"Nimesulide": xyuas, kev siv ntawm analogues

Nonsteroidal antiinflammatory agents yog ib tug tshwj xeeb hauv chav kawm ntawv ntawm cov tshuaj muaj teeb meem loj peb los: antiinflammatory, antipyretic thiab analgesic. Vim cov pharmacodynamic yam ntxwv ntawm no pab pawg neeg ntawm cov tshuaj yog dav siv nyob rau hauv kev kho mob xyaum. Cia saib nta hauv daim ntawv thov "Nimesulide" tshuaj, ua siab ntev testimonials txog qhov no lam khoom, raws li zoo raws li cov tau phiv los thiab nta ntawm dosing.

pharmacodynamic yam ntxwv

"Nimesulide" yog tus neeg sawv cev ntawm ib pawg ntawm cov uas tsis yog-tshuaj anti-inflammatory siv tshuaj. Nyob rau hauv nws cov tshuaj pab pawg neeg hais txog xim inhibitors ntawm lub enzyme cyclooxygenase-2, uas yog zoo mus cuag inhibition ntawm zus tau tej cov prostaglandins nyob rau hauv o.

Lwm yus feature ntawm lub mechanism ntawm qhov kev txiav txim "nimesulide" formulation yog nws muaj peev xwm inhibit tso ib qho enzyme hu ua myeloperoxidase, uas ho cheeb zus tau tej cov dawb radicals uas tshwm rov rau dab chemo- thiab tigmotaksisa thiab phagocytosis. Nyob rau hauv tas li ntawd, "nimesulide" muaj txhawb rau kev tsuj ntawm lub tsim ntawm qog necrosis tau thiab lwm yam kev sib kho kev koom tes nyob rau hauv inflammatory kev tshua ntawm tus kab mob.

Lub pharmacokinetic yam ntxwv ntawm

Lub ntsiab txoj kev ntawm thawj coj ntawm lub medicament yog qhov ncauj, vim lub high bioavailability ntawm cov tshuaj, tus nqi ntawm ntau concentration nyob rau hauv ntshav ntawm cov neeg mob. Yog li, lub siab tshaj plaws concentration yog tiav tom qab 120-180 feeb tom qab cov thawj coj, thiab cov neeg kawm ntawv ntawm thwj toob ntawm yeeb tshuaj nrog ntshav cov nqaijrog yog nyob ze rau 98% ntawm cov muas thaum chiv thawj ua tswvcuab nqi "nimesulide" npaj (kev cov neeg mob thiab cov kws kho mob paub meej tias nws).

Lub cev lub ntsiab nyob rau hauv uas cov tshuaj metabolism yog lub siab. Nyob rau hauv tus txheej txheem ntawm biotransformation rau hauv active metabolite hu ua hydroxynimesulide. Lub ntsiab txoj kev ntawm feem ntawm cov tshuaj yog nws feem nyob rau hauv cov zis (li qhia txog 65% yeeb tshuaj), hais txog 35% ntawm cov tshuaj yog tas nyob hauv cov faeces.

Zoo tag nrho cov neeg ua ntej yuav noj kom zoo dua ntawm tej ntaub ntawv qhia ntxiv txog cov tshuaj "Nimesulide". Cov lus qhia rau kev siv, analogs, indications thiab contraindications, sab los - lub feem ntau nquag nug cov lus nug.

indications

Indications rau cov tshuaj "Nimesulide" tsis yog li ntawd ntau npaum li cas. Cov lawv nws muaj nqis ntsoov teev mob tshwm sim, nrog rau thawj osteoarthritis mob thiab thawj dysmenorrhea tshwm sim. Nyob rau hauv xyuas xyaum raws li txoj kev siv ntawm cov tshuaj. Qhov no yog evidenced los ntawm kev txais neeg kawm tawm "Nimesulide" txhais tau tias kev xyuas. nws yog tsis pom zoo kom yuav rau cov me nyuam nyob rau hauv 12 lub xyoos ntawm hnub nyoog - yuav tsum tau paub txog qhov no.

