"Cymbalta": cov lus qhia rau kev siv. Xyuas, nqi, indications

Niaj hnub no peb yuav qhia rau koj tias yog ib tug yeeb tshuaj "Cymbalta." Cov lus qhia rau kev siv ntawm cov tshuaj, nws muaj pes tsawg leeg, phiv, thiab kev nyeem ntawv yuav tau piav rau hauv qab no. Tsis tas li ntawd los ntawm cov xa tsab xov xwm, koj yuav kawm txog hauv daim ntawv nyob rau hauv uas cov tshuaj yog muaj, ntau npaum li cas nws raug nqi, seb nws muaj ib tug contraindication thiab yuav ua li cas thov nws kom raug.

tso tawm daim ntawv

Nyob rau hauv dab tsi daim ntawv nws muaj peev xwm yuav cov tshuaj "Cymbalta" qhia uas yog muab ntim rau hauv lub hnab? Tam sim no tus yeeb tshuaj yog tsuas yog tso tawm nyob rau hauv daim ntawv ntawm cov enteric tsiav tshuaj. Txhua uas muaj cov pellets, uas muaj ib tug dawb los yog grayish dawb xim.

cov tshuaj

Yuav ua li cas Cheebtsam muaj xws li tshuaj "Cymbalta?" Cov lus qhia rau kev siv ntawm tsiav tshuaj hais tias lawv lub ntsiab active caij yog ib yam khoom uas duloxetine. Nws yuav tsum tau muab sau tseg tias cov qauv ntawm qhov suav hais tias medicament thiab muaj xws li ntxiv tshuaj raws li sucrose, hypromellose, talc, succinate, dawb colorant, hypromellose acetate, titanium dioxide, triethyl citrate, gelatin, sodium sulfate lauryl thiab daj hlau oxide xim.

Tsiav tshuaj tej zaum yuav muaj 60 thiab 30 mg tshuaj. Lawv tau ntim rau hauv cov hlwv ntawm 14 los yog 7 tsiav tshuaj. Nyob rau hauv ib thawv pob yuav ua tau 1, 2 los yog 6 hlwv.

Pharmacological yam ntxwv ntawm cov tshuaj

Yuav ua li cas yog lub active tshuaj xws li duloxetine? Cov lus qhia rau kev siv ntawm medicinal tshuaj hais tias xws li ib tug yeeb tshuaj acting nrog hais tias lub caij no yog heev zoo kev nyuaj siab. Nws yog ib qho inhibitor ntawm lub reuptake ntawm norepinephrine thiab serotonin. Nws weakly cheeb dopamine uptake thiab tsis muaj affinity rau dopamine, histamine, thiab adrenergic receptors holino-.

Yuav ua li cas puas Duloxetine? Phau Ntawv Qhia no muaj cov nram qab no txog lub ntsiab no: lub hauv paus ntsiab lus ntawm kev txiav txim ntawm lub tshuaj yog inhibit reuptake ntawm norepinephrine thiab serotonin. Raws li ib tug tshwm sim, ho tsub kom noradrenergic thiab serotonergic neurotransmission nyob rau hauv lub paj hlwb. Nws yuav tsum tau muab sau tseg tias duloxetine sai sai suppress mob.

Tshuaj ntawm cov tshuaj

Formulations ntawm lub kev nyuaj siab ntawm lub "Cymbalta" absorbed los ntawm tus mob huam, haum pib ib tug ob peb teev tom qab thawj coj. Qhov siab tshaj plaws concentration yog tiav tom qab 6 teev. Tib mus txais tos ntawm cov zaub mov tsis cuam tshuam rau concentration thiab tsub kom lub sij hawm mus cuag ib tug 6 mus rau 10 xuab moos. Kws txawj hais tias nws kov thiaj li raws li ntawm haum (11%).

Thwj toob ntawm yeeb tshuaj mus ntshav cov nqaijrog yog siab txaus thiab nce mus txog ntau dua 90%.

Lub ib nrab neej ntawm cov tshuaj yog 12 teev. Nyob rau tib lub sij hawm nws mus tawm nyob rau hauv cov zis li metabolites.

Raws li kev tshawb fawb, muaj cov sib txawv ntawm cov pharmacokinetic dab uas tshwm sim nyob rau hauv cov poj niam thiab cov txiv neej. Yog li, qhov nruab nrab clearance ntawm lub active ingredient hauv qab no lub fairer nrog txiv neej pw. Txawm li cas los, koob tshuaj hloov yog tsis tsim nyog.

