"Ortanol": dab tsi pab, cov lus qhia rau kev siv, tiag tiag

Yuav ua li cas yog cov tshuaj "Ortanol"? Los ntawm tej yam yuav pab kom cov tshuaj? Cov lus teb rau cov lus nug no yuav tsum nyob hauv qab no. Nyob rau hauv tas li ntawd, peb tuaj tus nqi ntawm hais tias cov khoom, nws contraindications, analogs thiab tso daim ntawv no.

Ntim cov tshuaj, nws muaj pes tsawg leeg, hauj lwm, daim ntawv

Kev npaj "Ortanol" yog ua nyob rau hauv daim ntawv ntawm ib qho nyuaj tsiav tshuaj loj № № 1 los yog 2. Qhov no txhais tau tias muaj ib tug dawb xim, raws li zoo raws li inscription «OME 20» los yog «OME 40 '(nyob ntawm seb siv npaum li cas). Cov ntsiab lus lam tsiav tshuaj nruab nrab yog cov daj pellets.

Uas muaj xws li tshuaj "Ortanol"? Xyuas hais tias yooj yim yam khoom uas yog suav hais tias yog tshuaj omeprazole. Tsis tas li ntawd nws muaj koom haum pab Cheebtsam xws li croscarmellose sodium, tsis tshua muaj pawg giproloza, lactose anhydrous, microcrystalline cellulose, hypromellose phthalate, povidone, polysorbate 80, talc thiab dibutyl sebacate.

Muaj pes tsawg leeg ntawm lub tshuaj ntsiav plhaub muaj xws li: propylene glycol, hypromellose, butanol, carrageenan, anhydrous ethanol, shellac, poov tshuaj tshuaj dawb, anhydrous isopropanol, titanium dioxide, number case rau inscribing thiab dej.

Nyob rau hauv kev muag khoom medicament "Ortanol" (capsule) nkag mus rau hauv sawv hlwv, fej mus rau hauv cov duab los qhia thawv.

Pharmacological kev txiav txim ntawm cov tshuaj

Yuav ua li cas yog ib tug "Ortanol" (los ntawm dab tsi pab no tshuaj, koj yuav kawm tau hauv qab no)? Raws li cov lus qhia, cov tshuaj yog ib qho inhibitor ntawm proton twj tso kua mis. Nws thiaj li acid ntau lawm, piv txwv li, slows cia cov kev ua ntawm K + -H + -ATPase nyob rau hauv lub plab, los yog es nyob rau hauv nws parietal hlwb. Tsis tas li ntawd nws blocks lub theem kawg ntawm pais plab acid secretion.

Tshuaj "Ortanol", tus nqi ntawm uas muaj npe teev hauv qab no, yog ib tug prodrug. Qhov cuab yeej no yog tshuab txais nyob rau hauv lub acidic nruab nrab ntawm lub tubules (secretory) parietal hlwb. Nyob rau hauv tas li ntawd, nws thiaj li tsa thiab basal secretion hais txog ntawm qhov xwm ntawm tus stimulus.

Antisecretory thaj chaw ntawm lub medicament tshwm sim nyob rau hauv lub thawj 60 feeb (nyiaj pab ntau tshaj tom qab 2 teev). Inhibition ntawm 50% ntawm cov nyiaj pab ntau tshaj secretion tseem thoob plaws hauv lub hnub.

Ib tug tib koob tshuaj ntawm cov tshuaj muab zoo thiab ceev ceev tsuj ntawm hmo ntuj thiab nruab hnub pais plab tso pa tawm. Nws siab tshaj plaws nws nce mus txog lub 4 hnub ntawm kev kho mob thiab ploj tom qab peb hnub tom qab kev kho mob.

