Tshuaj rau cholesterol: yuav ua li cas zoo lawv

Nws yog tsis muaj daim card uas tshaj cholesterol nyob rau hauv cov ntshav yog teeb meem rau kev noj qab nyob, tshwj xeeb tshaj yog rau cov mob thiab leeg tshav systems. Thaum lub substance pib tshaj tso lub sij hawm rau ntawm cov phab ntsa hauv cov hlab ntsha, cov tsim cholesteric plaques es lub zog ntawm cov ntshav uas muaj txhawb mus rau lub pathology ntawm lub plawv thiab leeg tshav txawv txav.

cholesterol hom

Nws yog to taub hais tias lub cev xav tau ib co roj, tsis muaj nws yog tsis yooj yim sua rau cov txiv neej lub neej. Qhov no cov ntaub ntawv uas yog ib feem ntawm lub cell daim nyias nyias, nws yog tsim nyog rau cov hauj lwm ntawm lub paj hlwb thiab lwm yam kabmob.

Thaum nws yog ua rau tshaj cov ntsiab lus caij yog hais txog mus rau lub thiaj li hu ua cov cholesterol, uas yog txuam nrog ib tug protein tsim tau ib cov lipoprotein - ib tug kiag li tshiab compound. Nws muaj ob hom ntawm lipoproteins: siab thiab tsis muaj kev ceev. Yog li ntawd, muaj zog ntshav ntawm tsawg-density lipoprotein thiab yog ib tug kev hem thawj rau kev noj qab nyob.

Nyob rau hauv thawj zaug rau theem ntawm tus kab mob nws yog pom zoo kom raws li ib tug tshwj xeeb kev noj haus thiab ua ce uas koom nrog lub cev ua si. Tab sis cov no ntsuas yog tsis txaus, thiab yuav tsum tau tu hlab ntsha los ntawm roj uas txhaws taus tshuaj.

Zaum tau ntev tau sim los ua ib tug tshuaj uas zoo txo cov roj cholesterol. Txawm li cas los, ib tug tshuaj zoo meej tsis muaj nyob, thiab txhua pab pawg neeg ntawm cov tshuaj, thiaj li cholesterol, nws muaj ob zoo thiab disadvantages.

Kev siv cov statins

Rau hnub tim, statins - yog qhov zoo tshaj plaws tshuaj rau cholesterol. Lawv yeej xav kom tau nyob rau hauv thawj qhov chaw nyob rau ib tug kom theem ntawm substance. Feem ntau cov feem ntau, cov kws kho mob muab cov tshuaj yuav ua rau cov hauv qab no pab pawg:

• simvastatin ( "Zocor", "Vasilip");
• atorvastatin ( "Tulip" "Torvakard" "Lipitor" "Atoris" "Liptonorm");
• rosuvastatin ( "Rozukard", "AKORT" "Crestor", "Roxer").

Nyob rau hauv tsawg zaus, statins siv, muaj feem xyuam rau cov thawj tiam tshuaj rau roj. Nyob rau hauv pab pawg neeg no muaj xws li fluvastatin ( "Lescol"), lovastatin ( "Mevacor" "Holetar") pravastatin. Txhua qeb nws muaj nws tus kheej cov tshuaj miv nyuas siv zug thiab heev ntawm lipid tej kev txiav txim. Qhov tseem hwj chim statins yog tam sim no pom tau hais tias rosuvastatin thiab atorvastatin. Qhov siab tshaj plaws tolerable hnub ntau npaum ntawm thawj pab pawg neeg yog 40 mg, lub thib ob - 80 mg.

Noj tshuaj rau cholesterol yog tsim nyog ib zaug ib hnub twg nyob rau hauv lub yav tav su. Qhov no yog vim lawv mechanism ntawm qhov kev txiav txim. Statins thaiv lub siab enzyme uas nkoos tsim ntawm roj uas txhaws taus. Thiab txij li thaum lub siab tshaj plaws tu tub tu kiv ntawm cholesterol cai nyob hmo ntuj, siv ib tug statin yuav tsum ua ntej yuav mus pw. Qhov no txoj cai yog tshwj xeeb yog muaj feem xyuam rau cov thawj ob tiam ntawm cov tshuaj (simvastatin, lovastatin thiab pravastatin). Niaj hnub nimno rosuvastatin thiab atorvastatin ntev tshem tawm los ntawm lub cev, thiaj li lub sij hawm ntawm lawv cov kev siv tsis tau.