Nws yuav tsum tau muab sau tseg tias cov sib txawv ntawm cov pharmacokinetic dab uas tshwm sim nyob rau hauv cov neeg laus thiab nruab nrab-hnub nyoog cov neeg mob tau tsim thaum lub sij hawm tshawb nrhiav. Nws qhia hais tias lub ib nrab-lub neej ntawm cov tshuaj yog siab dua nyob rau hauv cov neeg laus dua cov hluas. Tsis ntau npaum hloov yog tsis yuav tsum tau yog.

Nyob rau hauv cov neeg mob uas mob raum insufficiency nyob rau hauv davhlau ya nyob twg theem, uas yog nyob rau hauv kev lim ntshav, lub concentration ntawm kev ua tau zoo thiab AUC ntawm duloxetine qab ntawm raws nraim 2 lub sij hawm. Uas yog vim li cas nws yog pom zoo kom xav txog lub advisability ntawm kev txo ntau npaum ntawm cov tshuaj nyob rau hauv cov neeg mob uas mob loj heev puas raum muaj nuj nqi.

Cov neeg mob cov tsos mob siab tsis ua hauj lwm yuav qeeb metabolism thiab tshem tawm ib nrab-lub neej ntawm duloxetine.

Indications rau cov kev siv ntawm cov nyiaj

Thaum prescribers "Cymbalta?" Cov lus qhia rau kev siv muaj xws li cov nram qab no daim ntawv teev cov nyeem tej no:

• ntshav qab zib neuropathy mob zoo lawm;
• kev nyuaj siab thiab kev nyuaj xeev;
• generalized kev ntxhov siab vim teeb meem;
• mob mob licas syndrome, nrog rau cov tshwm sim los ntawm fibromyalgia thiab osteoarthritis.

Contraindications rau kev siv ntawm cov nyiaj

Thaum twg koj tsis noj tshuaj "Cymbalta?" Cov lus qhia rau kev siv muaj xws li cov nram qab no daim ntawv teev cov contraindications:

• simultaneous daim ntawv thov ntawm hwj chim inhibitors ntawm isoenzyme CYP1A2 (e.g., enoxacin, ciprofloxacin los yog fluvoxamine);
• Nce rhiab heev rau tus neeg mob txhais tau tias yam;
• cov me nyuam nyob rau hauv 18 lub xyoos ntawm hnub nyoog;
• ib lub momentary txais tos nrog Mao inhibitors;
• Arterial tawg yog uncontrolled;
• uncompensated kaw glaucoma;
• mob loj heev mob raum tsis ua hauj lwm (nrog CC tsawg tshaj li 30 ml / min);
• isomaltase tsis muaj peev xwm los yog saccharase, qabzib-galactose malabsorption thiab fructose intolerance;
• siab cov kab mob uas yog los ntawm hepatic insufficiency.

Thaum yuav tsum tau siv nrog ceev faj cov tshuaj

Nws yuav tsum tau siv tib zoo hais tias cov tshuaj nyob rau hauv bipolar tsis meej thiab mania, convulsions yuav raug nres lub-kaw glaucoma. Tsis tas li ntawd, kev saib xyuas yuav tsum tau coj thaum ocular tawg, suicidal xav, hyponatremia, daim siab thiab lub raum.

Tshuaj "Cymbalta": cov lus qhia rau kev siv

Tus nqi ntawm cov khoom no yog heev. Txawm li cas los, nws cov hauj lwm zoo yog tsis raug mus rau kev tsis ntseeg.

Nthuav tshuaj yog tshuaj tsuas yog rau qhov ncauj thawj coj. Lub tsiav tshuaj yuav tsum tau nqos tag nrho tsis muaj crushing los yog zom lawv. Nws yuav tsum tau muab sau tseg tias nyob rau hauv txhua rooj plaub yuav tsis muab ntxiv rau cov tshuaj los yog khoom noj khoom haus sib tov nws nrog tej kua, txij thaum xws txiav txim yuav yooj yim ua mob rau tus enteric txheej.

Formulations ntawm lub kev nyuaj siab yuav tsum tau noj thawj zaug ntau npaum ntawm 60 mg ib zaug ib hnub twg. Nyob rau hauv thiaj li yuav ua tau zoo tau nyob rau hauv ib co neeg mob yuav kom hais tias tus nqi rau ib tug tshaj plaws tshuaj ntawm 120 mg ib hnub ob zaug.

Cov neeg mob thiaj paub hais tias mob raum tsis ua hauj lwm, uas tshwm sim nyob rau hauv lub davhlau ya nyob twg theem, thawj zaug ntau npaum ntawm lub medicament yog 30 mg ib zaug ib hnub twg. Yog hais tias cov neeg mob muaj siab malfunction, lub qhia nqi ntawm cov tshuaj yog pom zoo kom txo los yog txo lub multiplicity ntawm kev txais tos.