Kev tig tau thaj chaw ntawm cov tshuaj

Thaum tau txais cov "Ortanol" npaj nws achieves siab haum. Ncov ntau ntawm omeprazole nyob rau hauv cov ntshav cai tom qab 0.5-3 lub sij hawm. Lub meej bioavailability ntawm cov tshuaj yog 30-40%, thiab cov medicament kev twb kev txuas nrog ntshav cov nqaijrog - 95%.

Omeprazole metabolism nyob rau hauv lub siab mus rau daim ntawv rau pharmacologically tsaug zog derivatives.

Lub ib nrab-lub neej noj tshuaj lub sij hawm yog 0.5-1 lub sij hawm. Tso zis rau nws raws li derivatives los ntawm raum (70-76%) thiab ua ke nrog rau cov kua tsib (18-24%).

Cov neeg uas muaj mob daim siab kab mob bioavailability ntawm cov tshuaj no yog ho muaj zog, thiab cov ntshav ib nrab-lub neej nce mus txog 3 teev.

Nyob rau hauv cov neeg mob uas mob raum kab mob feem slows cia. Qhov no tshwm sim nyob rau hauv kev faib ua feem rau cov yuav txo tau nyob rau hauv CC.

Medicament "Ortanol": dab tsi pab?

Saib kev npaj yog qhia rau kev siv nyob rau hauv cov nram no cov kab mob:

• reflux esophagitis;
• hnyuv rwj kab mob lub cev (xws li relapse tiv thaiv);
• hypersecretory lub xeev (kev nyuaj siab ulcers ntawm lub hnyuv, Zollinger-Ellison syndrome, mauj mastocytosis, polyendocrine adenomatosis);
• eradication ntawm Helicobacter pylori kis tus kab mob cov neeg mob uas ulcerative kab mob ntawm lub digestive ib ntsuj av tau (nyob rau hauv ua ke nrog txoj kev kho);

• kev kho mob thiab kev tiv thaiv ntawm txoj hnyuv mucosal kev puas tsuaj kabmob uas yog tshwm sim los NSAID (mucosal yaig, dyspepsia, peptic rwj).

Bans siv tshuaj

Yuav ua li cas yog cov contraindications tshuaj muaj "Ortanol" (los ntawm dab tsi ua rau qhov cuab tam, peb tau hais rau saum toj no)? Raws li cov lus qhia, xam tau tias yog cov tshuaj yuav siv tsis tau thaum:

• lactation;
• nyob rau hauv thaum yau;
• npau taws me ntsis mus rau yeeb tshuaj substance.

Nrog tshwj xeeb ceev faj xam tau tias yog tshuaj kws kho rau lub raum thiab lub siab tsis ua hauj lwm.

Tshuaj "Ortanol": daim ntawv qhia

Qhov no tshuaj yog tshuaj xwb hauv. Nws yog coj cia li ua ntej ib tug noj mov (feem ntau yog nyob rau hauv thaum sawv ntxov ua ntej noj tshais).

Cov tshuaj ntsiav uas muaj cov tshuaj yog nqos tau nyob rau hauv tag nrho nrog dej. Nyob rau hauv cov ntaub ntawv uas, yog hais tias tus neeg mob yog tsis tau siv cov tshuaj nkaus, nws txheem yuav ua neej nyob rau hauv ib tug me me npaum li cas yog tsis heev acidic kua.

Cov tshuaj ntawm cov tshuaj nyob rau hauv lub pov thawj.

Thaum ulcers 12 duodenal rwj medicament yog muab nyob rau hauv 20 mg ib zaug ib hnub twg rau ob lub lis piam. Nyob rau hauv cov kev tshwm sim hais tias tom qab thawj xyoo ua kom tiav caws pliav tsis tshwm sim, rov taw ob-lub lim tiam txoj kev kho.

Nyob rau hauv ulcerative kab mob resistant rau kev kho mob, qhov no neeg sawv cev yog pom zoo kom noj ib ntau npaum ntawm 40 mg ib zaug ib hnub twg. Hoob no ntawm txoj kev kho nrog cov tshuaj no tej zaum yuav ncua mus rau plaub lub lis piam.

