"Osterepar": phau ntawv qhia, xyuas, chaw tsim tshuaj paus, analogues

Txo cov theem ntawm cov zaub mov nyob rau hauv cov pob txha cov ntaub so ntswg yog qhov ua rau ntawm ib tug lossis loj npaum li cas ntawm kev puas tsuaj rau tus pob txha thiab articular apparatus nyob rau hauv cov tib neeg sib txawv ntawm cov muaj hnub nyoog pawg. Heev feem ntau, cov pob txha ceev dua li qub vim muaj zog pob txha tawg - thiaj li hu ua pob txha resorption. Lub normalization ntawm muaj sia dab ntawm kev puas tsuaj thiab creation ntawm cov pob txha - lub ntsiab lub hom phiaj ntawm kev kho mob ntawm cov kab mob ntawm no zoo. Ib tug ntawm cov tshuaj siv rau kev kho mob ntawm kab mob, yog "Osterepar". Cia peb kawm saib lawv hais dab tsi txog "Osterepar" npaj cov lus qhia rau kev siv, tiag tiag cov kws kho mob thiab cov neeg mob.

pharmacological characterization

Lub active tshuaj ntawm cov kev npaj "Osterepar" yog alendronic acid, uas yog sawv cev nyob rau hauv daim ntawv ntawm cov sodium ntsev - sodium alendronate. Lub mechanism ntawm qhov kev txiav txim ntawm no yam khoom uas yog tsis siab txug, txawm li cas los nws yog lub npe hu hais tias lub endpoint ntawm alendronate sodium raug yog los ib tug zoo nqi koj tshuav ntawm kev puas tsuaj thiab kho tshiab ntawm cov pob txha cov ntaub so ntswg. Ib feem ntawm tus txheej txheem no yog pom tau hais los ntawm inhibiting osteoclasts - tshwj xeeb pob txha hlwb lub luag hauj lwm rau nws cov kev puas tsuaj.

Tsis tas li ntawd, nws yog lub npe hu hais tias tus yuav txo tau ntawm cov ntshav calcium ua nws txuam nyob rau hauv cov pob txha cov ntaub so ntswg thaum noj cov tshuaj "Osterepar". Cov lus qhia rau kev siv hais tias nws yuav ntxiv zog rau cov pob txha qauv thiab txo txoj kev pheej hmoo ntawm cov pob txha lov.

Lub pharmacokinetic yam ntxwv ntawm

Txawm tias muaj tseeb hais tias alendronate sodium yog nkag soluble nyob rau hauv cov dej thiab aqueous lub ntsiab, tshuaj haum los ntawm lub plab hnyuv lumen tsis yog ib tug zoo - qhov haum no tsuas yog hais txog 25%. Nws yog lub npe hu hais tias "Osterepar" zoo nkauj zoo binds rau ntshav cov nqaijrog (lub losis tswvyim dabtsi degree yog 70-75%) yog tsis metabolized nyob rau hauv lub cev.

Indications "Osterepar" npaj

Cov lus qhia rau kev siv hais tias cov tshuaj yog qhia rau deforming pob txha mob uas yog lub npe hu ua kab mob (xws li postmenopausal txha nyob rau hauv cov poj niam). Alendronate sodium ntse siv rau kev kho mob ntawm kom ntshav calcium theem nyob rau hauv cov neeg mob uas phem dab.

Contraindications

Official mus rau yeeb tshuaj "Osterepar" phau ntawv muaj tag nrho daim ntawv teev cov contraindications mus rau yeeb tshuaj npaj. Yog li ntawd, "Osterepar" yog contraindicated rau cov kev siv nyob rau hauv cov me nyuam, raws li qhov kawg khoom thiab cov efficiency ntawm kev ruaj ntseg ntawm nws siv yog tsis meej.

Alendronate sodium yog tsis qhia thaum lub sij hawm tsim ntawm lactation, noj thiab nqa cev xeeb tub. Tsis tas li ntawd, cov tshuaj yog ua rau txo ntshav theem ntawm calcium deficiency rickets thiab vitamin D. Ceev faj medicament yuav tsum tau siv nyob rau hauv cov neeg mob uas tsis txaus raum excretory muaj nuj nqi.

phiv

Ua ntej cov kev taw qhia mus rau hauv cov kev soj ntsuam xyaum ntawm alendronate sodium yog double-dig muag, placebo-tshuaj txoj kev tshawb no. Raws li kev soj ntsuam ntawm cov kev tshawb fawb lub zaus ntawm sab tshua cov neeg noj alendronate sodium, yog ib nyuag qis tshaj cov zaus kev phiv tshuaj nyob rau hauv cov neeg mob kho nrog placebo.