Nws yuav tsum tau muab sau tseg tias kom tsis txhob ceev ntsoos ntsoos tau txais medicament. Tus nqi ntawm cov tshuaj tsim nyog los txo maj tshaj 1-2 lub lis piam. Yog hais tias qhov no tom qab, muaj pronounced tej yam tshwm sim ntawm lub syndrome, nws yog pom zoo kom mus ntxiv cov kev kho nyob rau hauv lub xaiv npaum li cas. Tom qab, tus kws kho mob tej zaum yuav mus ntxiv kom txo tau cov koob tshuaj, tab sis ntau maj mam.

tus neeg mob ntawm overdose

Yuav ua li cas cov kws txawj hais txog cov tshuaj overdose mob, "Cymbalta?" Xyuas ntawm cov kws kho mob muaj ntaub ntawv hais tias xws li cov ntaub ntawv muaj rau lawv. Rau hnub tim, muaj mob ntawm overdose los ntawm haus ntawm cov tshuaj nyob rau hauv cov nqi mus txog 3000 mg, thiab thaum twg nws yog ua ke nrog lwm yam tshuaj mas siv. Incidentally, tsau thiab ib tug tuag.

Tej yam tshwm sim ntawm overdose los yog raug rho ua ke xws li cov nram qab no mob: clonic convulsions, somnolence, ntuav, coma, serotonin syndrome thiab tachycardia. Raws li rau preclinical kev tshawb fawb (thwmsim rau tej tsiaj txhu), lub ntsiab ntawm cov tsos mob toxicity txuam nrog uncontrolled txais medicament, yog mob ntawm lub hauv paus poob siab thiab digestive systems. Tsis tas li ntawd, cov neeg mob tej zaum yuav tshwm sim co, ataxia, clonic convulsions, ntuav thiab tsis qab los noj mov.

Yuav ua li cas nyob rau hauv cov ntaub ntawv ntawm ib tug overdose? Nrog rau txoj kev loj hlob ntawm serotonin syndrome yuav tsum tau sai li sai tau nqa tawm kho txoj kev kho cyproheptadine, raws li zoo raws li txoj kev siv rau normalize tus neeg mob lub cev kub.

Tus neeg mob yuav tsum tau muab huab cua ntshiab. Koj yuav tsum tau saib xyuas cov hauj lwm ntawm lub plawv thiab cov saib xyuas tseem ceeb heev tshwm sim. Tag nrho cov no yuav tsum tau ua nyob rau hauv nrog cov tuav nyiaj them yug thiab symptomatic kev kho mob.

Yog hais tias tom qab cov thawj coj ntawm cov tshuaj yog tsis ntev, nws yog tsim nyog los ntxuav tawm lub plab. Tsis tas li ntawd, nyob rau hauv thiaj li yuav txo tau qhov tsawg ntawm cov tshuaj tus neeg mob yog hais kom haus dej haus tshuab txais charcoal.

sab nyhuv

Tau ib yam tsis zoo rau tib neeg noj qab haus huv uas tau txais hais tias cov tshuaj? Xav txog cov tshwm sim los ntawm kev nyuaj siab cov tshuaj nyob rau hauv ntau yam:

• Heev feem ntau (nyob rau hauv 10% ntawm cov neeg) nyob rau hauv lub soj ntsuam kev tshawb fawb, cov neeg mob muaj cov nram qab hais tias: kiv kiv taub hau, mob taub hau, qhov ncauj qhuav, insomnia, insomnia, xeev siab, nkees nkees thiab cem quav.
• Tsawg kawg yuav (ntawm 1 mus rau 10% ntawm cov neeg) nyob rau hauv cov neeg mob muaj cai flashes, raws plab, qhov muag plooj tsis pom kev, ntuav, tawm hws, co, nce anorgasmia, tsis qab los noj mov, poob libido, poob phaus, qaug zog, erectile kawg, raws li zoo raws li ib tug kev ncua los yog txawv txav ejaculation.

Peb yuav tsis tau hais tias hais tias xws li tshwm sim raws li kiv taub hau (tej zaum mob taub hau thiab xeev siab), feem ntau pom nrog ceev tshem tawm ntawm ib tug medicament. Los ntawm txoj kev, nyob rau hauv cov neeg mob uas mob ntshav qab zib neuropathy ntaub ntawv tej zaum yuav muaj ib qho kev nce rau hauv cov ntshav qab zib nyob rau hauv ib qho kev npliag plab.

