"Rosuvastatin": cov lus qhia rau kev siv, xyuas. Pheej Yig analogue "rosuvastatin"

Cov tshuaj "Rosuvastatin" tau paub txij li thaum 2003 thiab yog muaj raws li ib tug statin Tiam IV. Nws yog ib tug niaj hnub thiab high-zoo inhibitor ntawm gamma-methylglutaryl-CoA reductase. Qhov no enzyme yog lub luag hauj lwm rau lub synthesis ntawm cov roj uas txhaws nyob rau hauv tib neeg lub cev. Nws inhibition ua rau ib tug txo ntawm endogenous cholesterol thiab txo qhov uas yuav muaj kab mob plawv.

Nyob rau hauv tas li ntawd mus rau "rosuvastatin" muaj ntau ntau chav kawm ntawv counterparts, cov mej zeej ntawm lub statin pab pawg neeg. Qhov no "Simvastatin" "Pravastatin", "cerivastatin," "Lovastatin," "Fluvastatin," "Atorvastatin", "pitavastatin." Soj ntsuam miv nyuas siv zug thiab ceev kom txhob muaj tag nrho cov roj uas txhaws taus thiab tsawg-density "Rosuvastatin" zaum ob tsuas yog mus rau "pitavastatin," uas yog tseem tsis tau siv lug vim muaj tsawg sau database ntawm kev soj ntsuam tej kev txom nyem.

Rau hnub tim, "atorvastatin" yog siv ntau tshaj li lwm yam statins vim tias yog lub feem ntau kev tshawb fawb puag pov thawj ntawm nws cov kev soj ntsuam hauj lwm zoo. Tsis tas li ntawd, nws thiab nws Generics yog npaum li cas pheej yig dua, "rosuvastatin". Tab sis raws li lub xeem nyhuv (normalization ntawm lub lipid profile ntawm cov ntshav ntshav) yog sai, thiab ces nws pib mus thov ntau lug. Qhov no yog ib tug tiag tiag zoo cov khoom, rau cov uas nws yuav tsum tau them tus nqi.

Muab "rosuvastatin" nyob rau hauv pharmacotherapy

Nyob rau hauv kev npaj "Rosuvastatin" daim ntawv thov, txawm lub hav zoov ntawm chav kawm ntawv counterparts, haum sab. Nws yog txhais indications thiab contraindications txwv. Lub indications yog tam sim no nyob rau hauv yuav luag tag nrho cov hom ntawm hypercholesterolemia thiab mob ntawm lipid metabolism. Tus thawj atherogenic lipid fractions muaj zoo los ntawm tus kab mob. Vim li no, qhov yuav ua rau txoj kev loj hlob ntawm atherosclerotic txhab yog txo, thiab lub neej expectancy (thiab zoo) kom dog dig.

Kev npaj "Rosuvastatin" tej zaum yuav siv rau kev tiv thaiv ntawm cov kab mob plawv, thiab kho lawv. Xeem niche pharmacotherapy tshwm sim vim cov kev tsim txom ntawm cov txheej txheem ntawm atherosclerosis thiab endothelial stabilization ntawm cov quav hniav. Txij li thaum cerebral infarction thiab lub plawv tsim los ntawm ib tug mob thrombosis ua cov hlab ntsha, ces tus soj ntsuam cov nyhuv yeej pab tiv thaiv kom txhob mob coronary txheej xwm.

Cov lus qhia rau kev siv

Txuas mus rau lub tshuaj "Rosuvastatin" phau ntawv qhia (analogues xws ntaub ntawv muaj) muaj ib tug nqaim ntau yam ntawm indications rau siv. Txawm li cas los, nws tsis muaj ib yam tus neeg mob cov ntaub ntawv uas yog yuav tsum tau ua ntej yuav siv los mus txiav txim lub feem ntawm cov roj uas txhaws. Nyob rau hauv lub neej yav tom ntej, lawv hloov yuav soj ntsuam qhov kev soj ntsuam miv nyuas siv zug ntawm kev kho mob nyob rau hauv ib tug tej yam ntau npaum. Tsis tas li ntawd daim ntawv muaj cov lus qhia txog kev ruaj ntseg ceev faj thiab nta ntawm kev kho mob, contraindications, thiab lub feem ntau heev thiab tseem ceeb tshwm sim.

