Tshuaj "Cyclophosphamide": cov lus qhia rau kev siv, nqe, analogs, tsim kom muaj thiab xyuas

"Cyclophosphamide" yog ib qho alkylating compound. Qhov no tshuaj antitumor neeg sawv cev. Nws yuav ua raws li ib tug dawb los yog yuav luag xws crystalline hmoov. Ntxiv cov ntsiab lus hais txog cov tshuaj no.

"Cyclophosphamide" - tsim

Ua lub tshuaj nyob rau hauv Lavxias teb sab lub tuam txhab JSC "Biochemistry." Nws yog nyob rau hauv lub nroog ntawm Saransk rau hauv txoj kev Vasenko, d. 15A.

nqi ntawm

koj yuav tau yuav tus hmoov №1 «Cyclophosphamide" nyob rau hauv tej lub tsev muag tshuaj. Nws nqi yog nyob ib ncig ntawm 90-98 rubles.

Cov tshuaj ntaub ntawv

Los ntawm no hmoov, cov tshuaj yog npaj. Nws yog npaj rau intramuscular thiab tso dej thawj coj

nta muaj pes tsawg leeg

Muaj pes tsawg leeg ntawm txhua vial nrog rau cov hmoov muaj xws li active hom tshuaj hu ua "cyclophosphamide". Tej yam yog nws tus xov tooj. Namely muaj "Cyclophosphamide" 200 mg ntawm hais tias substance ib vial. Qhov no lam khoom tsis muaj cam.

Hauj lwm ntawm lub pharmacological txiav txim

Raws li cov lus qhia rau kev siv, "Cyclophosphamide" - yog ib tug alkylating cytostatic tshuaj. Nws tshuaj muaj pes tsawg leeg yog zoo li yam tshuaj xws li nitrogen mustard. Pharmacological nyhuv "cyclophosphamide" yog siv lub transverse hom crosslinking ntawm DNA thiab RNA strands. Tsis tas li ntawd kev npaj no yeej txhawb protein synthesis inhibition.

"Cyclophosphamide" - analogues

Nyob rau hauv cov ntaub ntawv no, yuav tsum khaws cov nyiaj uas phim lub code ATH plaub qeb. Heev peculiar yog qhov "Cyclophosphamide". Analogs ntawm cov tshuaj no muaj ib tug txiav txim tus naj npawb. Cov feem ntau yog:

1. "Endoxane".
2. "Ifosfamide".
3. "Alkeran."
4. "Holoxan"
5. "Ribomustin".
6. "Leykeran".

Xaiv ntawm txhua tus ntawm cov kev npaj ua los ntawm tus kws kho mob rau ib tug neeg zus. Nyob rau hauv cov ntaub ntawv no, nws yuav siv sij hawm mus rau hauv tus account lub noj qab haus huv thiab kam Cheebtsam.

Nyob rau hauv tej rooj plaub, ib tug?

Cia peb xav txog qhov no taw tes rau ntau yam. Heev peculiar yog qhov siv ntawm xws li ib tug yeeb tshuaj raws li "Cyclophosphamide". Cov lus qhia rau kev siv nyob rau hauv no hais txog yog ib tug indispensable cuab tam. Nws hais tias cov tshuaj no yog muaj nyob rau hauv cov nram no mob:

1. Yog hais tias koj muaj kev mob thiab mob lymphocytic leukemia.
2. Nyob rau hauv lub xub ntiag ntawm ntau yam myeloma.
3. Yog hais tias cov tsos mob uas tsis yog-Hodgkin nqaij hlav.
4. Nyob rau hauv cov kev tshwm sim ntawm mycosis fungoides thiab retinoblastoma.
5. Nyob rau hauv lub xub ntiag ntawm Hodgkin tus kab mob thiab ntawm zes qe menyuam thiab mis qog nqaij hlav.
6. Thaum lub manifestation ntawm cov tsos mob ntawm neuroblastoma.

