Cov tshuaj "salofalk": analogs thiab cov lus qhia rau kev siv

Cov tib neeg lub cev yog tawm tsam nrog ib tug ntau yam ntawm cov kab mob, tej yam yooj yim thiab complex, thoob plaws nws lub neej. Far ntawm ua cov feem ntau tsis ntev los no nyob rau hauv ib tug series ntawm cov teeb meem mob nyob inflammatory plob tsis so tswj kab mob. Yuav kom sib ntaus nrog lawv mus tsim ib tug xov tooj ntawm txawv tshuaj uas sib txawv hauv paus ntsiab lus ntawm kev txiav txim.

Substance mesalazine yog tus thawj xib fwb feem ntawm ib tug txaus loj pab pawg neeg ntawm cov tshuaj ( "salofalk" analogs) rau tshwj kom txhob kev inflammatory plob tsis so tswj kab mob.

Muaj pes tsawg leeg "salofalk", pharmacodynamics

Raws li hais ua ntej lawm, lub ntsiab active khoom sib ua zaub mov yog mesalazine medicament. Raws li koom haum pab ua hauj lwm pab ib tug xov tooj ntawm Cheebtsam, nyob rau hauv particular, xws li sodium carbonate, glycine, povidone, microcrystalline cellulose, silicas, thiab titanium, calcium stearate, croscarmellose sodium, hypromellose ntsiab butylmethacrylate copolymer.

"Salofalk" (granules, ntsiav tshuaj, suppositories, ncua kev kawm ntawv) cheeb (depresses) cov txheej txheem ntawm Neutrophil thiab lipoxygenase synthesis nyob rau hauv tib neeg prostaglandins thiab leukotrienes. Lub active tshuaj thiaj li tus nqi ntawm tsiv teb tsaws, phagocytosis thiab degranulation qe, thiaj lub tso pa tawm ntawm lymphocytes. Tsis tas li ntawd, lub medicament muaj peev xwm sawv ntawm losis tswvyim dabtsi dawb radicals thiab tom qab kom lawv puas tsuaj, i.e. exhibits antioxidant nyhuv. Tsis tas li ntawd mesalazine muaj peev xwm ntawm losis tswvyim dabtsi nrog dawb radicals tsim los ntawm reactive pa hom.

Indications rau kev siv

Lub ntsiab cheeb tsam nyob rau hauv uas pom cov kev siv ntawm "salofalk" - ib tug kev kho mob rau ulcerative mob plab thiab Crohn tus kab mob.

Tus thawj kab mob no yog ib tug mob inflammatory txheej txheem twb tsis tau clarified qhov. Nws txoj kev loj hlob yog tshwm sim los ntawm ib tug kev sis raug zoo ntawm caj yam thiab tej yam kev mob.

Crohn tus kab mob yuav tsiag ntawv raws li mob granulomatous o ntawm tus mob huam. Qhov no txoj kev muaj peev xwm ntes tag nrho qhov chaw ntawm lub digestive system, nws muaj feem xyuam rau tag nrho cov khaubncaws sab nraud povtseg ntawm cov digestive raj. Lub qhov tsim nyog tau tej zaum yuav txoj kev loj hlob ntawm lymphadenitis, ulceration thiab cirrhosis ntawm plob tsis so tswj phab ntsa yog tsis.

Daim ntawv tshuaj tso tawm

Manufacturers muab lawv cov neeg muas zaub cov tshuaj "salofalk" (zoo li nyob rau hauv no hwm tej zaum yuav txawv) nyob rau hauv ib tug ob peb ntau yam ntaub ntawv ntawm ntau lawm.

Nyob rau hauv cov ntsiav tshuaj daim ntawv yuav muaj 250 los yog 500 mg ntawm lub ntsiab active tivthaiv - mesalazine. Nyob rau hauv ib sachet yuav muaj 500 mg los sis 1 g ntawm lub ntsiab substance. Lub medicament nyob rau hauv daim ntawv ntawm cov suppositories (suppositories rau qhov quav thawj coj) no kuj muaj nyob rau hauv ob noj tshuaj npaum cas - 250 thiab 500 mg ntawm lub ntsiab tivthaiv. Kuj yuav tsum yuav nyob rau hauv khw muag tshuaj thiab ua npuas ncauj ncua kev kawm ntawv rau lub qhov quav thawj coj. Qhov zoo tshaj rau txhua tus neeg neeg mob tso tawm daim ntawv no yuav pab koj xaiv tus kws tus kws kho mob.

ntsiav tshuaj noj regimen

Standard ntau npaum rau cov neeg laus - peb zaug ib hnub twg 500 mg. Yog hais tias mob mob loj heev degree ntawm tus kab mob, lub mus kawm tus kws kho mob muaj txoj cai yuav ua tau kom lub koob rau 3-4 g tauj ib hnub. Hoob no ntawm txoj kev kho tej zaum yuav nyob ntev li ntawm 2 mus rau 3 lub hlis. Yog hais tias cov tshuaj yog muab raws li ib tug tiv thaiv kev ntsuas, nws yog ua los ntawm ib tug txheej txheem tswvyim (1.5 g nyob rau hauv peb koob tshuaj thaum lub sij hawm ib hnub).

