"Neofilin" (ntsiav tshuaj): cov lus qhia rau kev siv. "Neofilin 100 mg": kev piav qhia txog cov kev npaj

Rau cov kev kho mob ntawm tus kab mob pulmonary tshwm sim los ntawm ib tug spasm ntawm cov pa ib ntsuj av tau, yog siv bronchodilators ntawm Methylxanthine pab pawg neeg. Lawv lub ntsiab tus neeg sawv cev ntawm lub substance theophylline.

Nws yog raws li nyob rau hauv cov tshuaj pab kev mob hawb pob tawm tsam nyob rau hauv bronchial hawb pob, obstructive ntsws thiab pw tsaug zog apnea.

hauj lwm cov tshuaj

Lub medicament "Neofilin" (ntsiav tshuaj) cov lus qhia rau kev siv raws li ib tug medicament yus pom Ukrainian kws khov "Darnitsya" nyob rau hauv ob koob tshuaj: 100 thiab 300 mg. Cov tshuaj muaj ib lub caij nyoog zoo.

Effect rau lub cev

Lub active ingredient ntawm cov tshuaj (theophylline) muaj ib tug bronchodilatory ntxim rau cov kab mob nyob rau hauv uas sim adenosine receptors inhibited phosphodiesterase tsub kom cov ntsiab lus ntawm intracellular Camp, decreases concentration ntawm calcium ions. Nws relaxes du nqaij nyob rau hauv lub bronchi, mob huam, biliary ib ntsuj av tau, lub tsev me nyuam, coronary, pulmonary, cerebral hlab ntsha, dilation ntawm coronary hlab ntsha, txo nyob rau hauv peripheral vascular kuj.

Nyob rau hauv tus ntawm cov tshuaj cai nce nyob rau hauv lub suab nrov ntawm ua pa nqaij, uas muaj xws li cov intercostal nqaij thiab lub diaphragm. Nyob rau hauv tas li ntawd, txo pulmonary vascular kuj, pab txoj kev oxygenation ntawm cov hlab ntsha, qhib rua ntawm lub pa chaw nyob rau hauv lub medulla oblongata, tsub kom nws nyhav rau carbon dioxide, paub alveolar cua.

Qhov no thiaj li heev thiab zaus ntawm nres txo pa taw. Theophylline formulation "Neofilin" (ntsiav tshuaj) phau ntawv qhia no qhia txog li txhais tau tias kev tshem tawm cov vasoconstriction, ua rau kom collateral ntshav txaus thiab cov pa saturation ntawm cov ntshav, txo ntawm perifocal thiab lub hlwb edema, yuav txo tau cawv thiab intracranial siab.

Lub medicament yog npaj los txhim kho lub rheological yam ntxwv ntawm cov ntshav, tiv thaiv lub tsim ntawm cov ntshav txhaws, txo platelet clumping hlwb normalize microcirculation. Theophylline muaj antiallergic txiav txim, nyob rau degranulate mast hlwb thiab txo lub concentration ntawm kev tsis haum muab kev sib kho, xws li histamine, serotonin, leukotriene.

Los ua raum ntshav txaus cai diuretic nyhuv nyob rau hauv uas cov qhov tso zis dej, chloride ions thiab sodium.

Hais tias, khoom siv yeeb tshuaj

Tshuaj "Neofilin 100" (ntsiav tshuaj) phau ntawv qhia kom los kho bronchial hawb pob, asthmatic raws li txoj cai, bronchitis, obstructive mob daim ntawv no, bronchial ntsws, pulmonary tawg, nocturnal pa raug ntes.

Cov tswv yim kuj pab tau loj npaum tshuaj - 300 mg.

Yuav ua li cas mus noj

Lub medicament "Neofilin" (ntsiav tshuaj) phau ntawv qhia xav noj ib koob tshuaj uas yog muab cais rau txhua tus kab mob thiab nyob rau cov kev ceev ntawm lub metabolic dab, hnub nyoog thiab nyhav qeb nta tus neeg mob.

Cov tshuaj haus dej haus 1 lub sij hawm ib hnub twg thaum lub sij hawm noj tshais los yog noj hmo. Medicament "Neofilin" (ntsiav tshuaj) qhia qhia coj nruj hom. Nws yog tsis yooj yim sua nyob rau hauv ib hnub mus haus dej haus ib yam tshuaj thaum lub sij hawm ib tug noj mov, thiab tom ntej no - tom qab cov pluas noj.