Muaj yog ib tug stereotype hais tias cov kev kho cov roj teeb meem rau lub siab. Txawm li cas los, qhov no lub taub Tawvv yog tsis muaj tseeb. Nyob rau hauv ib co siab ailments statins pab rau kev txhim kho cov mob ntawm lub nrog cev (e.g., kev kho mob ntawm fatty siab). Tab sis nyob rau hauv kev mob loj hepatic pathologies coj statins txwv tsis pub vim hais tias lub siab concentration ntawm cov ntsiab nyob rau hauv cov ntshav yuav ua rau txoj kev loj hlob ntawm txaus ntshai phiv los: raum tsis ua hauj lwm, thiab rhabdomyolysis. Yog li, nws yuav tsum tau nco ntsoov tias twb statin tshuaj loj heev, yuav ua tau (tsis tshua muaj) sab tshua, lawv cov kev siv tsuas yog tau los ntawm kev muab tshuaj tom qab txhij txhua kev xeem.

Qhov zoo ntawm statins

Tshuaj tsis txhob cia li txo tus nqi ntawm cov roj uas txhaws taus, tab sis kuj txo tau txoj kev tsim lub plawv thiab leeg tshav teeb meem. Lawv muaj ib tug high degree ntawm kev ruaj ntseg thaum lub sij hawm heev siv. Cov nyhuv ntawm statins los tom qab tsuas yog ob tug lub lis piam los ntawm thaum pib ntawm kev siv.

shortcomings

Lub xub ntiag ntawm lub tsis zoo tshua ntawm tus kab mob (nyob rau hauv uas tsis tshua muaj neeg mob): nqaij mob, mob plab, xeev siab. Thaum lub sij hawm kev kho mob txhua txhua rau lub hlis twg yuav tsum tau coj lub siab muaj nuj nqi kev ntsuam xyuas. Thaum siab koob tshuaj yuav ua rau kev phiv, tuag taus.

Kev siv cov fibrates

Cov tshuaj no fibric acid derivatives. Cov pab pawg neeg ntawm cov roj uas txhaws tshuaj muaj xws li fenofibrate, ciprofibrate, bezafibrate, gemfibrozil thiab clofibrate. Qhov zoo tshaj tshuaj ua "Traykor", xa mus rau cov qeb ntawm fenofibrate.

Fibrates statins yog ua tsis tau zoo nrog kev xav txog tej yam nyob rau theem ntawm cov uas tsis muaj kev ceev lipoprotein thiab tag nrho cov roj uas txhaws taus, tab sis tus nyob rau hauv high-density lipoproteins thiab triglycerides yog superior rau lawv. Los ntawm kev siv ntawm fibrates rau lub caj theem yog ib tug kev hloov ntawm cov roj uas txhaws thauj. Cov tshuaj rau cholesterol tshuaj yog ib tug thib ob kab yog thov tom qab statin txoj kev kho rau cov kev kho mob ntawm hypercholesterolemia. Formulations pom zoo thaum theem ntawm triglycerides, cais gipoalfaholesterinemii.

cholesterol haum inhibitors

Niaj hnub no nyob rau hauv Russia, tsuas yog ib cov tshuaj ezetimibe pab pawg neeg. Lub npe ntawm cov tshuaj cholesterol - "Ezetrol '. Muab kuj noj tshuaj "Inedzhi", uas combines ua ke nrog ntawm simvastatin nrog ezetimibe. Lub mechanism ntawm qhov kev txiav txim ntawm cov tshuaj mas siv yog nyob rau hauv yuam cai ntawm cov roj uas txhaws haum los ntawm lub plab hnyuv ib ntsuj av tau, yog li kom txhob muaj cov ntshav theem ntawm ib yam khoom.

