"Moxifloxacin": cov lus qhia rau kev siv, hauj lwm, muaj pes tsawg leeg

Lub medicament "Moxifloxacin" pharmacological nyhuv ntawm uas yuav tsum tau los sib tham hereinafter, yog hais txog cov pab pawg neeg ntawm quinolones. Lub cuab tam muaj ib tug bactericidal, antibacterial nyhuv. Tom ntej no, peb tham txog dab tsi tshwm sim tawm ib cov tshuaj "Moxifloxacin". Cov lus qhia rau kev siv, analogues yuav kuj yuav tau nyob rau hauv tsab xov xwm.

nyhuv

Yuav ua li cas yog active neeg sawv cev "Moxifloxacin"? Hauj lwm ntawm cov tshuaj yuav tsum tau pib nrog ib tug piav qhia ntawm lub mechanism ntawm nws cov nyhuv rau cov kab mob. Bactericidal nyhuv txhais tau hais tias txuam nrog inhibition (hluav) ntawm cov kab mob topoisomerase IV thiab II. Qhov no, nyob rau hauv lem, ua rau teeb nyob rau hauv lub replication kev ntawm transcription, DNA kho biosynthesis microbial hlwb. Raws li ib tug tshwm sim, muaj los lawv puas tsuaj. Medicament "Moxifloxacin" phau ntawv qhia no qhia txog li ib tug broad spectrum tshuaj tua kab mob.

kuj

Nyob rau antibacterial kev ua ntawm cov tshuaj "Moxifloxacin" tsis muaj feem xyuam rau cov mechanisms uas ntxias cov kuj mus tetracyclines, macrolides, aminoglycosides, cephalosporins thiab penicillins. Nws tsis cim zoo thiab cov nyhuv ntawm tus ntoo khaub lig-kuj. Kom txog rau thaum tam sim no, tus neeg mob ntawm ntshav stability tau tsis tau. Tshuaj kuj "Moxifloxacin" tsim heev maj mam los ntawm ntau yam change.

ntau yam ntawm kev ua si

Txhais tau hais tias "Moxifloxacin (phau ntawv qhia - ntawv pov thawj) muaj feem xyuam rau ntau hom ntawm Gram-zoo thiab Gram-tsis zoo kab mob, acid-ceev cov kab mob, anaerobes, atypical kab mob (mycoplasma, chlamydia, thiab lwm yam), thiab kuj kab mob uas yog resistant rau macrolide thiab beta-lactam tshuaj tua kab mob tshuaj .

suction

Thaum tau txais lub qhov ncauj haum ntawm cov tshuaj "Moxifloxacin" sai thiab ze li ntawm tag nrho. Tsis bioavailability thaum muab intravenously thiab thov inwards - ntawm qhov kev txiav txim ntawm 91%. Thaum muab lus (50-1200 mg tshuaj, 600 mg / hnub rau 10 hnub) linear tshuaj ntawm cov tshuaj. Qhov siab tshaj plaws concentration nrog 400 mg cai tom qab 0.5-4 lub sij hawm. Thaum ua ntawv thov ib txhij nrog cov zaub mov ua tau ib qho kev nce nyob rau hauv lub caij lub sij hawm Cmax (ob teev) thiab nws cov txo los ntawm hais txog 16%. Duration haum li tseem unchanged. Cuaj kaum, cov ntaub ntawv no tsis muaj tus soj ntsuam nqi uas tso cai rau kev siv ntawm cov tshuaj "Moxifloxacin", hais txog ntawm cov zaub mov. Tom qab ib tug tib tso dej Txoj kev lis ntshav ntawm 400 mg rau ib teev nyiaj pab ntau tshaj concentration tshwm sim nyob rau thaum xaus ntawm Txoj kev lis ntshav.

