"Fosinopril": cov lus qhia rau kev siv. "Fosinopril": indications rau siv, tiag tiag counterparts

"Fosinopril" yog ib qho inhibitor ntawm angiotensin converting enzyme. Cov tshuaj muaj hypotensive txiav txim, nws yuav siv tau rau ntshav siab, nyob ib leeg thiab nyob rau hauv txoj kev kho mob. Tsis tas li ntawd, lub medicament niamntiav natriuretic, vasodilating thiab cardioprotective txiav txim, nws yog siv nyob rau hauv ua ke nrog nrog lwm yam tshuaj thaum lub sij hawm kev kho mob ntawm lub plawv tsis ua hauj lwm.

Pharmacological "fosinopril"

Kev npaj "Fosinopril" nyob rau hauv lub cev yuav siv sij hawm rau hauv daim ntawv ntawm cov active metabolite uas depressing ntxim rau angiotensin converting enzyme. Cov tshuaj thiaj li tus nqi ntawm tsim ntawm angiotensin 2, normalizes lub mauj ntshav siab, zoo ntxim rau cov hlab ntsha.

Angiotensin converting enzyme ua si siv 10, 20 thiab 40 mg tshuaj no yog tshuam txo nyob rau nruab nrab rau 7 teev (tsis muaj sai tshaj li 2 teev, tab sis tsis pub tshaj 12 teev tom qab noj cov tshuaj). Thaum lub sij hawm lub hnub nws yog txo los ntawm 7-15%.

"Fosinopril" Ntsiav tshuaj pub rau cais myocardial hypertrophy thiab dilation ntawm sab laug ventricle, nyob rau hauv lub xub ntiag ntawm xws tej yam kev mob ua rau kom lawv tshem tawm. Cov tshuaj cheeb qhov uas cov tsim ntawm aldosterone uas yog nqa tawm nyob rau hauv lub adrenal qog, tsub kom cov kev ua ntawm ib tug kallikrein-kinin system, tswj lub bradykinin cov ntsiab lus nyob rau hauv cov nqaij thiab cov ntshav. Vim txoj kev kho raws li nyob rau kev siv ntawm "fosinopril" nce liberatiou tshuaj uas txhim kho cov ntshav mov rau lub ob lub raum, muaj natriuretic, vasorelaxant kev txiav txim. Lub medicament thiaj li ntau lawm arginine vasopressin thiab endothelin-1, uas txiav txim vasoconstrictor.

Los ntawm kev txo lub siab (diastolic, systolic) tsis tsim, thiab postural orthostatic tachycardia cov tshuaj tiv thaiv tsis hloov BCC. Muaj tsis muaj kev hloov nyob rau hauv lub reflex kev ua si ntawm lub myocardium, raum thiab cerebral ntshav txaus. Muaj tsis muaj kev ua txhaum cai ntawm cov ntshav mov rau ntawm daim tawv nqaij, hauv nruab nrog cev, skeletal nqaij.

Raws li cov phau ntawv qhia, "Fosinopril" siv nyob rau hauv ib koob tshuaj, muaj ib tug hypotensive kev txiav txim uas yog feem ntau cov lus hais tom qab txog tsib teev. Cov uas ua cov nyhuv yog muab khaws cia tseg ib hnub twg, uas tso cai rau koj kom ib tug ntshav siab tsis. Yuav kom tso saib cov nyiaj pab ntau tshaj tau cov nyhuv yog yuav tsum tau mus tau dhau ib tug ob peb lub lis piam.

Thaum lub sij hawm kev kho mob "fosinopril" tawg yuav ua tau kom lub cev lus teb rau cov ceev ceev txo nyob rau hauv mauj cov ntshav siab. Thaum ua ke kho nrog thiazides thiab "Fosinopril" txhais tau tias zoo nkaus li ntau pronounced antihypertensive kev ua si. Yog hais tias tsim nyog, rho tus "fosinopril" tsis tsim lub syndrome, nws tsis yog txawm nyob rau hauv lub rooj plaub thaum lub tso tseg yog ua dramatically. Kev npaj pab tus neeg mob thaum nyuaj ntws daim ntawv mob hauv lub plawv tsis ua hauj lwm, raws li zoo raws li lub cev lo lus teb rau lub cev kev nyuaj siab.

