"Kardosal": phau ntawv qhia, xyuas, piav qhia, analogs

"Kardosal" (thoob ntiaj teb lub npe - "olmesartan medoxomil") yog ib tug antagonist ntawm angiotensin receptor II (hom AT1) - thawj vasoactive lawm RAAS hais txog txoj kev loj hlob ntawm qhov tseem ceeb tawg.

Daim ntawv tso yeeb tshuaj, nws Cheebtsam

Cov tshuaj no muaj nyob rau cov ntsiav tshuaj uas yog them los ntawm nws lub hnab. Basic yeeb tshuaj, uas ib tug medicament ntawm olmesartan medoxomil siv nyob rau hauv lub ntsiav tshuaj muaj xws li los ntawm 10 mus rau 40 mg ( "Kardosal 10", "20 Kardosal", "Kardosal 40").

Tsis tas li ntawd, cov tshuaj ntxiv magnesium stearate, microcrystalline cellulose, lactose monohydrate. Tsis tas li ntawd, raws li pab koponentov siv giproloza thiab tsawg pawg giproloza. Lub plhaub yog tsim los ntawm titanium dioxide nrog ntxiv talc thiab hypromellose.

pharmacological los

Nws yog assumed tias cov tshuaj "Kardosal" kuj nyob rau hauv cov kab mob, muaj txhawb rau thaiv cov hlab cov teebmeem ntawm angiotensin II, _AT1 receptor kho hom haum xeeb. Nyob rau hauv tawg medicament txo arterial siab, qhov no ua rau kav rau ib ntev lub sij hawm. Yog tsis muaj cov ntaub ntawv lees tias qhov tshwm sim ntawm hypotension tom qab thawj zaug siv cov pib koob tshuaj siv yeeb tshuaj thiab tachycardia vim ntev-lub sij hawm kev kho ( "Kardosal 20", "Kardosal 40"), qhov tsos ntawm ntsoos ntsoos nrog los ntawm ib tug ntse nce nyob rau hauv cov ntshav siab.

Cov kev siv ntawm cov tshuaj ib hnub ib zaug tau nyob rau hauv ib tug me me txo nyob rau hauv cov ntshav siab ntsuas. Cov nyhuv muaj tshaj 24 teev. Feem ntau, cov hypotensive cov nyhuv yog tiav nyob rau hauv kaum plaub hnub ntawm kev kho mob, qhov zoo tshaj plaws kev tshwm sim cai tom qab kev kho mob ntawm txog ob lub hlis.

tshuaj

Lub haum ntawm yeeb tshuaj, nws muab faib rau

Drunk ntsiav tshuaj sai heev yuav siv sij hawm rau hauv daim ntawv ntawm ib tug pharmacologically active metabolite nyob rau hauv cov hnyuv (vim qhov kev txiav txim sib sib zog tsa los ntawm enzymes) thiab portal ntshav (thaum lub sij hawm haum los ntawm tus mob huam).

Thaum lub sij hawm kho pes tsawg leeg ntawm cov ntshav ntshav yog tsis kuaj active tshuaj unchanged. Nruab nrab bioavailability yog hais txog 26%. Cov qib siab tshaj plaws ntawm cov tshuaj pom nyob rau hauv ib tug nruab nrab ntawm ob teev tom qab noj nws, nrog kom muab (tib koob tshuaj - 80 mg) ntawm nws tsub kom.

"Kardosal 40", raws li zoo raws li khoom nrog sib txawv ntau npaum ntawm lub active ingredient, yuav npaum li cas tsis muaj ntawm rau cov mov noj noj. Noj zoo tsis ntxim rau bioavailability.

Kev twb kev txuas nrog cov ntshav protein yog yuav luag tiav, thiab sau raws nkaus Ii 99,7%. Txawm li cas los, lub simultaneous siv "Kardosala" vysokosvyazyvayuschimisya nrog lwm yam tshuaj nws yog tshuam txo.

Drug metabolism thiab nws cov feem ntawm lub cev

Yeej tshuaj muab siab (60%), tus so (40%) - ob lub raum. Intrahepatic ncig ntawm lub active tshuaj yog tsis tseem ceeb txaus. Txij li thaum feem yog ua tsuas yog los ntawm lub siab, kev kho mob nrog agents "Kardosal plus" nws yog txwv tsis pub, yog hais tias tus neeg mob muaj biliary ib ntsuj av tau dab tsi thaiv. Tom qab rov siv tshuaj cov tso tawm rau hauv nruab nrab rau 12 xuab moos. Zoo nyhuv yog cai raws li qhov uas tau txais ib tug ntau npaum ntawm cov tshuaj, uas sib raug mus rau ob peb koob tshuaj "Kardosala". Ib tug tseem ceeb nyhuv yog tam sim no thiab tom qab kaum plaub hnub ntawm kev kho mob, hereinafter txuam nrog tsis tshwm sim. Nyob rau hauv no daim duab, raws li lub raum clearance yog tsis cuam tshuam los ntawm ntau cov tshuaj ntau npaum, nws yog nyob rau hauv lub chav los ntawm 0.5 mus 0.7 L / h (kwv yees li).

