Chloramphenicol (ntsiav tshuaj) - phau ntawv qhia

Ntsiab lus npaj chloramphenicol ntau npaum daim ntawv - cov ntsiav tshuaj, coated ntsiav tshuaj los sis tsiav tshuaj.

qauv

Active tshuaj:

• chloramphenicol - 250/500 mg (1 ntsiav tshuaj)

cam:

• calcium stearate;
• qos hmoov txhuv nplej.

Lub pharmacological kev txiav txim ntawm cov tshuaj chloramphenicol

Chloramphenicol cov ntsiav tshuaj yog broad-spectrum tshuaj tua kab mob, uas yog zoo tawm tsam ib tug plurality ntawm ob gram-zoo thiab gram-tsis zoo kab mob. Tsis tas li ntawd, active tshuaj tej zaum yuav ua rau kab mob los uas yog resistant mus rau lub nram qab no tshuaj tua kab mob - penicillin, sulfonamides, streptomycin.

Cov tshuaj ua rau ib tug microorganism, cuam tshuam nws protein synthesis, yog li nyob rau hauv kho koob, tshuaj no muaj peev xwm pheev bacteriostatic kev txiav txim.

Cov kam mus rau lub tshuaj nyob rau hauv kab mob yog qeeb, thiab yog li tsis cross-resistant mus rau lwm cov tshuaj tua kab mob ib tug zoo li tus qauv.

Indications chloramphenicol npaj

Ntsiav tshuaj ntawm cov tshuaj siv nyob rau hauv ib tug xov tooj ntawm cov kab mob uas muaj peev xwm muab tau los ntawm cov kab mob kab mob:

• paratyphoid;
• typhoid;
• salmonellosis;
• shigellosis;
• brucellosis;
• rickettsial kab mob;
• tularemia.

Tshwm sim los ntawm cov tshuaj chloramphenicol

Thaum tshuaj lom, los yog tsuas yog hais tias koj yog hypersensitive tej zaum yuav muaj kev phiv, uas muaj feem rau ntau yam systems ntawm lub cev.

Sab los muaj feem xyuam rau cov ntshav:

• thrombocytopenia;
• leukopenia;
• reticulocytopenia;
• txo tus nqi ntawm cov qe ntshav liab nyob rau hauv cov ntshav;
• aplastic anemia.

Sab los muaj feem xyuam rau tus mob huam thiab qog ua kua week:

• ntuav;
• xeev siab;
• tsam plab;
• raws plab;
• mucosal irritations;
• stomatitis;
• glossitis;
• goiter;
• rov muaj dua ntawm lub fungal kab mob.

Sab los mus txog rau lub hauv paus poob siab system:

• tsis hnov lus (reversible);
• hallucinations;
• optic neuritis;
• peripheral neuritis;
• encephalopathy;
• kev nyuaj siab;
• mob taub hau.

Sab los muaj feem xyuam rau kev tsis haum tshuaj:

• kub taub hau;
• daim tawv nqaij sawv pob;
• anaphylaxis;
• Angioedema.

Contraindications rau kev siv ntawm chloramphenicol npaj

Ntsiav tshuaj ntawm cov tshuaj yog tsis pom zoo nyob rau hauv rooj plaub yog tias tus neeg mob muaj ib tug los yog ntau tshaj ntawm cov nram qab no tej yam kev mob (xeev):

• ntshav kab mob, xws li inhibition ntawm cov ntshav;
• psoriasis;
• fungal kab mob ntawm daim tawv nqaij;
• eczema;
• impaired siab muaj nuj nqi;
• Ari;
• Cev xeeb tub thiab lactation;
• porphyria;
• muaj hnub nyoog txog li 3 xyoos.

tshuaj overdose

Nyob rau hauv cov ntaub ntawv ntawm overdose, yog hais tias tus yeeb tshuaj yog siv chloramphenicol, tej zaum yuav muaj cov nram qab no cov tsos mob - tau teeb meem ntawm hematopoietic nruab nrog cev thiab tshuab, uas yog feem ntau yog txuam nrog heev siv loj heev koob tshuaj ntawm cov tshuaj. Teeb meem tshwm sim mob caj pas, daim tawv nqaij pallor, los ntshav, ua npaws thiab kev tsis muaj zog ntawm lub cev.

Nyob rau hauv cov me nyuam, ib tug overdose yuav tsum tau cai:

• ntuav;
• tsam plab;
• gray daim tawv nqaij xim;
• arrhythmic ua tsis taus pa;
• hypothermia;
• plawv cev qhuav dej.

Nyob rau hauv thiaj li yuav tau tshem ntawm cov tsos mob no, koj yuav tsum tam sim ntawd tom qab lawv cov tsos mob tsis txhob noj cov tshuaj, ntxuav lub plab, pib tau txais sorbents thiab pib symptomatic kev kho mob raws li xav tau.

Drug sis raug zoo nrog cov tshuaj chloramphenicol

Cov ntsiav tshuaj yuav tsum tsis txhob noj nyob rau hauv cov kev tshwm sim hais tias ib tug neeg mob muab rau cov tshuaj cheeb qhov uas cov tsim ntawm cov ntshav, thiab nyob rau hauv particular cov cuab yeej xws li cytostatics, pyrazolone derivatives thiab sulfonamides, raws li tau hais tias yuav muab rau lawv tsis muaj lub sij hawm, ces nws yog tsim nyog los renounce kev siv cov chloramphenicol thiab nrhiav tau nws ib tug lwm txoj.

Cov tshuaj xws li phenobarbital, rifampin, rifabutin thiab zoo heev txo lub concentration thiab cov hauj lwm zoo ntawm chloramphenicol.

Cov tshuaj thiaj li antibacterial nyhuv ntawm penicillins thiab cephalosporins. Tsis tas li ntawd, nws yuav txo tau miv nyuas siv zug ntawm erythromycin, lincomycin, thiab clindamycin, thiab.