Hais txog cov qauv qhia ntawm mutagenic thiab genotoxic khoom nyob rau hauv lub sij hawm ntawm kev kho mob "Fosinopril" tshuaj daim ntawv qhia qhia lawv qhaj ntawv. Txawm li cas los, cov kev siv ntawm cytotoxic koob tshuaj ua rau ib co mob txuam nrog chromosomal aberrations. Kev tshawb fawb tau ua nyob rau hauv nas thiab nas tsom tias txhua hnub koob tshuaj tsis tshaj 400 mg / kg tsis ua cov tsos mob ntawm carcinogenicity. Vim ntau dua koob tshuaj nyob rau hauv cov txiv neej nas txuj lom ntau nyob lipomas. Txhua hnub koob tshuaj ntawm cov tshuaj mus rau 60 mg / kg nyob rau hauv nas tsis ua mob txuam nrog qhov kev siv ntawm kev ua me nyuam muaj nuj nqi. Thaum muab medicament cev xeeb tub nas (txhua hnub koob tshuaj txog li 400 mg / kg ib hnub twg) thiab luav (txhua hnub koob tshuaj 40 mg / kg) tshwm sim intoxication, tshuaj adversely cuam tshuam hauv chav kawm ntawm cev xeeb tub.

Suction txhais tau tias "Fosinopril" Neeg Daim Ntawv Thov yus li qeeb, vim koos ntau noj mov. Los ntawm yog vim li cas ntawm thawj-pass metabolism bioavailability me ntsis (36%). "Fosinopril" hydrolyzed, tus txheej txheem no tshwm sim nyob rau hauv cov ntshav, daim siab thiab hnyuv plhaub vim nws siv fozinoprilat tsim, uas yog ib tug active metabolite. Cov qib siab tshaj plaws ntawm cov tshuaj nyob rau hauv lub cev yog nyob rau nruab nrab peb teev tom qab nws daim ntawv thov. Ib nrab-lub neej tshwm sim 12-15 teev. Kev sib txuas lus nrog cov ntshav yog yuav luag tiav - mus txog rau 98%, lub volume ntawm tis yog me me.

Tshuaj tsis txhaum cov kev txwv placental thiab cov ntshav-hlwb tej, lub sij hawm ntawm kev kho mob yog tam sim no nyob rau hauv lub kua mis. Nyob rau hauv mob npuas paug (dej, biliary) tsis clearance, hydrolysis hais maj mam. Nyob rau hauv lub raum insufficiency tshwm sim muaj kev cuam tshuam diatsidnyh active metabolites feem, tshuaj tej zaum yuav noog nyob rau hauv lub cev. Kev siv cov kev lim ntshav kom tshem tawm cov tshuaj los ntawm tus kab mob "Fosinopril" phau ntawv qhia no qhia raws li ib tug kev txiav txim uas tsis tsim tus yam tshwm sim.

Indications "Fosinopril" npaj

"Fosinopril" kws kho rau lub plawv tsis ua hauj lwm thiab tawg. Nyob rau hauv thawj cov ntaub ntawv, cov tshuaj yog lub hauv paus rau ntxiv txoj kev kho, nyob rau hauv lub thib ob complex yog siv rau txoj kev kho thiab monotherapy.

Kev kho mob nrog "Fosinopril"

Feem ntau, ntsiav tshuaj haus ib los yog ob zaug ib hnub twg nyob rau hauv lub tib lub sij hawm. Nyob rau hauv cov kev kho mob ntawm kub siab pom zoo ua ntej 10 mg ntawm cov tshuaj, thiab tom qab ntawd - 20-40 mg. Nyob rau hauv lub neej coj kev kho mob, tsuas yog thaum "fosinopril" yog siv diuretic, noj 10 mg ntawm yeeb tshuaj. Nyob rau hauv cov ntaub ntawv no, mus xyuas ntawm cov ntshav siab, lub siab tshaj plaws tau koob tshuaj ntawm cov tshuaj yog 80 mg ib hnub twg. Yog hais tias cov tshuaj, lwm koob tshuaj tsis ob npaug yog raug hla lawm. Kev Kho Mob koob tshuaj uas siv cov cuab yeej pom zoo los ntawm ib tug kws kho mob yuav tsis siv sij hawm ib tug loj los yog me me npaum li cas ntawm cov tshuaj thiab ua rau kom nws cov zaus uas siv, los yog muaj peev xwm ua tau lub tso tseg "fosinopril" tsis muaj kev noj kev haus ib tug kws kho mob.

