"Mirapex": cov lus qhia rau kev siv, hauj lwm, xyuas

Nyob rau hauv no tsab xov xwm koj yuav kawm tag nrho hais txog cov kev npaj "mirapex": yuav ua li cas los hloov cov tshuaj no, dab tsi yog nws cov nyhuv, contraindications, phiv, tej lus qhia nrog nws txhais tes. Cov tshuaj yuav ua rau kev txawv txav tus cwj pwm thiab tej yam nyob rau hauv tus neeg mob lub teb. Yog li ntawd, ua ntej yuav noj cov tshuaj no "mirapex" cov lus qhia rau kev siv yuav tsum tau ua tib zoo kawm. Peb kuj qhia koj txog cov compatibility ntawm cov tshuaj nrog lwm yam tshuaj.

Ntev "mirapex": lus qhia dav dav txog cov tshuaj thiab indications rau kev siv

Lub active tshuaj ntawm cov kev npaj "mirapex" yog pramipexole. Koom haum pab Cheebtsam cov ntsiav tshuaj: povidone, mannitol, starch, aerosil, magnesium stearate.

Nrog rau qhov no tshuaj kho yog nqa idiopathic (ywj siab ntawm lwm qhov txhab) syndrome ntawm "nyob tsis tswm ob txhais ceg" thiab Parkinson tus kab mob raws li zoo li lwm yam ua kom zoo zoo lub cev muaj zog thiab extrapyramidal ntshawv siab.

Khoom: tshuaj "mirapex PD" 3 mg, 4.5 mg, 1.5 mg, 0.75 mg, 0,375 mg. Lawv tau ntim rau hauv cov hlwv ntawm 10 daim, thiab ces nyob rau hauv cov duab los qhia thawv.

tshuaj dawb. Lawv muaj ib tug beveled ntug thiab tiaj tus zoo rau ob tog, yog ib tus uas muaj ib tug profound kev pheej hmoo.

Ntsiav tshuaj yuav tsum tau coj hais lus, tsis hais txog ntawm cov zaub mov. Noj cov khoom uas tshuaj no yog tso cai thaum twg los tau lub sij hawm. Nyob rau hauv cov ntaub ntawv no, nws yuav tsum tau ntxuav nrog dej. Pom zoo txhua hnub koob tshuaj yog muab faib ua peb theem.

Lub mechanism ntawm qhov kev txiav txim (pharmacodynamics) "mirapex" Ntsiav tshuaj

Pib pramipexole tshuaj uas muaj cov kev npaj "mirapex" yeej thiab nrog siab selectivity tej cov lus teb ntawm lub pab pawg ntawm dopamine receptors D2. Ua tsaug rau nws, compensated rau tus tsis muaj lub cev ua si nyob rau hauv cov ntaub ntawv ntawm Parkinson tus kab mob. Qhov no yog vim ua kom cov dopamine receptors nyob rau hauv lub striatum. Yog li pramipexole tiv thaiv lub degeneration ntawm neurons uas tshwm sim vim neurotoxicity los yog ischemia. Nws cheeb los yog thiaj li tus nqi ntawm synthesis, metabolism, thiab tso dopamine. Tsaug rau pramipexole neurons muaj kev tiv thaiv los ntawm cov tshuaj lom los ntawm anti-Parkinson agents "Levodopa". Tsis tas li ntawd vim nws cov nyhuv txo prolactin (koob tshuaj-dependent).

Nyob rau hauv cov ntaub ntawv ntawm heev siv cov tshuaj "mirapex" rau cov kev kho mob ntawm Parkinson tus kab mob (ntau tshaj peb lub xyoos) thiab cov syndrome ntawm "nyob tsis tswm ob txhais ceg" (ntau tshaj ib xyoo) yeej tsis qhia txo efficiency ntawm pramipexole.