Tshwj xeeb soj ntsuam tus neeg mob

Cov neeg mob uas muaj nyob rau hauv yuam cai ntawm lub raum muaj nuj nqi (me ntsis, hauj sim, loj), AUC nce los ntawm 62, 82 thiab 179%, thaum tus mob yog ruaj khov.

Thaum teeb meem siab, me ntsis thiab mob pesnrab qhia, ib koob tshuaj AUC ua txhais tau tias yuav pab tau 6 thiab 65%.

zaj lus tim khawv

Lub sij hawm teem tseg txhais tau tias "Kardosal" qhia ntawv nyob rau daim ntawv thov enables nrhiav kom tau ntawm qhov tseem ceeb tawg.

Kho "Kardosalom" thaum lub sij hawm cev xeeb tub yog tsis tsim nyog. Yog hais tias lub cev xeeb tub yog nyob rau hauv txoj kev kho mob, nws yog tsim nyog los ua tus abolition ntawm cov tshuaj.

Vim tsis muaj cov ntaub ntawv txhawb kev ruaj ntseg ntawm cov kev kho mob ntawm lub mis noj thaum lub sij hawm ntawm kev kho mob cease pub niam mis.

Yuav tsum tau mus yuav "Kardosal" thiab pib yuav tsum tau kho nrog nws, tus kws kho mob yuav tsum sau ib cov tshuaj.

Contraindications

Contraindications xws li meem kev txhawj xeeb rau cov neeg tshuaj uas yog muaj nyob rau hauv lub formulation, tus me nyuam (nyob rau hauv 18 xyoo), cev xeeb tub, mis-pub mis. Nyob rau hauv tas li ntawd, cov ntsiav tshuaj yog tshuaj nyob rau hauv cov nram no mob:

• rhuav txhua ntawm lub biliary ib ntsuj av tau;
• lub xub ntiag ntawm malabsorption syndrome, galactosemia;
• tsis muaj lactase;
• lub sij hawm tom qab ib lub raum hloov;
• raum tsis ua hauj lwm thaum uas tsis muaj QC (tsawg tshaj li 20 ml / min).

"Kardosal" - ib tug yeeb tshuaj uas yog muab nrog huab ceev faj rau cov neeg mob nrog tej yam kev mob:

• coronary artery kab mob;
• hyperaldosteronism (thawj);
• mob ntawm lub siab;
• raum tsis ua hauj lwm, nyob rau hauv uas KK yog ntau tshaj 20 ml / min;
• stenosis, lesion nrog mitral los yog aortic valve;
• mob hauv lub plawv tsis ua hauj lwm txaus;
• cerebrovascular kab mob;
• noj cov zaub mov nrog limited sodium kom tsawg;
• hyponatremia, hyperkalemia (muaj ib tug uas yuav ntawm lub raum insufficiency, hypotension los yog lub cev qhuav dej);
• lub xeev thaum BCC txo tshwm ntuav, raws plab;
• stenosis, ntaus ib leeg xwb raum, ob sab sib dho stenosis, nyob rau hauv uas cuam tshuam raum leeg;
• hypertrophic obstructive cardiomyopathy;
• muaj hnub nyoog tshaj 65 xyoo;
• qhov yuav tsum tau rau diuretics.

Siv "Kardosala"

"Kardosal" phau ntawv qhia kom siv 10 mg, uas sib raug mus rau thawj lub koob. Thaum tsis txaus normalization ntawm cov ntshav siab yuav tsum tau noj ib hnub mus rau 20 mg ntawm yeeb tshuaj. Tshaj koob tshuaj ntawm 40 mg tshuaj ib hnub twg yog tsis tsim nyog. Txhua hnub noj tshuaj yuav tsum haus dej haus ib lub sij hawm, nyob rau ib thiab tib lub sij hawm. Rau cov neeg mob uas raum teeb meem tau tshwm sim me ntsis heev, thaum lub clearance yog nyob rau hauv lub chav los ntawm 20 mus rau 60 ml / min, lub siab tshaj plaws tshuaj "Kardosala" tsis tau ntau tshaj li 20 mg. Nyob rau hauv tus neeg mob qhov twg muaj ib tug yuav tsum tau ntxiv dag zog rau ua cov nyhuv yog ua complex kev kho mob (tsuas yog "Kardosala" thov "Hydrochlorothiazide").