indications

Ntawm tag nrho cov kab mob txuam nrog nce ntshav lipid fractions, tseem ceeb ib co kev soj ntsuam indications:

• heterozygous raws roj ntsha (familial) hypercholesterolemia;
• txwv kom muab zais los ntawm Fredrickson polygenic hypercholesterolemia hom IIa;
• ua ke dyslipidemia, txwv kom muab zais los ntawm Fredrickson yuav ua li cas IIb;
• Homozygous familial (familial) hypercholesterolemia;
• coronary, cerebral los yog lub raum arteriosclerosis, occluding lub lumen ntawm leeg;
• Atherosclerosis ntawm cov hlab ntsha ntawm lub qis extremities, xws li Leriche syndrome ;
• hypertriglyceridemia (IV hom raws li Fredrickson);
• kev kho mob ntawm myocardial infarction thiab lub hlwb, txij thaum lub mob lub sij hawm;
• kev tiv thaiv ntawm myocardial infarction thiab mob stroke.

Contraindications

Tej cheaper analog "rosuvastatin" muaj cov tib tshwm sim raws li cov thawj "Crestor". Nyob rau lub hauv paus ntawm lawv spectrum contraindications tsim, uas yog raws li nram no:

• hepatic cytolysis syndrome kab mob nrog hepatocytes thiab ntau tshaj peb-fold nce nyob rau hauv transaminase ntau;
• siab tsis ua hauj lwm, mob npuas paug nrog cov qhab nia ntawm 9 Child-Pugh;
• mob raum tsis ua hauj lwm qhia kev khiav dej num nrog creatinine clearance tsawg tshaj li 30 ml \ min.;
• Myopathy ntawm tej keeb kwm;
• kev tsis haum tshuaj mus rau lub formulation Cheebtsam lossis "Rosuvastatin".

Muaj yog ib pab pawg neeg lwm contraindications rau 40 mg ntau npaum:

• mob raum tsis ua hauj lwm nrog ib tug qhia creatinine clearance tsis tsawg tshaj li 60 ml \ min.;
• tej roj ntsha myopathies;
• concomitant siv rau cov fibrates;
• alcoholism;
• Mongoloid haiv neeg;
• siv ntawm ib tug statin rau thawj lub sij hawm.

Nta ntawm cov tshuaj

Tag nrho cov "rosuvastatin" - tshuaj, analogues ntawm uas yog lug muaj nyob rau ntawm lub lag luam. Thiab los ntawm kev xaiv ib qho kev hom lub npe, tus neeg mob yuav tsum noj cov tshuaj thiab nyob rau. Hais tias yog, hloov mus rau lwm cov tshuaj tsis tsimnyog. Sam tshuaj no yog coj tsis hais txog noj mov txhua lub sij hawm ntawm lub hnub. Muaj ob peb lwm yam tswv yim pom zoo ntawm cov kws txawj uas muaj yav tas los ua hauj lwm nrog tus thawj tiam statins. Lawv muaj cov ntaub ntawv uas statins yuav tsum tau coj thaum mus pw. Txawm hais tias nws tsis yog yuav tsum muaj qhov tseem ceeb, raws li ntev raws li lub tshuaj noj tib lub sij hawm thiab tsis tu ncua.

Tswj lawv tus kheej lub xeev yuav tsum tau tas li kom txog thaum txais "Rosuvastatin" (analogues). Xyuas pub cov kws txawj mus ua hauj lwm tawm qhov zoo tshaj plaws tactics ntawm soj. Nyob rau hauv kev, tom qab lub tsev lag luam ntawm lub xub ntiag ntawm hypercholesterolemia tau pib noj cov tshuaj nrog ib tug taag koob tshuaj. Tom qab 2 lub hlis ntawm kev soj ntsuam - lipidogram pheej ua thiab soj ntsuam cov kev ua ntawm aminotransferases.