Biochemical dab uas npaj "mirapex 'nyob rau hauv ib tug neeg mob lub cev (tshuaj)

Active tshuaj "mirapex" cov tshuaj no kiag li thiab sai heev absorbed tom qab qhov ncauj thawj coj. Nws muaj peev xwm rau assimilation (bioavailability) yog yuav luag tsis - ntau tshaj 90%. Qhov siab tshaj plaws concentration ntawm cov tshuaj nyob rau hauv ntshav cai tom qab 1-3 teev tom qab noj mov. Thaum noj mov pramipexole haum tus nqi txo. Nyob rau hauv cov ntaub ntawv no, tus nqi ntawm cov khoom noj khoom haus digestible yog tsis tau hloov.

C cov nqaijrog uake pramipexole me ntsis (tsawg tshaj li 20%). Nws muaj ib tug loj muab faib rau volume - 400 litres, uas txhais tau tias cov concentration hauv cov ntshav yog cov uas tsis muaj. Yuav kom ib tug me me raws li raug mus rau yeeb tshuaj metabolism txheej txheem. Kwv yees li 90% ntawm cov koob tshuaj "mirapex" pellets tas los ntawm ob lub raum, nrog 80% - unchanged. Cov quav pramipexole yog pom nyob rau hauv ib tug npaum li ntawm tsawg tshaj li 2% ntawm cov ntim nyiaj ntawm cov tshuaj. Cov ntaub so ntswg thiab lub cev yog lim los ntawm "mirapex" ntsiav tshuaj nyob rau ntawm ib nqi nruab nrab ntawm 500 ml / min.

Siv "mirapex" tshuaj thaum lub sij hawm cev xeeb tub

Kuv yuav siv thaum lub sij hawm cev xeeb tub "mirapex" ntsiav tshuaj? Cov lus qhia rau kev siv ntawm cov tshuaj yuav ua rau nws paub tseeb hais tias tej yam uas cov tshuaj rau txoj kev loj hlob ntawm lub fetus nyob rau hauv lub plab thiab lactation tsis tau soj ntsuam.

Cov tau ntxim ntawm pramipexole rau systems thiab cov tub ceev xwm lub luag hauj lwm rau lub fertilization txheej txheem tau kawm nyob rau hauv thwmsim rau tej tsiaj txhu. Nws tsis qhia nws ua txhaum ntawm me nyuam hauv plab kev loj hlob thaum lub sij hawm cev xeeb tub nyob rau hauv luav thiab nas.

Feem ntawm pramipexole rau hauv niam cov kua mis tsis tau kawm. Ib tug yuav tsuas xav hais tias cov tshuaj yeeb dej caw yuav inhibit lactation, txij li thaum cheeb lawm luteotrophic lawm. Yog li ntawd, tsis txhob noj "mirapex" ntsiav tshuaj thaum lub sij hawm pub niam mis.

Thaum lub sij hawm uas cev xeeb tub, cov tshuaj yuav tsum tau noj xwb, yog hais tias lub peev xwm pab rau cov niam ntau tshaj rau yav tom ntej uas yuav muaj rau lub fetus.

Contraindications rau kev siv ntawm cov ntsiav tshuaj 'mirapex "

Tshuaj "mirapex" tsis tau noj nyob rau hauv cov ntaub ntawv ntawm npau taws me ntsis rau pramipexole, raws li zoo raws li cov neeg uas tsis tau mus txog 18 xyoo ntawm lub hnub nyoog.

Nrog tshwj xeeb ceev faj yog pom zoo kom siv cov ntsiav tshuaj nyob rau hauv txo cov ntshav siab thiab raum tsis ua hauj lwm.

Sab los "mirapex" tshuaj nyob rau hauv lub paj hlwb

Kev npaj "mirapex" - ntsiav tshuaj uas yuav ua rau lub paj hlwb hauv qab no tshua:

• tsis meej pem;
• ntev li yees rau pw tsaug zog los sis tsis muaj thereof;
• hallucinations;
• amnesia;
• asthenia;
• kiv taub hau;
• extrapyramidal syndrome;
• hypoesthesia;
• co;
• myoclonus;
• dystonia;
• kev nyuaj siab;
• fem;
• suicidal tendencies;
• hypokinesia;
• ataxia;
• ntxhov siab vim;
• neuroleptic phem syndrome.