phiv

Nyob rau hauv kev kho yeeb tshuaj "Kardosal" phau ntawv qhia pub xws phiv:

• tsis zoo tshuaj tiv thaiv los ntawm cov pa thiab digestive systems, cov tsos ntawm teeb nyob rau hauv lub licas, mob txeeb zig thiab ob lub raum, hloov ib co kuaj tsis, txoj kev loj hlob ntawm ib tug general cim mob (xws phiv tshwm sim feem ntau);
• txoj kev loj hlob ntawm angina, cov tsos mob rau lub paj hlwb (tej zaum yuav tshwm sim);
• kev hloov nyob rau hauv cov hlab plawv system, txoj kev loj hlob ntawm hyperkalemia (tsis tshua pom).

Sab teebmeem uas tshwm sim heev tsis tshua tom qab tau txais medicament "Kardosal" cov lus qhia rau kev siv muaj xws li:

• teeb nyob rau hauv lub hematopoietic system;
• hnoos;
• mob hauv daim ntawv ntawm lub raum tsis ua hauj lwm;
• daim tawv nqaij muaj teeb meem;
• asthenic syndrome;
• mob taub hau, kiv taub hau tsos;
• myalgia;
• convulsive lub xeev;
• xeev siab nrog ntuav, mob plab;
• nce ntawm urea, creatinine nyob rau hauv cov ntshav;
• kev hloov nyob rau hauv daim siab - nce nyob rau hauv kev ua si ntawm nws cov enzymes.

overdose

Overdose yog ua tau, nws manifests ib tug ntaus cim yuav txo tau ntawm cov ntshav siab ntsuas. Nyob rau hauv cov ntaub ntawv ntawm xws li ib tug tshwm sim ntawm kev kho mob yuav tsum xyuas ntawm cov neeg mob. Yuav kom tshem tawm cov tsos mob uas nrog overdose txhais tau tias "Kardosal", cov kws kho mob pom zoo kom hais tias koj ua tau xyuas symptomatic kev kho mob thiab txhawb nqa txoj kev kho kom normalize cov ntshav siab. Nyob rau hauv cov ntaub ntawv ntawm overdose tus neeg mob pw rau nws rov qab thiab tsa nws ob txhais ceg. Nyob rau hauv tas li ntawd, thaum uas siv cov ib tug loj koob tshuaj ntawm cov tshuaj no yog pom zoo kom ua pais plab lavage, muab tus neeg tshuab txais carbon. Muaj yog ib tug yuav tsum tau rau lub ntim hloov, tshem tawm ntawm lub cev qhuav dej thiab kho tshiab ntawm dej-ntsev tshuav nyiaj li cas. Ntaub ntawv hais txog cov tau ntawm feem ntawm tshuaj olmesartan medoxomil los ntawm kev lim ntshav muaj.

ceev faj

Nyob rau hauv cov neeg mob uas ua ntej cov kev kho sib kho nrog diuretics thiab adhered mus rau ib tug noj cov zaub mov uas excludes noj nqos tau cov ntsev, tej zaum yuav ua rau hypotension raws li ib tug tshwm sim ntawm cov tshuaj thawj zaug siv cov tshuaj. Cov tib yam yuav tsum muaj cai nyob rau hauv cov neeg mob uas tau tshwm sim ntuav los yog zawv plab. Yog vim li cas rau qhov no cov tshuaj tiv thaiv ntawm lub cev - yuav txo tau ntawm BCC. Phiv kev tshwm sim ntawm no xwm yuav tsum tau tiv thaiv. Qhov uas nws tshwm sim yuav tsum raug xam tias yog ua ntej pib txoj kev kho.

Yog hais tias ib tug neeg tau tawg lub ob lub raum, nws yog ib qho tseem ceeb rau tsis tseg xyuas cov nuj nqis twb ntshiab li creatinine, poov tshuaj. Kev siv ntawm ACE inhibitors los ntawm cov neeg mob uas tau raug tshuaj lawm hyperaldosteronism (thawj), yog meaningless, kom lawv tsis txhob muab txhais tau tias "Kardosal" (kev qhia tias tsis muaj lo lus teb rau ACE inhibitors).