Tsis tag li ntawd no, cov tshuaj no yog siv nyob rau hauv ua ke nrog nrog lwm yam tshuaj antitumor agents rau cov kev kho mob ntawm cov nram qab no tej yam kev mob:

1. Thaum tus kab cell hlav.
2. Zais zis mob cancer thiab mob ntsws.
3. Sarcoma ntawm nqaij mos hom.
4. Nyob rau hauv cov kev tshwm sim ntawm prostate thiab lub tsev me nyuam mob cancer.
5. Thaum Ewing lub sarcoma.
6. Nyob rau hauv cov ntaub ntawv ntawm Wilms 'hlav.
7. Thaum retikulosarkome.

Kuj yog xws li kev npaj raws li "Cyclophosphamide", teb uas yog zoo, yog zoo li ib tug immunosuppressive neeg sawv cev yam uas hnyav manifestation ntawm cov kab mob autoimmune. Nyob rau hauv cov ntaub ntawv no nws txhais tau tias cov tsos ntawm psoriatic thiab mob caj dab rheumatoid, autoimmune hemolytic anemia, collagen, nephrotic syndrome. Kuj hais tias txhais tau tias suppresses graft rejection cov tshuaj tiv thaiv.

Contraindications

"Cyclophosphamide" muaj tej yam contraindications. Nws yuav siv tsis tau:

1. Thaum lub sij hawm pub niam mis lub sij hawm thiab cev xeeb tub.
2. Nyob rau hauv ntaus cim ua txhaum ntawm pob txha tsim muaj nuj nqi.
3. Yog hais tias cov tsos mob ntawm npau taws me ntsis.
4. Thaum ncua tso zis.
5. Nyob rau hauv lub xub ntiag ntawm active kab mob.
6. Thaum lub sij hawm lub manifestation ntawm cystitis.

Cov kev ceev faj yog tsim nyog "Cyclophosphamide", analogues ntawm uas yog saum toj no, muab nyob rau hauv tej yam mob. Namely, nyob rau hauv lub xub ntiag ntawm lub nram qab no cov kab mob:

1. Nefrourolitiaza.
2. Loj kab mob plawv, siab thiab raum.
3. Gout.
4. Pob infiltration ntawm hlwb pob txha hlwb.
5. Adrenalectomy.
6. Hluav ntawm pob txha tsim muaj nuj nqi.

Hauj lwm ntawm cov kev phiv

"Cyclophosphamide", txhais (analogues) uas yog teev saum toj no, tej zaum yuav pab mus rau rov tshwm sim ntawm cov nram qab no tshwm sim tsis zoo:

