Npaj "Pentas": cov lus qhia siv, analogues thiab xyuas

Hauv cov koob tshuaj twg lawv muab cov tshuaj Pentasa los kho dua? Cov lus qhia rau kev siv, tshuaj xyuas thiab tsim tawm ntawm cov tshuaj yog tham hauv qab no. Tsis tas li ntawd nyob rau hauv cov ntaub ntawv ntawm tsab xov xwm yog cov ntaub ntawv ntawm cov ntaub ntawv tso tawm ntawm cov tshuaj no thiab nws cov khoom.

Cov cwj pwm, cov ntaub ntawv ntawm cov tshuaj

Muaj ntau hom kev tso tawm ntawm cov tshuaj nyob rau hauv nqe lus nug. Xav txog lawv tam sim no.

Cov tshuaj "Pentasa" - ntsiav tshuaj (500 mg, 100 mg) tau ntev. Lawv yog xim dawb nrog tawb greyish, thiab nrog rau ntau lub teeb xim av, thaj chaw zoo li, muaj qhov teeb meem, cov cim thiab cov ntawv sau rau ntawm ob sab.

Lub caij pib ntawm no siv tshuaj yaj yeeb yog mesalazine. Tsis tas li ntawd muaj nyob rau hauv cov composition ntawm cov khoom xyaw uas tsis muaj nyob hauv daim ntawv pov thawj, ethylcellulose, magnesium stearate, talc thiab microcrystalline cellulose.

Nyob rau hauv lub muag ntawm yeeb tshuaj "Pentasa" (ntsiav tshuaj), ib daim duab ntawm uas yog nyob rau hauv tsab xov xwm, los nyob rau hauv blisters, uas yog nyob rau hauv pob khoom ntawm cardboard.

Nws kuj tseem yuav tsum tau sau tseg tias cov tshuaj kho mob yuav tsum tau muab xam rau hauv daim ntawv ntawm cov khoom siv, cov tshuaj tso tawm thiab tso quav tawm ntawm qhov quav.

Pharmacology ntawm ib tug medicinal khoom

Dab tsi yog cov tshuaj Pentasa? Cov lus qhia rau kev siv hais tias qhov no neeg sawv cev nrog anti-inflammatory kev txiav txim thiab siv los kho ulcerative mob plab thiab Crohn tus kab mob.

Cov tshuaj tua kab mob ntawm cov yeeb tshuaj no tau pom tshwj xeeb nrog kev siv hauv zos. Cov nyhuv no yog vim cov khoom siv ntawm leukotrienes thiab prostaglandins, nrog rau kev cuam tshuam ntawm lipoxygenase (neutrophilic) kev ua si. Ntxiv mus, cov tshuaj no ua tau kom qeeb qeeb ntawm immunoglobulins nrog lymphocytes thiab inhibit degranulation, tsiv teb tsaws thiab phagocytosis ntawm neutrophils.

Ntaus ntawm plab hnyuv quav

Pentika tshuaj (ntsiav tshuaj), muaj pes tsawg leeg uas tau nthuav tawm saum toj no, qhia tau hais tias muaj kev tiv thaiv kev tiv thaiv tawm tsam qee cov cocci thiab Escherichia coli. Nws kuj muaj cov kab mob antioxidant vim yog lub peev xwm ntawm cov khoom ua si kom khi rau dawb radicals (oxygen) thiab ua kom puas rau lawv.

Kev ua ntaub ntawv thov ntawm tus neeg sawv cev no yuav ua rau kev pheej yig dua nyob rau hauv Crohn tus kabmob, xws li hauv cov neeg uas muaj tus kab mob nrog rau (nrog rau lub sijhawm ntev ntawm tus kabmob).

Lub hauv paus ntawm kev txiav txim ntawm kev kho mob

Cov tshuaj Pentasa ua haujlwm licas? Cov lus qhia rau kev siv ua pov thawj tias qhov tshuaj kho ntawm cov tshuaj no ua rau nws tus kheej tshwm sim tam sim ntawd tom qab hu rau mesalazine nrog cov hnyuv mucosa.

Tom qab noj cov tshuaj hauv qhov ncauj, lub ntsiav tshuaj tam sim ntawd decomposes rau microgranules uas yog ua lwm hom ntawv thiab tso tawm cov khoom nquag, mesalazine, maj mam. Qhov no ua kom cov tshuaj zoo tshaj 12-tus ntiv tes mus rau lub qhov quav ntawm txhua lub pH.

Pharmacokinetics ntawm tus neeg sawv cev

Ua li cas yog kev nqus ntawm Pentika tshuaj? Kev qhia rau kev siv qhia tias microgranules ntawm cov tshuaj tua kab mob tau ncav lub duodenum thaum thawj 60 feeb.