Ua ntej yuav noj cov tshuaj "Fosinopril" phau ntawv pom zoo tias koj ntsuam xyuas cov degree ntawm kev nce rau hauv cov ntshav siab. Nyob rau hauv lub sij hawm ntawm kev kho mob yuav siv sij hawm mus rau hauv tus account qhov sib txawv kev soj ntsuam tshwm sim, tus kws kho mob yuav tsum tsis tu ncua saib xyuas qhov mob ntawm tus neeg mob.

Yuav kom txo tau txoj kev pheej hmoo ntawm kev loj hlob ntawm ob tawg, ib tug me me koob tshuaj yog pom zoo nyob rau hauv yuav mus pw. Antihypertensive kev kho mob rho xya hnub ua ntej yuav pib ntawm txoj kev kho, "fosinopril". Yog hais tias koj muaj yav tas los ua diuretic txoj kev kho yog txo txoj kev pheej hmoo ntawm symptomatic hypotension, kev kho dej thiab mob electrolyte tshuav nyiaj li cas, diuretic txo lub koob tshuaj, nyob rau hauv tej rooj plaub, tsis txhob noj cov tshuaj nkaus (rau 4-7 hnub ua ntej mus rau tus thawj koob tshuaj "fosinopril").

Tom qab myocardial infarction txoj kev kho txhais tau tias "Fosinopril" qhia ntawv nyob rau daim ntawv thov tso cai rau koj mus pib peb hnub tom qab ntawd. Thaum lub sij hawm kev kho mob yuav tsum ntsuas ntawm cov ntshav siab thiab check qauv ntawm peripheral cov ntshav (soj ntsuam ua ntej kev kho, lwm yam tsis pub dhau 3-6 lub hlis ntawm txoj kev kho nyob rau hauv lub neej yav tom ntej pov thawj yog ua txhua xyoo, ntau heev xyuas tej zaum yuav tsim nyog thaum ib tug siab ntau yam ntawm tshwm sim ntawm neutropenia). Tsis tas li ntawd, nws yog tsim nyog los tswj lub cev hnyav, xyuas tus txheej xwm ntawm ob lub raum thiab creatinine ntau ntau, poov tshuaj nyob rau hauv nyob tus yeees ntawm cov ntshav protein, cov ntshav urea nitrogen. Thaum lub sij hawm kev kho mob uas koj xav tau kom ua raws li ib tug khoom noj.

Cov neeg mob uas nws phem tawg muaj cim tshuaj txhaj koob tshuaj maj zog (txhua txhua hmo ntuj), xav tias cov kev hloov nyob rau hauv cov ntshav siab, thaum lub sij hawm zoo yuav tsum maximized.

Contraindications tau txais "Fosinopril" tshuaj

Thaum muab cov ntsiav tshuaj "Fosinopril" indications rau kev siv yog xam tau tias yog ib txhij nrog contraindications. Cov tshuaj tsis yog siv nyob rau hauv cov ntaub ntawv ntawm npau taws me ntsis rau nws cov Cheebtsam thiab lwm yam zoo xws tshuaj. Tshuaj tsis muab rau cov neeg mob twg uas muaj tsawg tshaj li 18 xyoo ntawm lub hnub nyoog thiab cev xeeb tub cov poj niam, pub niam mis rau cov poj niam. Contraindication hnyav ncawv ntws raum tsis ua hauj lwm. Contraindications xws li angioedema (idiopathic, raws roj ntsha) raws li ib tug tam sim no nyob rau ntawm lub lub sij hawm ntawm lub sij hawm ntawm cov tshuaj, raws li zoo raws li cov neeg uas muaj ib tug keeb kwm qhia hyperkalemia, hypotension.

cev xeeb tub

Ntsiav tshuaj "Fosinopril" phau ntawv qhia txwv tsis pub siv thaum lub sij hawm cev xeeb tub, vim hais tias cov tshuaj ntawm no hom yuav ua tau kom loj hlob mob thiab me nyuam hauv plab tuag.

