Cov tshuaj "Lamikon": kev qhia, daim ntawv thov kev xyuas, analogues, Muaj pes tsawg leeg

Yuav ua li cas ntau npaum li cov tshuaj no raws li "Lamikon"? Tus nqi ntawm cov tshuaj no yuav tsum tau nthuav tawm nyob rau hauv no tsab xov xwm. Kuj muaj koj yuav nrhiav tau ncauj lus kom ntxaws qhia rau kev siv ntawm cov tshuaj, nws contraindications, analogs, indications, phiv tshuaj, tso tawm daim ntawv no, cov qauv thiab thiaj li nyob.

Muaj pes tsawg leeg, zoo lawm thiab ntim ntawm tshuaj

Tau pom tias cov tshuaj yuav ua tau nyob rau hauv cov nram no cov ntaub ntawv:

• "Lamikon" aerosol. Tshuaj tsuag muaj cov active tshuaj xws li terbinafine. Raws li ntxiv Cheebtsam ntawm daim ntawv no yog propylene glycol, macrogol cetostearyl ether 20, benzoic acid, disodium edetate, thiab dej rau txhaj Poloxamer 407. epicutaneous tshuaj no yog tso tawm nyob rau hauv ib lub raj mis nrog ib tug metering twj tso kua mis nyob rau hauv 25 g.
• Cov tshuaj nplaum "Lamikon" (tshuaj pleev). Phau Ntawv Qhia hais tias lub active caij ntawm daim ntawv no kuj ua hauj lwm pab terbinafine. Ntxiv cov khoom xyaw ntawm daim ntawv no yog: ntxhia roj, sodium hydroxide, dawb mos mos paraffin, cetostearyl cawv thiab phenylethyl, macrogol cetostearyl ether 20, propylene glycol, poloxamer 407 thiab lim dej. Nyob rau hauv lub qhov muag ntawm tus tshuaj pleev los nyob rau hauv cov hlab ntawm 15 g
• "Lamikon" qhov ncauj kev npaj. Ntsiav tshuaj, cov kev qhia ntawv uas yog muab ntim rau hauv ib lub thawv uas ua los ntawm cov duab los qhia, kuj muaj xws li ib active tshuaj yog terbinafine. Nrog kev xav txog ntxiv Cheebtsam, lawv muaj xws li: cov pob kws starch, sodium cov hmoov txhuv nplej glycolate, microcrystalline cellulose, colloidal anhydrous silica, hydroxypropylmethylcellulose thiab magnesium stearate. Cov ntsiav tshuaj muaj nyob rau hauv lub hlwb ntawm lub contour ntawm 7 daim.

pharmacodynamics

Pharmacological ib pab neeg uas siv yeeb tshuaj - noj. Raws li cov lus qhia, lub ntsiab muaj ntawm no neeg uas sawv cev alilamin uas exhibits ib tug active kho nyhuv on ib tug loj tus naj npawb ntawm ntau fungi hom.

Lub fungicidal thaj chaw ntawm terbinafine (qub concentration) thiab faib rau dermatophyte fungi, raws li zoo li ib co hom dimorphic fungi.

Nyob ntawm seb lub hom, tiv thaiv yeasts tshuaj no tej zaum yuav muaj tag nrho ob qho fungicidal thiab fungistatic kev ua si.

hauv paus ntsiab lus ntawm cov lag luam

Yuav ua li cas puas cov tshuaj "Lamikon"? Phau Ntawv Qhia hais tias qhov no neeg sawv cev uas cheeb qhov uas cov thaum ntxov rau theem ntawm sterol biosynthesis nyob rau hauv fungal cell week. Cov tshwm sim ntawm tej raug nyob rau hauv haum intracellular txuam nrog ntawm squalene, thiab ib tug tsis muaj ergosterol. Qhov no ua rau cov kev puas tsuaj ntawm fungal hlwb.

Lub mechanism ntawm qhov kev txiav txim ntawm cov nyiaj ncaj qha kev cob cog rua nrog cov txheej txheem ntawm inhibition ntawm cov enzyme squalene epoxidase li, uas koom mus rau ib tug cytochrome P-450.