Kawg tau pom nyob rau hauv daim ntawv ntawm cov hyperthermia, teeb nco qab thiab xav, nqaij rigidity, autonomic lability, akathisia.

Tshwm sim los ntawm cov tshuaj "mirapex" nyob rau lwm yam systems ntawm tib neeg lub cev

Licas yuav teb tau txoj kev siv cov tshuaj "mirapex" xws ces:

• hypertonic nqaij, lawv convulsions, laim;
• tshwm sim ntawm kev mob caj dab, myasthenia Heavy kev los yog bursitis;
• mob nyob rau hauv lub hauv siab, caj dab los yog tus txha nqaj (nyob rau hauv lub lumbosacral).

Lawv muaj peev xwm kuj tshwm sim variations nyob rau hauv lub digestive system. Thaum zoo li no tshwm sim:

• tsis qab los noj mov;
• cem quav;
• xeev siab;
• dyspepsia;
• flatulence;
• raws plab;
• ntuav;
• qhov ncauj qhuav;
• txiav lawm nyob rau hauv lub plab.

Ua pa txais tos "mirapex" ntawm cov tshuaj yuav ua rau txoj kev loj hlob ntawm sinusitis, pharyngitis, rhinitis, khaub thuas zoo li syndrome. Nws tseem yog tau tshwm sim ntawm ua tsis taus pa, muaj zog hnoos thiab lub suab hloov.

Yuav ua li cas yog cov nyhuv rau cov hlab plawv system "mirapex" ntsiav tshuaj? Cov lus qhia rau kev siv ntawm cov tshuaj qhia txog tej kev loj hlob tachycardia, arrhythmia, angina pectoris, orthostatic hypotension.

Lwm yam kev phiv

Thaum tau txais cov tshuaj "mirapex" xws teeb meem yuav tshwm sim nyob rau hauv lub urogenital system, raws li cov ntau heev plob tsis so tswj taw, kab mob. Yog li txawm yuav tsum tsis libido thiab potency.

Nyob rau hauv tas li ntawd, tej zaum koj yuav muaj kev muab ob npaug rau pom kev, cataract, conjunctivitis, tuag tes tuag taw ntawm kev pab, kev ua xua, thiab impaired lub rooj sib hais, cov intraocular siab.

Lwm yam kev phiv tshuaj ntawm lub cev:

• retroperitoneal fibrosis;
• pleural effusion;
• pulmonary infiltration;
• poob;
• peripheral edema.

Ntau npaum thiab Administration "mirapex" Ntsiav tshuaj

Yuav kom siv cov tshuaj uas koj xav tau hauv, txhua hnub 3 zaug. Initial koob "mirapex PD" ntsiav tshuaj - 0,375 mg ib hnub twg. Maj mam ua kom tus nqi ntawm cov tshuaj tsim nyog (txhua txhua 7 hnub) mus muab tau cov kev kawm kho nyhuv. Nyob rau hauv lub lim tiam thib ob ntawm kev kho mob txhua txhua hnub yuav tsum tau noj los ntawm 0.75 mg nyob rau hauv lub thib peb - mus 1,5 mg rau plaub - los ntawm 2.25 mg nyob rau hauv lub thib tsib yuav tsum tau haus dej haus tshuaj "mirapex" 3 mg ib hnub twg, nyob rau hauv lub thib rau lub - 3,75 mg, xya - 4.5 mg.

Nyob rau hauv ntev raum tsis ua hauj lwm, ntau npaum yog tom raws li nyob rau hauv qhov kev kawm theem ntawm creatinine clearance. Lub caij nyoog npaum li cas ntawm cov tshuaj yuav tsum tau xaiv ib tug kws kho mob.

Qhov yuav tshwm ntawm overdose ntsiav tshuaj "mirapex"

Yog hais tias koj siv "mirapex" tshuaj ntau npaum twb tawg, cov tsos mob no tej zaum yuav tshwm sim txawm hallucinations, hyperkinesia, xeev siab, ntuav, poob cov ntshav siab thiab arousal.

