Interferon inductors, kev npaj rau cov me nyuam: sau, txiav txim. High-speed inducers ntawm endogenous interferon

Rau lub hom phiaj ntawm kev tiv thaiv thiab kev kho mob ntawm tus kab mob cov kab mob interferon inducers siv. Lawv mechanism ntawm qhov kev txiav txim yog txuam nrog rau cov kev loj hlob ntawm cov protein tshuaj uas tiv thaiv tus npaug ntawm pathogens. raws li inductors tshuaj yuav sib ntaus sib tua ua pa kab mob, herpes thiab hepatic mob mob khaub thuas.

Kev txiav txim ntawm interferon

Li ntawd, yog ib pab pawg neeg ntawm tebchaw muaj protein keeb kwm. Lawv ua hlwb uas raug kis kab mob los ntawm tus kab mob pathogens.

Interferon tshuaj yog yam tseem ceeb uas tsis yog-kev tiv thaiv mechanism nyob rau hauv lub cev tiv thaiv kab mob, chlamydial, opportunistic fungal kab mob, mob cell lug. Lawv kuj ua si lub luag hauj lwm ntawm lub regulators ntawm intercellular kev sib tshuam mauj kev tiv thaiv. Lawv hu ua immunomodulators nrog lub endogenous xwm.

Muaj ntau ntau yam ntaub ntawv ntawm tib neeg interferon tshuaj leukocyte los yog ib tug-interferon, fibroblast, los yog b-interferon, thiab tiv thaiv kab mob los yog g-interferon.

Tsav mechanism ntawm lub lag luam pib nrog cov losis tswvyim dabtsi cov nqaijrog thiab receptors nyob rau hauv lub hlwb ntawm ib tug xwm. Thaum xws li ib tug kev sis raug zoo yog tsim protein molecules hauv peb caug. Nrog stimulation ntawm ntxawg peptides nqa cov kev ua ntawm T-lymphocytes thiab macrophage-hom lug tshwm sim tiv thaiv ingress ntawm cov kab mob los ntawm lub cell daim nyias nyias thiab lawv tu tub tu kiv. Nws yog lawv uas yog lub luag hauj lwm rau tus tiv thaiv cov khoom.

Ntuj interferon inducers - ib tug kab mob hlwb uas infiltrated rau hauv lub chav cev. Lawv yog cov muaj zog thiab tsis muaj zog stimulators ntawm zus tau tej cov kev tiv thaiv proteins. Feem ntau ntawm cov neeg loj cov kab mob yog cov neeg pluag inducers. Cov no muaj xws cytomegalovirus thiab HIV, herpes, kab mob siab C thiab B daim ntawv Tab sis muaj ntau yam ntawm cov pathogens uas ua rau ua pa kab mob cov kab mob, pom tau hais tias lub hwj chim stimulators ntawm zus tau tej cov kev tiv thaiv proteins.

Interferon inducers (tshuaj): nws yog dab tsi

Feem ntau nws yog hais txog mus rau ib tug hauv chav kawm ntawv ntawm cov khoom cua tshuaj immunomodulators. Lawv yog ua los ntawm cov kws tuam txhab uas muag. Interferon inducers (tshuaj) yog ranked raws li ib tug loj chav kawm ntawv ntawm qhov sib txawv tshuaj qauv ntawm lub tebchaw. Active Cheebtsam tej zaum yuav tsawg-thiab high-molecular yeeb tshuaj, ib tug hluavtaws los yog tej yam ntuj tso keeb kwm. Lawv muab ib qho feature, uas tso cai rau lub cev mus rau ntxias nyob rau hauv lub hlwb ntawm koj tus kheej, los yog endogenous interferon. Tej npaj yuav muaj antiviral thiab immunomodulating cawv.

Yuav ua li cas mus thov

Inducers ntawm endogenous interferon - npaj tswj, nyob rau hauv Feem ntau, sib ntaus kab mob. Lub mechanism ntawm lawv cov nyhuv yog raws li nyob rau hauv kev sib cuag nrog lub active tshuaj tshuaj cellular thiab cov nqaij mos cov ntsiab lus uas tau nyob rau hauv zus tau tej cov ib tug tiv protein.

Interferon inducers - Pharmaceuticals qhov uas txhim khu lub rho tawm ntawm cov protein artificially. Lawv cov nyhuv yog zoo li ib tug natural stimulants, uas muaj xws li tus kab mob, kab mob hlwb thiab ntau yam tshuaj.

