Daim ntawv thov thiab cov nyhuv ntawm "Cefotaxime." "Cefotaxime": ib tug analogue ntawm cov tshuaj

Tshuaj tua kab mob "cefotaxime" - ib tug haib siv yeeb tshuaj rau kev kho mob ntawm kis kab mob thiab kev tiv thaiv ntawm postoperative teeb meem. Cov tshuaj nkag tau rau hauv lub cev los ntawm kev txhaj tshuaj, nws yog feem ntau kws kho rau ob qho tib si cov neeg laus thiab cov me nyuam. Nws yog ib tug semisynthetic tshuaj tua kab mob nrog rau cov active tshuaj sefotaksim sodium.

pharmacological los

"Cefotaxime" - Tus Neeg Sawv Cev cephalosporins, bactericidal kev txiav txim yog ensured los ntawm cov hluav ntawm lub tsim ntawm cell phab ntsa ntawm cov kab mob.

Antimicrobial yog npaj rau parenteral siv, nws yog zoo thaum raug Gram-tsis zoo kab mob uas yog resistant mus rau lwm cov tshuaj tua kab mob, tau ua rau gram-zoo cocci, tab sis tsawg active tshaj gram-tsis zoo kab mob.

tshuaj

Lub tshuaj no yog sai absorbed, nyob ntawm seb ntau npaum yog nyob rau hauv cov ntshav ntawm tsib feeb los yog ib nrab ib teev tom qab txhaj thiab koom tes bactericidal ntau nyob rau hauv cov ntshav rau ntau tshaj 12 teev. Cov tshuaj no yog nkag mus rau cov ntaub so ntswg thiab kua, zoo faib nyob rau hauv lawv. Thaum siv nyob rau hauv lactation tshuaj yuav tau txais mus rau hauv niam cov kua mis. Qhov siab tshaj plaws cov nyhuv "Cefotaxime" yog tiav thaum zoo ntau nyob rau hauv lub synovial, peritoneal thiab pleural kua. Derivation yog ua unchanged nyob rau hauv cov zis (txog 60%) thiab nyob rau hauv daim ntawv ntawm cov metabolites. Rau ib nrab-lub neej raws li ib tug tshwm sim ntawm V / m thiab / nyob rau hauv yuav tsum tau 1 hr.

Indications rau kev siv ntawm lub medicament

Indications rau kev siv cov tshuaj yog kab xwm ntawm o provoked los ntawm micro-kab uas txawv sensitivities rau "cefotaxime" (mas gram-tsis zoo). Muab tsuas txhais tau tias rau tshuaj "Cefotaxime" analogs nyob rau hauv cov ntsiav tshuaj muaj, cov tshuaj no yog siv nyob rau hauv kev txheeb xyuas xws xeev:

• kab mob rau lub plab kab noj hniav;
• txhab ntawm daim tawv nqaij, pob qij txha, nqaij mos thiab pob txha;
• kab mob ntawm cov pa ib ntsuj av tau, qhov ntswg, caj pas, pob ntseg;
• kab mob rau lub urinary system;
• Lyme kab mob;
• inflammatory kev ntawm kab xwm nyob rau hauv lub pelvic kabmob, gonorrhea;
• kub nyhiab, raug tus kab mob txhab;
• meningitis, endocarditis, Septicemia;
• kab mob ntawm immunocompromised;
• kev tiv thaiv ntawm cov kab mob tom qab phais cov txheej txheem (ua hauj lwm nyob rau hauv lub mob huam kabmob, obstetric thiab gynecological thiab urological cov txheej txheem).

Contraindications

"Cefotaxime" analogues nyob rau hauv lub tshuaj muaj tej yam contraindications uas yuav tsum raug xam tias yog ua ntej thawj coj ntawm cov tshuaj.

Cov tshuaj yog ua rau cov ntaub ntawv ntawm npau taws me ntsis rau penicillins, carbapenems thiab lwm yam cephalosporins. Nws ua tib zoo tshuaj rau daim siab thiab lub raum kab mob, ulcerative mob plab, lactation. Cev xeeb tub poj niam cov kws kho tsuas yog hais tias muaj yog ib tug loj kev pheej hmoo rau tus me nyuam hauv plab los yog leej niam ntawm lub cev yuav tsum tau txais txiaj ntsim ho outweigh cov tau txaus ntshai. Thaum siv nyob rau hauv kev sib raug zoo rau cov me nyuam nyob rau hauv lub hnub nyoog ntawm 2.5 xyoo, tsis tau tso cai rau siv cov qauv ntawm cov intramuscular txhaj tshuaj.

Siv cov tshuaj, tshuaj

Yuav kom paub yuav ua li cas yug "cefotaxime", nws yog tsim nyog los nyeem cov ntaub ntawv muab nyob rau hauv cov lus qhia rau kev siv ntawm cov tshuaj. Tshuaj npaj rau ib tug / m thiab / nyob rau hauv cov kev taw qhia (ntawm ib tug dropper los yog bolus).