Yog hais tias lub cev xeeb tub yog lub sij hawm ntawm kev siv ntawm cov kev kho yuav tsum ceev ceev abolition ntawm cov tshuaj. Nyob rau hauv xws li mob, ib tug ultrasound txoj kev kawm kom qhia tau tias mob mus rau lub fetus.

Ib tug me nyuam mos uas nws niam twb kho thaum lub sij hawm cev xeeb tub "fosinopril", yuav pom hyperkalemia, hypotension, oliguria. Yog hais tias tsim oliguria, nws yog ib qho tseem ceeb los mus muab kev pab txhawb nqa rau raum perfusion thiab ntshav siab soj ntsuam tsis tu ncua. Yog hais tias lub raum ua hauj lwm thiab nyob rau hauv thiaj li yuav normalize ntshav siab mogzhet tsum tau ua ntshav los yog lim ntshav.

Cov kev txwv txog kev siv "Fosinopril" npaj

Thaum tsis yog cov tswv yim cov kab mob autoimmune yuav tsum coj mus rau hauv tus account tus piv ntawm cov kev pab thiab tej zaum kev txaus ntshai ntawm cov kev kho mob txhais tau hais tias "Fosinopril". Cov lus qhia rau kev siv, cov lus teb qhia hais tias yuav tsum tau xav txog cov kev txaus ntshai thiab cov kev pab nyob rau hauv cov nram no mob:

• coronary artery kab mob;
• lub xub ntiag ntawm ib tug neeg mob transplanted raum;
• gout;
• mob ntshav qab zib;
• angioedema keeb kwm;
• mob ntaub ntawv ntawm obstructive tus kab mob ntsws;
• hyperkalemia nrog index siab tshaj 5.5 mmol / l;
• desensitization;
• mob npuas paug;
• obstructive hloov, nrog los ntawm impaired cov ntshav outflow ntawm lub plawv (aortic stenosis, mitral);
• mob loj heev lub plawv tsis ua hauj lwm;
• noj cov zaub mov, muab ib tug tsawg tsawg ntawm cov ntsev cov ntsiab lus los ntawm qhov tsawg kawg nkaus tus nqi ntawm sodium nyob rau hauv cov zaub mov noj;
• hyponatremia;
• leukopenia, thrombocytopenia;
• ib co txheej txheem (kev lim ntshav, tshuaj loog) lag luam;
• atherosclerosis, uas muaj feem xyuam rau lub sab nqua;
• lub cev qhuav dej;
• raum tsis ua hauj lwm creatinine saum toj no 300 pmol / L;
• hnub nyoog laus;
• kab mob siab;
• teeb meem nrog rau lub hlwb thiab coronary ntshav txaus;
• stenosis;
• tej yam kev mob nyob rau hauv uas zuj zus lawm BCC.

Sab los ntawm lub "Fosinopril" tshuaj

Qhov mus rau lub medicament "Fosinopril" xyuas thiab qhia kev cuam tshuam cov ntxim yuav zoo siv ntawm kev tsim tej yam kev phiv. Zaum yuav tshwm sim nyob rau hauv mob ntawm hematopoiesis system thiab hlab plawv system. Tau kev hloov ntawm poob siab system, digestive system, txoj kev loj hlob ntawm kev ua hauj lwm tsis totaub. Ib txhia neeg muaj kev hloov nyob rau hauv laboratory tsis thiab phiv cov txheej xwm, cov manifestation ntawm cuam tshuam daim tawv nqaij licas. Zaum yuav tshwm sim teeb nyob rau hauv lub ua pa thiab urogenital system. Cov lwm phiv lub cev tshua - hyperhidrosis, poob phaus, ntuav, kub taub hau, angioneurotic edema, lub cev txoj kev loj hlob nyob rau hauv kab dab los yog inflammatory dab nyob rau hauv cov qog o, lymphadenopathy, worsening ntawm gout. Tej teeb meem thaum lub sij hawm kev kho mob yuav tsum tau qhia rau koj tus kws kho mob. Ntau dua uas yuav muaj kev phiv tej uas yuav muaj kev siv ntawm cov tshuaj.

