub-tsib hnub ntawm 90 feem pua yog tiav equilibrium concentration. Yog hais tias thawj hnub yuav coj ib koob tshuaj nyob rau hauv excess ntawm lub niaj zaus ob zaug, koj yuav muaj qhov thib ob hnub mus cuag 90 feem pua ntawm cov equilibrium txuam nrog. Kaum ib mus rau kaum ob feem pua ntawm cov fluconazole khi rau ntshav proteins. Nyob rau hauv peripheral ntshav metabolites tsis kuaj. Tshuaj nyob yeej tseem zoo rau ob lub raum, vim hais tias cov tshuaj no yog tas mas qhia lawv, thiab hais txog yim caum feem pua - unchanged. Tsis pub dhau peb teev ntawm kev lim ntshav hauv lub concentration ntawm active tshuaj nyob rau hauv cov ntshav yog txo los ntawm ib nrab.

indications rau

Nws yog pom zoo kom siv cov tshuaj "Mikosist" qhov ncauj tawm, xws li generalized, disseminated, qhov chaw mos, thaum lwm cov ntaub ntawv ntawm tus Candida kab mob, candidemia, thiab nyob rau hauv lub xub ntiag ntawm yam uas yog conducive mus rau lub rov tshwm sim ntawm qhov ncauj tawm. Tsis tas li ntawd qhia yog kev siv ntawm cov tshuaj rau cov neeg uas mucosal Candidiasis: lub caj pas; qhov ncauj Candidiasis xws li atrophic, nej sawv ntawm hnav cov hniav yas; txoj hlab nqos mov. Tshuaj "Mikosist" phau ntawv qhia xav muab rau cov neeg mob kev txom nyem los ntawm cryptococcal meningitis, los yog sepsis, cryptococcosis, cryptococcal kab mob ntawm daim tawv nqaij los yog lub ntsws. Nws kuj tau thov rau cov kev tiv thaiv ntawm kev rov muaj dua ntawm cov kev txawv txav nyob rau hauv cov neeg mob uas AIDS thiab nyob rau hauv lwm tus neeg mob ntawm immunodeficiency. Tshuaj siv los mus tiv thaiv fungal kab mob nyob rau hauv cov neeg uas muaj phem hlav, raug raws li ib tug tshwm sim ntawm hluav taws xob los yog cov kws khomob rau defeat cov ntaub ntawv. Tsis tas li ntawd, cov tshuaj "Mikosist" yog siv nyob rau hauv cov kev kho mob ntawm fungal kab mob puab tais thiab npog tas ib ce, sib sib zog nqus teb mycoses, xws li paracoccidioidomycosis, coccidioidomycosis, histoplasmosis nyob rau hauv cov neeg mob uas ib txwm muaj zog.

Cov tshuaj daim ntawv no, ntim, muaj pes tsawg leeg

Ob tug ntau npaum ntaub ntawv ntawm medicament muaj "Mikosist": tsiav tshuaj thiab cov tshuaj rau cov Txoj kev lis ntshav. Tsiav tshuaj no yog ua los muaj 50, 100 thiab 150 milligrams ntawm fluconazole. Tag nrho cov ntawm lawv yog cov nyuaj gelatin, nrog ib tug opaque dawb lub cev, thiab txawv xwb nyob rau hauv cov xim hau: y tsiav tshuaj uas muaj 50 milligrams ntawm active ingredient, lub teeb xiav hau 100 milligrams - turquoise, 150 milligrams - xiav. Cov ntsiab lus yog ib tug hmoov khoom loj los yog dawb (yuav luag dawb) hmoov. Accessory cov khoom xyaw ua magnesium stearate, lactose anhydrous, colloidal silicon dioxide, talc, titanium dioxide, pob kws starch, gelatin, indigo carmine. Tsiav tshuaj uas muaj 50 thiab 100 mg ntawm fluconazole, yog marketed nyob rau hauv pob khoom nrog ib tug, ob tug, plaub blisters, xya daim txhua. Thiab cov neeg uas muaj 150 milligrams ntawm active ingredient - nyob rau hauv ib los yog ob daim.