Ntawm cov kev phiv tshuaj los ntawm cov tshuaj "Osterepar" cov neeg mob sau tseg mob ntawm tus mob huam (dyspepsia, mob plab, mob ntawm lub rooj zaum nrog ib tug ib txwm mus cem quav) thiab central lub paj hlwb (mob taub hau). Nws muaj lwm yam phiv nrog rau kev siv ntawm "Osterepar" tshuaj. Cov lus qhia rau kev siv qhia tsis tshua muaj heev kev tsis haum tshuaj xws li mob ua pob xua los yog khaus.

ceev faj

Noj "Osterepar" ntsiav tshuaj yuav tsum tau haus zoo tib yam dej haus li lwm cov dej qab zib (ntxhia dej, mis nyuj, txiv hmab txiv ntoo kua txiv) yuav cuam tshuam rau bioavailability thiab qeeb nws haum. Txij li thaum lub sodium alendronate tej zaum yuav khaus mus rau lub sab sauv feem ntawm tus mob huam, cov ntsiav tshuaj yuav tsum tau noj kom ntau ntawm cov dej (tag nrho khob). Nyob rau hauv lub kab rov tav txoj hauj lwm, muaj ib tug raug mob ntawm cov esophageal txhab ntawm txais tos "Osterepar" tshuaj. Cov lus qhia rau kev siv sau hais tias nws yog tsis tsim nyog rau ntawm tsawg kawg yog ib nrab ib teev mus pw tom qab noj cov tshuaj, raws li zoo raws li kev noj cov tshuaj ua ntej yuav pw.

Ceev faj cov tshuaj kho rau cov neeg mob muaj kev kho hniav kab mob, xws li mob genesis. Thaum muab "Osterepara" yog pom zoo kom yauv ib tug tag nrho cov kev kho hniav kev soj ntsuam thiab nqa tawm ib tug ua kom tiav es rov ntawm lub qhov ncauj kab noj hniav. cov kev kho hniav yuav tsum tau zam thaum lub sij hawm txais tos.

Thaum ntev-lub sij hawm kev kho (ntau tshaj ib thiab ib nrab xyoo) cov tshuaj los ntawm cov pab pawg neeg ntawm bisphosphonates, tej zaum yuav ua rau hip lov nyob rau hauv lub proximal feem. Nyob rau hauv cov kev tshwm sim ntawm ib tug pob txha lov ua ntawm tus neeg mob yog pom zoo kom xa rau kev soj ntsuam ntawm tus thib ob ntawm lub femur rau kom txhob muaj cov yuav ua rau muaj re-puas. Nyob rau hauv tas li ntawd, "Oseoreparom" txoj kev kho yog nres kom txog rau thaum txoj kev pheej hmoo-kev pab soj ntsuam kev kho mob.

Tshwj xeeb mloog yuav tsum tau lub sij hawm ntawm "Osterepara" nyob rau hauv cov neeg mob noj glucocorticoids. Cov tshuaj muaj peev xwm ntawm kev txo haum thiab, ntsig txog, lub calcium thiab vitamin D kom tsawg nyob rau hauv lub cev. Nyob rau hauv cov neeg mob no, hypocalcemia yuav hnav asymptomatic thiab qhia yam mob loj heev nyob rau hauv lub xub ntiag ntawm ib tug kev tshuaj ntsuam genetic predisposition. Nyob rau hauv thiaj li yuav tiv thaiv no yam tab kaum thiab raws sij hawm mob hypocalcemia pom zoo kom txaus calcium thiab vitamin D. txais tos

Cov tshuaj no yog tshuaj rau cov neeg mob nrog ib tug tsawg thiab txhob tshwm sim los cov kab mob txuam nrog lactose intolerance.

Cov tshuaj muaj tsis ntxim rau cov tshuaj tiv thaiv tus nqi thiab lub peev xwm los khiav lag luam machinery. Txawm li cas los, peb yuav tsum nco ntsoov hais tias muaj teeb meem thiab kev phiv tshuaj tom qab noj cov "Osterepara" yuav ua rau cov dab.

Tshuaj kev sib tshuam

"Osterepar" tsis pom zoo rau ob leeg siv rau cov tshuaj aspirin, txij li thaum cov tshuaj aspirin tsub kom lub sab los ntawm alendronate sodium (nyob rau hauv particular nws cov nyhuv rau lub plab hnyuv ib ntsuj av tau). Txawm li cas los, "Osterepar" zoo taus nyob rau hauv cov neeg mob uas tau txais ntxiv kho nrog tshuaj anti-inflammatory siv tshuaj. Dua li no fact, ib tug yuav tsum caiv txhob ua ke siv cov tshuaj raws li anti-inflammatory siv tshuaj nonsteroidal lawv tus kheej muaj peev xwm ua rau kuv haj phiv.

