Luv peptides thiab polypeptides raws li ib feem ntawm kev ua si kev noj haus. Yuav ua li cas los xaiv?

Peptides yog ib tug nrov txhais tau tias uas yog siv nyob rau hauv tshuab rau hauv qhov kev npaj ntawm cov kev ua si kev noj haus ntawm ncaws pob nyob rau hauv pib xyaum ua thiab kev ua si nawv [3]. Tag nrho cov peptides - cov kev ua si kev noj haus yam - yuav tsum tau muab faib ua 2 pab pawg: luv luv (me me) peptides thiab polypeptides ( "loj"). Lub peptides yog muaj li ntawm tej yam yooj yim Cheebtsam - amino acids. Yog hais tias ib tug peptide muaj ib tug me me muaj pes tsawg tus ntawm cov amino acids, piv txwv li 3 los yog 4, - nws yog ib tug luv luv peptide. Yog hais tias lub peptide yog 20-30 amino acids, thiab ntau - nws yog ib tug polypeptide. Polypeptides - qhov no yog yuav luag tib yam li hais tias ntawm cov nqaijrog - tseem ceeb molecules nyob rau hauv peb lub cev. Yog vim li cas yog nws thiaj li tseem ceeb mus rau lub division rau hauv luv luv peptides thiab polypeptides? Los ntawm qhov ntev ntawm lub peptide nyob rau nws txoj kev ua, ua hauj lwm zoo thiab kev ruaj ntseg thaum uas siv nyob rau hauv cov kev ua si kev noj haus.

Tam sim no nrov raws li ib tug kev ua si nawv kev noj haus Cheebtsam yog polypeptides uas txhawb roj burning, kom nqaij loj, ua rau kom kev tiv thaiv, ua kom tag nrho noj qab haus huv. Txawm li cas los, lawv muaj teeb meem loj drawbacks. Polypeptides, tshwj xeeb tshaj yog peptide cov tshuaj hormones, tej zaum yuav incompatible nrog txhua lwm yam, txhob cuam tshuam txog lub ntuj cov tshuaj hormones rau hauv lub cev. Nyob rau hauv tas li ntawd, tag nrho cov "loj" peptides yog txawv teb chaws mus rau hauv lub cev thiab yuav ua kom ua xua. High cev kev ua si uas lossi mus rau lub ua kis las, feem ntau ua rau kom ib tug txo nyob rau hauv kev tiv thaiv, uas ntxiv tsub kom lub sab kev tsis haum tshuaj los ntawm kev siv lub polypeptides. Vim hais tias cov polypeptides yog feem ntau cais los ntawm cov tsiaj kab mob [2, 3, 9], hla dhau tu technology nyob rau hauv lawv teeb meem impurities tej zaum yuav tam sim no - txawv teb chaws cov nqaijrog, DNA tawg tsam, cov kab mob, prions, uas kuj muaj immunogenicity (muaj peev xwm ntxias tsis haum tshuaj) thiab yuav ua tau kom txoj kev loj hlob cov kab mob.

Yog nws tau ua li ntawd, kom pab tau thaj chaw ntawm bioregulatory polypeptides thiab nyob rau tib lub sij hawm kom tshem tawm lawv shortcomings? Yog, tam sim no nws tau ua tau. Raws li ib tug tshwm sim ntawm lub xyoo ntawm kev tshawb fawb, nws twb pom hais tias txhua tus polypeptide yog ib tug active center - hais tias ib tug me me ib feem ntawm nws, uas yog lub luag hauj lwm rau cov nuj nqi ntawm lub peptide. Raws li tus tsom xam ntawm nyob tus yeees ntawm polypeptides raws li ib tug tshwj xeeb technology Lw Pharma GmbH luv luv peptides tau tsim, muaj raws ntawm 2, 3 los yog 4 amino acid residues [5, 6, 7]. Tej luv luv peptides tsis tsim nyog cais tawm los ntawm cov tsiaj ntaub so ntswg, thiab lawv yuav tsum tau tsim tshuaj. Nws yog kev ruaj ntseg vim hais tias hluavtaws peptides tsis muaj cov khoom xyaw uas ua rau ua xua. Yog li IPH luv luv peptides rau cov qauv kiag li zoo tib yam rau tej yam ntuj tso active (functional) polypeptide molecules chaw zov me nyuam thiab yog tsis ntaus nqi los ntawm lub cev raws li txawv teb chaws tshuaj. Nws yog ib qho tseem ceeb kom nco ntsoov tias luv luv peptides IPH, ua tseem "muaj nuj nqi" ntawm ib tug polypeptide molecule siv nyob rau hauv cov kev ua si kev noj haus ntawm theem qis tshaj qhov "loj peptides."