1. Lub digestive system yuav manifest cov tsos mob xws li ntuav, xeev siab, anorexia, tsis xis nyob, stomatitis, mob nyob rau hauv lub plab cheeb tsam, raws plab los yog cem quav. Tsis tas li ntawd paub yog tus neeg mob ntawm daj ntseg thiab hemorrhagic mob plab.
2. Nyob rau hauv lub hematopoietic system ces muaj cai neutropenia, anemia, thrombocytopenia, leukopenia. Nyob rau hnub 7-14 txais tos zaum yuav ib nyuag txo tau cov naj npawb ntawm cov qe ua ntshav khov thiab leukocytes.
3. Nyob rau hauv daim tawv nqaij ces alopecia cai. Loj hlob cov plaub hau dua tom qab ua tiav tshuaj. Nyob rau hauv tas li ntawd, thaum lub sij hawm kev kho mob tej zaum yuav tshwm sim nyob rau hauv daim tawv nqaij ua pob liab vog. Tej zaum kuj yuav muaj cov pigmentation ntawm daim tawv nqaij thiab ntsia thawv hloov.
4. Nyob rau hauv cov hlab plawv system thaum muab siab koob tshuaj ntawm cov tshuaj tshaj ib tug ntev lub sij hawm lub sij hawm tej zaum yuav ua tau ib tug manifestation ntawm cardiotoxicity. Nws yog ib qho tseem ceeb rau koj nco ntsoov. Nyob rau hauv tas li ntawd, peb pom tus emergence ntawm complex, thiab tej zaum kuj tuag, tus neeg mob ntawm lub plawv tsis ua hauj lwm. Qhov no yog vim qhov tshwm sim ntawm myocarditis hemorrhagic hom.
5. Nyob rau hauv lub mob txeeb zig yuav ua necrosis ntawm lub raum raws (xws li kev tuag), hemorrhagic cystitis los yog urethritis, urinary zis fibrosis. Nyob rau hauv tsawg tus neeg mob, daim ntawv thov ntawm siab noj tshuaj npaum cas ntawm cov tshuaj tej zaum yuav tshwm sim nephropathy, hyperuricemia thiab raum muaj nuj nqi. Lub xub ntiag ntawm epithelial hlwb nyob rau hauv cov zis tej zaum yuav tshwm sim.
6. Nyob rau hauv lub pa system tej zaum yuav ib tug manifestation ntawm interstitial pulmonary fibrosis.
7. Cov me nyuam system kev ntshawv siab yuav tshwm sim oogenesis thiab spermatogenesis, thiab sterility. Xeem cov tsos mob tej zaum nws tej zaum yuav irreversible. Feem ntau ntawm cov poj niam nyob rau hauv daim ntawv thov ntawm tus neeg saib xyuas cai txoj kev loj hlob ntawm amenorrhea. Tom qab cov kev kho mob, lub regularity ntawm menses feem ntau zaug. Txiv neej noj cov tshuaj yuav ua tau kom lub rov tshwm sim ntawm oligospermia los yog azoospermia, raws li zoo raws li cov zaubmov ntawm testicular Atrophy.
8. Nyob rau hauv cov ntaub ntawv no muaj peev xwm muaj cai thiab kev tsis haum tshuaj loj. Uas yog ib tug manifestation ntawm daim tawv nqaij sawv pob, khaus, ua xua, anaphylactic tshua.
9. Tsis tas li ntawd nyob rau hauv cov ntaub ntawv no tej zaum yuav muaj qhov tshwm sim ntawm cov kev phiv. Xws li ntshav mus rau lub ntsej muag daim tawv nqaij, lossis puas liab liab, malignant theem nrab hlav, tawm fws, mob taub hau.

ntaub ntawv ntawm kev sis raug zoo

Thaum tau txais cov tshuaj no, ib txhia hais tias ua rau kom microsomal oxidation nyob rau hauv lub siab, tej zaum yuav siv cov txheej txheem ntxias microsomal metabolism ntawm cyclophosphamide. Qhov no ua rau tej yam yam. Namely, mus rau ib tug loj tsim alikiliruyuschego hom metabolites. Qhov no thiaj li lub sij hawm uas tus ib nrab-lub neej ntawm cyclophosphamide yog nqa tawm, thiab kuj yuav tsub txoj kev. Cyclophosphamide, uas yog markedly ntev thiab cheeb cholinesterase kev ua si, thiab txhawb nqa qhov kev txiav txim ntawm suxamethonium. nws kuj yuav pab tau kom tsis txhob los qeeb lub metabolism ntawm yeeb. Raws li ib tug tshwm sim, kho kom zoo los yog muaj zog ntev ntawm nws cov nyhuv thiab tsub kom kev pheej hmoo ntawm tshuaj lom los. Qhov no muaj ib tug tsis ntxim nyob rau tag nrho kab mob. Nyob rau hauv tas li ntawd, lub simultaneous daim ntawv thov ntawm allopurinol yuav ua rau kom lom los ntawm cov hlwb pob txha.

Thaum co-xeem nrog cyclophosphamide allopurinol, colchicine, probenecid, sulfinpyrazone yuav tsum tau kho koob tshuaj protivopodagricakih hom tshuaj nyob rau hauv cov kev kho mob ntawm gout thiab hyperuricemia. Tsis tas li ntawd, thaum zoo li no nce thov tsa tes nephropathy kev pheej hmoo tias yog txuam nrog ntau zog lawm ntawm uric acid siv cyclophosphamide.

Cov yav tas substance yuav ua rau ib qho kev nce nyob rau hauv anticoagulant kev ua si. Vim qhov no synthesis nyob rau hauv lub siab txo yam kev qhia cov ntshav txhaws thiab lus platelet ntau lawm. Txawm li cas los, muaj tej zaum kuj tshwm sim ib tug txo anticoagulant kev ua si los ntawm ib tug tsis paub mechanism hom.