Cov tshuaj no yog tshuaj rau cov neeg mob laus tshaj 12 xyoo, thaum lub cev hnyav yog ntau tshaj 50 kilograms:

• kis kab mob ntawm cov mob txeeb zig thiab nyob rau hauv cov neeg mob thaum tau tus kab mob tshwm sim tsis muaj teeb meem kab mob los ntawm txhua txoj muaj muab 1 g ntawm cov kev npaj nrog cov Team sib ntawm 8-12 teev;
• uncomplicated mob gonorrhea ntaub ntawv muab singly los ntawm cov intramuscular lawv 1 g ntawm yeeb tshuaj;
• siv ib tug yeeb tshuaj rau kev kho mob ntawm cov kab mob ntawm cov kab xwm, cov heev uas yog nruab nrab, ib yam ntawm cov tau txoj kev ntawm 1-2g yog xeem nrog ib tug periodicity txhais tau tias 12 teev (ua ntej cov nroj tsuag "Cefotaxime", nws yog tsim nyog los ua tib zoo kawm txog cov kev cai raws li uas lub ntsiab yog npaj cov kev txhaj tshuaj) ;
• nyuaj tshwm sim kab mob, e.g., meningitis, yuav tsum tau cov kev taw qhia mus rau hauv lub cov hlab ntsha 2 g ntawm cov tshuaj ntawm ua mib ntawm 4-8 teev, nrog lub siab tshaj plaws tshuaj ib hnub twg tej zaum yuav tsis ntau tshaj li 12 g; ntev ntawm kev kho mob yog txiav txim los ntawm lub heev ntawm tus mob;
• ua ntej ua hauj lwm thaum lub sij hawm tshuaj loog los mus tshem tawm cov ntxim yuav zoo siv ntawm kab mob yog muab 1 g ntawm yeeb tshuaj, nyob rau hauv tej rooj plaub 6-12 teev yog nqa reintroduction txhais tau tias;
• phais plab yug seem yog ua los ntawm plaug 1 g ntawm "Cefotaxime" tom qab tus txheej txheem rov qab.

Cov tshuaj no kuj siv intravenously nyob rau hauv relation mus ntxov ntxov cov me nyuam mos thiab cov me nyuam mos:

• muaj hnub nyoog yog tsawg tshaj li 1 lub lim tiam - siv 50 mg rau ib 1 kg ntawm lub cev hnyav nrog ib zaus 12 teev;
• hnub nyoog ntawm 1 mus rau 4 lub lis piam - 50 mg rau ib 1 kg ntawm lub cev hnyav nrog ib tug periodicity ntawm 8 teev.

Cov me nyuam uas luj tsawg tshaj li 50 kilograms ntawm lub hnub nyoog ntawm 2.5 xyoo, taw 4-6 Introduction ib qhov tau txoj kev 50-180 mg rau ib kilogram ntawm lub cev qhov ceeb thawj (yuav tsum to taub raws li "cefotaxime" tsiaj novocaine, koj yuav tsum tau nyeem cov lus qhia kom zoo) . Yog hais tias muaj yog ib tug loj heev thaum kawg ntawm tus kab mob, kev siv cov 100-200 mg / kg. Thaum hnub yog siv tau rau 12 g ntawm cov tshuaj.

Kev npaj ntawm kev daws cov kev txhaj tshuaj

tso dej txhaj tshuaj

Cov menyuam tsis taus dej rau txhaj (4 ml) twb diluted nrog 1 g ntawm cov tshuaj. Cov tshuaj yog muab tshaj 3-5 feeb, nws yog ib qho tseem ceeb los mus muab ib tug qeeb tus me nyuam mus rau hauv lub cev.

Tso dej Txoj kev lis ntshav (nrog)

Thaum 50-100 mL ntawm hnyav (dextrose 5% los yog sodium tshuaj dawb 0.9% th) diluted 1-2 g ntawm cov tshuaj thiab Txoj kev lis ntshav yog nqa tawm rau 50-60 feeb.

intramuscular

Nyob rau hauv 4 ml ntawm cov kua (1% novocaine tshuaj -th, dej kev txhaj tshuaj) noj 1 g ntawm yeeb tshuaj, ua tshuaj nyob rau hauv lub pob tw, lub koob yuav tsum nkag mus rau heev rau hauv cov nqaij.

Raws li noj tshuaj cov lus qhia siv

"Cefotaxime" analogues nyob rau hauv cov ntsiav tshuaj rau cov uas muaj muaj, thov nyob rau hauv kev ua raws cai nrog rau cov lus qhia. Ua ntej thov kev cov tshuaj tsim nyog los tshem tawm cov ntxim yuav zoo siv ntawm kev ua xua. Cov neeg mob uas muaj peev xwm ua tau ib tug kev tsis haum cov tshuaj tiv thaiv rau penicillin, cov tshuaj yuav tsum tau siv nrog huab ceev faj. Yog hais tias muaj yog rhiab heev rau lub tshuaj muaj nyob rau hauv lub lam khoom, nws siv yog nres. Nyob rau hauv cov kev kho mob ntawm ntau tshaj 10 hnub yuav tsum tau periodic soj ntsuam ntawm peripheral cov ntshav ncig. Yuav kom tshem tawm undesirable tshua thaum lub sij hawm kev kho mob yuav tsum muab cawv.