faib

Tsis pub dhau peb hnub ntawm daim ntawv thov no mus txog equilibrium. Ruaj rau ntshav cov nqaijrog - txog 45%. Nws sau ntawv ncaj sai muab faib rau cov tshuaj "Moxifloxacin" nruab nrog cev thiab cov nqaij. Ntau tshaj plaws yog nyob rau hauv lub ntsws cov ntaub so ntswg thiab bronchi txheej, daim tawv nqaij thiab subcutaneous lug, sinuses, inflammatory foci. Cov qaub ncaug thiab interstitial kua medicament yog pom nyob rau hauv unbound cov nqaijrog, free daim ntawv. Nws concentration yog siab tshaj nyob rau hauv ntshav. Ua ke nrog cov tshuaj no yog muaj nyob rau hauv loj nyiaj nyob rau hauv nruab nrog cev peritoneum ntaub so ntswg poj niam qhov chaw mos nruab nrog cev thiab nyob rau hauv lub peritoneal kua.

metabolism

Tshuaj "Moxifloxacin" (piav qhia ntawm cov tshuaj nyob rau hauv lub annotation cov ntaub ntawv muaj cov lus qhia) kis tus thib ob biotransformation theem. Raum feem siv system thiab hnyuv unaltered nyob rau hauv daim ntawv ntawm cov sulpho tebchaw thiab tsaug zog glucuronide. Lub metabolites yog pom nyob rau hauv ntshav. Lawv concentration qis tshaj hais tias ntawm lub thawj compound. Kev tshawb fawb tau qhia tias cov degradation cov khoom tsis muaj ib tug yam ntxwv tsis zoo rau lub cev.

Txhais tau hais tias "Moxifloxacin", los ntawm uas nws yog tshuaj?

Cov tshuaj no yog pom zoo rau cov kab mob inflammatory pathologies rau cov neeg laus provoked los ntawm kab mob muaj rhiab heev thereto. Nyob rau hauv kev, lub readings txog ib tug exacerbation ntawm tus kab mob hlab ntsws txaus, mob sinusitis, lub zej lub zos-kis tau mob ntsws (tshwm sim los ntawm kab mob los ntawm cov kab mob seeb ntau kuj nyob rau hauv t. H. Cov tshuaj tua kab mob). Txhais tau hais tias "Moxifloxacin" cov lus qhia rau kev siv pom zoo rau mob ntawm cov nqaij mos thiab tawv nqaij, subcutaneous lug nyuab txhab (kis tau kab mob ntshav qab zib ko taw zoo li), thiab intra-plab kab mob (polymorphic dab, intraperitoneal paug thiab thiaj li tawm). Yog muab thaum lub medicament los ntawm tus kab mob Streptococcus pneumoniae resistant mus rau ntau yam antibacterials, xws li muaj cov resistant lim rau penicillin, ob lossis ntau pab pawg ntawm cov tshuaj ntawm lub thib ob tiam cephalosporins, macrolides, tetracyclines. Los ntawm indications kuj muaj xws li inflammatory txhab nyob rau hauv lub pelvic kabmob uncomplicated xwm. Thaum endometritis thiab salpingitis kuj xav kom xav txog cov txhais tau tias (raws li qhia los ntawm lub txuas mus rau yeeb tshuaj "Moxifloxacin" cov lus qhia rau kev siv). Qhov muag dauv kws kho rau tus kab mob conjunctivitis, provoked los ntawm kab mob rhiab rau lub medicament. Nws tseem yog tsim nyog los noj mus rau hauv tus account uas twb muaj lawm kev kho mob ntawm cov kab pathologies coj noj coj ua.

Medicament "Moxifloxacin": ntau npaum thiab qhov lawv ntawm koom haum saib xyuas

Nyiaj xws inwards (lus) thiab intravenously. . Duration ntawm kev kho mob lub medicament "Moxifloxacin", ntau npaum ntawm uas - 400 mg / hnub, nyob ntawm seb lub hom ntawm tus kab mob thiab nws heev, raws li zoo raws li lub cai kho nyhuv:

• Exacerbation ntawm tus kab mob hlab ntsws chav kawm - 5-10 hnub.
• Community-kis tau mob ntsws - 7-14 hnub tshwm sim los muaj txoj kev kho (tso dej raws li los ntawm qhov ncauj kom tsawg).
• Mos ntaub so ntswg, daim tawv nqaij (uncomplicated), thiab mob sinusitis - 7 hnub.
• Thaum intra-plab kab mob (nyuab) - 5-14 hnub tshwm sim los muaj txoj kev kho.
• Thaum nyuab txhab thiab subcutaneous lug ntawm daim tawv nqaij - 7-21 hnub.
• Nyob rau hauv inflammatory pathologies ntawm lub pelvic kabmob - 14 hnub.