Xyuas ntawm medicament

Raws li cov kws tshwj xeeb, thiab cov neeg mob xam tau tias yog tshuaj tag nrho daws nrog neeg ua hauj lwm. Thaum tau txais nws eliminates ib tug ntxhov siab vim teeb meem, raws li tau zoo raws li txhawb lub disappearance ntawm depressive lub xeev. Nyob rau hauv tas li ntawd, active medicament zoo relieves mob syndromes nyob rau hauv lub licas.

Sis nrog rau lwm cov txhais tau tias

Yog nws ua tau rau pa roj carbon monoxide-thawj coj ntawm lwm yam tshuaj nrog tshuaj "Cymbalta?" Guest kws txawj hais tias tus txhais tau tias yog ib tug ncaj qha feem rau cov hauj lwm zoo ntawm ib co tshuaj.

Yog li ntawd, muaj ib tug uas yuav muaj serotonin syndrome, duloxetine yog siv nyob rau hauv ua ke nrog nrog MAOIs.

Vim hais tias CYP1A2 isoenzyme yog kev koom tes nyob rau hauv lub metabolism ntawm "Cymbalta 'kev npaj, lawv simultaneous siv yuav ua tau kom muaj zog ntau ntawm lub yav tas.

Tsis pom zoo rau hais tias medicament ua ke nrog lwm yam tshuaj uas cuam tshuam rau lub hauv paus poob siab system. Tsis tas li ntawd thaum lub sij hawm nws mus kawm yuav tsum tsis txhob haus dej haus cawv.

Tej zaum, thaum lub sij hawm siv SSRIs thiab serotonergic cov neeg ua hauj nyob rau hauv cov neeg mob cai serotonin syndrome. Yog li ntawd, koj yuav tsum ib ce muaj zog huab ceev faj thaum siv cov tshuaj no nrog serotonergic antidepressants.

Vim lub fact tias muaj yog ib tug neeg raug mob los ntshav yuav tsum tsis txhob siv ob qho tib si duloxetine thiab anticoagulants (antithrombotics).

Kev pub niam mis thiab cev xeeb tub

Kuv yuav siv cov tshuaj "Cymbalta", tus nqi ntawm uas yuav tsum tau nyob rau hauv, thaum lub sij hawm cev xeeb tub? Vim cov tsis muaj txaus cov lus qhia, cov kev siv ntawm cov tshuaj yeeb dej caw duloxetine thaum lub sij hawm hnub cov tshuaj tej zaum yuav muab yog hais tias qhov kev pab mus rau lub expectant niam yog ntau ntau tshaj qhov uas yuav rau tus me nyuam.

Nws yuav tsum tau muab sau tseg tias cov neeg noj no neeg sawv cev yuav tsum tau qhia rau koj tus kws kho mob txog qhov tshwm sim los yog npaj ib tug cev xeeb tub.

Kev tshawb fawb tau qhia tias cov poj niam noj antidepressants nyob rau hauv lub xeev, tshwj xeeb tshaj yog nyob rau hauv lub tom qab ua sawv, zoo heev tsub kom qhov uas yuav pheej pulmonary tawg ntawm tus me nyuam mos cov me nyuam mos. Nyob rau hauv cov ntaub ntawv no, lub syndrome kuj nquag pom nyob rau hauv cov me nyuam nyob rau hauv cov ntaub ntawv ntawm ib tug cia li nres siv duloxetine neej yav tom ntej leej niam ntawm ib tug lig theem ntawm cev xeeb tub. Feem ntau ntawm cov tsos mob ntawm tus mob no muaj cai thaum lub sij hawm tus me nyuam los yog nyob rau hauv thawj hnub tom qab.

Vim hais tias duloxetine yog tau txeem mus rau hauv niam cov kua mis, nws tsis yog ntshaw kom pub niam mis rau koj tus menyuam thaum lub sij hawm txoj kev kho. Txwv tsis pub, lub concentration ntawm cov tshuaj yeeb dej caw nyob rau hauv lub fetus yuav nyob rau hauv ib tug npaum li ntawm 0,14% ntawm cov concentration nyob rau hauv lub niam.

Cov kev taw qhia nyob rau kev siv ntawm cov tshuaj

By muab cov tshuaj rau nws tus neeg mob "Cymbalta", tus kws kho mob yog yuam ua hauj lwm kom qhia rau nws hais tias categorically txwv tsis pub ib tug ib-lub sij hawm kev txais neeg kawm ntawm tus neeg saib xyuas nrog Mao inhibitors. Txwv tsis pub, nws yuav hem neeg tuag taus thiab loj teeb meem ntawm hyperthermia, myoclonus thiab qhia excitation hloov mus rau hauv ib tug coma.