Overdose "Fosinopril" tshuaj

Nyob rau hauv cov tshuaj kho mob, "Fosinopril" cov lus teb qhia qhov hav zoov yuav ib tug overdose raws li ib tug tshwm sim ntawm tau siab tshaj lub pom zoo koob. Overdose yog nrog los ntawm mob ces hypotension, raum tsis ua hauj lwm, stupor, poob siab, bradycardia, disturbance ntawm dej thiab ntsha tshuav nyiaj li cas.

Tsim ib koob tshuaj yuav txo tau los yog tshem tawm ntawm ib tug medicament ntxuav lub plab thiab muab tus neeg mob haus ib sorbent. Nws tseem ceeb heev uas cov neeg coj ib tug kab rov tav txoj hauj lwm, nws yog ib qho tseem ceeb rau kev ntsuas tsom ntawm ua lub BCC. Nws kuj yuav tsum tau symptomatic txoj kev kho. Hemodialysis nyob rau hauv cov ntaub ntawv no tsis muab cov nyhuv.

Drug sis "Fosinopril" npaj

Qhov ntau yam ntawm tshwm sim ntawm hyperkalemia siab tshaj plaws thaum uas siv cov yeeb tshuaj, uas yog tsim los ntawm cov poov tshuaj ntsev hloov, cyclosporine, supplementation nrog poov tshuaj, poov tshuaj-sparing diuretics.

Cov nyhuv ntawm cov tshuaj yuav qhia ntau kom meej meej nyob rau hauv kev siv ntawm lwm yam txhais tau tias, muaj ib tug hypotensive nyhuv, thiab dej caw. Ib tug weaker nyhuv tshaj qhov xav pom yog tam sim no raws li ib tug tshwm sim ntawm txoj kev siv ntawm tshuaj uas qhib lub renin-angiotensin-aldosterone system, cov tshuaj no, narcotics yuav muab thiab sympathomimetics. Nyob rau hauv xws li mob nws yog tsim nyog los tsis kam txais yuav cov nyiaj los yog hloov "Fosinopril". Analogs raug xaiv los ntawm cov kws kho mob. Nyob rau tau ntawm combining cov tshuaj noj lwm yam tshuaj yuav muab tau los ntawm ib tug tshwj xeeb.

Analogs, "Fosinopril" txhais tshuaj

"Fosinopril" muaj lus thiab analogues. Rau lus yuav "Fosinopril-Teva", "Monopril." Los ntawm no pab pawg neeg ntawm cov tshuaj ua "Fosinopril-OBL», «Fozikard". Ntawm txhais koj yuav xaiv "Fozinal", "Fozinotek".

Thaum cov kev kho mob tsis pub txhais tau hais tias "Fosinopril" cov lus qhia rau kev siv, txhais los yog analogs tsa tus kws kho mob. Analogs "Berliprilom ',' Renitec '" ramipril "," Moeksom "," lisinopril ". Paub analogs kuj yog tswv "Prestarium", "Enap" thiab "enalapril". Ntawm analogues yuav muab "Tritatse", "Akkupro", "captopril". Tau kev kho mob siv lub "Charter" los yog "Prenessa".

Yog hais tias txwv tsis pub siv cov tshuaj "Fosinopril" cov lus qhia rau kev siv, analogs los yog txhais xaiv txiav txim siab tshwj xeeb.

Xyuas ntawm kev npaj "Fosinopril"

Nws yog ib qho tseem ceeb los mus xaiv tus muaj txoj cai los tiv thaiv-hypertensive tshuaj rau tus neeg mob, noj mus rau hauv tus account lub peculiarities ntawm nws lub cev. Yog hais tias "Fosinopril" tshuaj haum tus neeg, lub siab yog txo zoo, thiab kev phiv los tsis tshwm sim. Raws li cov kev txheeb xyuas, muaj ib tug stabilization ntawm cov ntshav siab, pab txoj kev noj qab haus huv zuag qhia tag nrho. Yog hais tias phiv tshua ntawm lub cev thiab muaj cai, lawv yog me me, feem ntau saj ntxaug, kais, hnoos.

Ntshav siab yuav ua rau teeb meem loj txuam nrog kev puas tsuaj rau siab ntsws tseem ceeb, ces koj yuav tsum lub sij hawm yuav ua rau cov tsim nyog txoj kev kho thiab nyeem cov lus qhia noj tshuaj "Fosinopril" analogues, mus ntsib nrog rau lwm cov ntaub ntawv uas pab.