"Nalbuphine": kev qhia, piav qhia, muaj pes tsawg leeg, xyuas

Nws mob ... Nws mob ... Tsis muaj ib tug neeg uas yuav tsis tau hais tias cov lus no. Thaum peb muaj ib yam dab tsi mob, tag nrho cov lwm yam teeb meem ploj mus rau hauv lub keeb kwm yav dhau. Qhov tseem ceeb tshaj thiab tseem ceeb tshaj nyob rau ntawm no point - mus ua qhov tsis zoo nyob zoo.

Niaj hnub nimno Tshuaj yog npaj txhij rau kev nws cov neeg muas zaub ib tug lossis loj cov lus nug ntawm kev ua kom loog tshuaj uas sib txawv hauv paus ntsiab lus ntawm kev txiav txim. Ib tug xws li tshuaj yog "nalbuphine." Instruction regulates nws raws li ib tug agonist thiab ib tug opioid receptor antagonist, ib tug narcotic analgesic, muaj nyob rau hauv daim ntawv teev cov thib peb daim ntawv teev cov narcotic tshuaj.

Muaj pes tsawg leeg thiab pharmacodynamics

Lub ntsiab active ingredient "Nalbuphine" yog nalbuphine hydrochloride. Cov tshuaj no yog ib qho analgesic opioid pab pawg neeg (cov tshuaj uas muab cawv rau ib tug tib neeg lub cev, zoo ib yam li qhov kev txiav txim ntawm opium). Lub hauv paus ntsiab lus ntawm kev txiav txim ntawm cov tshuaj "nalbuphine" qhia ntawv nyob rau daim ntawv thov hais cov nram no: lub ntsiab active khoom sib ua zaub mov cheeb qhov uas cov kis tau tus mob ntawm kev mob impulses ntawm neurons nyob rau hauv lub paj hlwb. Cov tshuaj nkoos lub siab qhov chaw ntawm lub paj hlwb, li no hloov lub siab ntsws xaav ntawm qhov mob.

Nyhuv "Nalbuphine" rau tib neeg lub cev yog piv nrog cov nyhuv ntawm "morphine". Nalbuphine hydrochloride nkoos ntuav chaw, yog tau suppress lub conditioned reflexes, muaj ib tug sedative nyhuv. Tshuaj suppresses pa chaw, tab sis rau ib tug npaum li cas me me thiab teev tshaj li tus "morphine", "Promedol" los yog "Fentanyl".

Tso daim ntawv thiab ntau npaum regimen

Manufacturers muab lawv cov neeg muas zaub ib tug yeeb tshuaj nyob rau hauv vials "nalbuphine 10" thiab "20 nalbuphine." Txhua ampoule - 1 ml ntawm medicament. Tus thawj ( "nalbuphine 10") ntim rau hauv ib lub pob ntawm 10 vials, thiab lub thib ob - mus 5. "Nalbuphine" (tshuaj) cov lus qhia rau kev siv, tiag tiag noj qab haus huv cov tub txawg pom zoo kom taw nruj me ntsis tus neeg tswvyim, nyob ntawm seb lub cev hnyav, heev ntawm mob nrog cov kab mob.

Lub medicament tej zaum yuav muab intravenously, intramuscularly los yog subcutaneously. Ib tug tib koob tshuaj rau ib tug neeg laus tib neeg tej zaum yuav yog los ntawm 100 .mu.g mus rau 1 mg ib kg lub cev hnyav. Cov thawj zaug koob tshuaj rau ib tug me nyuam - yog tsis ntau tshaj 300 g ib 1 kg ntawm lub cev hnyav. Tus zaus ntawm daim ntawv thov ntawm cov medicament nyob rau tag nrho cov kev soj ntsuam daim duab. Cov kev kho mob kawg yuav tsum tsis txhob kav ntau tshaj li 3-4 hnub, txij li thaum cov tshuaj yog ib tug narcotic, thiab rau ntev thawj coj tej zaum yuav muaj yees.

Indications rau kev siv "Nalbuphine"

"Nalbuphine" phau ntawv qhia xav noj nyob rau hauv muaj zog mob syndromes uas tej zaum yuav txuam nrog postoperative lub sij hawm, gynecological phais tiv thaiv nyob rau hauv cov kev kho mob ntawm lub plawv thiab mob cancer.