Cyclophosphamide tej lub cardiotoxicity ntawm daunorubicin thiab doxorubicin. Lwm yam immunosuppressive agents (chlorambucil, azathioprine, tacrolimus, corticosteroids, mercaptopurine, etc.) tej zaum yuav ua rau kom cov tseem ntawm ob kab mob thiab qog.

Lub simultaneous siv lovastatin nyob rau hauv cov neeg mob uas lub plawv sib hloov yuav ua rau kom txoj kev pheej hmoo ntawm cov kab mob xws li rhabdomyolysis thiab mob raum tsis ua hauj lwm.

Yog hais tias nyob rau hauv ua ke nrog nrog cov tshuaj no yog siv myelosuppressive tshuaj los yog tawg txoj kev kho, yog nws ua tau manifestation additive inhibition ntawm pob txha tsim muaj nuj nqi.

Tib mus thawj coj ntawm cytarabine nyob rau high school koob tshuaj nrog ib tug khoom xws li cyclophosphamide, nyob rau kev npaj mus theem rau hlwb pob txha hloov txheej txheem ua rau cardiomyopathy nrog ua zaus pib ntawm txoj kev tuag.

Lub ntsiab kev

Nyob rau hauv daim ntawv thov yuav siv sij hawm mus rau hauv tus account lub nram qab no:

1. Thaum lub sij hawm kev kho mob nrog cov tshuaj no yuav tsum tsis tu ncua nqa tawm ib tug ntshav mus kuaj ntsuam xyuas cov neeg kawm ntawv ntawm myelosuppression. Nws yog tshwj xeeb yog tsim nyog them sai sai mus rau tus xov tooj ntawm platelets thiab qe.
2. Koj yuav tsum tau tsis tu ncua thiaj li tawm tau ib tug tso zis kuaj no rau lub xub ntiag ntawm koj cov ntshav liab ntawm tes suav. Lawv muaj yuav ua rau kom txoj kev loj hlob ntawm tej kab mob raws li hemorrhagic cystitis. Thaum nrhiav kom tau ntawm tej tsos mob kev kho mob nrog "Cyclophosphamide", tus nqi ntawm uas muaj npe teev saum toj no, koj yuav tsum nres.
3. Raws li tus naj npawb ntawm platelets (tsawg tshaj li 100,000 / ml) thiab / los yog cov ntshav dawb (<2500 / L) ntawm lub tau txais txhais tau tias yuav tsum tau nres.
4. Thaum kab mob no tshwm sim nyob rau hauv lub sij hawm ntawm kev siv yeeb tshuaj kho, hais tias kev kho mob yuav tsum tau txiav los yog tu ncua. Tog twg los nyob rau hauv cov ntaub ntawv ntawm tau txais ntau npaum yuav tsum raug txo. Tus txiv neej thiab cov poj niam thaum lub sij hawm kev kho mob, "cyclophosphamide" yog tsim nyog los siv txhim khu kev qha txoj kev pov.
5. Thaum lub sij hawm txoj kev kho nrog cov tshuaj no yuav tsum tsis txhob haus cawv.
6. Nyob rau hauv lub rooj plaub uas lub elapse thawj zaug kaum hnub tom qab lub lag luam, uas yog nqa tawm nyob rau hauv kev tshuaj loog, thiab tus neeg mob tau tshuaj "Cyclophosphamide", tus nqi ntawm uas muaj npe teev saum toj no, koj yuav tsum qhia lub anesthesiologist muab.
7. Tus Neeg Mob tom qab nws twb muaj nyob rau adrenalectomy, nws yog tsim nyog los nqa tawm tuav ib tug ntau npaum hloov raws li cov corticosteroids, uas yog siv rau cov hloov txoj kev kho cov txheej txheem, thiab xws li ib tug yeeb tshuaj, raws li ib tug kev kho mob, "Cyclophosphamide".

