Calcium antagonists - broad-spectrum tshuaj

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Nyob rau hauv lub neej ntawm tus kab mob tswj calcium ions ua si ib tug theej ib qho tseem ceeb luag hauj lwm. Lub fact tias nws yog calcium, ces mus rau lub hlwb uas ua kom tag nrho cov zhiznenovazhnye intracellular dab nyob rau hauv ib tug kab tsiaj txhuv, e.g., lub hloov dua siab tshiab ntawm ATP rau hauv yeej thoj nam los yog protein ntsev dab.

Cai ntawm calcium ions nyob rau hauv lub cev

Calcium penetrates hlwb los ntawm tshwj xeeb raws, uas yog loj protein molecules uas ris los ntawm cov multilayer membrane ntawm lub hlwb. Cov "raws", inter alia, muaj kev receptors, uas yog nqa tawm cov cim ntawm calcium ions, tsis muaj es nrog lwm tus.

Lub ndlwg ntawm calcium ions nyob rau hauv ib tug kab tsiaj txhuv yog tswj los ntawm kev endogenous yam tseem ceeb uas tej zaum yuav muaj raws li neurogenic keeb kwm thiab yuav endocrine kev sib kho xws li acetylcholine los yog serotonin.

Tshuaj uas thaiv lub nkag mus ntawm calcium ions mus rau lub hlwb

Kev tshawb fawb ntawm cov tshuaj uas yuav inhibit calcium raws ntawm lub tso cai pib nyob rau hauv lub 60s thiab tseem yuav mus nyob rau. Thaum pib ntawm cov kev tshawb fawb tau qhib tshuaj fenilakilamina derivatives, uas thaum lub sij hawm muaj tau npaj rau kev siv raws li koronorasshiryayuschih npaj. Niaj hnub no qhib ib tug loj heev tooj ntawm xws tshuaj, uas yog tag nrho rau hauv ib pab pawg neeg, uas tau txais lub npe - calcium antagonists.

Siv calcium antagonists

Calcium antagonists yog tam sim no dav siv nyob rau hauv ntau yam teb ntawm cov tshuaj, qhov no yog vim lub fact tias lawv muaj ib tug heev ntau yam ntawm kev txiav txim. Yog li, piv txwv li, calcium antagonists yuav cuam tshuam myocardial contractility, atrioventricular conduction thiab qhov ntswg ntawm kev ua si.

Ib tug zoo xws li cov nyhuv yog aldosterone antagonists uas thaiv qhov kev txiav txim vim nws conductivity aldosterone receptor, li no ua rau tus nqi ntawm calcium nyob rau hauv lub hlwb.

Nyob rau hauv ib co ntaub ntawv ntawm pathological tej yam kev mob, xws li hypoxia los yog ischemia, ntau calcium ions yuav txhim khu intracellular dab, yog li ua cov ntaub so ntswg oxygen thov, uas yuav ua tau rau ntau yam pathological los. Nyob rau hauv cov ntaub ntawv no, cov calcium uas antagonists muaj ib tug kho nyhuv, limiting qhov kev txiav txim ntawm calcium ions rau hauv lub cell muaj dab.

Calcium antagonists rau cov kev kho mob ntawm cov kab mob txuam nrog CAS

Nws thawj siv cov calcium channel blockers pom niaj hnub no nyob rau hauv cov kev kho mob ntawm cov hlab plawv tus kab mob. Tshuaj yuav cuam tshuam rau conductivity thiab excitability ntawm lub plawv, muaj antianginal los, txhim kho coronary ntshav txaus thiab txo cov ntshav siab.

Cov tshuaj uas cuam tshuam rau mob conduction thiab excitability hnub no siv raws li antiarrhythmic tshuaj, uas tau nyob rau hauv xaiv ntawm ib tug nyias muaj nyias ib pharmacological pab pawg neeg (angianginalnye txhais tau tias).

Antagonists ho muaj kev cuam tshuam platelet aggregation, txo lawv cov coalescence thiab yooj yim lub disaggregation ntawm platelets. Cov tshuaj yog siv los txo koj cov ntshav viscosity thiab ua rau kom lub elasticity ntawm platelets. Yuav kom nce lub peev xwm ntawm cov ntshav anticoagulant yuav thov thiab vitamin K antagonists uas cuam tshuam qhov ua kom ntawm prothrombin, thaiv cov hlab qhov tsim ntawm fibrin txhaws.

Lub spectrum ntawm kev txiav txim ntawm cov tshuaj

Lub spectrum ntawm kev txiav txim ntawm calcium antagonists yog tiag tiag muaj ntau haiv neeg, vim hais tias lawv yog tam sim no siv tsis tau tsuas yog rau kev kho lub ntsiab hom kab mob, tab sis kuj rau cov kev kho mob ntawm migraine, mob hawb pob, mob ntawm cerebral ncig. Calcium antagonists ua si ib qho tseem ceeb luag hauj lwm nyob rau hauv cov kev kho mob ntawm hlwb kev ntshawv siab, siv nyob rau hauv cov kev kho mob ntawm qaug dabpeg thiab dyskinesia nyob rau hauv cov neeg mob uas schizophrenia.