Khaws nyob rau hauv lub siab hais tias ib tug muaj zog poob rau hauv cov ntshav siab nyob rau hauv cov neeg mob uas atherosclerosis, uas muaj feem xyuam rau lub paj hlwb hlab ntsha, los yog nrog coronary artery kab mob no yuav ua rau txoj kev loj hlob ntawm txaus ntshai tej yam kev mob xws li ischemic stroke thiab heart attack myocardial infarction.

Yog hais tias ib tug neeg tau ua txij nkawm ntawm technically complex machinery los yog tsav ib lub tsheb, nws yog ib qho tseem ceeb kom paub hais tias noj "Kardosala" yuav ua rau ib tug deterioration ntawm kev noj qab nyob (qaug zog, tsis muaj zog, kiv taub hau), txawm tias qhov no tsis tshua muaj tshwm sim.

Vim lub lactose cov ntsiab lus nyob rau hauv cov tshuaj noj nws txwv tsis pub rau cov neeg mob nrog raws roj ntsha galactose intolerance cim. Tib yam siv rau cov neeg mob uas malabsorption syndrome galactose thiab piam thaj, lactase tsis muaj peev xwm nyob rau hauv lub cev.

Sis nrog lwm yam tshuaj

Tus kws kho mob yuav tsum sau ib cov tshuaj thiab nrhiav tawm yog hais tias tus neeg mob yog kho los ntawm lwm txoj kev los tiv thaiv kom txhob pliaj tshua. Nws tsis pom zoo kom siv ob qho tib si "Kardosalom" thiab cov nram qab no ntawm cov tshuaj:

• txhais tau tias muaj poov tshuaj;
• ntsev hloov, uas muaj xws li cov neeg ntawm poov tshuaj yog tam sim no;
• Poov tshuaj-sparing diuretics;
• cov tshuaj uas cuam tshuam rau poov tshuaj ntau ntau nyob hauv cov ntshav ntshiab (ua no daim duab).

Ib qho piv txwv ntawm xws yog cov "heparin". Nws yog tau los txhawb lub ntsiab lus ntawm poov tshuaj nyob rau hauv cov ntshav. Thaum impossibility ntawm kev kho mob "Kardosal" analogues muab ib lub sij hawm los mus ua kom nws hloov.

Strengthening ntawm lub antihypertensive cov nyhuv yog cai thaum cov kev kho mob ntawm cov lwm antihypertensive tshuaj thiab narcotics yuav muab, piv txwv li qhov kev siv ntawm kev kho mob. Therapy nrog integrated mus kom ze yuav siv cov COX-2 inhibitors, acetylsalicylic acid (txhua hnub koob tshuaj - ntau tshaj 3 g). Qhov kev txiav txim ntawm angiotensin receptor II antagonists yuav ua tau synergistically influencing glomerular filtration los ntawm nws txo.

Nrog simultaneous siv xws medicaments li angiotensin receptor II antagonists, thiab narcotics yuav muab, yog ib tug ntxim yuav zoo siv ntawm tus neeg mob tus mob raum tsis ua hauj lwm zoo lawm. Vim li no, xyuas ntawm lub raum raws li txoj cai nyob rau thawj zaug rau theem ntawm kev kho mob yuav tsum tau ua tsis tu ncua. Tej kev kho mob yuav tsum twv yuav raug hu haus txaus kua. Txawm li cas los, cov tau txo nyob rau hauv lub heev ntawm antihypertensive txiav txim, uas deterioration yog cai nquag hauj lwm zoo ntawm txoj kev kho.

Yog hais tias "Kardosal" yog siv nyob rau hauv cov kev kho mob lub sij hawm antacids, namely txhuas hydroxide thiab magnesium, muaj yog ib tug uas yuav txo tau nyob rau hauv lub bioavailability ntawm lub active tshuaj (ntsis).

Nws qhia reversible nce lithium theem nyob rau hauv cov ntshav ntshiab thiab tso saib lom zog uas ua los ntawm cov sib koom ntawm ACE inhibitors, angiotensin receptor II antagonists thiab tshuaj uas muaj lithium. Nyob rau hauv kev twb kev txuas nrog xws li thaum lawv tseem kho messaging "Kardosalom" thiab cov tshuaj, ib tug ntawm cov uas Cheebtsam - Lithium, tsis pom zoo. Txawm li cas los, Yog hais tias xws li ib tug yuav tsum tau tshwm sim, cov kev tswj ntawm cov ntshav yuav tsum tau kev.

