Proton twj tso kua mis inhibitors: mechanism ntawm qhov kev txiav txim thiab daim ntawv thov nyob rau hauv cov tshuaj

Los ntawm proton twj tso kua mis inhibitors yog cov pab pawg neeg ntawm pharmacological neeg uas txo tus nqi ntawm secretion ntawm hydrochloric acid nyob rau hauv lub plab. Muaj ib tug tib neeg ntxim rau cov secretory canaliculi, lawv zoo ua rau cov yam kho nyhuv ulcers, erosive gastritis, GERD. Cov pab pawg neeg no muaj xws li ib tug plurality ntawm cov tshuaj uas zoo xws li tshuaj qauv, tab sis muaj ntau pharmacodynamic tsis, i.e. suab tib yam tshuaj ua rau lub secretory hlwb, tab sis ua li ntawd nyob rau hauv sib txawv ntau thiab nrog sib txawv speeds.

Proton twj tso kua mis inhibitors: molecular yam cawv npaj

Proton twj tso kua mis yog ib tug complex cov protein kav allergic ntawm hydrogen ions nyob rau hauv lub pais plab lumen. Nws muaj ob sib txawv hais, txwv tsis pub hu ua subunits. Tus thawj yog heev dua lwm yam uas muaj protein ntau thiab ua tau los ntawm cov amino acids. Nyob rau hauv daim nyias nyias cell stuffer nws behaves nyob rau hauv ib tug tshwj xeeb txoj kev, hla nws 10 lub sij hawm, uas ua rau yus mus rau tsim ntawm 5-secretory channel loops. Dhau los ntawm cov kab noj hniav ntawm ions poob nyob rau hauv lub pais plab lumen thiab muab cov acidification ntawm qhov nruab nrab thiab ntog hydrogen index. Nyob rau hauv cov ntaub ntawv no nws yog ib tug ntawm cov loops yog lub active chaw ntawm cov protein - ib theem ntawm 800 amino acids, uas catalyzes lub neej puas ATP, lub ntsiab zog cell substrate.

Lwm yam subunit yog ib tug protein complex uas yog tsim ntawm lub polypeptide ib theem zuj zus, feem ib yam kom cov qauv thiab glycoprotein chains. Cov kev nyuaj siab loj ib feem ntawm lub molecule yog nyob sab nraum lub cytoplasm, thiab ib feem ntawm glycoprotein yog tej zaum ekstratsitoplazmaticheskim receptor complex uas picks lub teeb liab ntawm qhov ua kom ntawm lub enzyme H + \ K + -ATPase. Nyob rau hauv rooj plaub no tus protein feem ntawm lub molecule crosses daim nyias nyias ib zaug, tawm tswv yim nws tus nqi raws li ib tug txuas caij nruab nrab ntawm cov txheej thiab cov thawj receptor subunit lub luag hauj lwm rau kev ib tug catalytic cov tshuaj tiv thaiv ntawm synthesis ntawm protons.

Raws li, cov qauv ntawm cov proton twj tso kua mis secretory tubules parietal hlwb yuav xaus li cas yooj yim yam yuav suppress lub tso pa tawm ntawm H + mus rau hauv lub cev muaj kab noj hniav. Qhov tseem justified embodiment - yog inhibition ntawm cov enzyme lub luag hauj lwm rau lub synthesis uas ua rau proton twj tso kua mis inhibitors.

Siv inhibitors nyob rau hauv kev soj ntsuam xyaum

Nyob rau hauv cov tshuaj, proton twj tso kua mis inhibitors yog dav siv, tshwj xeeb tshaj yog nyob rau hauv Gastroenterology, uas muaj feem xyuam rau lawv muaj peev xwm txo cov acidity ntawm pais plab tso pa tawm, thiab yog li txo cov kev siv ntawm cov ua ntxim rau lub plab phab ntsa, uas yog tshwj xeeb tshaj yog ib qho tseem ceeb thaum nws yog kub lug. Nyob rau hauv rooj plaub no tus kho nyhuv yog ywj siab ntawm lub etiology ntawm lub inflammatory txheej txheem, raws li nws yog muab tshem tawm los ntawm lub txhoj puab heev tus ntawm ib puag ncig rau lub sam xeeb ntawm lub cev. Tsis tas li ntawd lub spectrum ntawm pathologies uas kho mob rau txoj kev siv ntawm proton twj tso kua mis inhibitors tau txhab los pais plab rwj thiab duodenal rwj, erosive thiab uas tsis yog-erosive GERD cov ntaub ntawv.

Ntawm cov feem ntau cov tshuaj muaj xws li proton twj tso kua mis inhibitors cov nram qab no generic npe omeprazole, rabeprazole, pantoprazole, lansoprazole, esomeprazole, thiab lwm tus neeg. Ntawm lawv yog cov pauv npe sawv tawm, xws li "Omez". Tshuaj no nws muaj nyob rau hauv cov tshuaj ntsiav daim ntawv. Lawv yog npaum li cas hais nyob rau hauv lub kws tshuaj ntawm ib tug kws, uas txawv nyob ntawm seb cov hom ntawm tus kab mob. Thaum uas nws tus kheej-cov thawj coj, raws li muaj ib pab pawg neeg ntawm cov neeg mob uas tsis txaus siab ntawm raws caij nyoog exacerbation ntawm tus kab mob pais plab los yog duodenal ulcers. Nyob rau hauv lwm yam mob, tus txais tos yog khom nrog tus kws kho mob thaum lub sij hawm ntawm kev txais neeg kawm.