Yog hais tias muaj yog ib tug normalization ntawm lub lipid profile ntawm cov ntshav ntshav, nws yuav tsum tau mus ntxiv tau txais nyob rau hauv tib lub koob tshuaj. Yog hais tias tag nrho cov roj uas txhaws taus tshua siab, thiab tus nqi ntawm cov uas tsis muaj kev ceev cholesterol significantly txo, nce lub koob tshuaj yuav tsum tau. Yog hais tias transaminase nce peb lub sij hawm, yuav tsum tau tshem tawm ntawm statins. Nws yuav tsum tau tshwj xeeb yog muab sau tseg tias tsawg tshaj plaws nyiam ua cytolysis ntawm tag nrho cov statins yog "Rosuvastatin." Analogs (Ukraine kuj maj mam hloov los ntawm "atorvastatin" mus rau "rosuvastatin") hauv chav kawm ntawv muaj tsawg ruaj ntseg. A "pitavastatin" tseem tsawg kawg yog kawm.

Analogs "rosuvastatin"

Raws li ib tug analogy, "rosuvastatin" ( "Crestor") twb muaj ntau tshaj li 10 khoom. Ntawm lawv, "AKORT", "Merten", "Rozart", "Rozistark" "Rosuvastatin Canon", "Rosuvastatin SOTEX" "Rosuvastatin NW", "Rozulip", "Rozukard", "Roxer", "Rustor" " Tevastor ". Tus nqi ntawm cov kev kho lawv yog sib txawv, raws li zoo raws li efficiency. Rau nqi ntawm cov tshuaj yuav tsum tau muab faib mus rau hauv peb pawg:

• tus nqi qis (los ntawm 250 mus rau 650 rubles), "Rosuvastatin NW", "Rosuvastatin Canon", "AKORT" "Rosuvastatin SOTEX";
• Nruab nrab nqi (ntawm 400 rau 900 rubles), "Merten", "Rozart", "Roxer", "Rozukard", "Tevastor", "Rozulip";
• siab nqi (los ntawm 1100 mus 2200 rubles): "Crestor".

nqi tsom xam yog tau los ntawm muab piv rau tus nqi ntawm cov tshuaj, qhov hnyav ntawm active compound uas yog 10 mg. Cov nqi ntau qhia tus nqi ntawm ib lub hlis ntawm cov roj uas txhaws-txos txoj kev kho. Cov uas pheej yig tshaj analog "rosuvastatin" manufactured los ntawm "Northern Star". "Rosuvastatin Canon" thiab "AKORT" kuj txawv me ntsis nyob rau hauv nqe. Lawv nqi kuj yuav tsis hloov nyob rau pauv tus nqi hloov mus hloov los.

Ib tug txheej txheem cej luam ntawm qhov pheej yig heev generic "CRESTOR"

Cov tshuaj "Rosuvastatin" tso tawm los ntawm AstraZeneca, yog hu ua "Crestor". Qhov no yog cov thawj cov tshuaj, uas yuav tsum tau muab piv tag nrho cov lwm leej lwm tus. Tib yam siv rau cov lus: tus yam ntxwv ntawm ib tug generic khoom yuav tsum tau raws li nyob rau hauv nws cov kev sib piv nrog "Krestorom". Tab sis vim hais tias ntawm nws cov siab kuj nqi, ntau cov neeg mob tam sim ntawd pib kev kho mob ntawm hypercholesterolemia nrog cheaper Generics.

Lub hom phiaj cov ntaub ntawv xwb tshwj xeeb muaj peev xwm muab nyob rau hauv ib tug saib xyuas, uas yog feem ntau ntsib nrog rau kev siv Generics thiab "rosuvastatin" thiab cov thawj "CRESTOR". Ib tug thov mus rau yeeb tshuaj "Rosuvastatin cov lus qhia rau kev siv, ua siab ntev testimonials thiab kev soj ntsuam yuav cia lwm tus neeg mob tau xaiv ib tug kev lag luam lub npe.