Kev siv ntawm interferon inducers yuav ua hyporesponsiveness. Nyob rau hauv lub xeev no, raws li qhov rov thawj coj ntawm cov tshuaj tsis yog yuav mus tsim ib tug tiv thaiv teb protein, pom nws cov hluav. Rau ntawm no theem tsis tau yus los muab cov tshuaj. Lub caij ntawm lub xeev no yog txiav txim los ntawm lub inductor. Kev hloov ntawm cov nquag muaj, raws li zoo raws li kev cuam tshuam ntawm kev kho mob nrog rau cov tib neeg uas sawv cev pab rau tshem tawm hyporesponsiveness.

Sij hawm ntawm cov tshuaj uas tsim kho lub zus tau tej cov kev tiv thaiv protein tsis ua mob loj heev phiv los yuav tau tshem tawm lawv cov.

Qhov kom zoo dua ntawm inducers ntawm endogenous protein

Muaj ob txoj kev uas yuav txhim khu kev tiv thaiv interferon. Qhov no compound yuav muab ncaj qha los yog exogenously nyob rau hauv ib tug kab tsiaj txhuv. Lwm txoj kev yuav cov endogenous interferonizatsiyu nrog cov kev taw qhia ntawm yam uas tsim kho lub ntau lawm ntawm nws tus kheej interferon. Qhov no qhia tau hais tias protein tsis muaj antigenicity, uas tsis yog lub kev siv interferon. Ntev lub sij hawm thawj coj ntawm ib tug tiav lawm protein tshuaj ua rau txoj kev loj hlob ntawm kev phiv tshuaj.

Inducers ntawm endogenous interferon nyob rau hauv txoj kev tshawb no ntawm lawv cov hauj lwm zoo tsom pharmacological kev ua si nyob rau hauv ib tug broad spectrum ntawm kab mob. Nws twb pom lawv bifunctional vaj tse, yus muaj los ntawm pronounced antiviral nyhuv, thiab immunomodulating nyhuv.

Qhov kev txiav txim ntawm interferon inducers ua rau yus lub synthesis ntawm cov nqaijrog, uas nyob rau hauv lawv cov kev ua ub no zoo li npaj txhij-tiv proteins. Xws li ib tug txheej txheem yog balanced, nws cov kev tswj mechanisms uas zoo tiv thaiv tus kab mob los ntawm ntau tsim ntawm cov tebchaw.

Rau ib daim ntawv thov ntawm kev npaj inducing interferon yog haum heev ncig ntawm tus tiv thaiv protein nyob rau hauv yuav tsum tau kho koob tshuaj. Yog xav tau xws li ib tug ntau npaum nyob rau hauv lub sij hawm ntawm ib tug exogenous protein yuav tsum tau hais ntau ntau zaus muab nyob rau hauv loj tagnrho. Qhov no kev kho mob yog hais tias yuav kim kim.

Daim ntawv teev cov tshuaj

Tam sim no, cov kws kho mob yog nce siv interferon inducers - tshuaj uas sau txhua lub xyoo ntxiv tshiab tshuaj. Ib tug loj tus naj npawb ntawm immunomodulating agents tso cai rau koj mus sib ntaus sib tua ntau cov kab mob.

Raws li ib feem ntawm lub cev yog tam sim no feem interconnected Cheebtsam uas nqa tawm cov tshem tawm ntawm txawv txawv kab keeb kwm antigenic tebchaw. Txhua lub caij muaj ib tug meej tiv thaiv kab mob nrog. Qhov no piav txog cov ntau haiv neeg ntawm cov khoom uas pab rau txoj kev loj hlob ntawm ib tug tiv thaiv protein.

Muaj ntau ntau yam interferon inducers (tshuaj), daim ntawv teev cov uas yog taws los ntawm ib tug yeeb tshuaj "Poludan". Qhov cuab yeej no yog suav hais tias yog thawj stimulator tiv thaiv cov nqaijrog, uas tau pib yuav tsum tau siv txawm nyob rau hauv lub 70s. Nws muaj xws li poliuridinovaya thiab polyadenylic acid. Nws cov hauj lwm zoo yog los tsim interferon me me. Qhov muag dauv thiab tshuaj ntawm cov tshuaj "Poludan" kho herpetic keratitis thiab keratokonyunktivity. Tshuaj cov tshuaj ua rau daim ntaub ntawv rau cov kev kho mob ntawm herpes vaginitis thiab vulvovaginitis.

Interferon inducers - tshuaj "Aktaviron", "Lavomax", "Tilaksin" "dihydrochloride tilorona", "Amiksin", "Tiloram" - nyob rau hauv cov qauv muaj active ingredient tilorona.