Yau cov neeg mob 'salofalk "Neeg Daim Ntawv Thov (analogs tej zaum yuav txawv nyob rau hauv ntau npaum regimen) qhia rau muab nyob rau hauv raws li qhov nyhav ntawm tus me nyuam. Cov me nyuam mos nrog lub cev hnyav tsis tshaj 40 kg, tus kws kho mob prescribes 250 mg ntawm cov tshuaj peb zaug ib hnub twg. Yog hais tias tus me nyuam hnyav tshaj 40 kg, nws qhia tau hais tias cov tib ntau npaum li rau cov neeg laus: 500 mg peb zaug ib hnub twg.

Ntsiav tshuaj zoo tshaj plaws coj tom qab kawm tiav ntawm lub noj mov, tsis ntxo thiab haus dej haus kom ntau kua (dua li dej).

Lub tswvyim ntawm cov granules

Qhov kev tso cai hauv daim ntawv ntawm cov tshuaj "salofalk" (granules) raug taw los ntawm lub mus kawm tus kws kho mob tshwj xeeb tshaj yog ib tus zuj zus, raws li nyob rau hauv tag nrho cov kev soj ntsuam daim duab ntawm tus neeg mob lub noj qab haus huv. Nyob rau hauv feem ntau thaum lub sij hawm exacerbation ntawm ulcerative mob plab tus neeg mob yog muab rau tau txais ib koob tshuaj ntawm 500 mg los sis 1 g peb zaug thaum lub sij hawm lub hnub (t. E. Lub hnub volume ntawm medicament yog los ntawm 1.5 mus 3.0 g). Koj muaj peev xwm coj ib tug hluas koob tshuaj ib zaug 3 lub hnab. Yog hais tias tus neeg mob yog nyob rau hauv txoj kev zam txim, "salofalk" coj ib koob tshuaj ntawm 1.5 g ib hnub twg: nws muaj peev xwm yuav muab faib ua 3 koob tshuaj noj los yog tag nrho ntawm cov tshuaj nyob rau hauv ib zaug.

Yog hais tias peb yuav sib tham txog ib tug exacerbation ntawm ulcerative mob plab nyob rau hauv cov me nyuam (los ntawm 6 xyoo thiab laus dua), cov kws kho mob prescribes cov tshuaj ntawm tus nqi ntawm 30-50 mg mesalazine ib 1 kg ntawm qhov ceeb thawj. Tag nrho cov koob tshuaj tej zaum yuav tsum tau noj nyob rau hauv ib lub sij hawm los yog muab faib ua 3 koob tshuaj thoob plaws hauv lub hnub.

Lub granules yuav tsum tau muab tso rau hauv tus nplaig thiab, tsis muaj zom, nqos. Cov tshuaj yuav tsum haus dej kom ntau. Mus rau kho nyhuv yog resistant granules yuav tsum tau coj tsis tu ncua thiab li qhia siv kuj. Mob theem ntawm ulcerative mob plab feem ntau tuag tsis pub dhau 2-3 lub hlis, ntau tau txhua txhua hnub koob tshuaj txo kom 1.5 g ib hnub twg.

Lub hom phiaj thiab cov hom ntawm daim ntawv thov ntawm suppositories

"Salofalk" (taws tswm ciab) phau ntawv qhia kom ib tug ntau npaum ntawm 500 mg (1 qhov quav suppository 500 mg los sis 2 - 250 mg) peb zaug ib hnub twg. Yog hais tias tus kab mob no nyob rau hauv lub mob nyob ntev, txhua hnub koob tshuaj yuav tsum ob npaug. Yog hais tias ib tug neeg mob yog muab ib tug ntev kawg ntawm txoj kev kho los yog lub hom phiaj txais tos - purely prophylactic (relapse tiv thaiv), li ib txwm koob tshuaj nyob rau hauv cov ntaub ntawv no yog 250 mg (1 tswm ciab) peb lub sij hawm thaum lub sij hawm ib hnub.