Lub hom phiaj ntawm alendronic acid cov poj niam tau txais estrogens nyob rau hauv ntxiv ua ke nrog ib tug progesterone, pab mus rau ib tug ntau pronounced nce nyob rau hauv cov pob txha loj nrog ib tug tseem ceeb txo nyob rau hauv cov theem ntawm cov pob txha resorption.

Thiazide diuretic kho nyob rau hauv ua ke nrog nrog kab los alendronic acid ua rau ib tug txo ntawm calcium poob thiab thiaj li muaj cov nyhuv ntawm "Osterepara".

Lom thiab tshuaj overdose

Yog hais tias lom alendronate cai los ntawm ib tug plob tsis so tswj tsis meej, manifested nyob rau hauv daim ntawv ntawm cov ntuav, kub siab, esophagitis thiab ulceration nyob rau hauv lawv cov quav lumen. Nyob rau hauv ib feem ntawm lub skeletal system thiab ntshav system yuav ua hypocalcemia thiab hypophosphatemia.

Kev kho mob ntawm lom thiab overdose yog raws kev coj kom tshuaj losis tswvyim dabtsi nyob rau hauv lub plab hnyuv lumen thiab nws cov inactivation. Koj siv tau cov mis nyuj, antacids, calcium-raws li binders. Self-ntxias ntuav yuav tsum tsis txhob yuav, vim hais tias cov tshuaj yuav ua rau voos thiab kub yus ntawm cov hlab pas. Rau pais plab lavage yog tsim nyog los siv ib tug kev sojntsuam. Symptomatic txoj kev kho, thiab tswj stabilizing cov calcium uas qib nyob rau hauv cov ntshav ntshav.

Xyuas ntawm cov kws kho mob thiab cov neeg mob

Nyob rau hauv kev npaj "Osterepar" cov lus teb varied, tiam sis feem ntau zoo. Los ntawm cov neeg mob noj cov tshuaj, lub indignation tshwm sim los ntawm ib tug irritant nyhuv ntawm cov tshuaj nyob rau hauv lub mucosa ntawm lub plab hnyuv ib ntsuj av. Los ntawm qhov seem yus pom ntawm cov kws kho mob, cov tshuaj "Osterepar" analogs ntawm cov tshuaj uas muaj alendronate sodium yog zoo nyob rau hauv kev kho kab mob los ntawm ntau yam genesis raws li cov kab mob ntawm lub licas.

analogs medicament

Nyob rau hauv lub chaw ua tshuaj ua lag luam yog sawv cev los ntawm ib tug txaus tus naj npawb ntawm analogs ntawm cov tshuaj uas muaj alendronate sodium li ib tug active ingredient. "Alendronate" "Alendronic acid," "Alental", "Strongos" Tevanat ". Tag nrho cov no, thiab ntau lwm yam tshuaj - analogues ntawm cov tshuaj "Osterepar".

Cov lus qhia rau kev siv ntawm analogues ntawm cov tshuaj tsis qhia, txawm li cas los, yog hais tias muaj yog ib feem ntawm alendronic acid - cov tshuaj yuav siv uniquely rau cov kev kho mob ntawm kab mob.

xaus

Txha - insidious kab mob, thiab nws kev kho mob yog complex thiab lengthy. Yuav ua li cas mus tham txog kev siv yeeb tshuaj "Osterepar cov lus qhia rau kev siv, cov chaw tsim tshuaj paus, cov neeg mob thiab cov kws kho mob, cov kev siv ntawm txhais tau tias ntawm ib tug nyhuv lig rau hauv lub skeletal system, normalizing cov calcium thiab phosphorus metabolism thiab zuj zus lawm cov pob txha resorption.

Txawm li cas los, thaum lub sij hawm cov thawj coj ntawm cov tshuaj, rau siab tshaj plaws ua hauj lwm, koj yuav tsum ua raws li ib tug ob peb yam yooj yim cov kev cai uas tau muab piav qhia nyob rau hauv cov lus qhia rau kev siv, thiab qhov kev sib txuas lus nrog koj tus kws kho mob kom tsis txhob muaj lub undesirable los ntawm cov tshuaj. Thaum lub sij hawm kev kho mob, tsis txhob tsis saib tsis xyuas cov sij hawm teem tseg ntawm cov kws tshwj xeeb, raws li lawv yog cov tseem ceeb rau kev vam meej kev kho mob thiab ib tug hais rov qab.