Qhov zoo xws li siab ezetimibe kev nyab xeeb ntawm cov tshuaj, vim hais tias cov tshuaj tsis txeem mus rau hauv cov hlab ntsha. Lawv yuav tsum tau muab rau cov neeg uas muaj lub siab tus kab mob, raws li tau zoo raws li cov neeg mob uas rau ntau yam yog vim li cas yog txhob siv ntawm statins. Qhov no kev kho cov roj (xyuas hais txog nws) yuav siv tau ua ke nrog ib tug statin, uas tso cai rau rau enhanced kho nyhuv.

Qhov tsis zoo ntawm ezetimibe yog tsawg npaum piv nrog statins, raws li zoo raws li siab nqi.

Kua tsib acid sequestrants

Cholesterol txhawb rau tu tub tu kiv ntawm cov kua tsib acids, uas yog tsim nyog rau lub cev zom. Daim ntawv thov sequestrants tswj losis tswvyim dabtsi kua tsib acids, lawv transformation mus rau hauv insoluble tebchaw thiab feem. Lub cev, tsoov ib tug tsis muaj kua tsib acids, pib rau cov me nyuam lawv sib los ntawm cov roj uas txhaws, uas txo cov ntsiab lus. Tiag tiag kho mob xyaum, cov tshuaj rau cholesterol yog siv heev tsis tshua muaj. Nws sau npe ob tshuaj teej tug mus rau cov pab pawg neeg ntawm cov kua tsib acid sequestrant, - "Colestipol" thiab "Cholestyramine". Txawm li cas los, lawv tsis tau siv nyob rau hauv lub teb chaws ntawm Russia.

Qhov kom zoo dua ntawm cov tshuaj yog lawv lub zos txiav txim, lawv tsis absorbed rau hauv cov hlab ntsha. Qhov tsis zoo muaj xws li tsis kaj siab saj, ntev mus kawm, teeb absorbability ntawm cov nqaijrog thiab vitamins. Lub medicament yuav ua nce los ntshav.

Cov tshuaj "Niacin"

Vitamin PP los yog nicotinic acid, paub zoo tias kom ntau. Medicament "Niacin" - cholesterol tshuaj - cov kws kho mob pom zoo kom noj cov lus teb nyob rau high school koob tshuaj (txhua hnub volume ntawm mus txog rau 4 grams). Lub caij nplooj zeeg ntawm cholesterol yuav siv sij hawm qhov chaw nyob rau hauv ib tug ob peb hnub ntawm kev siv ntawm nicotinic acid. Lipid tej nyhuv ntawm cov tshuaj "Niacin" yog tsis siab kawm. Cov soj ntsuam ntawm hais tias lub vitamin PP tiv thaiv txoj kev khiav ntawm roj depot acids, pab txo cov cholesterol.

Qhov kom zoo dua ntawm cov tshuaj yog sai tau, tau simultaneous siv satin. Cov tshuaj pab txoj kev microcirculation, muaj ib tug vasodilatory nyhuv. Tsis muaj cov tshuaj no yog siv loj koob tshuaj rau lipid tej nyhuv, lub xub ntiag ntawm sab los xws li reddening lub ntsej muag.

Kev siv cov omega-3 polyunsaturated fatty acids

Qhov no pab pawg neeg yog sawv cev lug txawv lom active additives thiab tshuaj yeeb. Qhov zoo tshaj plaws paub yog ntses roj thiab "Omacor." Lub hauv paus ntsiab lus ntawm cov lag luam lus dag nyob rau hauv txo tu tub tu kiv nyob rau hauv daim siab triglycerides thiab ua pes tsawg tus receptors muab kev koom tes nyob rau hauv fatty acid oxidation. Cov no ib tug poob rau hauv uas tsis muaj-density lipoproteins. Qhov zoo ntawm cov tshuaj yog siab kev ruaj ntseg, concomitant anti-arrhythmic kev txiav txim.

Tsis tshua muaj efficiency, siv tsuas yog raws li ib tug adjunct mus rau kev kho mob pa (fibrates thiab statins) yog disadvantageous tshuaj cov ntaub ntawv.