Rau qhov teeb meem no, lub antidote yog tsis ntsia. Mob ntawm tshuaj overdose "mirapex" yog tsis tsau. Pom zoo symptomatic txoj kev kho, pais plab lavage thiab dynamic soj. Yog hais tias muaj cov cim qhia ntawm ib tug overdose ntawm excitation ntawm lub hauv paus poob siab system, nws yog tsim nyog los thov cov kev npaj, neuroleptics.

Sib tshuam ntsiav tshuaj "mirapex" nrog rau lwm cov tshuaj

Pramipexole txuam ntshav protein me ntsis thiab biotransformation. Yog li ntawd, nws kev sis raug zoo nrog lwm yam tshuaj uas cuam tshuam rau cov txheej txheem yog tsis zoo li.

Tshuaj uas inhibit los yog suppress zus tau tej cov active tshuaj los yog cationic samovyvodyaschiesya los ntawm lub raum tubules, yuav hnov mob nrog tshuaj "mirapex". Cov lus qhia rau kev siv piav tias nyob rau hauv rooj plaub no tus ceev yuav txo tau tshwm sim cleansing ntaub so ntswg thiab lom kua los yog los ntawm ob leeg medicaments los yog ib tug ntawm lawv.

Yog hais tias ib txhij nrog cov tshuaj 'mirapex "siv cov tshuaj, koj yuav tsum xyuam xim rau cov tau hallucinations, dyskinesia, ntxhov siab. Yog hais tias cov cim tshwm sim, ntau npaum ntawm cov tshuaj yuav tsum raug txo.

Compatibility ntsiav tshuaj "mirapex" nrog tshuaj "Amantadine" thiab "L-dopa"

Yuav ua li cas tshwm sim thaum lub neej coj txais tos "Levodopa" tshuaj thiab "selegiline" tshuaj "mirapex PD"? Instruction hais tias cov tshuaj ntawm lub active neeg sawv cev tsis muaj feem xyuam tsis thawj los yog tus thib ob. Nyob rau tib lub sij hawm nyob rau hauv tag nrho cov assimilation thiab feem ntawm cov tshuaj nyob rau hauv ib tug tej yam ntuj tso txoj kev "Levodopa" ntsiav tshuaj "mirapex" yog tsis paub.

Pramipexole twb tsis tau kawm txog tus sis ntawm cov tshuaj "Amantadine". Tab sis compatibility yog tau nyob rau hauv txoj kev kho, vim lawv muaj zoo sib xws mechanisms ntawm feem.

Thaum koob "mirapex" npaj muaj zog, daim ntawv thov nyiaj "Levodopa" pom zoo kom txo tau. Lub xov tooj ntawm lwm antiparkinsonian tshuaj yuav tsum tau muab khaws lossi nyob rau tib theem.

Nta Compatibility npaj "mirapex" nrog rau lwm cov tshuaj

Vim tau cumulative los nrog huab ceev faj yog pom zoo kom siv cov ntsiav tshuaj "mirapex" nyob rau hauv ua ke nrog nrog sedatives, haus dej cawv, thiab cov tshuaj uas pab tau kom pramipexole concentration hauv cov ntshav (e.g., ib tug yeeb tshuaj "Cimetidine").

Cov kev taw qhia nyob rau hauv qhov kev siv ntawm "mirapex" ntsiav tshuaj

Peb piav txog cov tshuaj yog tsis pom zoo kom coj nyob rau hauv nrog antipsychotics.

Nyob rau hauv cov kev kho mob ntawm dopamine agonist paub phiv yog tsis meej pem thiab hallucinations. Nyob rau hauv tus neeg mob ntawm "mirapex" ntsiav tshuaj nyob rau hauv ua ke nrog nrog yeeb tshuaj "Levodopa" xws txawv txav ntau heev nyob rau hauv lub tom qab ua sawv ntawm tus kab mob tshaj nyob rau hauv thaum ntxov monotherapy.

