Lupus anticoagulant - yuav ua li cas txaus ntshai

Nyob rau cov ntshav txhaws tej zaum yuav cuam tshuam los ntawm ntau tsis, uas yog txiav txim los ntawm lub biochemical tsom xam ntawm cov ntshav thiab kawm txog coagulation, tab sis nyob rau hauv txhua rooj plaub nws yog tsim nyog los nco ntsoov tias tag nrho cov indicators yuav tsum ntsuam xyuas cov kws kho mob thiab cia siab nyob rau hauv cov ntaub ntawv no tau tsuas yog mus ntsuam xyuas ib tug qhov taw qhia, thiab nyob rau hauv kev tshwm sim ntawm ib tug kev tshawb fawb no. Nyob rau hauv tej rooj plaub, cov ntshav coagulation thiab anticoagulation system ntawm kev luj xyuas tau ua thiab immunological kev ntsuam xyuas, piv txwv li, mus pub cov ntshav rau cov tshuaj rau cardiolipin thiab lupus anticoagulant.

Yuav ua li cas yog lupus anticoagulant thiab nws tseem ceeb nyob rau hauv tib neeg lub cev

Nyob rau hauv tej yam kev mob, ntshav coagulation thiab anticoagulation systems yog nyob rau hauv nruab nrab, - flowability ntawm cov ntshav yog muab khaws cia tseg li no nyob rau hauv cov hlab ntsha nyob rau hauv lub qhaj ntawv ntawm kev puas tsuaj thiab thrombus tsim nrog kev raug mob thiab qhov txhab ntawm tej qhov chaw. Raws li, thaum lub concentration ntawm tej yam tshuaj nyob rau hauv cov ntshav ntshiab yuav tsum tau nce pab kom txawm peem thiab lwm yam - tsuas yog nyob rau hauv cov ntaub ntawv no nws yog tau ceeb toom thrombosis. Tab sis tib neeg lub cev yuav pab kom txawm peem rau cov kev hloov tsuas mus rau ib tug tej yam kev txwv, tom qab uas muaj los ib lub sij hawm thaum txawm muaj ib tug ib txwm mus thrombosis yuav los ua ib tug ua los ntshav - yam lub luag hauj lwm rau lub txhaws ntawm cov ntshav, cia li tsis nyob twj ywm nyob rau hauv lub ntshiab. Nws yog ib yam khoom uas yuav ua rau coagulation mob muaj xws li lupus anticoagulant - ib tug tshwj xeeb tshuaj uas muaj protein ntau cov xwm, uas belongs rau tib neeg immunoglobulin.

Ua cov tshuaj raws li zoo raws li cov tshuaj rau cardiolipin thiab phospholipids nyob rau hauv Feem ntau, nyob rau hauv lub hlwb ntawm lub cev, thiab feem ntau ntawm cov tshuaj nyob rau hauv cov ntshav twb ntes tau nyob rau hauv ib tug ntau yam ntawm cov kab mob autoimmune. Tab sis qhov teeb meem lus dag nyob rau hauv lub fact tias lupus anticoagulant zoo thaum lub sij hawm cev xeeb tub, tej zaum nws yuav ua qhov ua rau ntawm ntau yam teeb meem nyob rau ib feem ntawm lub cev xeeb tub poj niam, thiab los ntawm lub fetus. Nws yuav tsum tau to taub hais tias lub nrhiav kom tau ntawm lupus anticoagulant nyob rau hauv lub qhaj ntawv ntawm cov tshuaj mus txawv neeg mob DNA, phospholipids, cardiolipin hais lus xwb ntawm tau ntawm cov kev phiv thiab qhov yuav tsum tau rau qhov kev kho mob saib xyuas ntawm tus neeg mob.

Nws yuav tsum tau nco ntsoov tias lupus anticoagulant, uas yog lub cai nrog cov ntshav ntshiab yog hom twg los ntawm 0.8 mus 1.2 arbitrary units, yog tsis txaus txhim khu kev qha qhov taw qhia. Yog li ntawd, cov nrhiav kom tau ntawm kom ntau los yog txawm doubtful tshwm sim txoj kev tshawb no yog tsim nyog los ua ib tug complex nrog coagulation yuav tsum txhais tau cov D-dimer, coagulation lub sij hawm (APTT) thiab tejzaum nws ib tug loj tus naj npawb ntawm ntsuas txoj kev kawm - yog nyob ntawm no twv ua ntej, thiab tactics tau kev kho mob ntawm ib tug neeg mob.

Lupus anticoagulant - qhov twg kev tshawb fawb uas yuav tsum tau

Tam sim ntawd cov ntshav mus kuaj lupus anticoagulant yuav tsum tsis tsuas mus rau cev xeeb tub cov poj niam. Qhov no tsom xam yog tau thiab muab cov neeg mob uas ua ntej muaj hnub nyoog 40 xyoo nyob arterial thiab venous thrombosis ntawm tej qhov chaw, thromboembolism, cia li hemorrhagic los yog ischemic stroke tsis muaj cov neeg cov kab mob nyob rau hauv uas muaj peev xwm tsim cerebral ncig (arterial tawg, atherosclerotic cardio). Tshwj xeeb yog noteworthy yog cov ntxhais hluas, uas nyob rau hauv lawv lub neej tau raug tus mob cia li tuag ntawm tus me nyuam hauv plab thaum twg theem ntawm cev xeeb tub nyob rau hauv qhov qhaj ntawv los ntawm kev tshuaj ntsuam genetic cov kab mob thiab me nyuam hauv plab kab mob. Tsuas yog nrog rau qhov xyuas ntawm coagulation tsis, coagulate lupus, tshuaj rau phospholipids thiab cardiolipin yuav xaiv ib txoj kev kho - tsuas yog nyob rau hauv cov ntaub ntawv no nws yog ua tau los mus tiv thaiv cov mob ntawm los ntshav mob.