Yog xav paub ntxiv, muaj txuas mus rau cov tshuaj "Moxifloxacin" phau ntawv qhia. Ntsiav tshuaj yuav tsum tsis txhob tso cai rau nws xo. Ntxuav cia nrog dej yog tsim nyog nyob rau hauv ib tug me me volume.

zos siv

Tshuaj "Moxifloxacin" (dauv) tej zaum yuav muab rau cov neeg mob los ntawm lub xyoo. Xyaum qhia tau hais tias cov kev txhim kho los rau hnub thib tsib. Tom qab ntawd koj yuav tsum kho mob rau lwm 2-3 hnub. Cov neeg mob nyob rau hauv lub qhov muag cov instilled ib tug nco peb lub sij hawm ib hnub twg. Yog hais tias muaj yog tsis muaj cov nyhuv rau tsib hnub yuav tsum tsa cov nqe lus nug ntawm cov correctness ntawm txoj kev kho los yog mob. Lub caij ntawm kev kho mob nyob rau hauv lub bacteriological thiab soj ntsuam kawm thiab heev ntawm lub pathology.

Ntxiv rau Txoj kev lis ntshav tov

Medicament "Moxifloxacin" phau ntawv qhia xav kom koj nkag mus rau rau ib teev. Cov tshuaj li yuav ua tau nyob rau hauv undiluted los yog nyob rau hauv diluted daim ntawv. Cov tshuaj yog tsis tau tshaj sodium tshuaj dawb 0.9%, dej kev txhaj tshuaj, dextrose daws nyob rau ib concentration ntawm 10% thiab 40%, 20% xylitol, "ringer". Siv dej ntshiab. Tom qab dilution ntawm lub medicament tseem ruaj khov rau hnub nyob rau hauv chav tsev kub. Yuav tsum tsis txhob yuav khaws cia nyob rau hauv lub tub yees txhais tau tias. Yog hais tias lub Txoj kev lis ntshav yog muab nrog lwm yam kab mob, txhua tus uas yog xeem nyias.

phiv

Vim cov kev kho mob tshuaj "Moxifloxacin" yuav muaj fungal kab mob, leukopenia, anemia, thrombocytopenia. Nyob rau hauv tej rooj plaub, txoj kev kho muaj yog ib qho kev nce rau hauv prothrombin lub sij hawm, thromboplastin ntau hloov. Nyob rau hauv ib co neeg mob cov tshuaj yuav ua kom ua xua, laryngeal edema, urticaria, anaphylactic poob siab, pruritus, eosinophilia, tawm pob. Nyob rau hauv tsawg zaus, muaj yog hyperglycemia, hyperlipidemia, hyperuricemia. Nyob rau hauv cov kev kho mob ntawm tej zaum kev puas hlwb kev ntshawv siab. Nyob rau hauv kev, cov neeg mob tej zaum yuav muaj hyperactivity, ntxhov siab vim, kev nyuaj siab, depersonalization, hallucinations, psychotic tshua, nrog suicidal xav. Common phiv xws li mob taub hau, kiv taub hau, tshee, nkees nkees, tsis meej pem, saj rhiab heev mob, pw tsaug zog ua cuam tshuam, tsis meej pem. Nyob rau hauv tej rooj plaub, thaum lub sij hawm kev kho mob muaj tshuaj tej zaum yuav tsis hnov sib haum, qaug dab peg, nrog los ntawm ntau yam kev soj ntsuam ces, hypoesthesia, teeb meem ntawm kev nkag siab ntawm tsis hnov tsw. Ib tug xov tooj ntawm cov neeg mob tau ntsuas ntawm kev hais lus, mloog, peripheral neuropathy, amnesia, polyneuropathy. Thaum ua ntawv thov topically, tsis pom kev tej zaum yuav deteriorate kom txog rau thaum nws poob. Txawm li cas los, lub tom kawg yog pom tias yuav tsum muaj ib tug nraum mob.