Tshuaj "Ridostin" thiab "sodium ntsev ntawm ob-tso tseg ribonucleic acid" manufactured nrog sodium ribonukleat kuj substance.

umifenovir tshuaj muaj nyob rau hauv lub "Arbidol" Pharmaceuticals, "Arbivir", "Immustat" thiab "Arpeflyu".

Muaj kuj interferon inducers, tshuaj uas yog hu ua los ntawm lub npe ntawm lub active tshuaj. Cov no muaj xws "Kagocel" ntsiav tshuaj thiab "tilorona".

Raws li akridonatsetata meglumine manufactured tshuaj "Meglumine akridonatsetat" thiab "TSikloferon" thiab oksodigidroakridinilatsetat sodium yog tam sim no nyob rau hauv lub tshuaj "Neovir".

Muaj pes tsawg leeg txhais tau tias "Jodantipyrin" xws li muaj 1-phenyl-2,3-dimethyl-4-yodpirazolon, thiab nyob rau hauv "Alpizarin" ntsiav tshuaj muaj magniferrina ntsev.

Inductors interferon rau cov me nyuam, lawv cov hauj lwm

Muaj ntau ntau tug neeg laus cov tshuaj uas yuav tsum tau muab rau ib tug me nyuam, tiam sis tsuas yog mus rau ib tug tej yam uas muaj hnub nyoog. Piv txwv li, cov tshuaj "TSikloferon" pib kho cov plaub xyoos, thiab txhais tau tias "Ridostin" taw los ntawm lub hnub nyoog ntawm xya. Ob tshuaj muaj ib tug ntau ntawm cov teebmeem. Lawv yog tsim rau cov kev kho mob ntawm ua pa kab mob ntawm tus kab mob xwm, lub xeev kab mob khaub thuas, kab mob siab, herpes kab mob. Lawv disadvantage yog cov tau undesirable sab tshua.

Interferon inducers - preparations uas tsim los rau cov me nyuam nyob rau hauv tus me nyuam ntawd daim ntawv. "Arbidol" Ntawm lawv yog cov ib tug txhais tau tias. Nws yog siv nrog cov muaj hnub nyoog ntawm ob tug. Cov me nyuam medicament daim ntawv manufactured nyob rau hauv daim ntawv ntawm cov tshuaj rau hauv koom haum saib xyuas. Cov kev npaj muaj antiviral thiab immunomodulatory los.

Nws koom antiviral neeg uas inhibit tus kab mob no ntawm tes B thiab A hom. Nrog nws koom tes tsa zus tau tej cov internal interferon, uas tiv thaiv kev sib cuag thiab allergic rau hauv lub cell kab mob. Nyob rau hauv qhov kev txiav txim ntawm tus tiv thaiv lipid kis lub hnab ntawv protein yog tsis muaj peev xwm mus txuas nrog rau cov cell daim nyias nyias.

Interferon inducers rau cov me nyuam pab txog ua kev tiv thaiv ntawm lub humoral hom nyob rau ntawm lawv qhov kev txiav txim lub cev yuav paub ntau tshaj resistant kom kis kab mob, txo tus naj npawb ntawm cov teeb meem.

Tshuaj "Kagocel" muaj ib tug zoo li cov nyhuv rau tus me nyuam lub cev. Nws yuav ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj rau hauv kev siv. Muaj hnub nyoog txwv kev siv cov tshuaj - nrog peb lub xyoos.

Kev kho mob ntawm cov kab mob ua pa

Interferon inducers - tshuaj los kho SARS, uas ua rau kom cov tsim nyob rau hauv lub hlwb ntawm tus kab mob ib tug tiv protein. Lawv kuj tau xaiv nrog kab mob khaub thuas mob.

Qhov tseem txhais tau tias zoo yog xam tau tias yog cov tshuaj raws li tilorona, uas muaj xws li tshuaj "tilorona" thiab "Amiksin". Rau kev kho mob ntawm kev mob ua npaws thiab mob ua pa kab mob cov kab mob nws yog pom zoo kom siv ib tug neeg laus hauv 125 mg ntawm ib lub sij hawm. Qhov no tshuaj yog faib nyob rau hauv thawj ob hnub, ces 125 mg coj ib hnub. Chav Kawm nqi ntawm medicament yog 750mg.

Rau nqa tawm tiv thaiv kev ntsuas siv los ntawm 125 mg ntawm ib lub sij hawm, ces 6 hnub so. Xws li ib tug Hoob no yog pheej rov qab ua txog rau lub lim tiam.

raws li tilorona tshuaj txhob nyob rau hauv uas twb muaj lawm ib tug neeg intolerance, thaum lub sij hawm cev xeeb tub thiab thaum mis-pub mis rau koj tus me nyuam.