Raws li cov kws tshwj xeeb, tshuaj "Lamikon" muaj tsis muaj cawv rau cov teebmeem ntawm lwm yam tshuaj, thiab nyob rau hauv hormonal metabolism.

tshuaj

Raws li cov tshuaj no yog absorbed, "Lamikon"? Phau Ntawv Qhia hais tias thaum lub zos los sis tshuaj pleev daim ntawv thov haum ntawm lub active tshuaj yog tsawg tshaj li 5% ntawm cov tshuaj siv. Yog li ntawd, nws mauj raug yog tsawg.

Thaum muab topically cov tshuaj sai li sai tau pib muaj cov nyhuv thiab yog zoo heev rau ib tug luv luv lub sij hawm (kwv yees li 8-13 hnub).

Los ntawm kev coj raws li siab xav concentration ntawm cov tshuaj nyob rau hauv lub stratum corneum ntawm lub epidermis, uas twb tau thaum lub sij hawm kho, tus fungicidal kev txiav txim ntawm lub medicament yog txuas ntxiv rau ib lub lim tiam tom qab nws tshem tawm.

Thaum noj ntawm ncauj, "Lamikona" active tshuaj accumulates nyob rau hauv daim tawv nqaij, rau tes thiab cov plaub hau. Lub concentration ntawm kev siv yeeb tshuaj nyob rau hauv cov ntaub so ntswg kiag muab nws fungicidal zog.

Haum ntawm cov ntsiav tshuaj yog 70%, thiab lawv tsis bioavailability - 50%.

Cov tau txais formulation nyob rau hauv ib tug npaum li ntawm 250 mg yog lub siab tshaj plaws nyob rau hauv concentration cov ntshav tom qab ib tug ib nrab teev. Lub ib nrab-lub neej lub sij hawm yog hais txog 30 teev.

Cov zaub mov yog tsuas yog me ntsis cuam tshuam rau bioavailability ntawm cov tshuaj. Nrog cov ntshav protein uake mus rau lub active tshuaj ntawm 99.5%. Tshuaj es sai sai penetrates rau hauv lub dermis thiab accumulates nyob rau hauv lub stratum corneum.

Rho tawm "Lamikona" ua los ntawm cov qog sebaceous. Tsis tas li ntawd, nws yog pom nyob rau hauv cov plaub hau, daim tawv nqaij thiab cov plaub hau hauv paus. Nyob rau hauv thawj lub lim piam ntawm txoj kev kho, cov tshuaj penetrates tus ntsia thawv phaj.

Terbinafine yog metabolized sai sai nrog cytochrome P 450. Tom qab biotransformation khoom muab tau tsaug zog metabolites los ntawm ob lub raum.

Thaum ib tug abnormality nyob rau hauv lub siab thiab lub raum clearance ntawm terbinafine ceev slows ho, ua rau nws ib tug ntau dua concentration nyob rau hauv ntshav.

indications

Los ntawm ces taw zos ntau npaum ntaub ntawv "Lamikon" tshuaj? Tshuaj pleev, cov lus qhia rau kev siv uas yog tau piav rau hauv qab no, raws li zoo raws li cov tshuaj tsuag muaj cov nram qab indications:

• fungal daim tawv nqaij qhov chaw mob, uas tau tshwm sim los ntawm fungi ntawm lub genus Trichophyton, Microsporum thiab Epidermophyton (dermotofitiya taw, puab tais, npog tas ib ce, thiab lwm yam);
• multicolor (los yog pityriasis) versicolor, uas originated los ntawm tej yam ntawm Malassezia fungi;
• Candidiasis ntawm daim tawv nqaij, uas txhais los ntawm fungi ntawm lub genus Candida.

Vim li cas siv qhov ncauj ntaub ntawv "Lamikon" (ntsiav tshuaj) ntawm cov tshuaj? Phau Ntawv Qhia ceeb toom txog cov nram qab no indications:

• fungal kab mob ntawm daim tawv nqaij, qhov twg lawv loj heev, concentration los yog qhia xws li tias lawv yuav tsum tau kho raws nraim lub qhov ncauj txoj kev (tsuas txiav txim seb tus kws kho mob);
• mycosis lub taub hau thiab onychomycosis (ntsia thawv kab mob cov phiaj).