Tsis tas li ntawd, cov tshuaj yog dav siv nyob rau hauv cov ntaub ntawv ntawm prednarkoznoy premedication (pre lam npaj ntawm tus neeg mob yuav ua kom tsaug zog thiab kev phais). Ua tau, lub hom phiaj tseem ceeb ntawm txoj kev ua no - kom txhob muaj cov theem ntawm kev ntxhov siab vim nyob rau hauv tus neeg mob thiab cov strengthening ntawm kev txiav txim ntawm cov tshuaj rau tshuaj loog. Nyob rau hauv qhov tseeb, qhov no yog qhov tseem ceeb cheeb tsam ntawm daim ntawv thov ntawm nalbuphine hydrochloride.

Leej twg yuav tsum caiv txhob noj?

"Nalbuphine" kev qhia ntawv, cov tswv yim thiab cov kws muaj txuj tswv yim raug txwv tsis pub tau txais cov neeg mob uas muaj mob loj npau taws me ntsis mus rau lub ntsiab active khoom sib ua zaub mov. Inadmissible siv medicament rau cov kev kho mob ntawm cov neeg mob kev txom nyem los ntawm tag nrho cov hom ntawm cov kab mob ntawm daim siab thiab ob lub raum. Qhov no yog vim lub fact tias metabolized "Nalbuphine" nyob rau hauv lub siab. Lub daim ntawv pib ntawm lub medicament yog tas nyob hauv cov zis (70%) nyob rau hauv daim ntawv ntawm cov derivatives tas nyob hauv cov bile.

Tsis tshuaj los siv rau cov neeg mob uas muaj haus dej haus cawv thiab siv yeeb tshuaj dependence. Tsis ceev yuav tsum tau rau cov tshuaj yog tsis pom zoo rau siv nyob rau hauv cov me nyuam. Txij li thaum "nalbuphine" muaj ib feem nyob rau hauv lub siab chaw ntawm lub paj hlwb, nws yog tsis pom zoo thaum lub sij hawm txoj kev kho siab tsis ruaj tsis khov neeg mob (rau psychosis, kev nyuaj siab thiab thiaj li nyob. N.).

Spillover nyhuv "Nalbuphine"

"Nalbuphine", rau kev siv uas yog vim qhov tus ntawm narcotic rau tib neeg lub cev, yuav ua rau tej yam kev phiv los ntawm ntau yam systems thiab kabmob. Yog li, cov hlab plawv system yog muaj peev xwm mus rau teb rau daim ntawv thov ntawm medicament txoj kev loj hlob tachycardia, arrhythmias, ntshav siab hloov mus hloov los.

Los ntawm lub paj hlwb yuav ua rau mob taub hau, ib tug muaj zog sedative nyhuv (nkees), kev zoo siab. Muaj psychic ces xws li hyperactivity, nce kev ntxhov siab vim. Mob huam yuav nco koj tus kheej manifestation ntawm dyspepsia (kem plab tag nrho cov xaiv).

Nyob rau hauv tej rooj plaub, tshuaj 'nalbuphine "(phau ntawv muaj tshwj xeeb cov lus qhia) yuav ua rau ib tug ntau yam ntawm kev tsis haum tshuaj (anaphylaxis muaj).

Thiab, raws li tau hais ua ntej lawm, "nalbuphine" - ib tug narcotic tshuaj, li ntawd, yuav ua rau hom.

Ntev li koob tshuaj

Ntau npaum medicament nruj me ntsis zuj zus rau txhua tus neeg mob tshuaj xaiv nyob ntawm seb cov kev mob, heev ntawm kev mob, qhov hnyav thiab thiaj li nyob. N. Cais nws daim ntawv thov tsis tus kws kho mob saib xyuas muaj peev xwm ua rau overdosing. Nyob rau hauv cov ntaub ntawv no, raws li ib tug txoj cai, muaj yog li nram qab no cov tsos mob: kev nyuaj siab ntawm lub hauv paus poob siab system, nkees, dysphoria (lub cov lus rov ntawm "zoo siab" morbidly nyuaj siab mus ob peb vas, manifesting nws tus kheej nyob rau hauv txob taus, heev rau lwm tus neeg, yooj yim ntawm aggression, nquag mus ob peb vas kab mob). Overdose yuav ua rau malfunction ntawm lub pa chaw.