Tau txais xws tshuaj yuav ua rau xeev siab, kub taub hau, tsis haum cov tshuaj tiv thaiv.

Kev npaj "umifenovir" muaj interferon-inducing kev ua si, stimulation ntawm cellular hom kev tiv thaiv, mus pab tau txoj lub stability ntawm tag nrho cov kab mob rau kis cov kab mob.

Rau kev tiv thaiv thaum nyob rau hauv kev sib cuag nrog cov neeg mob tus kws kho ib tug txhua txhua hnub koob tshuaj ntawm 200 mg rau ib lub lim tiam. Lub caij nyoog sij hawm ntawm qhov kab mob npaws thiab ua pa kab mob siv ib tug txhua txhua hnub koob tshuaj ntawm 100 mg ntawm ib lub sij hawm, ces ua ib tug so rau ob hnub. Hoob no kav peb lub lis piam. Rau cov kev kho mob ntawm mob khaub thuas muab 200 mg plaub zaug ib hnub twg, rau peb hnub.

Tshuaj nrog umifenovir tsis siv nyob rau hauv uas twb muaj lawm ib tug neeg intolerance thaum lub sij hawm muaj mob loj Somatic pathology. Txais ntawm xws tshuaj yuav ua kom ua xua.

Kev kho mob ntawm cov kab mob autoimmune

Tej cov kab mob xws li pathological lub xeev nyob rau hauv uas tsim tshuaj los yog muab autoaggressive killer cell clones nyob rau hauv cov lus teb rau noj nqaij. Qhov no ua rau puas tsuaj thiab kev puas tsuaj ntawm kev noj qab nyob ntaub so ntswg, lub txiaj ntsim ntawm uas yog ib qho autoimmune o.

Feem ntau siv nyob rau hauv cov kev kho mob ntawm interferon inducers. Formulations muab nyob rau hauv cov kab mob autoimmune, cov neeg muaj immunosuppressive kev txiav txim.

Rau cov kev kho mob ntawm ntau yam sclerosis siv yeeb tshuaj tawg khiav ri niab "Amiksin". Thaum lub slightest tej yam tshwm sim ntawm mob ua pa kab mob xwm, uas aggravates cov mob muab koob tshuaj 125 mg los sis 250 mg ntawm cov tshuaj tom qab haus. Ntsiav tshuaj haus dej haus nyob rau hauv ib hnub twg, tus txais tos ntev - los ntawm 6 mus rau 12 hnub.

Rau kev tiv thaiv ntawm ua li khiav ri sclerosis exacerbation yog muab 125 mg ntawm cov tshuaj, 2 lub sij hawm ib 7 hnub.

Thaum lub complex ntawm lub active theem ntawm tus kab mob los mus kho uas twb muaj lawm tej yam tshwm sim ntawm mob tshuaj npaum li cas los 10 mus rau 125 mg txhua txhua 30 hnub rau 6 lub hlis. Kev npaj "Amiksin" yog muab nrog cov peptide bioregulators zuag qhia tag nrho cov nyhuv uas thiaj li muaj qhov lub cev rhiab heev rau nce myelin protein.

Ua ke txoj kev kho yeeb tshuaj "TSikloferon" tso cai rau koj mus rau tshwj kom txhob dav hlau nrog rau mob caj dab thiab rheumatoid, cov kab mob uas cuam tshuam connective cov ntaub so ntswg. Nws ua hauj lwm yog tswj cov hluav ntawm autoimmune dab, uas muab anti-inflammatory thiab analgesic nyhuv ntawm qhov. Siv txhais tau tias tswj lub cev mob nyob rau hauv ntau immunodeficient hloov. "TSikloferon" Lub tshuaj no yog ua nyob rau hauv cov ntsiav tshuaj daim ntawv no, nyob rau hauv daim ntawv ntawm cov tshuaj tov thiab liniment.

Rau cov kev kho mob ntawm kev mob caj dab tshuaj no yog muab intravenously los yog intramuscularly 1 lub sij hawm ib hnub. Cov tshuaj ntawm 250 mg siv cov thawj los ntawm lub kaum ob hnub rau txawm hnub. Nyob rau hauv mob cov kab mob siv zog thawj zaug koob tshuaj ntawm 500 mg.

Therapy ntawm Viral kab mob

Tshuaj "Amiksin" yog hais txog interferonovym inductors fluoreonovogo tsawg molecular ceeb thawj hoob kawm. Nrog nws koom tes tsim tag nrho cov hom ntawm kev tiv thaiv cov nqaijrog, uas theem ib hnub tom qab daim ntawv thov ntawm cov medicament nce mus txog nws siab tshaj plaws nqi nyob rau hauv cov ntshav.