Xyuas ntawm cov kws tshwj xeeb "Crestor" thiab Generics

Piv "CRESTOR" nqa tawm tsuas yog tshwj xeeb ntawm lub Lavxias teb sab Society of Cardiology. Cov ntaub ntawv no yog feem ntau luam tawm nyob rau hauv cov phau ntawv journal "Meej pem pharmacotherapy nyob rau hauv Cardiology." Nyob rau hauv kev, nws chaw nyob tej teeb meem ntawm bioequivalence ntawm generic tshuaj "Crestor". Raws li kev soj ntsuam ntawm pharmacoeconomic kev tshawb fawb pom tau hais tias cov tshuaj "Merten", "Rozart", "Roxer", "Rozukard" thiab "Rozulip" bioequivalent "Crestor".

Qhov no txhais tau tias tej "rosuvastatin" Qhov no analogy muaj ib tug kho nyhuv zoo xws li cov thawj cov tshuaj muaj tib lub xov tooj thiab heev ntawm sab los. Thaum cov tshuaj "Rosuvastatin NW", "Rosuvastatin Canon", "Rosuvastatin SOTEX" thiab "AKORT" nyob rau hauv xws ntsuam xyuas yog tsis siv. Vim hais tias cov statistical cov kev tshawb fawb tsis tau nyiaj pab los ntawm kws tuam txhab uas muag, cov ua ntaub ntawv yog lub hom phiaj thiab muaj raws li qhov kev soj ntsuam nta ntawm cov kev kho mob ntawm hypercholesterolemia. Txawm li cas los, cov kev tshwm sim rau cov txawv teb chaws Generics.

Xyuas ntawm cov tub txawg pheej yig Generics "rosuvastatin"

Niaj hnub nimno analogue ntawm ib tug pheej yig "rosuvastatin" yuav tsum ua pov thawj lawv bioequivalence "Crestor" thiab ces nws cia li tau txais tus hwm ntawm cov tub txawg. Tsis muaj bioequivalence kev tshawb fawb cov kws txawj yuav hais tsuas yog tus soj ntsuam nta hauv daim ntawv thov. Ib tug ntawm lawv yog li no: yog tias siv li qhia siv kuj cheaper counterparts "rosuvastatin" (tshuaj teev saum toj no), lub zaus ntawm cov nyom txheej xwm piv rau uas tau cai thaum uas siv cov generic bioequivalent "Crestor".

Hloov mus hloov los nyob rau hauv cov ntshav concentration "rosuvastatin" sawv los ntawm kev siv ntawm ib tug khoom noj daim ntawv nrog ib tug txawv pes tsawg leeg, pom tau hais tias tsis tseem ceeb txaus nyob rau hauv cov ntaub ntawv no. Vim hais tias pheej yig Lavxias teb sab analogue ntawm "rosuvastatin" yeej hloov tus thawj tshuaj "Crestor" thiab nws cov generic tshuaj rau kev kho mob ntawm hypercholesterolemia.

Cov yam ntxwv ntawm cov neeg mob xyuas

Raws li cov lus teb ntawm cov neeg mob uas qhia lawv impressions hais txog kev siv cov tshuaj nrog koj tus kws kho mob, muaj ntau ntau zajlus kom xaus. Firstly, cov neeg mob kev txiav txim hais txog qhov zoo ntawm cov tshuaj biased. Secondly, vim hais tias ntawm lub imperceptible rau tus neeg mob soj ntsuam cov nyhuv ntawm kev ua raws li txoj kev kho yog tsis tshua muaj, txawm hais tias cov kev kho mob yog tsim nyog los tiv thaiv kom txhob qhov uas yuav ntawm mob coronary txheej xwm. Peb, cov neeg mob yuav exaggerate qhov tseem ceeb ntawm sab los thiab underestimate zog ntawm ntshav lipid profile.