Contraindications mus rau yeeb tshuaj

Zoo li tag nrho cov nonsteroidal anti-inflammatory siv tshuaj "nimesulide" yog ua rau lub xub ntiag ntawm pais plab rwj los yog duodenum defect (12 duodenal rwj) nyob rau hauv lub mob nyob ntev, tej lub detoxifying siab muaj nuj nqi, thaum appointing cov tshuaj noj hepatotoxic tshuaj. Cov tshuaj yog ua rau cov neeg mob uas muaj teeb meem loj txo nyob rau hauv lub excretory raum muaj nuj nqi (creatinine clearance tsawg tshaj li 30 mL / min), Hematological mob thiab txhaws teeb meem, cov neeg mob nrog impaired plawv muaj nuj nqi.

"Nimesulide" yog ua rau hauv lub xub ntiag ntawm cov neeg mob phais pathology, cev xeeb tub thiab laus leej niam, thiab cov me nyuam nyob rau hauv 12 lub xyoos ntawm hnub nyoog vim hais tias ntawm lub high school ntau yam kev phiv tshuaj. Nws yog tsis tsim nyog muab "Nimesulide" rau cov kev kho mob ntawm kev mob ua npaws thiab mob khaub thuas zoo li tej yam kev mob ntawm hyperthermia.

phiv

Qhov no txhais tau hais tias tsis tsuas yus muaj los ntawm siab anti-inflammatory kev ua si tab sis kuj yog ib tug siab tshwm sim ntawm kev phiv tshuaj. Lawv tshwm sim feem ntau yog nyob rau hauv lub thawj lub lim tiam ntawm txoj kev kho nrog "Nimesulide". Xyuas ntawm qhov tshwm sim ntawm cov kev phiv tawm npaum li cas yuav tsum tau kawm.

Ntawm daim tawv nqaij thiab daim tawv nqaij sab los yog txuam nrog rau cov kev muaj kev tsis haum tshuaj mus rau yeeb tshuaj thiab cov uas muaj qhia ua qhov tshwm sim ntawm daim tawv nqaij khaus thiab ua pob ua xyua, dermatitis, lossis puas liab liab, urticaria. Ntau tsawg phiv tshwm sim xws li tshuaj lom epidermal necrolysis, Stevens-Johnson syndrome.

Nyob rau hauv ib feem ntawm tus mob huam tsis tshua yuav ua rau los ntshav, perforation ntawm ulcers. Ntau zaus tshwm sim mob nyob rau hauv lub epigastric cheeb tsam, xeev siab, ntuav, raws plab los yog cem quav.

Nyob rau hauv ib feem ntawm lub hauv paus poob siab system yuav ua nkees, ntev li tsaug zog, pheej mob taub hau thiab undue kiv taub hau, vestibular ntshawv siab.

Los ntawm cov sab ntawm hematopoiesis system thiab hlab plawv system yuav tsim eosinophilia, thrombocytopenia, thiab pancytopenia, anemia syndrome, tachycardia, ntshav siab, txoj kev loj hlob ntawm hyperkalemia.

Txoj kev siv "Nimesulide" thiab xyuas

Siv cov "Nimesulide" nrees coj nws qhov chaw nyob rau hauv kev soj ntsuam rheumatologic cov kab mob ntawm lub licas. Dua li ntawm qhov tseem ceeb rau cov kev txwv nyob rau hauv zaj lus tim khawv rau cov tshuaj "nimesulide" zoo tswv yim hais txog nws vim nws cov high efficiency nyob rau hauv cov kev kho mob ntawm rheumatic kab mob. Qhov no yog vim lub tseem los ntawm cov cyclooxygenase-2 thiab ib tug high degree ntawm selectivity rau no enzyme.

ceev faj

Yuav ua li cas yuav tsum tau ceev faj thaum noj cov tshuaj no raws li "Nimesulide"? Cov lus qhia rau kev siv, ua siab ntev xyuas qhia txog ib co lus ceeb toom. Ib qho tseem ceeb taw tes rau hauv cov lo lus uas "nimesulide" npaj yog siv cov yam tsawg kawg nkaus kho koob tshuaj ntawm cov tshuaj. Nyob rau hauv lub qhaj ntawv ntawm miv nyuas siv zug muaj tsawg heev dosing tau txais cov tshuaj yuav tsum tau txiav.