Yau cov neeg mob ntau npaum nyob ntawm lub cev muaj ceeb thawj. Cov me nyuam uas tsawg tshaj li 40 kg "salofalk" (taws tswm ciab) cov lus qhia rau kev siv regulates taw ½ ntau npaum rau ib tug neeg laus, t. E. 250 mg peb zaug ib hnub twg. Yog hais tias tus me nyuam hnyav tshaj 40 kg, nws yog muab tso rau cov tshuaj ntau npaum li rau cov neeg laus cov neeg mob (peb zaug ib hnub twg 500 mg).

qhov quav ncua kev kawm ntawv

Tshuaj "salofalk" - ncua kev kawm ntawv yog muaj nyob rau hauv hwj muab rau qhov quav thawj coj. Tus txheej txheem yog ua ib zaug nyob rau hauv lub yav tsaus ntuj ua ntej yuav mus pw. Tus neeg mob ua ntej thawj coj ntawm cov tshuaj yog pom zoo kom tso cov hnyuv. Lub sij hawm npaum li cas ntawm cov tshuaj no yog xaiv raws li nyob rau hauv tus neeg mob lub qhov ceeb thawj (nyob rau hauv cov nqe lus ntawm 30-50 mg / kg). Yog hais tias tus kab mob no yog mob loj heev los yog nyob rau hauv tus txheej txheem ntawm raug ntau zog, lub siab tshaj plaws tshuaj thaum lub sij hawm lub hnub yuav mus txog li 3 xyoos los mus tiv thaiv tsis tshua mob heev kws txawj feem ntau yog pom zoo kom noj "salofalk" lus (ntsiav tshuaj). Nyob rau hauv rooj plaub no tus koob tshuaj (txhua hnub) yog tseem muab rau tus luj ntawm - 15-30 mg / kg lub cev hnyav. Tag nrho txhua txhua hnub ntim tshuaj thoob plaws hauv lub hnub yog pom zoo kom muab faib mus rau hauv ob ua sawv.

Contraindications tau txais "salofalk"

Kev siv lub tshuaj "salofalk" (analogues - yog tsis muaj exception) yog contraindicated rau cov neeg uas muaj hypersensitivity mus rau lub ntsiab thiab tej koom haum Cheebtsam ntawm cov tshuaj. Nws yog tsis tsim nyog rau taw ntsiav tshuaj rau cov me nyuam nyob rau hauv 3 xyoos, granules - 6-xyoo-laus. Koj tsis muaj rau noj tshuaj rau ib tug neeg mob kev txom nyem los ntawm sab kev raum los yog hepatic insufficiency.

Tsis txhob xaiv "salofalk" cov neeg uas muaj ib tug ib txwm mus tsim los ntshav, ntau yam hematopoietic system kab mob. Txom nyem los ntawm hemorrhagic diathesis xwm ntawm lub rwj kab mob ntawm tej mob huam kuj yuav tsum tsis txhob noj tshuaj rau lub hauv paus ntawm mesalazine.

Lub granules tsis tsim nyog medicament los siv rau cov neeg mob kev txom nyem los ntawm phenylketonuria (raws roj ntsha kab mob txuam nrog impaired metabolism ntawm phenylalanine ua rau muaj mob loj Cns txhab nyob rau hauv daim ntawv ntawm cov kev txawj ntse xiam oob khab).

Nrog hais txog cev xeeb tub thiab lactating cov poj niam, cov kev siv ntawm cov tshuaj nyob rau hauv thawj 3 lub hlis uas cev xeeb tub yuav tsum tau kev txaus cai los ntawm kev cai nruj heev indications. Tsis pub dhau 2-3 trimesters lub sij hawm "salofalk" yog tau tsuas yog nyob rau hauv tus neeg mob uas tau raug zoo ntxim rau cov kev kho mob ntawm cov poj niam dominates tau pheej hmoo rau tus me nyuam. Raws li cov tib zaj lus tim khawv yog tau mus thov cov granules 'salofalk "lactation. Txawm li cas los, yog hais tias tus me nyuam muaj raws plab, nws yog tsim nyog los tso tseg pub niam mis. Thiab nyob rau hauv Feem ntau, optimally npaj ua ntej qhov pib ntawm cev xeeb tub, tsis txhob noj "salofalk" los yog, yam tsawg kawg, cov tshuaj tsawg tau txais.

Tej kev phiv

Sab los yog yuav luag txhua cov tshuaj. Muaj yog ib qho kev zam thiab "salofalk" (Lavxias teb sab counterparts zoo li). Cns phiv yog tau cov tsos mob li mob taub hau, kiv taub hau, tshee, tinnitus, kev nyuaj siab, convulsions, paraesthesia. Mob huam yuav teb tau txoj kev siv cov "salofalk" los ntawm kev mob nyob rau hauv lub plab mog, plab, raws plab, xeev siab, ntuav. Tau txoj kev loj hlob ntawm tus kab mob siab, hepatic transaminase qhov tseem ceeb hloov. Cardio-leeg tshav system yuav tau txais tachycardia, ntshav siab fluctuation (hyper- los yog hypotension), mob hauv siab, dyspnea.