Tus kws kho mob yuav tsum qhia rau tus neeg mob ntawm tus tau tshwm sim ntawm qhov muag pom hallucinations. Qhov no sab nyhuv muaj feem xyuam rau cov muaj peev xwm tsav tsheb thiab ua lub luag hauj lwm txiav txim siab.

Nyob rau hauv ntse discontinuation ntawm cov ntsiav tshuaj nyob rau hauv cov ntaub ntawv ntawm Parkinson tus kab mob tau kuaj cov tsos ntawm cov tsos mob uas tsa neuroleptic phem syndrome.

Anomalous tus cwj pwm nyob rau hauv qhov kev siv ntawm "mirapex" tshuaj

Cov neeg mob thiab cov neeg tu rau lawv, nws yog tsim nyog los paub hais tias cov kev txais tos ntawm dopaminergic tshuaj, xws li "mirapex" ntsiav tshuaj (xyuas paub meej tias qhov no), feem ntau ua rau txawv txav tus cwj pwm ntawm tus neeg mob. Tej zaum koj yuav muaj kev hyperphagia (overeating yees), pathological khw (obsessive siab mus ua ib tug ntau ntawm kev yuav khoom), compulsive twv txiaj thiab hypersexuality. Nyob rau hauv xws li mob nws yog tsim nyog los txo cov tshuaj ntawm cov tshuaj los yog maj mam tsis txhob noj nws.

Ceev faj nyob rau hauv qhov kev siv ntawm "mirapex" ntsiav tshuaj

Tshuaj "mirapex" yuav tsum tau noj nrog ceev faj rau cov neeg mob nrog lub xub ntiag mob cov kab mob ntawm cov hlab plawv system. Nyob rau hauv kev kho nrog dopaminergic tshuaj muaj ib tug uas yuav ntawm orthostatic hypotension. Yog li ntawd, ib tug ntshav siab tswj, tshwj xeeb tshaj yog nyob rau thawj zaug rau theem ntawm kev kho mob.

Thaum pom tau qhov sib puas yog tsim nyog los tsis tu ncua mus saib nws tam sim ntawd tom qab lub sij hawm teem ntawm cov ntsiav tshuaj "mirapex" thiab ntxiv txhais Team sib.

Cov neeg mob yuav tsum tau muab rau lub fact tias cov tshuaj yuav muaj ib tug sedative nyhuv. Muaj mob ntawm cia li pw tsaug zog thiab ntev li tsaug zog thaum lub sij hawm ib hnub rau ib hnub kev ua si. Xws li no tej zaum yuav tshwm sim nyob rau txhua lub sij hawm nyob rau hauv cov kev tswj ntawm txoj machinery los yog tsav tsheb tsheb.

Cov tau tsim melanoma

Raws li ib tug tshwm sim ntawm epidemiological kev tshawb fawb pom tau hais tias cov neeg mob uas Parkinson tus kab mob muaj feem yuav melanoma. Yog nws qhov ua rau ntawm tus kab mob no, los yog lwm yam, xws li kev siv ntawm "mirapex" cov tshuaj tsis tau tsim muaj.

Ntxiv dag zog rau ntawm lub syndrome ntawm "nyob tsis tswm ob txhais ceg"

Yuav ua li cas puas muaj tus syndrome ntawm "nyob tsis tswm ob txhais ceg" tshuaj "mirapex"? Testimonials qhia tias dopaminergic tshuaj tej zaum yuav txhim khu nws. Qhov no yog manifested nyob rau hauv daim ntawv ntawm cov ua ntej lawm pib ntawm cov tsos mob nyob rau hauv lub yav tsaus ntuj syndrome thiab tej zaum nyob rau hauv lub yav tav su. Nyob rau hauv cov ntaub ntawv no, cov tsos mob kis rau lwm tus nqua. Cov nyob rau 26 lub lis piam ib tug soj ntsuam tswj txoj kev tshawb no, uas yog tsim los kawm no nyhuv, ib tug tseem ceeb sib txawv ntawm pramipexole thiab placebo pawg nyob rau hauv pab tau cov yam ntxwv ntawm cov syndrome tau lawm tias.