Nws yuav tsum tau muab sau tseg tias txwv tsis pub tau txais hais tias noj tshuaj rau ob lub lis piam tom qab kev kho mob Mao inhibitors.

Raws li kev tshawb fawb, nyob rau hauv cov neeg mob uas manic lub xeev thaum uas siv cov lwm yam tshuaj uas cuam tshuam rau lub paj hlwb, nrog rau cov txhais tau tias "Cymbalta" tej zaum yuav paug uas twb muaj lawm tus kab mob.

Vim lub fact tias nyob rau hauv depressive lub xeev muaj ib tug yuav tua yus tus kheej npaj siab, yuav tsum tshwj xeeb tshaj yog saib xyuas cov neeg mob teej tug mus rau txoj kev pheej hmoo pab pawg neeg.

Txais ntawm cov tshuaj yuav ua tau heev yooj yim mus ua koj nkees nkees. Yog li ntawd, cov neeg mob uas noj cov tshuaj no, koj yuav tsum tau siv sij hawm ntxiv kho mob thaum tsav tsheb thiab thaum ua hauj lwm nrog yus mus machinery.

Nqe thiab analogues ntawm cov tshuaj

Yuav ua li cas npaum li cas yog cov "Cymbalta" enteric tsiav tshuaj? Lawv cov nqi tej zaum yuav txawv. Nws nyob rau ntawm lub khw tsim hom thiab lub tsev muag tshuaj chains margins. Txawm li cas los, nws yuav tsum tau muab sau tseg tias nyob rau hauv nruab nrab, cov tshuaj nqi txog 1,050 Lavxias teb sab rubles (30 mg, 14 daim). Yog hais tias koj xav tau los yuav ib tug tshuaj nyob rau hauv tib lub npaum li cas, tab sis nyob rau ib lub tshuaj ntawm 60 mg, ces koj yuav tau them txog 1150 rubles.

Tam sim no uas koj paub ntau npaum li cas yog duloxetine. Nws nqi tej zaum yuav nce los yog yuav txo nyob rau tej yam tseem ceeb. Tam sim no, lub purchase yog hu ua cov tshuaj yog tsis muaj teeb meem. Txawm li cas los, koj yuav tau yuav nws xwb los ntawm cov tshuaj.

Tab sis yog hais tias koj rau ib co yog vim li cas tsis tau mus yuav ib tug "Cymbalta" lam tsiav tshuaj? Analogs ntawm cov tshuaj no yog muaj nyob rau hauv txhua lub chaw muag tshuaj. Txawm hais tias tshaaj yuav tau yuav tsum tau muaj ib tug ntawv los ntawm ib tug kws kho mob.

Cov tshuaj yuav tau muab hloov "Cymbalta?" Ntawm nws cov phooj ywg yuav nyiam mus tshwj xeeb tshaj yog tseem ceeb nyob hauv cov nram qab no cov tshuaj:

• "Intro";
• "Azafen" (ntsiav tshuaj);
• "Duloxetine Canon" (enteric tsiav tshuaj);
• "Venlafaxine Sandoz";
• "Alvent";
• "Mirtazapine Canon";
• "Eprobemide" (daws nyob rau hauv / thiab tus / m);
• "Wellbutrin";
• "Eprobemide" ntsiav tshuaj;
• "Agomelatine";
• "Neyroplant";
• "Velafaks";
• "Calixtus";
• "Venlaksor";
• "Vensuert";
• "Dapfiks";
• "Venlift OD";
• "Despres ';
• "Efevelon retard";
• "Doppelgerts Nervotonik" raws li ib elixir;
• "Inkazana";
• "Efevelon";
• "Coaxil";
• "Esprital";
• "Lerivon";
• "Trittiko";
• "Normazidol";
• "Mirzaten";
• "Tetrindol";
• "Mirtazonal";
• "Remeron";
• "Mirtalan";
• "Pirazidol";
• "Negrustin";
• "Nyuvelong";
• "Noksibel".

Cov kev cia thiab txee-lub neej

Yuav ua li cas yog lub txee lub neej ntawm cov tshuaj "Cymbalta?" Raws li cov lus qhia, thiab lub hnub nyob rau hauv lub ntim, qhov cuab tam yuav tsum tsis txhob muab rau ib lub sij hawm ntawm peb lub xyoos. Nyob rau hauv cov ntaub ntawv no nws yuav tsum tau muab cia rau hauv lub qhov chaw tsaus nyob qhov twg qhov kub thiab txias tsis pub tshaj 20 degrees.