Cawv rau cov hlab plawv system

Ib feem ntawm tej yam hauv daim ntawv thov ntawm cov tshuaj "Moxifloxacin" yog cov QT-luv prolongation nyob rau hauv cov neeg mob uas hypokalemia, palpitations, vasodilation, tachycardia. Tsis tshua muaj kev phiv xws li tawg thiab hypotension, ventricular tachyarrhythmias, syncope. Heev tsis tshua cai plawv. Last feem ntau raug rau cov tib neeg yooj yim rau lawv mob ischemia, bradycardia (clinically tseem ceeb).

Impact nyob rau lwm lub tshuab thiab kabmob

Nyob rau hauv tej rooj plaub, cov tshuaj yuav ua rau ua tsis taus pa, xws li asthmatic mob. Ib tug xov tooj ntawm cov neeg mob muaj cai ntshawv siab nyob rau hauv lub digestive ib ntsuj av. Nyob rau hauv kev, tiv thaiv cov tom qab ntawm kev kho mob-emergent xeev siab, ntuav, raws plab, mob plab. Kuj ob peb sab los yog xam tau tias yog cov neeg pluag qab los noj mov, dyspepsia, flatulence, Gastroenteritis (tshwj tsis yog rau erosive), cem quav. Ib txhia neeg tau raug pom tias yog stomatitis, dysphagia, pseudomembranous mob plab. Cov kev kho tej zaum yuav ua rau kom nyob rau hauv transaminases, hepatic kawg, txoj kev loj hlob ntawm fulminant kab mob siab, hepatic tsis ua hauj lwm ua mus rau lub neej-sia. Heev tsis tshua cai bullous cutaneous tshua (toxic epidermal necrolysis, Stevens-Johnson syndrome). Ib txhia neeg tej myalgia, arthralgia, convulsions, nce nqaij laus, tendonitis, nqaij tsis muaj zog. txog leeg ruptures yuav tshwm sim nyob rau hauv tsawg tus neeg mob, mob caj dab, moj yam ntxaug raws li ib tug tshwm sim ntawm kev puas tsuaj rau lub licas. Cov neeg mob nyob rau hauv kev kho mob muaj tshuaj kuj yuav cai mob ntawm lub urinary system. Nyob rau hauv kev, cim lub cev qhuav dej (provoked raws plab los yog txo nyob rau hauv cov kua ntim ntim), lub raum tsis ua hauj lwm, insufficiency. Common phiv xws li tawm hws, nonspecific mob, malaise. Nyob rau hauv lub tso dej yuav thrombophlebitis los yog phlebitis.

Leej twg yog tsis muab rau cov txhais tau tias?

Nyob rau hauv cov tshuaj "Moxifloxacin" contraindications yog raws li nram no:

• Txog leeg pathology nyob rau hauv keeb kwm uas tsim raws li ib tug tshwm sim ntawm txoj kev kho quinolone tshuaj tua kab mob pab pawg neeg.
• Muaj elongate QT-luv (congenital los yog kis tau).
• Ntsha teeb (tshwj xeeb yog hypokalemia uncorrected).
• Bradycardia (clinically tseem ceeb).
• Lub plawv tsis ua hauj lwm nrog txo ncaws muaj nuj nqi nyob rau hauv rau sab laug ventricle.
• Kev ua txhaum lub plawv atherosclerosis (nyob rau hauv keeb kwm).