Muab xam los ntawm cov tshuaj rau tej lub raum clearance

Rau thawj zaug thiab ntxiv kho tus nqi ntawm cov tshuaj tsim nyog los mus txiav txim cov kev siv tseem ceeb purification ntawm cov ntshav ntshav los ntawm ntau yam tshuaj los ntawm ob lub raum.

Kev npaj "Neofilin" (ntsiav tshuaj) cov lus qhia rau kev siv rau cov me nyuam los ntawm 12 mus rau 15 xyoo nrog ib tug lub cev hnyav tsawg tshaj li 45 kg pom zoo kom siv cov thawj peb hnub ntawm txoj kev kho nyob rau hauv ib tug txhua txhua hnub koob tshuaj ntawm 12 mus rau 14 g ib 1 kg lub cev hnyav. Tab sis koj muaj peev xwm tsis tau ntau tshaj 300 mg ntawm cov tshuaj.

Tom qab peb hnub ntawm kev kho mob xws nyob rau hauv ib txwm zam txhua txhua hnub koob tshuaj ntau zog rau 16 mg rau ib 1 kg ceeb thawj. Tab sis nws yuav tsum tsis txhob ntau tshaj 400 mg ib hnub twg.

Tom qab ib tug ntxiv peb hnub nyob rau hauv ib txwm taus koob tshuaj nce mus rau 20 mg rau ib 1 kg ceeb thawj. Tab sis tam sim no nws yuav tsum tsis txhob yuav ntau tshaj 600 mg.

Kev npaj "Neofilin" (ntsiav tshuaj) cov lus qhia rau kev siv rau cov me nyuam ntawm 16 xyoo thiab cov neeg laus thiab 60 xyoo nrog ib tug lub cev hnyav ntau tshaj 45 kg nyob rau hauv thawj peb hnub ntawm kev kho mob tswv yim siv nyob rau hauv ib tug npaum li ntawm 300 rau 400 mg ib hnub twg hais lus.

Tom qab peb hnub nyob rau hauv ib txwm taus koob tshuaj nce mus 400-600 mg.

Tom qab peb hnub, nyob rau hauv tus tib yam txhua hnub koob tshuaj yuav ntau tshaj 600 mg, tab sis nws yuav tsum tau mus nrhiav kom tau kev tswj ntawm lub theophylline concentration nyob rau hauv tus neeg mob cov ntshav.

Muab xam los ntawm cov tshuaj uas raum clearance thiab rau cov neeg laus

Yuav ua li cas puas tau txais lwm yam pawg ntawm cov neeg mob cov tshuaj "Neofilin" (ntsiav tshuaj)? Cov lus qhia rau cov me nyuam pom zoo yuav tau txais nws nyob rau hauv lub koob, uas yuav tsum tau tsis muaj siab tshaj 16 mg rau ib 1 kg ntawm lub cev hnyav ib hnub twg, tab sis tsis muaj ntau tshaj li 400 mg rau hauv tag nrho. Cov tswv yim pom zoo siv rau cov tub ntxhais hluas los ntawm 12 mus rau 15 xyoo uas raum clearance nqi, los yog nyob rau hauv lub qhaj ntawv ntawm cov muaj peev xwm yuav taug qab cov ntshav concentration ntawm theophylline.

Rau kev npaj "Neofilin 300" (ntsiav tshuaj) cov lus qhia rau kev siv muaj xws li cov nram qab no cov ntaub ntawv. Lawv txhawj xeeb yog cov kev siv ntawm cov tshuaj los ntawm cov hluas tom qab 16 xyoo, thiab cov neeg mob nyob rau hauv cov neeg laus uas raum clearance nqi, raws li zoo raws li cov neeg uas tsis tau ntsuas ntshav concentration ntawm theophylline. Feem ntau rau tej pawg ntawm cov neeg mob tus nqi ntawm cov active ingredient ntawm cov tshuaj yuav tsum tsis txhob ntau tshaj 400 mg.

Ntau npaum Muab xam los ntawm ntshav concentration ntawm theophylline

Nyob ntawm seb cov ntsiab lus ntawm active muaj nyob rau hauv cov ntshav yog nqa tawm txhaj koob tshuaj kho "Neofilin 100" (ntsiav tshuaj). Cov lus qhia xws nkaus yuav tsum tau mus tsim thiab thaum noj siab koob tshuaj noj tshuaj. Txo cov theem ntawm active ingredient thiab tswj tau tus nqi ntawm cov ntshiab yog tsim nyog nyob rau hauv cov kev tshwm sim ntawm kev phiv tshuaj, physiological teeb meem, uas cheeb qhov uas cov feem ntawm cov tshuaj.