Tsiav tshuaj "Ortanol" indications uas tau raug teev tseg saum toj no, ulcerative txhab ntawm lub plab noj 20 mg ib hnub ib zaug rau plaub lub lis piam. Yog hais tias cirrhosis tsis tshwm sim tom qab lub dhau lub xyoo, cov re-tsa plaub-lub lim tiam txoj kev kho. Nyob rau hauv pais plab rwj, resistant rau kev kho mob, cov tshuaj yog pom zoo kom noj ib koob tshuaj ntawm 40 mg ib zaug ib hnub twg (tus nqi mus txog rau yim lub lis piam).

Eradication ntawm Helicobacter pylori yog nqa tawm nyob rau hauv ib tug ua ke txoj kev kho. Nyob rau hauv cov ntaub ntawv no, lub medicament yog muab nyob rau hauv 20 mg ib hnub ob zaug ua ntej noj mov (rau ob lub lim tiam) nyob rau hauv ua ke nrog nrog antibacterial nrog.

Thaum reflux esophagitis tshuaj no yog pom zoo siv nyob rau hauv ib tug npaum li ntawm 20 mg (ib zaug) rau plaub lub lis piam. Yog hais tias cov txheej txheem no cov tshuaj tsis yog conducive mus ua kom tiav kev kho, tus neeg mob yog tus kws kho ib tug thib ob cov hoob kawm (plaub lub lis piam). Rau hauv loj heev reflux esophagitis kev kho mob qhov cuab tam yog ncua mus rau yim lub lis piam.

Thaum hypersecretory lub xeev yog ib tug tshuaj rau kub siab muab ib lub zuj zus. Cov pom zoo pib ntau npaum rau cov neeg laus yog 60 mg (ib zaug), thiab lub siab tshaj plaws - 120 mg.

Nyob rau hauv appointing cov tshuaj ntau tshaj li 80 mg ib hnub twg, nws yog muab faib ua ob peb theem.

Thaum hnyuv mucosa hloov khoom nruab nrog kev puas tsuaj, uas yog tshwm sim los ntawm NSAID, raws li zoo raws li rau kev tiv thaiv ntawm cov tshuaj ntsiav "Ortanol" pom zoo kom siv ntawm ib koob tshuaj 20 mg txhua txhua hnub, ua ntej noj tshais (rau tag nrho ntev ntawm NSAID txoj kev kho).

Rau cov neeg laus thiab cov neeg uas muaj mob loj heev ua daim siab mob siab tshaj plaws txhua txhua hnub koob tshuaj yog 20 mg.

Rau cov neeg mob nrog impaired raum muaj nuj nqi ntau npaum hloov yog yuav tsum tau.

phenomena sab

Yuav ua li cas tshua objectionable ua tshuaj "Ortanol"? Xyuas hais hauv qab no phiv:

• mob taub hau, qhov muag plooj tsis pom kev, kiv taub hau, erythema multiforme, paresthesia;
• nkees nkees, xeev siab, saj ntxaug, raws plab, insomnia, flatulence;
• ntxhov siab, qhov ncauj qhuav, kev nyuaj siab, kab mob, reversible puas siab puas ntsws tsis meej pem;
• encephalopathy, gynecomastia, kab mob siab, peripheral edema, ntuav, thiab photosensitivity;
• mob plab, thrombocytopenia, cem quav, pancytopenia, kev nce ntawm alkaline phosphatase kev ua si thiab daim siab transaminase;
• khaus khaus tawv nqaij, impaired siab muaj nuj nqi, leeg tsis muaj zog, tus tsim ntawm pais plab glandular hlwv;
• alopecia, eosinophilia, nce tawm hws, bronchospasm, agranulocytosis, angioedema;
• leukopenia, myalgia, kub taub hau, arthralgia, anaphylactoid tshua, urticaria, interstitial nephritis.