Txoj kev lis ntshav tov muaj hauv daim ntawv ntawm pob tshab, tsis muaj kob los yog maj mam dawb lias kua. Ib tug muaj ob milligrams ib milliliter ntawm lub active tshuaj. Cov theem nrab Cheebtsam yog dej rau txhaj tshuaj thiab sodium tshuaj dawb. Dispensed daws nyob rau hauv lub khob vials puas milliliters muab tso nyob rau hauv cov duab los qhia thawv. Ib pob muaj ib tug minyuam lam fwj.

Yuav ua li cas tau "Mikosist"? ntau npaum

Lub ib txwm koob tshuaj fluconazole nyob rau hauv cryptococcal kab mob yog thawj hnub ntawm kev kho mob, 400 mg, nyob rau hauv lub nram qab no hnub - 200-400 milligrams. Lub caij ntawm txoj kev kho nyob rau hauv lub paub tseeb hais tias mycological txoj kev tshawb no ntawm tus soj ntsuam miv nyuas siv zug, nws yog feem ntau tsis muaj ntau tshaj rau - yim lub lis piam. Nyob rau hauv cryptococcal meningitis siv ib cov tshuaj "Mikosist" cov lus qhia rau kev siv pom zoo rau kaum - kaum ob lub lis piam tom qab qhov tshwm sim yog tsis zoo txoj kev tshawb no kuaj ntawm hlwb txha nqaj qaum kua. AIDS cov neeg mob tom qab kawm tiav ntawm lub thawj zaug kev kho mob yog qhia rau kev tiv thaiv ntawm kev rov muaj dua ntawm cryptococcal meningitis rau ib ntev lub sij hawm ntawm kev txais tos txhais tau tias "Mikosist" nyob rau hauv ib koob tshuaj tsis tsawg tshaj li ob puas milligrams ib hnub twg.

Nyob rau hauv cov neeg mob uas disseminated Candidiasis, candidemia thiab lwm yam tus Candida kab mob, feem ntau yog nyob rau hauv thawj hnub ntawm kev noj plaub milligrams ntawm cov tshuaj, thiab nyob rau hauv lub tom ntej no ob peb hnub - ob puas milligrams txhua txhua hnub. Nyob rau hauv cov ntaub ntawv ntawm kev mob loj mauj poov tshuaj tej zaum yuav muab tau ntau zog mus rau yim puas milligrams ib hnub twg. Kev kho mob yuav tsum tau mus ntxiv rau ntawm tsawg kawg yog ob lub lis piam tom qab lub tshem tawm ntawm cov tsos mob thiab tau txais ib tug tsis zoo ntshav kab lis kev cai. Yog hais tias oropharyngeal Candidiasis, xws li nyob rau hauv cov neeg mob uas impaired kev tiv thaiv, tshuaj ntau npaum ib hnub twg yog tsib caug - ib puas milligrams, noj nws yuav tsum tau ib lub sij hawm ntawm xya - kaum plaub hnub. Nyob rau hauv atrophic candidosis uas ua los ntawm hnav cov hniav yas feem ntau tus kws kho txhua txhua hnub kom tsawg tsib caug milligrams ntawm cov tshuaj nyob rau hauv ua ke nrog nrog antiseptic. Kev kho mob txuas ntxiv ob lub lis piam. Rau lwm Candida kab mob (candiduria, esophagitis, daim tawv nqaij thiab mucosal Candidiasis) txhua hnub koob tshuaj noj tshuaj yog tsib caug - ib puas milligrams, txoj kev kho yog kaum plaub - peb caug hnub.

Nyob rau hauv thiaj li yuav tshem tawm ntawm chaw mos Candidiasis medicament "Mikosist" phau ntawv qhia qhia txais yuav singly nyob rau hauv ib tug npaum li ntawm 150 milligrams. Nws yuav ua tau rau plaub - kaum ob lub hlis ib zaug ib lub hlis rau haus dej haus ib cov tshuaj ntsiav (150 mg) rau txo lub zaus ntawm rov. Feem ntau kws kho rau Candidiasis nyob rau hauv tas li ntawd mus rau yeeb tshuaj "Mikosist" taws tswm ciab, piv txwv li, "Terzhinan", "Clione-D", "Ginezol". Nyob ntawm seb cov neeg kawm ntawv ntawm kev pheej hmoo ntawm fungal kab mob, rau kev tiv thaiv ntawm Candidiasis txhua hnub pom zoo koob tshuaj ntawm cov tshuaj yuav sib txawv ntawm tsib caug rau plaub puas milligrams.