Nws yuav tsum tau muab sau tseg hais tias "Lamikon" ntsiav tshuaj tsis yog siv rau cov kev kho mob ntawm cov dawb lias (los yog kuj) zoster.

Contraindications

Yuav ua li cas hom ntawm contraindications yuav tsum paub txog ua ntej koj siv cov tshuaj "Lamikon"? Phau Ntawv Qhia hais tias lub xwb tsis chov tag nrho cov ntaub ntawv ntawm cov tshuaj yog suav tias yog npau taws me ntsis rau nws cov tshuaj yeeb dej caw.

Raws li hais lub sij hawm uas cev xeeb tub, thaum yau thiab ob lub mis noj, lawv yog txheeb ze contraindications.

Tshuaj pleev "Lamikon": cov lus qhia rau kev siv

Tej ntaub ntawv ntawm qhov kev siv yeeb tshuaj, raws li ib tug tshuaj tsuag, thiab tshuaj pleev, muab lawv sab nraud daim ntawv thov. Ua ntej siv rau cov kev kho mob ntawm fungal kab mob, koj yuav tsum thawj huv si thiab qhuav lub cuam tshuam qhov chaw ntawm daim tawv nqaij.

Nyob ntawm seb heev ntawm tus kab mob thiab lub hom yav tshuaj "Lamikon" (tshuaj pleev) THOV ob zaug ib hnub twg. Aerosol yog siv nrog cov tib zaus.

Lub qab zib yuav tsum tau ua ntawv thov tsis tau tsuas yog rau cov tawv nqaij pwm, tab sis kuj cov adjoining chaw. Mus nqa tawm no txoj kev nws yog ntshaw kom nyias txheej maj muab tshuaj ntxuav tshuaj pleev npog.

Yog hais tias lub hom kab mob yog nrog pob tw ntse (e.g., nyob rau hauv lub ob lub mis, puab tais, pob tw los yog nruab nrab ntiv tes), cov kho thaj chaw yuav tsum npog gauze (thaum hmo ntuj).

Kev siv cov aerosol

Yuav ua li cas kuv yuav tsum tau siv cov tshuaj tsuag "Lamikon"? Xyuas cov tub txawg qhia hais tias nws yog siv nyob rau hauv txaus kom muaj nuj nqis rau moisten los ntawm txau rau qhov chaw yuav tsum tau amazed nrog fungi, raws li zoo raws li kev noj qab nyob daim tawv nqaij nyob ib sab mus rau nws.

Lub caij ntawm txoj kev kho yog nyob rau lub zos xov xwm tus kab mob heev (txog li ob lub lis piam).

Koom Haum Niam ntawm tus neeg mob sau tseg ib ob peb hnub. Yog xav paub ntxiv txoj kev kho yog yuav tsum tau ua raws li kev cai nruj heev cov lus qhia kom tsis txhob nco lwm daim ntawv thiab tsis txhob tso tseg kev kho mob prematurely. Txwv tsis pub muaj ib tug yuav muaj relapse.

Yuav ua li cas coj cov ntsiav tshuaj?

Pharmacological pab pawg neeg uas yog tswv rau cov tshuaj ua ntej peb, qhia nyob rau hauv cov lus qhia. Nws qhia txog yuav ua li cas paub tias lub cuab tam.

Raws li ib tug txoj cai, "Lamikon" tshuaj kho rau cov me nyuam los ntawm 6 xyoo, raws li zoo raws li cov laus cov neeg mob. Tau txais qhov ncauj npaj txuas ntxiv kom txog thaum tiav disappearance ntawm tag nrho cov tsos mob ntawm ib tug fungal kab mob (nyob ntawm seb qhov xwm thiab heev).

Lub pov tseg ntawm lub medicament ntau npaum rau cov neeg laus yog 250 mg, thiab rau cov me nyuam uas 20-40 kg - 125 mg. Nrog ib tug loj luj ntawm tus me nyuam raws li cov tshuaj 250 mg ntawm cov tshuaj.