Sab teebmeem uas tshwm sim nyob rau hauv daim ntawv thov ntawm cov qhia cov neeg ua hauj yog me me thiab nraum nyob rau hauv cov xwm.

tus neeg mob ntawm overdose

Thaum noj tshuaj rau kub siab nyob rau hauv ib tug neeg mob li nram qab no cov tsos mob tej zaum yuav tshwm sim: mob taub hau, qhov ncauj qhuav, tachycardia, nkees nkees, xeev siab, qhov muag plooj tsis pom kev, ntuav, tsis meej pem, muaj zog tawm hws.

Nyob rau hauv xws tej yam kev mob, symptomatic txoj kev kho.

tshuaj cov kev sib tshuam

Ua ke nrog cov kev txais neeg kawm omeprazole nce ib nrab-lub neej thiab muaj zog concentration "Diazepam", "warfarin", "phenytoin", raws li zoo raws li lwm yam tshuaj uas yog metabolized nyob rau hauv lub siab nrog isoenzyme CYP2C19.

Haum txhais tau tias tej zaum yuav cuam tshuam, cov bioavailability uas yog txiav txim los ntawm lub acidity ntawm pais plab kua txiv (e.g., "Itraconazole" "ketoconazole" esters ntawm ampicillin "cyanocobalamin" thiab hlau ntsev).

Lub bioavailability ntawm digoxin thaum co-xeem nrog omeprazole yog nce los ntawm 10%.

Saib cov tshuaj pab tau inhibitory ntxim rau cov system lwm yam hematopoietic tshuaj.

Tsis clinically tseem ceeb tshuaj cov kev sib tshuam nrog antacid tshuaj, caffeine, "theophylline", "Quinidine", "propranolol", ethanol, lidocaine thiab "metoprolol" yog tsis muab.

tej tswv yim pom zoo

malignancy yuav tsum raug tshem tawm ua ntej pib kho mob nrog omeprazole. Qhov no yog vim lub fact tias cov tshuaj no kev kho tej zaum daim npog qhov ncauj cov tsos mob thiab ncua lub tseeb mob daim ntawv qhia.

Tam sim no, yog tsis muaj cov ntaub ntawv nyob rau hauv tej yam ntawm cov nyiaj rau ib tug neeg muaj peev xwm tswj mechanisms thiab tsav tsheb.

Nqi thiab analogues

Yuav ua li cas npaum li cas yog no anti-rwj tshuaj, raws li "Ortanol"? Tus nqi ntawm cov tshuaj no yog hais txog 100-115 rubles. Rau feem ntau cov kev pab, tus nqi ntawm no yog siv tau.

Yuav ua li cas yuav hloov tau cov tshuaj "Ortanol"? Analogs ntawm kev npaj no yog hais nyob rau hauv daim ntawv ntawm "omez", "Loseprazol", "Gaseka", "Omelika", "omeprazole".

Xyuas

Xyuas ntawm tsiav tshuaj "Ortanol" yog zoo rau ib tug ntau dua twg. Cov neeg mob hais tias cov tshuaj yog zoo antiulcer neeg sawv cev. Nws sai sai eliminates kub siab thiab ib tug kev xav ntawm heaviness thiab hlawv nyob rau hauv lub plab.

Kws txawj hais tias cov tshuaj nyob rau hauv lo lus nug muaj ib tug zoo ntxim rau cov chav kawm ntawm cov kab mob ntawm lub digestive ib ntsuj av tau tsuas yog nws txais tos tau raug taw los ntawm ib tug gastroenterologist. Cov kws kho mob qhia hais tias lawv tus kheej yuav tau noj cov tshuaj no yog txwv tsis pub, raws li nws muaj ib tug heev muaj zog cov nyhuv.

Muaj kuj yog ib tug zoo sab ntawm cov tshuaj no muaj xws li nws muaj thiab tsis muaj nqi.