Kwv yees li ntawm 30-50% ntawm qhov noj npaum li cas yog absorbed hauv txoj hnyuv me. Qhov kev txuas ntawm mesalazine nrog plasma proteins yog 43%, thiab acids N-acetyl-tsib-aminosalicylic - 73-85%.

Mesalazine, raws li nws cov kev ua ub no tsis nkag mus rau BBB. Cov khoom ntawm lub yeeb tshuaj tsuas yog tshwm sim thaum siv cov tshuaj siv ntau (txog 1500 mg rau ib hnub).

Acetylation ntawm mesalazine yog raug nyob rau hauv plab hnyuv mucosa thiab siab. Cov tshuaj no tso tawm hauv cov zis, niam cov kua mis thiab quav.

Cov kev qhia rau kev siv cov tshuaj

Nyob rau hauv li cas mob tau lub tshuaj "Pentas" (tshuaj) yuav tshwm? Cov lus teb ntawm cov kws kho mob hais tias qhov tshuaj no zoo tshaj plaws thaum:

• Txhaj-xis tsis muaj ntsws;
• Crohn tus kab mob.

Txwv tsis pub siv cov khoom muag lam

Nyob rau hauv dab tsi mob tsis siv xws li ib lub cuab tam raws li "Pentasa"? Cov lus qhia (ntsiav tshuaj thiab lwm yam tshuaj ntawm cov tshuaj muaj qhov sib thooj tib yam) hais txog cov kev txwv nram no:

• Diathesis hemorrhagic;
• Cov kab mob ntshav;
• Lub sijhawm rau lub caij ua si;
• Hlab ntawm cov hnyuv;
• Lub xeem 2-5 lub lim tiam ntawm cev xeeb tub;
• Tsis muaj glucose-6-phosphate dehydrogenase;
• Hnub nyoog txog li ob xyoos;
• Lub raum tsis ua haujlwm tsis zoo;
• Kev mob siab rau kev quav tshuaj yeeb dej caw;
• Mob tsis siab ntsws yog mob hnyav.

Nrog kev saib xyuas tshwj xeeb, cov tshuaj yuav tsum tau siv rau thawj peb lub hlis ntawm cev xeeb tub, nrog rau cov tshuaj tsis tu ncua thiab mob plab.

Pentika tshuaj: cov lus qhia siv

Qhov kev xaiv ntawm kev siv tshuaj ntawm qhov kev siv tshuaj no nyob ntawm qhov chaw nyob ntawm tus txheej txheem ntawm cov txheej txheem pathological, as Well as ntawm qhov mob plab hnyuv.

Kev tsim ntawm "Pentas" thiab kev ncua kev kawm raug muab kho rau cov ntaub ntawv ntawm cov kab mob (proctosigmoiditis). Hauv qhov no, tswm ciab raug siv peb zaug ib hnub twg rau 500 mg.

Npaum li cas yog qhov kev npaj ntawm Pentasa (tshuaj)? Cov lus qhia rau kev siv hais tias hom tshuaj no raug nquahu kom siv rau cov kab mob sib kis. Rau kev tiv thaiv ntawm recurrences nrog Crohn tus kab mob, cov tshuaj siv plaub zaug ib hnub (1 g ntawm mesalazine). Thaum hais txog kev tiv thaiv ntawm kev rov qab los ntawm NNC, qhov no, cov tshuaj no tau sau peb zaug ib hnub twg rau 500 mg.

Thaum tus kab mob no phem, qhov kev kawm kho mob yuav tsum kav ntev li 8-12 lub lis piam. Hauv qhov no, 400-800 mg ntawm cov tshuaj yuav tsum tau noj txhua hnub (peb zaug ib hnub).

Nyob rau hauv loj heev zaus, ib qho kev nce nyob rau hauv txhua txhua hnub npaum li ntawm 3-4 grams yog tau.

Cov ntsiav tshuaj "Pentas" yuav tsum tau noj tam sim ntawd tom qab noj mov, tsis pub zom thiab ntxuav nrog dej dawb.

Tej teebmeem

Qee zaum, cov tshuaj hauv qhov teeb meem ua rau cov kev mob tshwm sim nram qab no:

• Stomatitis, tremor ntawm extremities, qhov ncauj qhuav, kiv taub hau, xeev siab, depressive parasite;
• Kev txo qis, kev xav ntawm lub plawv dhia ceev nrooj, kev kub ntxhov, ua pa ntawm lub cev ua si, ntuav;
• Hematuria, raws plab syndrome, tachycardia, kab mob siab, mob plab;
• Ua rau lub cev muaj zog enzymes, hloov mus rau hauv ntshav siab, pancreatitis, polyneuropathy;
• Crystalluria, tinnitus, proteinuria (protein secretion), mob plab migraine;
• oliguria, leukopenia, anuria (tsis tuaj kawm ntawv ntawm tso zis), thrombocytopenia, tsim nephrotic syndrome ;
• Hypoprothrombinemia, agranulocytosis, eosinophilia, ntshav tsis txaus.