Overdosing phiv

"Cefotaxime" analogues nyob rau hauv qhov kev ncua muaj ib tug loj tus naj npawb ntawm sab los:

• kev tsis haum tshuaj loj (urticaria, khaus, tawm pob, ua npaws, ua daus no, bronchospasm, anafillaksiya, eosinophilia, angioedema, tshuaj lom epidermal necrolysis thiab Stevens-Johnson);
• dyspepsia (mob nyob rau hauv lub plab mog, dysbacteriosis, flatulence, xeev siab, ntuav, quav tawv los yog zawv plab, mob ntawm lub siab, nyob rau hauv uas tsis tshua muaj mob - pseudomembranous mob plab);
• glossitis, stomatitis;
• teeb nyob rau hauv hematopoiesis system (hypocoagulation, hemolytic anemia, thrombocytopenia, granulocytopenia, neutropenia, leukopenia);
• kev txawv txav nyob rau hauv lub urinary kabmob (interstitial nephritis, anuria, oliguria, azotemia, theem ntawm urea nyob rau hauv cov ntshav);
• kiv taub hau, mob taub hau;
• tsis zoo dab nyob rau hauv cov hlab plawv system (arrhythmias nqa ib tug tej zaum kev hem thawj rau lub neej);
• undesirable zos tshua (infiltrate, mob / m, phlebitis);
• kev hloov nyob rau hauv laboratory tsis (cuav zoo Coombs 'test);
• superinfection (qhov ncauj Candidiasis, candida vaginitis).

"Cefotaxime" analogue ntawm cov tshuaj thaum uas siv nyob rau hauv siab koob tshuaj yuav ua tau kom overdose, ua raws li los ntawm convulsions thiab lwm yam kev mob, nrog rau lawv - lub ntxhov siab vim, tshee, encephalopathy (ntau heev no cov tsos mob muaj cai nyob rau hauv cov neeg mob kev txom nyem los ntawm lub raum tsis ua hauj lwm). Yuav kom tshem tawm cov teebmeem ntawm ib tug overdose symptomatic kev kho mob yog siv.

Drug sis raug zoo nrog lwm yam tshuaj

Yog hais tias koj yuav tsum nrhiav tus txhais tau tias nrog ib tug muaj pes tsawg leeg zoo ib yam li nyob tus yeees ntawm cov nyiaj "cefotaxime" analogue tuaj tos yuav tsis tau yooj yim. Tab sis tsis muaj teeb meem, nrog rau cov kev pab los ntawm cov tshuaj txoj kev kho yog ua siv tus thawj analogue los yog, nyob rau hauv txhua rooj plaub, koj yuav tsum nqa mus rau hauv tus account tus sis ntawm cov tshuaj nrog lwm yam tshuaj.

Thaum "cefotaxime" siv ob qho tib si rau feem nephrotoxic tshuaj xws li furosemide, aminoglycoside tshuaj tua kab mob, nws yog ib qho tseem ceeb mus soj ntsuam cov chaw ua hauj lwm ntawm ob lub raum, vim hais tias ntawm txoj kev pheej hmoo ntawm nephrotic tej yam.

Rau cov kev kho mob ntawm ntau cov kab mob thiab tiv thaiv lawv txoj kev loj hlob feem ntau siv "cefotaxime". Cov lus qhia rau kev siv, tshuaj analogues yuav tsum tau kawm, raws li qhov cuab tam yuav ua rau ua xua, muaj ib tug ntau ntawm cov mob tshwm sim thiab lwm cov nta. Lub ntsiab ntawm cov tshuaj yuav tsis tau siv nyob rau hauv ua ke nrog lwm yam kev daws teeb meem ntawm tshuaj tua kab mob, lawv muaj peev xwm tsis tsum kev cob cog rua rau lub txia chamber thiab cov syringe.

analogs

Txhais tau hais tias rau "cefotaxime" analog yuav tsum tau xaiv rau lub active tshuaj. Ntawm cov yam ntxwv analogues yuav qhia tau:

• cefotaxime sodium;
• cefotaxime vial, Sandoz, sodium thiab Lek;
• tsefosin;
• tsefantral;
• tsefabol;
• tsetaks;
• tirotaks;
• tartsefoksim;
• taltsef;
• tax-rau-twv;
• spirozin;
• rezibelakta;
• oritaksim;
• oritaks;
• liforan;
• klafotaksim;
• klaforan;
• klafobrin;
• kefoteks;
• intrataksim.

Txij li thaum muaj ib tug ntau yam ntawm cov cuab yeej rau kev npaj "cefotaxime" analog xaiv ib qho yooj yim, tab sis t. Yuav kom. Lub analogs yuav muaj lwm yam tshwm sim tsis zoo, thiab lawv kho nyhuv tej zaum yuav weaker, hloov cov thawj cov tshuaj yuav tsum tau xaiv kom zoo zoo. Kom tsis txhob undesirable txim, yuav tsum kawm kom ntau li ntau cov lus qhia txog cov tshuaj uas yog npaj yuav siv.