Nyob rau hauv cov ntaub ntawv ntawm sib sib zog nqus teb mycoses yuav tau coj cov tshuaj ntawm ib tug ntau npaum ntawm ob puas - plaub puas milligrams ib hnub twg rau ob lub xyoos. Lub caij ntawm kev kho mob nyob rau ntawm ib tug neeg thiab cov kev soj ntsuam daim duab: nrog coccidioidomycosis, nws yuav yog los ntawm kaum ib mus rau nees nkaum plaub lub hlis, paracoccidioidomycosis - los ntawm ob mus rau xya lub hlis, histoplasmosis - los ntawm peb mus rau xya lub hlis.

daim ntawv thov kev cai

Tso dej txia npaj yuav tsum tau muab ntawm ib tus nqi tsis ntau tshaj nees nkaum milliliters ib feeb. Muaj yog tsis muaj yuav tsum tau hloov txhua hnub koob tshuaj thaum Identify cov neeg mob los ntawm tso dej rau qhov ncauj tshuaj. Ib tug tov rau Txoj kev lis ntshav yog tau tshaj dvadtsatiprotsentnym zib tov; kev daws teeb meem Hartman thiab Ringer; tov ntawm sodium hydrogen carbonate, poov tshuaj tshuaj dawb nyob rau hauv ib tug zib, sodium tshuaj dawb (0.9%). Txoj kev lis ntshav yuav tsum nqa tawm siv tib yam fluconazole khoom siv rau ntshav, siv ib tug ntawm cov nram qab no lub ntsiab.

phiv

Feem ntau ntawm cov neeg mob uas coj lub tshuaj "Mikosist 'xyuas txog nws yoojyim ib tug zoo. Tshuaj ua tau zoo eliminates fungal kab mob, tiam sis yuav ua phiv los. Yog li ntawd, los ntawm lub digestive system yog muaj kev xeev siab, flatulence, txawv txav siab muaj nuj nqi, muaj teeb meem nrog cov kev txiav txim zoo ntawm saj, raws plab. Tsis tas li ntawd, ib txhia neeg xa mus rau qhov tshwm sim ntawm mob taub hau, qaug dab peg, kiv taub hau. Lawv hais tias xws phenomena muaj arisen tsocai tom qab noj cov tshuaj, "Mikosist". Xyuas ntawm lwm tus neeg mob muaj ntaub ntawv hais txog kev loj hlob ntawm txoj kev kho yeeb tshuaj tsis haum tshuaj nyob rau hauv daim ntawv ntawm cov erythema, tawm pob, angioedema, urticaria. Cov lwm tau sab los yuav tsum tau muab sau tseg alopecia, ventricular fibrillation, impaired raum muaj nuj nqi, hypertriglyceridemia, hypercholesterolemia, thiab hypokalemia.

Contraindications

Nyob rau hauv daim ntawv ntawm cov tshuaj yuav tsum tsis txhob yuav tshuaj noj rau cov me nyuam nyob rau hauv rau lub hlis ntawm hnub nyoog (rau cov me nyuam mos tso cai rau siv cov tshuaj nyob rau hauv daim ntawv ntawm cov tshuaj rau cov Txoj kev lis ntshav). Tsis txhob siv cov tshuaj no "Mikosist" lactating cov poj niam (cev xeeb tub cov poj niam yuav tsum muab nws saib xyuas), raws li zoo raws li cov neeg uas muaj rhiab heev rau cov khoom xyaw uas nyob rau hauv muaj pes tsawg leeg. Nrog lub nce yuav tsum tau siv kev ceev faj rau cov neeg mob raum / hepatic insufficiency, intolerance ntawm acetylsalicylic acid.

overdose

"Mikosist" sau ua ntaub ntawv mob ntawm tshuaj overdose. Xyuas ntawm cov neeg uas coj cov tshuaj nyob rau hauv ntev koob, qhia txoj kev loj hlob ntawm kev zawv plab, xeev siab, ntuav. Nyob rau hauv loj heev zaum, muaj cov tsos mob chua leeg hlwb, paranoid tus cwj pwm, hallucinations. Ib tug neeg uas cov tsos mob ntawm overdose yuav tsum raug coj mus rau tsev kho mob, qhov chaw uas pais plab lavage yuav tau ua rau nws, kev lim ntshav, yuam diuresis, symptomatic txoj kev kho.