Thaum lactose intolerance, qabzib-galactose malabsorption, lactase tsis muaj peev xwm no kuj tsis pom zoo medicament "Moxifloxacin" (tshuaj muaj pes tsawg leeg muaj lactose, yog li ntawd lub pathologies hais muaj nyob rau hauv daim ntawv teev). Tsis muab txhais tau hais tias cev xeeb tub los yog lactating. Ntsiav tshuaj thiab cov tshuaj twb tso cai rau lo lus uas peb cov neeg mob muaj 18 xyoo. Pom zoo tshuaj nyob rau hauv cov ntaub ntawv ntawm npau taws me ntsis rau lub Cheebtsam.

tshwj xeeb no

Ceev faj yog yuav tsum tau nyob rau hauv lub sij hawm ntawm cov tshuaj rau cov neeg mob nrog central tshee system txawv txav uas predispose rau txoj kev loj hlob ntawm qaug dab peg. Qhov uas yuav muaj pab pawg neeg no muaj xws li cov neeg mob uas proarrhythmic lub xeev. Cov no muaj xws, nyob rau hauv particular, xws li mob ischemia, tshwj xeeb tshaj yog nyob rau hauv cov neeg laus thiab cov poj niam. Tsis tas li ntawd soj ntsuam ceev faj nyob rau hauv cov neeg mob uas lub siab mob npuas paug. ntau npaum hloov tej zaum yuav tau thaum lub sij hawm txhawb txoj kev kho txhais tau tias tej lub concentration ntawm poov tshuaj.

Yog xav paub ntxiv,

Xyaum qhia tau hais tias cov tshuaj yog zoo zam nyob rau hauv ntau cov neeg mob. Tshwj xeeb feem ntau muab lub cuab tam rau cov kab txhab. Qhov no yog vim lub fact tias cov tshuaj muaj ib tug kuj high efficiency ntawm ntau cov kab mob. Txawm li cas los, muaj ib txwm txoj kev pheej hmoo ntawm kev phiv, uas muaj nyob hauv cov khoom ceeb toom "Moxifloxacin" phau ntawv qhia. Analogs ntawm cov tshuaj nyob rau hauv cov ntaub ntawv ntawm kev xav tau yuav tsum tuaj tos tus kws kho mob ib lub zuj zus. Hloov lub cuab tam tau xws cov tshuaj raws li: "Avelox", "Vigamoks", "Rotomoks", "Moksifur", "Moksin" thiab lwm tus neeg. Thaum lub tsis zoo los, ib tug ntse deterioration thiab tshwm sim los ntawm cov tsos mob uas tsis tau piav txog nyob rau hauv lub xaus, koj yuav tsum mus nrhiav kev pab tam sim ntawd kev kho mob. Thaum uas siv cov tshuaj yuav tsum tsis txhob sib cuag nrog ntev li ntawm nqi ntawm cov tshuaj lub qhov muag. Yog hais tias qhov no tshwm sim, koj yuav tsum tau sai li sai tau nrog ntau ntawm cov dej. Nyob rau hauv cov ntaub ntawv ntawm overdose li ntawm cov kev phiv.

Nyob rau hauv xaus

Cov tshuaj "Moxifloxacin" xam tau tias yog sufficiently hwj chim antibacterial. Nyob rau hauv kev twb kev txuas nrog rau qhov no tsis tshua muaj neeg nws yog tsis pom zoo mus ua txhaum tus kws kho mob tshuaj. Nyob rau hauv kev, nws txhawj xeeb tus naj npawb thiab zaus ntawm daim ntawv thov txhais tau tias. Tsis txhob noj tshaj ntau npaum. Tso dej txhaj tshuaj yuav tsum tau nqa tawm nyob rau hauv ib tug tshwj xeeb txoj kev tshawb no los ntawm ib tug tsim nyog cov neeg ua haujlwm uas yuav tsum tau los pab, yog hais tias tsim nyog. Koj yuav tsum tsis txhob self-medicate. Nyob rau hauv lub qhaj ntawv ntawm tau ntawm txoj kev kho yog tsim nyog los saib ib tug kws kho mob. Cia li ua ntej yuav siv cov tshuaj "Moxifloxacin" yuav tsum ua tib zoo nyeem cov lus qhia.