Nyob rau hauv tej rooj plaub, cov neeg mob yuav tau hnov nyob rau hauv txoj kev loj hlob ntawm myalgia, arthralgia. Nyob rau hauv tas li ntawd, cov tshuaj yuav ua rau anemia, leukopenia, thrombocytopenia, anuria, oliguria, hematuria, crystalluria.

Ntawm ib tug xov tooj ntawm kev tsis haum tshuaj yog tau khaus, daim tawv nqaij ua pob liab vog, erythema, bronchospasm, pericarditis thiab myocarditis. Nyob rau hauv cov neeg mob uas npau taws me ntsis rau mesalazine yuav tsim cov kab mob xws li interstitial nephritis, nephrotic syndrome, mob theem ntawm pancreatitis. Nyob rau hauv ib tug nyias muaj nyias ib pab pawg neeg ntawm cov neeg mob "salofalk" (zoo li nws zoo li) ua cov tsos mob xws li ib tug syndrome ntawm muaj quag lupus erythematosus.

Tshuaj analogues

Lub "salofalk" txaus kom muaj nuj nqis ntawm cov tshuaj analogues ntawm lub ntsiab active tivthaiv. Yuav ua li cas ua tau, piv txwv li, hloov "salofalk" - taws tswm ciab? Analogues, uas yog feem ntau cov kev txaus siab ntawm cov neeg thiab cov kws kho mob yog tsa - yog suppositories "Pentas" thiab "Samezil". Cov tshuaj no lub ntsiab active khoom sib ua zaub mov yog mesalazine, kom lawv muaj zoo sib xws pharmacological los rau tib neeg lub cev.

"Mesakol" - lwm lug siv analog "salofalk" (nyob rau hauv granules, ntsiav tshuaj).

Dhau li kev ua analog tivthaiv, muaj yog ib tug loj pawg ntawm cov tshuaj uas zoo sib xws nyob rau hauv kho nyhuv. Cov tshuaj yuav xyuam xim nqa "Azathioprine" thiab "Alginatol", "hydrocortisone" thiab "Dexamethasone" "Diprospan" thiab "Irmalaks", "prednisolone" thiab "Sulfasalazine". Daim ntawv mus rau.

tej tswv yim pom zoo

Ua ntej koj yuav pib kho mob thiab thaum lub sij hawm kev kho mob thiab tom qab nws txiav cov chaw pab kho kom tau ntau cov ntshav thiab zis kev ntsuam xyuas. Tsis tas li ntawd ua ntej cov kev kho mob thiab nyob rau hauv tus txheej txheem nws yog tsim nyog los saib xyuas lub ciaj ciam ntawm lub haumxeeb lub xeev ntawm lub siab. Xyuas yog zoo tshaj plaws ua tom qab 14 hnub tom qab pib ntawm txoj kev kho, thiab ces lwm 2-3 lub sij hawm ntawm ua mib ntawm 4 lub lis piam. Yog hais tias lub xeem tau hauv tej kev txwv, saib xyuas cov ntawv tshawb fawb nqa tawm txhua txhua 3 lub hlis. Yog hais tias mam li nco dheev tej yam sib txawv yuav tsum muaj cai nyob rau hauv lub tsom xam, nws yog tsim nyog los nqa tawm tswj kev ntsuam xyuas sai li sai tau.

Nyob rau hauv lub sij hawm ntawm ib daim ntawv tshuaj "salofalk" (taws tswm ciab, analogues ntawm cov ntsiav tshuaj, granules, ntawv) rau cov neeg mob kev txom nyem los ntawm bronchial hawb pob, cov kws kho mob yuav tsum tau ua tib zoo saib xyuas tus mob ntawm cov neeg mob thaum lub sij hawm txoj kev kho. Yog hais tias tus neeg mob muaj keeb kwm zoo nkaus li tau ntawm cov kev phiv thaum noj "Sulfasalazine" xeev kev kho mob ntawm cov neeg zoo li yuav tsum tau saib xyuas kom zoo nyob rau hauv thawj zaug rau theem ntawm kev kho mob "Salofalk." Yog hais tias lawv qhia ib tug mob intolerance tshua (convulsions, mob plab, ua pob liab vog, fever), cov kev siv ntawm cov tshuaj yuav tsum tau txiav sai li sai tau.

Thaum tsav tsheb los yog ua dej num uas yuav tsum tau kev kub ceev psychomotor tshua, cov neeg mob uas tau txais "salofalk", yuav tsum tau ceev faj heev.