Yog hais tias lub ncov concentration ntawm theophylline nyob rau hauv cov ntshav ntawm tsawg tshaj li 9.9 g ib 1 ml, cov tsis muaj cov nyhuv ntawm cov tshuaj nyob rau hauv ib txwm kam yuav tsum tau ib tug 25 tauj ib xees kev nce rau hauv ntau npaum. Tom qab peb hnub, rau tom ntej no hloov ntau npaum li cas ntawm cov tshuaj nqa los ntawm cov ntshav concentration ntawm theophylline.

Yog hais tias cov kev kho mob nyhuv thiab tolerability tuaj zoo qub koob tshuaj ntxiv kev kho mob yog tau tsuas yog tom qab qhov kev txiav txim ntawm ntshav ntau ntawm lub active ingredient. Nyob rau hauv no daim duab nws yuav tsum tau nyob rau hauv lub chav los ntawm 10 mus rau 14.9 micrograms per 1 ml. Yog hais tias muaj yog tsis muaj cov nyhuv, tab sis lub tsiv yog zoo, ntxiv rau lwm yam tshuaj.

Thaum cov tshuaj yuav tsum raug txo

Thaum cov ntshav concentration ntawm theophylline nyob rau hauv lub chav 15 mus rau 19,9 micrograms per ml, yuav tsum tau ntau npaum yuav txo tau ntawm 10%.

Thaum qhov taw qhia tshuaj 20 mus rau 24,9 micrograms per ml yog tsim nyog los txo tus nqi ntawm cov tshuaj yog 25%, txawm yog tias tsis muaj khees phiv tshua. Tom qab peb hnub tom qab txhaj koob tshuaj yuav txo tau yog nqa tawm xyuas ntawm ntshav theophylline taw qhia rau tau ntxiv siv ntawm cov tshuaj.

Yog hais tias cov theem ntawm active tshuaj yog los ntawm 25 mus rau 30 g ib 1 ml, uas tau txais tom ntej dosing yog dhau, thiab ntxiv txo cov kev tsim nyog tus nqi ntawm medicament 25%.

Tom qab peb hnub tom qab txhaj koob tshuaj yuav txo tau yog nqa tawm xyuas ntawm ntshav theophylline qhia los mus txiav txim lub neej yav tom ntej siv cov tshuaj. Yog hais tias tau cov tsos mob ntawm phiv los, coj uas tsim nyog ntsuas.

Thaum lub concentration ntawm theophylline nyob rau hauv cov ntshav siab tshaj 30 micrograms per 1 ml zaum yuav tshwm sim overdosing. Rau ntxiv daim ntawv thov koob tshuaj txo los ntawm ib nrab. Peb hnub tom qab, nqa tawm lub re-ntsuas ntawm tus nqi ntawm cov tshuaj nyob rau hauv ntshav thiab yog npaum li cas.

Nta ntawm daim ntawv thov

Thaum tau txais cov "100 Neofilin" haus luam yeeb ntsiav tshuaj Neeg daim ntawv thov ceeb toom txog tej kev yuav txo tau ntawm cov nyhuv ntawm cov kev kho mob.

Rau cov neeg uas muaj mob loj heev cov kab mob ntawm lub plawv, cov hlab ntsha, daim siab, kis kab mob, nyob rau hauv cov laus hnub nyoog ntau npaum yog tom ib lub zuj zus thiab noj cov tshuaj nyob rau hauv cov neeg uas muaj huab ceev faj.

tshaj tshuaj

Nyob rau hauv neeg laus cov neeg mob, cov tshuaj overdose "Neofilin 300" (ntsiav tshuaj) phau ntawv qhia txog tu-sauv, kub taub hau, plawv irregularities, xws li tachycardia, ventricular arrhythmia, hypotension.

Cov tsos mob yam ntxwv ntawm thaum yau, xws li muaj zog txob taus, cwm pwm mob, kub taub hau, xeev siab, convulsive lub xeev, tachycardia, hypotension, mob ua pa tshua.

Yuav kom kho tau yuav tsum xub tsis txhob noj cov tshuaj, thiab ces ntxuav tawm lub plab, cov hnyuv dej ntsev nrog polyethylene glycol, coj charcoal. Pom zoo ib clearance ntawm theophylline stimulation ntawm cov ntshav los ntawm txoj kev yuam diuresis, hemosorption, ntshav sorption, hemodialysis, peritoneal lim ntshav.

Nyob rau hauv cov ntaub ntawv ntawm xeev siab thiab ntuav neeg mob muab symptomatic agents, piv txwv li, kev txais tos "Ondansetron" los yog "MCP". Yuav kom tshem tawm qaug dab peg tau txais kev "Diazepam".