Tus nqi ntawm cov tshuaj, analogs, xyuas

Thaum muab "Kardosal" ntsiav tshuaj zoo li tus nqi yog tsis yog txhua txhua tus neeg mob, yog li lawv xav nyob rau hauv lub tau ntawm kev kho mob nrog rau kev siv lwm yam, ntau txhais tau tias zoo. "Kardosal" nrog cov ntsiab lus ntawm 10 mg ntawm lub active ingredient yuav raug muas tshiav 610, ib tug yeeb tshuaj uas muaj pes tsawg leeg muaj 20 mg ntawm active ingredient -. Nyob 756 xuas. "Kardosal", uas nws nqi yog hais txog 860 rubles., Muaj 40 mg ntawm lub ntsiab tivthaiv.

Raws li ib tug analogy, thaum koj yuav tau xaiv lwm txoj kev siv ntawm txoj kev kho, tsis txhob "Kardosala" koj yuav thov tau cov tshuaj "Olimestra" los yog tsim ib tug ua ke txoj kev kho raws li nyob rau kev siv ntawm "hydrochlorothiazide", "olmesartan medoxomil". Koj muaj peev xwm coj kom zoo dua ntawm xws cov phooj ywg raws li "Lozarel 'los yog' Cozaar '. Nyob rau hauv tas li ntawd, rau cov kev hloov ntawm haum cov tshuaj "Nortivan" "Valsartan Zentiva".

Paub ntawm xws formulations li "Olmesar", "Plaunak". Feem ntau hloov txawv los ntawm tus thawj cov nyiaj, yog ib qhov sib txawv yog tus nqi tsim nyog thiab txo bioavailability tsis, li ntawd, lawv yog tsis tshua zoo, tab sis nws muaj peev xwm tiv nrog lub hauj lwm.

Analogs yeej ib txwm siv nyob rau hauv lub qhov kev saib xyuas ntawm ib tug kws, nws yog tsim nyog los tsis tu ncua mus saib cov ntshav siab. Yog hais tias koj xav tau tuaj nqa analogue rau cov chaw "Kardosal" tshaj hloov cov tshuaj no, tus kws kho mob txiav txim siab, noj mus rau hauv tus account lub txawv lub sij hawm. Thaum nrhiav kom tau kev phiv cov txheej xwm thaum lub sij hawm kev kho mob lub sij hawm lub analogue yuav tsum ua kom qhov tsim nyog kev nqis tes ua nyob rau hauv ib tug raws sijhawm tswj nyob rau ntawm lawv tshem tawm. Thaum lub sij hawm kev kho mob nws yog tsim nyog los xyuas cov nyhuv rau lub cev.

Thaum tus thawj tsis tau hloov cuab yeej ua tsis tau, yuav tsum tau muab kev xaiv li cas rau cov tshuaj manufactured los ntawm European tuam txhab uas muag mus soj ntsuam. Thaum npaj yuav hloov tau "Kardosal" ntsiav tshuaj analogues koj cia li tau mus xaiv lub zoo tshaj plaws.

Comments sab laug rau tus kws kho mob-neeg mob forums, qhia tias cov tshuaj "Kardosal" thaum lub sij hawm kev kho mob feem ntau ua rau cov nyom tshua, feem ntau ntawm uas - lub hauv siab mob thiab qhov nkees. Tab sis txawm cov tsis kaj siab lub sij hawm, lub hypotensive nyhuv yog ib txwm zoo heev. Zoo li phiv los yuav tsum tau xa mus rau ib tug kws pab tswv yim, thiab tej zaum yuav hloov cov kev kho mob regimen.

Nyob rau hauv cov kev kho mob ntawm cov neeg mob nrog arterial tawg tau raug ices, nws yog ib qho tseem ceeb uas tus neeg mob tus mus tas li tswj. Yuav ua raws li ntawm txoj kev kho, yog li yuav muab lub nyhuv, thiab ua raws li lub xeev ntawm tus kab mob, thiab nyob rau hauv cov ntaub ntawv ntawm kev ua txhaum - mus txhim kho lawv nyob rau hauv lub sij hawm. Tseem ceeb kev mus kom ze, tab sis cov tshuaj kho mob yog tsis txaus, peb yuav tsum tau xaiv ib tug tshwj xeeb noj mov. Cov qhov yuav tsum tau kev kho mob tej yam kev mob - raws li maj hom ntawm kev ua hauj lwm, tau txais tshem ntawm tsis tau phem, tsis txhob cev ua ub no thiab kev ua raws cai nrog rau lwm cov pawg sab laj uas tau raug npaj rau tus kws kho mob qhov zoo tshaj plaws kev kho mob tau.