"Mikosist" los yog "Fluconazole": uas yog zoo dua?

Yog li ntawd, lo lus nug nquag nug los ntawm cov neeg mob. Nyob rau hauv qhov tseeb, ob leeg cov tshuaj yog tib yam, peb yuav hais tias lawv yeej zoo tib yam. Qhov txawv tsuas yog tias cov tshuaj "Mikosist" ua rau cov Hungarian kws lub tuam txhab "Gedeon Richter", thaum "Fluconazole" - qhov kev npaj ntawm domestic ntau lawm. Ntawm cov hoob kawm, qhov no muaj ib tug ncaj qha feem rau tus nqi ntawm cov tshuaj. Xaiv dab tsi yuav - "Mikosist" los yog "Fluconazole" - ntau xav mus rau yeeb tshuaj, uas yog cheaper. Tseeb, ib tug tseem ceeb sib txawv nyob rau hauv nqe. Yog li ntawd, rau lub ntim ntawm "Mikosista" (ib cov tshuaj ntsiav uas muaj 150 milligrams ntawm fluconazole) koj yuav tsum them ib tug nruab nrab ntawm 295 rubles, thaum lub sij hawm tib pob "Fluconazole" nqi tsuas 8-20 rubles. Qhov nruab nrab nqi ntawm ib tug 100 ml fwj tshuaj rau Txoj kev lis ntshav "Mikosist" yog 311 rubles.

Raws li hais tus pharmacological thaj chaw ntawm lub ob tshuaj, lawv yog zoo zoo tib yam, qhov txawv yuav pom tsuas yog hais tias tus nqi ntawm haum: raws li muaj nyob rau cov ntaub ntawv, lub siab tshaj plaws nyob rau hauv concentration ntawm lub cev "Fluconazole" yog attained tom qab 1-2 xuab moos tom qab daim ntawv thov, thiab "Mikosista" - 0.5 -1,5 teev. Txawm li cas los, tsis yog txhua txhua tus neeg mob teb rau ob tug tshuaj sib npaug. Ib txhia tsis pom tej yam txawv nruab nrab ntawm lawv, thaum lub caij nyoog kawg no ntseeg tau hais tias qhov zoo tshaj yog nyob ntawm tus nqi, uas txhais tau tias ib tug yeeb tshuaj yog kim kim, qhov zoo. Koj muaj peev xwm feem ntau nrhiav tau xyuas nyob rau hauv uas cov poj niam hais tias tom qab noj cov "Fluconazole" qhov ncauj tawm rov qab tuaj, tiam sis lub "Mikosist" pub kom tshem tau ntawm nws mus tas li. Nyob rau hauv txhua rooj plaub, cov kev xaiv yog koj li.

analogs

Nyob rau hauv tas li ntawd mus rau "Fluconazole", muaj lwm yam tshuaj uas yuav hloov cov tshuaj "Mikosist". Analogs medicament muaj raws li active ingredient tib yeeb tshuaj, yog zoo tuaj. Nyob rau hauv daim ntawv ntawm cov tshuaj rau kev kho mob ntawm cov poov xab thiab lwm yam fungal kab mob, koj muaj peev xwm siv tau "Diflucan" tshuaj "Flucostat", "mikomaks" thiab lwm tus neeg. Ib tug zoo txhais tau tias yog "Mikoflyukan" (ntsiav tshuaj). "Mikosist" los ntawm tag nrho cov txawv analogs los ntawm indicators xws li bioavailability, ib nrab-lub neej, tus nqi ntawm haum.