Leej twg yuav tsum tsis txhob coj

Nyob rau hauv kev npaj "Neofilin 100" (ntsiav tshuaj) qhia muaj xws li ib daim ntawv teev contraindications, uas yog tsis tau thaum cov tshuaj. Cov no muaj xws li ib tug muaj zog rhiab heev rau tag nrho cov Cheebtsam txhais tau hais tias cov tshuaj xanthine series, uas muaj xws li caffeine, theobromine, pentoxifylline.

Yuav tsis tau txais nyob rau hauv mob myocardial nqaij myocardial stunning, tachyarrhythmias, hypertrophic obstructive cardiomyopathy, mob tawg, qaug dab peg, hyperthyroidism, peptic rwj nyob rau hauv lub plab los yog duodenum, mob mob ntawm lub siab, porphyrin kab mob.

Txhais tau hais tias contraindicated rau cov me nyuam nyob rau hauv 12 lub xyoos ntawm hnub nyoog.

phiv tshua

Ib tug xov tooj ntawm cov kev phiv tej zaum yuav tsim los ntawm kev txais tos "Neofilin" npaj (ntsiav tshuaj). Cov lus qhia rau kev siv qhia neeg mob uas muaj ntaub ntawv nyob rau hauv lub tau ntawm mob nyob rau hauv lub hnyuv ib ntsuj av. Lawv tsiag ntawv los ntawm kev mob nyob rau hauv lub plab mog, xeev siab, gag reflex, Gastroesophageal reflux, kub siab, aggravation ntawm ulcers, raws plab, tsis qab los noj mov.

Phiv tshua pom nyob rau hauv cov hlab plawv system nyob rau hauv daim ntawv ntawm cov palpitations, tachycardia, mob arrhythmias, tej ntshav siab, cuav angina, angina pectoris.

Theophylline yuav muaj ib cov nyhuv rau lub hauv paus poob siab system. Nws yuav qhia los ntawm kiv taub hau, mob taub hau, nyob tsis tswm los yog zoo siab heev lub xeev, teeb meem tsaug zog, co, fem, convulsions thiab qaug dab peg.

Ua ntej cov tshuaj tsis haum tshuaj loj nrog qhov tshwm sim ntawm daim tawv nqaij sawv pob, erythema, exfoliative dermatitis, urticaria, ua npaws.

Lwm yam undesirable los ntawm kev kho mob muaj xws li cov plaub hau poob rau hauv lub taub hau, mob hauv siab, ntiav sai ua tsis taus pa, kais, albumin feem ntawm cov protein nyob rau hauv cov zis, hauv lub xub ntiag ntawm cov ntshav nyob rau hauv cov zis, muaj zog zis tso zis, muaj zog tawm hws thiab daim tawv nqaij kub.

Theophylline feem xyuam rau laboratory tsis. Nyob rau hauv kev kho yeeb tshuaj "Neofilin" tej zaum yuav hloov cov ntsiab lus ntawm poov tshuaj ions nyob rau hauv cov ntshiab downwards rau txoj kev loj hlob ntawm hypokalemia. Nyob rau tib lub sij hawm cov theem ntawm creatinine, ions, calcium oxalate, uas yog ntsev ntawm uric acid thiab suab thaj yog nce, uas ua rau yus hypercalcemia, hyperglycemia thiab hyperuricemia.

Tom qab dosing ntawm medicament kom txhob muaj cov degree ntawm sab los yog txo.

Cev xeeb tub thiab lactation

Ntsiav tshuaj Active tivthaiv yuav kis tau los ntawm cov placental barrier thiab ntws mus rau hauv niam cov kua mis.

Maternity txais tos yog tau tsuas yog thaum cov nyhuv ntawm kev kho mob ntawm cov leej niam superior kev pheej hmoo rau tus me nyuam hauv plab. Nyob rau hauv cov ntaub ntawv ntawm tej kev kho yuav tsum yog ib feem ntawm ib tug ntshav ntau ntawm theophylline, thiab ib tug coj kev hloov no txhais tau tias ntawm dosing. Undesirable noj cov tshuaj nyob rau hauv lub xeem lub hlis uas cev xeeb tub vim cov hluav ntawm uterine leeg.

Cov poj niam uas pub niam-pub thiab kho nrog theophylline yuav tsum tau saib xyuas rau cov tsos ntawm tus me nyuam npau taws me ntsis. Tau txoj kev loj hlob ntawm excitation los yog pw tsaug zog teeb meem, uas yuav tsum tau discontinuation ntawm cov tshuaj.