tsim nyog yuav tau ceev faj

Txais tos ntawm cov tshuaj yog tau tsuas yog nyob rau hauv lub saib xyuas ntawm ib tug kws kho mob uas muaj kev nyob rau hauv cov kws khomob. Nws yuav tsum tau tseem yuav nruj ua raws li cov tshuaj regime. Qhov no yuav tsum tau ua tshwj xeeb tshaj yog nyob rau hauv ua ke nrog txoj kev kho. Tsis tas li ntawd, tsis tas yuav mus siv tom ntej doubling ntawm cov tshuaj yog hais tias tus ib yav dhau los twb mus ntsib tsis tau. Nyob rau hauv qhov kev npaj ntawm cov tshuaj no rau siv nyob rau hauv cov me nyuam mos yog tsis pom zoo kom siv diluents uas muaj benzyl haus dej cawv. Vim qhov no yuav ua tau kom txoj kev loj hlob ntawm neeg tuag taus lom syndrome. Namely, mus rau lub tsos ntawm metabolic acidosis, Cns kev nyuaj siab, ua pa tsis ua hauj lwm, lub raum tsis ua hauj lwm, hypotension, qaug dab peg, intracranial hemorrhage.

Thaum lub sij hawm tag nrho cov hoob kawm ntawm kev kho mob yog pom zoo kom nqa tawm ib tug ntshav (1 lub sij hawm rau ib lub lim tiam 100-125 ml). Qhov no yuav tsum tau ua rau lub hom phiaj ntawm kev tiv thaiv ntawm cov kab mob xws li hyperuricemia thiab nephropathy, uas yog vim tus tsim ntawm muaj zog cov nqi ntawm cov uric acid. Cov tsos mob feem ntau tshwm sim thaum pib ntawm cov kev kho mob lub sij hawm. Tsis tas li ntawd, ua ntej hais tias cov tshuaj txoj kev kho thiab thaum lub sij hawm 72 xuab moos tom qab thawj coj los yog pom zoo kom ua tau ib tug tej yam dej kom tsawg (txog 3 litres ib hnub twg), kev siv cov allopurinol (nyob rau hauv tshwj xeeb mob), thiab txhais tau tias uas ua alkaline zis. Rau kev tiv thaiv ntawm kev muaj hemorrhagic cystitis yog feem ntau tsim nyog los nqa tawm muab nchuav ntawm lub zais zis thiab nqa mus siv "UROMITEKSAN". Yog hais tias muaj pib tej yam tshwm sim ntawm tus kab mob, tus kho hais tias kev npaj yuav tsum tau nres kom txog rau thaum tag nrho tshem tawm ntawm tej yam.

Yuav kom attenuate hom dyspeptic phenomena yuav coj cyclophosphamide nyob rau hauv lub thawj hnub nyob rau hauv me me koob tshuaj. Sau kom tiav los yog ib nrab alopecia, uas tej zaum yuav tshwm sim thaum lub sij hawm kev kho mob yog reversible thiab tom qab hauv chav kawm yog txo cov kev ua ntawm lub cev plaub hau kev loj hlob. Txawm li cas los, lawv cov nqaij daim tawv thiab cov qauv tej zaum yuav raug hloov.

Yog hais tias koj muaj kev ua daus no, ua npaws, hnoos los yog hawb pob, mob nyob rau hauv lub qis rov qab cheeb tsam, los yog nyob rau hauv lub sab, mob los sis tsis yooj yim tso zis, los ntshav los yog los ntshav, dub quav, ntshav nyob rau hauv cov quav los yog zis yuav tsum tam sim ntawd sab laj ib tug kws kho mob.

Cov tau thrombocytopenia, ua rau qhov yuav tsum tau rau kev pab tshwj xeeb thaum lub sij hawm ua ub no xws li tus txheej txheem thiab cov kev kho hniav. Nws yuav tsum tsis tu ncua los tshawb xyuas lub daim tawv nqaij thiab cov qog ua kua week thiab lub tso dej site. Qhov no yog nyob rau hauv kev txiav txim mus ntes tej yam tshwm sim los ntshav. Nws tseem yog tsim nyog los txwv cov zaus ntawm venipuncture thiab tsis kam intramuscular txhaj tshuaj. Nws yog tsim nyog los tswj cov ntshav cov ntsiab lus nyob rau hauv cov quav, ntuav, tso zis. Cov neeg mob uas muaj huab ceev faj yuav tsum tau ua shaving txheej txheem, manicure, dentifrices, toothpicks, thiab lwm yam tej Nyob rau tib lub sij hawm yuav tsum tau nruj me ntsis zam kev uas yuav ntog thiab lwm yam kev raug mob. Acetylsalicylic acid thiab haus dej haus cawv no kuj txwv tsis pub uas ua rau kom txoj kev pheej hmoo ntawm hnyuv los ntshav. Nyob rau hauv cov ntaub ntawv no nws yog tsim nyog los siv ib ncua sij hawm txhaj tshuaj tiv thaiv lub sij hawm (tom qab 3-12 lub hlis tom qab kawg cov kws khomob kawm tiav). Nws yog ntshaw kom tsis txhob sib cuag nrog cov kab mob. Thaum lub sij hawm kev kho mob nws yog tsim nyog los thov txaus contraceptive ntsuas.