Kev kho mob muaj nyob rau hauv daim ntawv thov ntawm antidote (rau "Nalbuphine", raws li rau feem ntau ntawm opioids - yog "Naloxone"), pais plab lavage thiab symptomatic txoj kev kho.

Tos mums ...

Thaum uas cev xeeb tub yog taw "nalbuphine" qhia pub tsuas nrog nruj indications. Nrog zoo ceev faj yog tshuaj rau ntxov ntxov yug thiab nyob rau hauv tus neeg mob qhov twg muaj yog lub sijhawm twg los ntawm me nyuam hauv plab kev coj li hluas. Cov kev ua yog hais txog qhov tseeb hais tias "nalbuphine" txaus nkag kis tus placental barrier thiab yuav ua rau ua pa nyuaj siab nyob rau hauv lub neonate.

Tsis tas li ntawd zoo heev pom zoo kom tshuaj thaum lub sij hawm kev pub niam mis, txawm hais tias "Nalbuphine" thiab faib nrog leej niam cov kua mis nyob rau hauv me me koob tshuaj, muaj tsis muaj kev soj ntsuam tseem ceeb (tsawg tshaj li 1% ntawm tag nrho cov muab tshuaj). Cuaj kaum, muaj yog tsis muaj yuav tsum tau phomsij ib tug me nyuam tsis muaj ib tug loj vim li cas.

Tshwj xeeb cov lus qhia

Ib tug tov cov kev txhaj tshuaj muaj nyob rau hauv nws muaj pes tsawg leeg 10 mg / mL ntawm nalbuphine hydrochloride ( "nalbuphine Farmeks"), phau ntawv xav zoo zoo heev thov nyob rau hauv mob ntawm ua pa muaj nuj nqi, vim nws yog tau txo tus nqi ntawm cov pa feeb ntim rau 25%. Nyob rau hauv cov kev tswj ntawm tus kws kho mob yuav tsum tau tus neeg mob noj "nalbuphine" thiab thaum uas tig mus rau lub kev txom nyem uremia thiab mob hauv daim ntawv ntawm malnutrition, raws li zoo raws li cov neeg laus.

Rau cov neeg mob raum los yog hepatic insufficiency tshuaj zoo zoo thiab nruj me ntsis zuj zus taub txua. Nws yuav tsum tau ceev ceev cessation ntawm "Nalbuphine" rau hauv pawg no ntawm cov neeg mob.

Nrog ceev faj yog kws tshuaj rau cov neeg uas raug mob rau lub taub hau me ntsis, raws li muaj qhov yuav tsim pa nyuaj siab txheej txheem. Ib tug heev ntshaw kom muab cov kev siv ntawm "Nalbuphine" nrog rau lwm cov analgesics, vim tau weakening kev ua kom loog.

Nyob rau hauv qhov kev kho mob saib xyuas thiab nyob rau hauv me me koob tshuaj cov tshuaj no yog siv nyob rau hauv lub keeb kwm yav dhau ntawm narcosis, pw tsaug zog tshuaj, anxiolytics, antidepressants thiab neuroleptics. Qhov no "zej zog" yuav ntxias ntev kev nyuaj siab ntawm lub hauv paus poob siab system thiab ua pa nyuaj siab center ntawm kev ua si.

Ceev faj "Nalbuphine" yog muab rau lub txais tos ntawm ambulatory cov neeg mob, uas yog tswj los ntawm txoj kev, los yog cov neeg uas nws ua hauj lwm muaj feem xyuam rau tus nqi ntawm psychomotor tshua.

nqi ntau

Tus nqi ntau yog dav txaus rau "nalbuphine" tshuaj. Cov lus qhia rau kev siv, tshuaj nqi yog pov thawj hais tias cov tshuaj yog nyob rau hauv coob cov tau txais kev pab. Ntxiv mus, lub analgesic tau tsim muaj nws tus kheej raws li ib tug zoo tshuaj nyob rau hauv kev pab kho mob ua hauj lwm. Khoom pob "nalbuphine 20" (5 vials) nws yog tau mus yuav nyob rau hauv pharmacies Russia rau ib tug npaum li nyob rau hauv ntau ntawm 620 rau 810 rubles. "Nalbuphine 10" yuav raug nqi los ntawm 650 mus 690 rubles (pob ntawm 10 vials).