Cia tej yam kev mob thiab txee lub neej

"Mirapex" ntsiav tshuaj yog hais txog mus rau ib tug kev npaj ntawm daim ntawv teev B. khw lawv yuav tsum nyob rau hauv ib tug maub qhov chaw. Nyob rau hauv cov ntaub ntawv no rau hauv chav tsev kub yuav tsum tsis pub tshaj 30 ° C.

Txee-lub neej ntawm cov tshuaj - 36 lub hlis (3 xyoos) los ntawm lub hnub ntawm lawm.

Txoj kev siv "mirapex" ntsiav tshuaj nyob rau hauv thaum yau thiab tej yam kev mob ntawm purchase

Cov tshuaj no yog contraindicated rau cov kev siv nyob rau hauv cov me nyuam. Tso Cai yog tso cai rau cov neeg tau txais cov ntsiav tshuaj, uas tau mus txog 18 xyoo ntawm lub hnub nyoog. Tshuaj "mirapex" tso tawm nyob rau hauv pharmacies rau kev nthuav qhia ntawm ib tug tshuaj.

Drug analogues "mirapex"

Koj tsis tau, txawm yog vim li cas, mus kis tau cov ntsiav tshuaj yog "mirapex"? Yuav ua li cas yuav hloov tau cov tshuaj, koj yuav tsum tau qhia rau tus kws muab tshuaj los yog tus kws kho mob. Thiab peb muaj cov nram qab analogues.

1. "Motopram" tshuaj. Indications rau kev siv: Parkinson tus kab mob. Nws yuav ua tau ib leeg los yog ua ke nrog tshuaj tshuaj 'levodopa'. Nws kuj yog siv rau yam mob loj heev los yog muaj mob loj tsawv idiopathic daim ntawv ntawm cov syndrome ntawm "nyob tsis tswm ob txhais ceg".
2. "Oprimeya" tshuaj. Hom phiaj: antiparkinsonian tshuaj hom dopaminergic kis tau tus mob nyob rau hauv lub central lub paj hlwb.
3. "Pramipexole" tshuaj. Tus kho neeg sawv cev siv nyob rau hauv Parkinson tus kab mob. Nws yog ntseeg hais tias lub mechanism ntawm qhov kev txiav txim yog ncaj qha mus txuas rau lub peev xwm ntawm ib yam khoom pramipexole hnia dopamine receptors nyob rau hauv lub striatum.

Ntsiav tshuaj "mirapex" - analogues los yog thawj? Tsis tus kheej!

Nyob rau hauv lub saum toj no uas muaj npe khoom, uas yog analogues ntawm 'mirapex "ntsiav tshuaj. Lawv muaj tib lub cim, thoob ntiaj teb uas tsis yog-tus qauv lub npe (los yog ATC-code), uas yog pom zoo los ntawm lub LEEJ TWG (World Health Organization).

Yog hais tias koj xav tau mus yauv mus kho mob siv cov ntsiav tshuaj "mirapex" analogs kuj yog ib tug zoo lwm txoj. Tab sis ua ntej koj hloov lub koomhaum txhais tau tias ntawm txoj kev kho, yuav tsum tham nrog ib tug tshwj xeeb. Nyob rau hauv tsis muaj tej yam ua tsis nws tus kheej! Qhov no yuav ua rau irreversible zoo txim rau koj noj qab haus huv.

Ceeb toom! Qhov tsab xov xwm yog ib tug piav qhia ntawm "mirapex" npaj supplemented thiab yooj yim zog version ntawm cov hauj lwm cov lus qhia rau kev siv. Drug ntaub ntawv yog hais rau lub hom phiaj ntawm kev soj ntsuam. Nyob rau hauv tsis muaj cov ntaub ntawv tsis siv nws li ib daim ntawv qhia rau nws tus kheej-tshuaj.