Thaum hu hais tias tshuaj nrog lub mucosa los yog daim tawv nqaij yuav tsum tau kom huv si rinsed nrog dej dawb lub feem los yog nrog cov tshuaj ntxuav tes, ntsig txog.

Kev pub niam mis thiab cev xeeb tub

Muaj yog ib tug peculiar kev txwv nyob rau hauv no hais txog, uas muaj cov "Cyclophosphamide". Phau ntawv ntawd hais tias txhob yog kev siv ntawm cov tshuaj no thaum lub sij hawm cev xeeb tub. Nyob rau hauv cov ntaub ntawv no, cov qeb ntawm tej yam nyob rau hauv lub fetus denoted «D» los ntawm FDA. Thaum lub sij hawm kev kho mob yog tsim nyog yuav tsum txhob muab pub niam mis.

overdose

Nyob rau hauv cov ntaub ntawv no, muaj tej yam nuances. Lub xub ntiag ntawm ib lub antidote nrog ib tug overdose ntawm hais tias formulation yog tsis paub. Nws yog ib tug txhim khu kev qha qhov tseeb. Nyob rau hauv overdose daim ntawv thov yuav tsum siv cov yuav txhawb tau kev ntsuas xws li tsim nyog kho mob ntawm kis kab mob, raws li tau zoo raws li occurrences ntawm mob thiab / los yog myelosuppression.

cia tej yam kev mob

Nyob rau hauv no hais txog, nws yuav tsum tau tej yam tej yam kev mob xws npaj raws li "Cyclophosphamide". Cov lus qhia rau kev siv qhia hais tias nws yuav tsum tau muab cia rau hauv kub tsis siab tshaj 10 ° C nyob rau hauv ib qho chaw uas yog qhuav thiab muaj kev tiv thaiv los ntawm lub teeb. Nyob rau hauv no cov me nyuam nkag tau mus rau nws yuav tsum tau txwv.

txee lub neej

Muaj yog ib tug tej lub sij hawm ntawm lub sij hawm thaum lub sij hawm uas xws li ib tug yeeb tshuaj muaj peev xwm yuav siv tau raws li "Cyclophosphamide". Cov lus qhia rau kev siv ntawd hais tias nws ua hauj lwm lub neej yog 3 lub xyoo. Nyob rau hauv cov ntaub ntawv no, koj yuav tsum ua raws li tej yam tej yam kev mob. Nws cov lus dag nyob rau hauv lub fact tias ncaj qha txwv tsis pub txoj kev siv cov tshuaj no tom qab lub sij hawm no tas sij hawm.

siv

Nyob rau hauv no cov kev taw qhia, muaj kuj yog ib tug mob uas yog "Cyclophosphamide". Cov lus qhia nyob rau hauv daim ntawv thov qhia tias cov tshuaj yog tso tawm xwb nyob rau hauv pharmacies los ntawm cov tshuaj.

xaus

Nyob rau hauv phau ntawv no, muaj ib tug ntau ntawm cov ntaub ntawv uas pab. Thiab yog vim li cas yog ib tug "Cyclophosphamide", cov lus qhia rau kev siv, tus nqi ntawm cov tshuaj no. Txawm li cas los, ib tug yuav tsum dais nyob rau hauv lub siab hais tias ua ntej koj ua ntawv thov cov tshuaj yuav tsum tham nrog ib tug tsim nyog tus kws kho mob.