Nyob rau hauv ib co chaw muab tshuaj yuav pom nyob rau cov muag khoom "Nalbuphine" nyob rau hauv tus xiaslias (10 mg / 1 ml), npaj rau ib tug kev txhaj tshuaj. Tus nqi ntawm daim ntawv no ntawm tso tawm yog nyob ib ncig ntawm 160 rubles.

Sis nrog lwm yam tshuaj

Raws li hais ua ntej lawm, "Nalbuphine" (neeg siv muaj cov lus qhia xws) ua ke nrog antidepressants, anxiolytics, neuroleptics, hypnotics, ua kom loog agents, antihistaminic tshuaj nrog ib tug sedative nyhuv, tej ethanol depressant ntxim rau cov central lub paj hlwb. Thov analgesic thaum uas tig mus nrog penicillin derivatives thiab phenothiazine yuav ua amplification kev xeev siab thiab ntuav.

"Naloxone" (antidote) yuav txo tau cov nyhuv ntawm raug opioids thiab yog li ntawd kom tsis txhob ua pa nyuaj siab thiab Cns kev ua ub txheej txheem txhais "Nalbuphine".

"Naltrexone" ho leeb cov tsos ntawm cov tsos mob ntawm lub tso tseg nyob rau tom qab ntawm cov tshuaj tiv ( "nyob rau hauv tag nrho nws cov hwjchim ci ntsa iab" cov tsos mob tej zaum yuav tshwm sim tom qab xwb 5 feeb tom qab thawj coj ntawm cov tshuaj, yuav ntxiv mus txog rau 48 teev). Symptomatology yog heev ruaj khov, nws yog heev yooj yim mus tshem tawm.

Lub tswv yim ntawm cov kev pab thiab kev kho mob cov tub txawg

Cov neeg mob tham txog "nalbuphine" raws li ib tug ncaj zoo tshuaj nyob rau hauv lub sij hawm tom qab phais tiv thaiv nyob rau hauv Oncology. Txawm tias muaj kev phiv yog tseem heev heev thiab feem ntau yog qhia nyob rau hauv mob taub hau, nkees nkees, apathy, digestive teeb. Raws li kws kho mob, "nalbuphine" (Instruction, nyob tus yeees ntawm cov medicament, lub hauv paus ntsiab lus ntawm tej yam piav saum toj no) yog ib tug zoo analgesic rau ib tug txaus loj kab mob txuam nrog mob heev.

Yog lwm qeb ntawm yeeb tshuaj cov neeg siv - quav. Ntawm no, cov kev sib tham thiab xyuas yog txo rau lo lus nug ntawm seb qhov kev txiav txim yog zoo li "Nalbuphine" thiab "morphine". Los ntawm txhua yam uas, raws li muaj tim khawv los no pab pawg neeg ntawm cov neeg, nws muaj peev xwm yuav xaus lus tias txaus nyiam rau cov neeg quav ua "nalbuphine" nqi (phau ntawv xam nyob rau hauv xws cov neeg mob yog tsis txais). Cov tshuaj yog pheej yig (kuj nyuaj yeeb siv tshuaj), nws muaj peev xwm yuav tau nyob tej chaw muag tshuaj, txawm li cas los, raws li hauv daim ntawv qhia. Txawm li cas los, nyob rau hauv lawv tus kheej cov lus, "ib tug tsis buzz, tab sis rhuav lub feem ntau tiag tiag."

Los ntawm cov saum toj no nws yuav xaus lus tias "nalbuphine," ntawm chav kawm, ib tug zoo heev analgesic. Txawm li cas los, nws yog muag tsuas yog nyob rau tshuaj - thiab rightly li ntawd. Txij li thaum lub ib lub zuj zus xaiv tus kws kho mob ntau npaum thiab hom ntawm daim ntawv thov - ib guarantee tias cov nyhuv uas cov tshuaj rau tus neeg mob lub cev yuav ua siab zoo, thiab txoj kev pheej hmoo ntawm kev phiv - yam tsawg kawg nkaus.