Nyob rau hauv cov ntaub ntawv ntawm hepatotoxicity ntawm cov tshuaj (uas yog saib xyuas los ntawm cov ntshav biochemistry) uas tau txais cov tshuaj kuj yuav tsum tau nres sai li sai tau. Qhov no pab pawg neeg ntawm cov neeg mob (uas tsim lub siab cell raug mob) ntxiv ntus txwv tsis pub "Nimesulide." Nws yuav tsum tau muab sau tseg tias txawm nyob rau hauv lub qhaj ntawv ntawm cov kev phiv siab tshuaj yuav tsum tsis txhob ua ke nrog hepatotoxic tshuaj, lwm yam narcotics yuav muab, analgesics. Tsis tas li ntawd, yuav tsum caiv txhob haus cawv.

"Nimesulide" yuav tsum muaj ib high degree ntawm kev ceev faj muab rau cov neeg mob muaj hepatic los yog lub raum insufficiency yuav tsum tsis txhob pheej hmoo ntawm kev vam meej ntawm lub caij nyoog kawg no.

Kev mloog yuav tsum tau them mus rau lub sij hawm ntawm cov tshuaj rau cov neeg mob nrog kab mob khaub thuas zoo li cov tsos mob. Qhov no yog vim lub fact tias "nimesulide" possesses antipyretic nyhuv thiab muaj peev xwm los npog cov tsos mob ntawm ib tug kab mob kab mob.

Tshuaj kev sib tshuam

Vim lub high school lub peev xwm ntawm cov tshuaj yuav ua tau kom plab hnyuv los ntshav "Nimesulide" yuav tsum tsis txhob ua ke nrog anticoagulants xws li "warfarin" raws li muaj ib tug yuav muaj kev phiv.

Lub peev xwm ntawm cov tshuaj cuam tshuam rau cov kev ua ntawm cytochrome P450. Nyob rau hauv view ntawm lub haumxeeb ua si ntawm inhibition ntawm cov enzyme ntau npaum cov tshuaj metabolized los ntawm txoj kev cytochrome yuav tsum tau kho downward.

"Nimesulide": analogues, xyuas

Lub ntsiab analogs (raws li active neeg sawv cev) yog "Nimid", "Nimesil", "Remesulid", "nyuj-sanovel". Cov tshuaj no muaj nyob rau cov ntsiav tshuaj daim ntawv 100 mg sachets los yog nyob rau hauv daim ntawv ntawm cov gel rau 10 mg (ib 1 g ntawm gel). Therapeutic kev ua ntawm analogues ntawm cov tshuaj yog zoo, yog li cov neeg mob yuav sab laug rau lawv xyuas thiab zoo. Cov neeg mob tawm hauv lub "Nimesulide" txhais tau tias kev xyuas, ntsiav tshuaj ua me dua cov tshuaj nyob rau hauv daim ntawv ntawm ib tug sachet.

xaus

"Nimesulide" yog ib tug muaj zog anti-inflammatory tus neeg saib xyuas los mus kho inflammatory kab mob, tshwj xeeb tshaj yog licas. nco ntsoov tham nrog koj tus kws kho mob txog kev noj "Nimesulide" tshuaj vim hais tias ntawm lub high school uas yuav muaj tshwm sim tsis zoo yog tsim nyog. Xyuas cov kws kho mob muab tshuaj yeeb tshuaj, thiab cov neeg mob noj nws zoo, txij li thaum nws txhawb nqa sai yuav txo tau ntawm tus kab mob mob.