tshuaj cov kev sib tshuam

Nws yog tsim nyog los ua tib zoo saib xyuas tus prothrombin lub sij hawm nyob rau hauv cov neeg mob uas tau txais fluconazole nrog indirect anticoagulants coumarin pab pawg neeg, vim hais tias muaj yog ib tug uas yuav zuj zus lub VWP. Thaum concomitantly nrog sulfonylureas tshuaj "Mikosist" tej zaum yuav sim haum lub ib nrab-lub neej ntawm lawv, yog li koj yuav tsum xav txog qhov tau ntawm hypoglycemia. Nyob rau hauv cov ntaub ntawv ntawm fluconazole thiab phenytoin sib koom tau clinically tseem ceeb degree ntawm kev nce ntawm lub xeem concentration, yog li ntawd, yog tias tsim nyog ua ke tau txais cov koob tshuaj yuav tsum raug txo. Ua ke nrog cov kev txais neeg kawm txhais tau tias "Mikosist" thiab rifampicin yuav tsum khij txo nyob rau hauv concentration ntawm fluconazole yog li ntawd KOOB "Mikosista" yuav tsum tau mus nce. Ua ke siv ib qho kev azole derivative nrog ib tug medicament nyob rau hauv ua ke nrog nrog terenadinom txhob, raws li muaj peev xwm tsim mob loj heev, lub neej-hem arrhythmia. Yog hais tias koj noj cov tshuaj "Mikosist" ua ke nrog cisapride, yuav manifest undesirable tshua nyob rau ib feem ntawm lub plawv, nrog rau ventricular tachycardia. Nrog rau cov simultaneous siv fluconazole thiab theophylline txo qhov nruab nrab clearance tus nqi los ntawm ntshav ntawm lub xeem ntshav, thiab yog li ntawd tsub kom qhov yuav ntawm kev loj hlob ntawm nws cov tshuaj lom los thiab overdose.

ceev faj

Yuav tsum kho mob nrog "Mikosist" kom txog thaum tus soj ntsuam thiab Hematological so ib pliag. Ntxov ntxov discontinuation ntawm txoj kev kho yog fraught nrog rov. Raws li twb tau hais, cov neeg mob uas raum insufficiency yuav tsum tau siv cov tshuaj noj nyiaj pab ntau tshaj ceev faj, vim hais tias nws yog tas tsuas yog los ntawm lub raum. Ntau npaum thaum lub sij hawm ntev-lub sij hawm kev kho mob yuav tsum tau ua, noj mus rau hauv tus account lub CC. Qee zaus fluconazole yuav lom los rau hauv lub siab, ces nws yog tsim nyog los saib xyuas cov hauj lwm ntawm lub cev. Thaum nrhiav kom tau ntawm qhov txhab tsos mob yuav tsum tsis txhob noj tshuaj.

Cov neeg mob nyob rau hauv lub keeb kwm yav dhau ntawm "Mikosist" txhais tau hais tias tau tsawg sightings exfoliative cutaneous tshua, xws li tshuaj lom epidermal necrolysis thiab Stevens-Johnson syndrome. Cov neeg mob uas phem neoplasms thiab AIDS yog nws muaj ntsis mus rau lub rov tshwm sim ntawm mob tawv nqaij tshua thaum uas siv cov kev npaj muaj fluconazole. Yog hais tias thaum lub sij hawm kev kho mob ntawm ces dag fungal kab mob cov pob zoo nkaus li, cov tshuaj uas koj xav tau mus rho. Yog hais tias koj muaj kev mob ua pob xua nyob rau hauv cov neeg uas muaj tus los yog mauj fungal kab mob tus kws kho mob yuav tsum ntxiv dag zog kev saib xyuas thiab tshem cov tshuaj nyob rau hauv cov kev tshwm sim uas yuav tsim erythema multiforme, los yog bullous txhab. Thaum lub sij hawm kev kho mob, cov tshuaj "Mikosist" (xyuas paub meej tias nws) tej zaum yuav ua rau kiv taub hau, yog li cov neeg mob yuav tsum tau tshwj xeeb tshaj yog ceev faj thaum ua hauj lwm nrog rau tus txheej txheem thiab cov kev tswj ntawm lub tsheb.