Cov tshuaj muaj ib tug loj ntau ntawm cov antiviral kev txiav txim. Nyob rau hauv tas li ntawd mus ua pa kab mob, nws yog siv nyob rau hauv kab mob siab C thiab mob thiab ntev, recurrent qhov chaw mos herpes, cytomegalovirus kab mob thiab chlamydial hom.

Muaj ntau tshuaj antiviral - interferon inducers, tsis muaj kev zam yog ib tug txhais tau tias ntawm "Neovir". Nrog nws koom tes, nws ua ib tug loj npaum li cas ntawm cov kev tiv thaiv protein, tshwj xeeb tshaj yog fibroblast-yam, uas piav txog cov immunomodulatory, anti kab mob thiab anti-mob nyhuv ntawm cov tshuaj no. Tshuaj "Neovir" treat encephalitis, kab mob siab C thiab B, urethritis, cervicitis, salpingitis tshwm sim los ntawm Chlamydia.

Lwm zoo xws li cov inducer ntawm kev tiv thaiv protein yog ib tug tsis tshua muaj molecular yuag tshuaj "TSikloferon", uas yog siv rau cov synthesis karboksimetilenakridona methylglucamine ntsev. Nrog nws koom tes tsim alpha interferon, cov ntsiab lus ntawm uas yog cia nyob rau hauv lub lymphoid cov ntaub so ntswg rau peb hnub.

B lymphocytes T thiab B-hom macrophages yog tsim ntawm ib tug tiv thaiv protein kom nyob rau hauv lub hlwb qia lug pob txha, stimulation ntawm zus tau tej cov granulocyte units. Cov tshuaj siv nyob rau hauv lub zuam-borne encephalitis, herpes, kab mob siab, cytomegalovirus, human immunodeficiency virus thiab papillomas.

Ntxiv antiviral raug txhais tau tias muaj kev ua si nyob rau hauv mob thiab ntev kab mob chlamydia, o erysipilatous xwm, bronchitis, postoperative teeb meem, genitourinary kab mob, ulcerative txhab.

Nws nyob rau hauv kev ua lag luam ib tug kws tshuaj "Lavomax" ua "Nizhpharm" tam sim no. Nws muaj immunomodulatory nyhuv, muaj peev xwm ntawm inducing interferons, antiviral nyhuv ib tug loj ntau yam.

Raws li ib feem ntawm "Lavomax" ntsiav tshuaj muaj 125 mg tilorona li cov active compound. Cov tshuaj no yog ib qho analogue ntawm cov tshuaj "Amiksin". Nws kev ua si yog raws kev coj kom lub stimulation tiam ntawm peb hom interferon nyob rau hauv T-lymphocytes, hepatocytes, epithelial hlwb ntawm lub plab hnyuv phab ntsa.

Cawv ntawm immunomodulating los yog vim los qhov nqi koj tshuav ntawm lub cev lub hlwb thiab lub normalization ntawm antibody ntau lawm. Lub hauv paus ntawm lub mechanism ntawm antiviral yam kev ua si yog qhov inhibition ntawm cov protein synthesis, tej kab mob nyob rau hauv kab mob qhov chaw ntawm lub cev. Qhov no txhaum lawv ntxiv tu tub tu kiv.

Kab mob khaub thuas zoo li tshuaj ntse kho tus mob, kab mob, ua pa xwm, kis kab mob siab thiab herpes pob.

Inductors ceev txiav txim

Feem ntau, thawj coj ntawm tej tshuaj ua rau yoo mov kev loj hlob ntawm ib tug tiv thaiv protein.
Fast-kuj inducer ntawm endogenous interferon nyob rau hauv ib ob peb teev nyob rau hauv lub cev yuav ua rau cov tsim ntawm protein uas proves cov hauj lwm zoo.

tilorona tshuaj nce tom qab lub internal siv protein concentration kom txog rau thaum ib tug nqi siab tshaj plaws twb tom qab 4 h. Muaj yog ib tug gradual tsim ntawm interferon nyob rau hauv thawj txoj hnyuv, ua raws li los ntawm lub siab thiab los ntawm hmo ntuj - nyob rau hauv cov ntshav.

Kev npaj "TSikloferon" induces protein tom qab 4 teev, thiab ib tug ncov yog cai tom qab 8 teev, tom qab uas muaj ib tug gradual txo nyob rau hauv concentration.