Lub caij ntawm txoj kev kho nrog trichophytosis thiab daim tawv nqaij candidosis yog 2-4 lub lis piam, thiab tom Tinea pedis - 2-6 lub lis piam.

Fungal kab mob ntawm lub taub hau yog ntau ntau nyob rau hauv cov me nyuam. Raws li ib tug txoj cai, lawv yog amenable rau kev kho mob yog hais tias tus yeeb tshuaj yog siv nyob rau hauv lub noj tshuaj npaum cas pom zoo los ntawm tus kws kho mob rau ib lub hlis.

Onychomycosis kev kho mob yuav siv sij hawm 6 lub lim piam rau tes thiab 12 - rau cov ntiv taw ntsia hlau. Nyob rau hauv luv loj hlob ntawm tus ntsia thawv daim hlau txoj kev kho tej zaum yuav ntev.

phiv tshua

Local tshuaj "Lamikon", analogues ntawm uas muaj li nram no, yuav ua rau cov tsos mob xws li daim tawv nqaij Zaubqhw, hlawv, khaus, mob, voos, impaired pigmentation, erythema thiab ua kiav txhab tsim. Tej zaum lawv kuj muaj kev tsis haum tshuaj loj.

Thaum tau txais cov ntsiav tshuaj, cov nram qab no undesirable los:

• neutropenia, agranulocytosis, Lyell syndrome, pancytopenia, Stevens-Johnson syndrome;
• thrombocytopenia, anaphylactoid tshua, saj ua cuam tshuam, cov tsos mob ntawm lupus, mob taub hau;
• photosensitivity, paresthesia, hypoesthesia, neuralgia;
• kiv taub hau, zoo nkaus li ntawm fullness nyob rau hauv lub plab mog, plab, tsis qab los noj mov;
• exacerbation ntawm psoriasis, xeev siab, psoriasiform ua pob ua xyua, mob plab, myalgia;
• urticaria, arthralgia, tawm pob, generalized pustulosis, plaub hau poob, kev nce ntawm daim siab enzymes;
• qaug zog, hepatobiliary kawg, jaundice, kab mob siab.

Analogs thiab nqi ntawm cov tshuaj

Yuav ua li cas npaum li cas yog ib tug yeeb tshuaj "Lamikon"? Tus nqi ntawm cov tshuaj no nyob rau ntawm nws lub lawm. Tshuaj pleev thiab tshuaj tsuag yuav tsum tau muas rau 180-220 rubles, thiab cov ntsiav tshuaj - rau 370-400 rubles.

Raws li rau counterparts, ntawm qhov ntau zoo koj yuav allocate tej nyiaj raws li "Amorolak" salicylic acid. "Mikoseptin", "Nitrofungin", "Mikolak", "Exoderil".

Xyuas ntawm medicament

Tswv yim los ntawm cov neeg uas tau siv cov tshuaj "Lamikon" yog cov tsis tshua zoo. Cov neeg mob qhia tias lub tshuaj miv nyuas siv zug ntawm cov tshuaj no tau raug cai rau ib tug ob peb hnub tom qab nws active siv. Feem ntau, ib tug fungal kab mob thiab disappears los ntawm tus kawg ntawm lub chav kawm ntawm kev kho mob.

Nyob rau hauv loj heev zaum, cov kws kho mob pom zoo kom ib tug neej coj ntau npaum daim ntawv (e.g., ntsiav tshuaj thiab tshuaj pleev, tshuaj tsuag thiab cov ntsiav tshuaj).

Nyob rau hauv tas li ntawd mus rau lub zoo lus hais txog "Lamikon" npaj ntsib thiab tsis zoo lub tswv yim. Lawv feem ntau txuas rau nws ineffectiveness. Txawm li cas los, kws txawj hais tias qhov no yog tau tsuas yog nyob rau hauv cov kev kho mob uas tsis yog-sensitive rau lub medicament fungi los yog siv tsis yog. Yog li ntawd, ua ntej koj thov cov tshuaj pleev, ntsiav tshuaj los sis cov tshuaj tsuag yog pom zoo kom mus ntsib ib tug kws kho mob thiab tsim kom muaj lub causative tus neeg saib xyuas ntawm fungal kab mob.