Nws kuj tseem yuav tsum tau sau tseg tias tiv thaiv tsis tau cov tshuaj no hauv cov neeg mob: oligospermia, alopecia, photosensitivity, tsis muaj zog hauv cov tawv nqaij, lupus-like syndrome, poob phaus dej ntau lawm, mob qog.

Overdose nrog medicinal khoom

Overdose ntawm cov tshuaj nyob rau hauv kev saib xyuas yog tshwm sim los ntawm nce kev tsaug zog, xeev siab, gastralgia, ntuav thiab tsis muaj zog thoob plaws hauv lub cev. Txhawm rau tshem tawm cov tsos mob xws li yuav tsum tau tu lub caij nyoog plab, nrog rau lub sij hawm ntawm cov tshuaj tua kab mob thiab kev kho mob ntawm kev kho mob tom qab.

Tshuaj Kev Sib Thoob

Pentika tshuaj tuaj yeem qeeb tus nqi ntawm qhov cyanocobalamin tsis haum. Tsis tas li ntawd, mesalazine pab txoj kev ua haujlwm ntawm cov tshuaj uricosuric (nrog rau cov kev tso pa tawm ntawm tubular).

Nws kuj tseem yuav tsum tau sau tseg tias cov tshuaj no ua rau lub cev muaj zog ntawm cov kab mob glucocorticosteroids, tsis muaj zog zuj zus ntawm rifampicin, ua kom muaj cov tshuaj lom methotrexate thiab muaj cov nyhuv ntawm cov tshuaj sulfonylureas, spironolactone, sulfonamides thiab furosemide.

Lus Qhia Tshwj Xeeb

Yog tias koj tsis nco qab cov tshuaj mesalazine, nws raug nquahu kom noj nrog lub tom ntej los yog tom ntej ze yav tom ntej. Yog tias ob peb lub hlis twg tsis tuaj, koj yuav tsum tau mus ntsib kws kho mob sai li sai tau. Tib lub sij hawm nws yog txwv tsis pub nres kev kho mob ntawm koj tus kheej.

Qee zaum, tiv thaiv keeb kwm ntawm daim ntawv thov tshuaj rau cov nqe lus nug, cov neeg mob tau pom cov dej ntshiab thiab hu rau lo ntsiab muag nyob rau hauv hawj yellowish-txiv kab ntxwv.

Nyob rau hauv txoj kev kho mob nrog mesalazine, kev kho mob tswj kev ua hauj lwm ntawm tus neeg mob lub raum system yog qhov tsim nyog. Nws tseem ceeb heev kom tsis tu ncua cov neeg mob ntawm tus neeg mob thiab nws cov ntshav (thaum lub sij hawm kev kho mob, thiab tom qab ua tiav nws).

Qhov tshwm sim ntawm qhov tshwm sim ntawm kev phiv tshuaj tiv thaiv tsis zoo rau cov keeb kwm ntawm kev noj tshuaj no nce rau cov neeg uas "qeeb acetylator".

Nrog rau txoj kev loj hlob ntawm ib qho mob syndrome ntawm kev ua siab tsis zoo rau cov khoom sib txuam ua ke, "Pentasa" npaj tau tam sim ntawd tso tseg.

Cov tshuaj zoo tib yam thiab cov neeg tau txais kev pabcuam

Koj puas paub dab tsi hloov tau cov tshuaj noj? Tus kws kho mob lub luag hauj lwm yuav tsum qhia koj txog qhov no. Raws li txoj cai, cov tshuaj nram qab no yog xav tias yuav yog cov yeeb yam ntawm cov tshuaj no: Mesakol, Salosinil, Salofalk, Mezavant, Mesalazin, Asakol.

Cov neeg tau txais kev pab hais dab tsi txog qhov chaw no? Raws li lawv cov kev ntsuam xyuas, cov tshuaj no yog cov tshuaj siv tau zoo heev uas yuav raug them tau los ntawm lub tsev muag tshuaj. Cov neeg mob hais tias mesalazine yog zoo heev manifests nws tus kheej tsis tau tsuas yog nyob rau hauv kev kho mob tab sis kuj nyob rau hauv kev tiv thaiv ntawm Crohn tus kab mob thiab ulcerative mob plab.