Ib qho tseem ceeb kom zoo dua ntawm IPH luv luv peptides yog lawv muaj peev xwm yog zoo dua absorbed los ntawm lub cev piv rau lub polypeptides. Yuav ua li cas no tshwm sim? Cov nqaijrog thiab polypeptides nkag mus rau hauv lub cev cov zaub mov, nkag mus rau hauv lub plab thiab hnyuv. Muaj lawv yog cov uas muaj kev pab los ntawm tshwj xeeb enzymes (peptidases) "txiav" mus rau hauv me me tawg tsam - luv luv peptides muaj 2 los yog 3 amino acid residues. Ces luv luv peptides nkag mus rau cov ntshav thiab thauj mus rau cov nqaij ntshiv thiab lwm yam kabmob thiab ntaub so ntswg, uas muaj ib tug ntxawg nyhuv. Feem ntau ntawm cov polypeptides, uas peb tau txais raws li ib feem ntawm kev ua si kev noj haus yuav yuav "txiav" peptidase thiab yuav tsis muaj lub Desired nyhuv, los yog cov nyhuv yuav yuav weaker. Nyob rau hauv luv luv no IPH peptides yog ib feem ntawm cov kev ua si kev noj haus yuav tam sim ntawd los ntawm lub plab thiab cov hnyuv nkag mus hauv cov hlab ntsha thiab cov nqaij mos, tsis rhuav. Tam sim no Lw Pharma GmbH tsim thiab tsim ib tug series ntawm luv luv peptides, hu ua IPH, rau tus kws, khoom noj khoom haus, kom hniav zoo nkauj thiab kev ua si kev lag luam, uas tsim kho lub cev, lub paj hlwb thiab endocrine systems, muaj antioxidant zog, qhib metabolism thiab pab rau kev tiv thaiv ntawm kev mob thiab nce thiav [5, 6, 7, 8]. Nws yuav tsum tau muab sau tseg hais tias polypeptides yeej tsis paub lub caij nyoog mechanism kev lom ua si, whereas rau luv luv peptides IPH xws tshawb fawb nqa tawm ntau yooj yim dua thiab peb yuav mus txog noob lw mechanism ntawm qhov kev txiav txim ntawm lub peptide [1, 5, 6, 7, 8, 10 ]. Qhov no tso cai rau koj mus confidently npaj rau lub miv nyuas siv zug thiab kev nyab xeeb ntawm luv luv IPH peptides ua los ntawm Lw Pharma GmbH (lub teb chaws Yelemees).

Yog li, lub luv luv peptides IPH, muaj tag nrho cov lom los ntawm polypeptides, nyab xeeb, uas tsis yog-immunogenic, muaj kev kawm raws li mechanism ntawm qhov kev txiav txim thiab yog qhov zoo tshaj plaws tshuaj raws li ib tug kev ua si kev noj haus yam [4] thiab cov vector ntawm kev loj hlob ntawm cov niaj hnub pharmacology thiab molecular tshuaj.

Qhov chaw paub meej tias cov miv nyuas siv zug thiab kev nyab xeeb ntawm luv luv peptides

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