Cov lus qhia "Gonal-F." Hauj lwm ntawm cov kev npaj, contraindications, analogs thiab xyuas

Ib tug ntawm cov txoj kev ntxiv lawm tshob kev kho mob yog mus tsim kho ovulation. Rau ntau qe haum rau fertilization, nws yog tsim nyog los ua kev cai ib tug tshwj xeeb pre-tshuaj kho. "Gonal-F" yog suav tias yog ib qho ntawm qhov zoo tshaj tshuaj nyob rau hauv cov cheeb tsam no. Cov lus qhia "Gonal-F" ntseeg tau pom zoo kom kho mob nyob rau hauv nruj kho mob saib xyuas.

hauj lwm ntawm

Sawv daws yeej paub tias tsis muaj ovulation cev xeeb tub yuav tsis tshwm sim. Yog li ntawd, muaj ntau yam ntawm cov ncaj ncees txiv neej pw, kev nyuaj siab nrog xws li ib tug yooj yim teeb meem yuav tsum tau solved rau stimulation thiab nyob rau hauv vitro fertilization. Cov mus kawm tus kws kho mob yuav tsum xub nqa tawm ib tug kev xeem, yuav tsum khaws cov coj tswvyim ntawm tus txheej txheem thiab tus uas tsim nyog npaj.

Qhov tseem nyab xeeb thiab zoo cuab yeej yog raws li nyob rau hauv follicle stimulating lawm - FSH (kev siv), uas yog lub luag hauj lwm rau lub maturation ntawm cov hauv paus nyob rau hauv cov poj niam. Cov lus qhia "Gonal-F" qhia tias cov tshuaj belongs rau hauv pawg no, thiab lub mechanism ntawm qhov kev txiav txim yog li ze rau lub ntuj FSH. Yuav noj tshuaj tsuas yog nyob rau tus kws kho mob tshuaj.

indications

Tshuaj thov nyob rau hauv lub gynecological teb thiab yog muab thaum mus qhib txoj kev loj hlob ntawm hauv paus. Indications rau kev siv "Gonal-F" muaj cov nram qab no:

• Qhaj ntawv ntawm ovulation thiab unsatisfactory tshwm sim tom qab ua ntawv thov "Clomiphene".
• Polycystic ntawm zes qe menyuam syndrome (pathology muaj feem xyuam rau hormonal ntshawv siab ua malfunction ntawm lub zes qe menyuam).
• Qhov yuav tsum tau rau stimulation ntawm ntau cov hauv paus rau IVF.

Heev heev kev kho mob cov kev tshawb fawb tau paub tseeb hais tias cov miv nyuas siv zug ntawm cov tshuaj thaum uas tsim nyog txoj kev loj hlob ntawm ntau yam hauv paus nyob rau hauv tus txheej txheem ntawm zes qe menyuam hyperstimulation (tshuaj). Nws yog tsim los uas cov active ingredient txhawb txoj kev loj hlob ntawm hauv paus, thiab yog li muaj nuj nqis thiaj li muaj cov kev pheej hmoo ntawm zes qe menyuam hyperstimulation.

Daim ntawv thov rau cov txiv neej

Thaum uas tsis yog raws kev cai nrog tus yooj yim zog ntawm tus txiv neej gonads ntawm spermatogenesis txheej txheem - cov tsim thiab kev loj hlob ntawm cov phev - yog lawm. Follicle stimulating lawm tsim nyog rau lub "pib" ntawm txoj kev no, uas tsuas kav 75 hnub. Ntes pathological lub xeev yog tau tsuas yog tom qab cov zaj ntawm kev kho mob diagnostics thiab tus me nyuam ntawm cov phev.

Stimulation (los yog rov qab los) lub cev tsim ntawm txiv neej nrog txiv neej pw gametes tej zaum yuav siv sij hawm ntev tshaj li ib tug zoo li txoj kev nyob rau hauv cov poj niam. Rau ib tug zoo tshwm sim ntawm kev kho mob yuav tsum tau ua raws li tag nrho nrog rau cov tswv yim pom zoo andrologist. Koj yuav tsum ua raws li ib tug qhia tshwj xeeb uas tsim los noj cov zaub mov, muab lub siv cawv thiab nicotine. Nws yog yuav tsum tau mus xaiv tshwj xeeb npaj. Cov lus qhia "Gonal-F" qhia tias cov tshuaj yuav siv tau los txhim khu spermatogenesis nyob rau hauv cov txiv neej uas muaj congenital los yog kis tau hypogonadism. Therapy yuav tsum nyob rau hauv qhov kev saib xyuas ntawm ib tug tshwj xeeb uas muaj kev nyob rau hauv cov kev kho mob ntxiv lawm tshob.

cov tshuaj

Active feem ntawm cov tshuaj ua follitropin Alfa - ib yam khoom uas nkoos txoj kev loj hlob ntawm hauv paus nyob rau hauv cov poj niam uas ua cuam tshuam nyob rau hauv lub hypothalamic-pituitary system. Lub bioavailability ntawm cov tshuaj thaum muab subcutaneously yog hais txog 70%.

Active muaj pib noog nyob rau hauv tus kab mob tom qab rov thawj coj. Thaum lub sij hawm ua ntej 3 hnub cai txoj hlua peb ua rau kom cov equilibrium concentration ntawm follitropin Alfa, uas pib stimulation txheej txheem.

Koom haum pab Cheebtsam muaj nyob rau hauv lub tshuaj ntawm sodium hydroxide thiab hydrogen phosphate dihydrate, phosphoric acid, methionine, sucrose, polysorbate 20.

tso tawm daim ntawv

"Gonal F" ua ib tug Italian kws lub tuam txhab "Kev lag luam Farmasyutika Serono Spa". Daim ntawv tso cai neeg sawv cev - tov rau subcutaneous txhaj tshuaj thiab lyophilisates rau kua.

Cov koob txhaj tshuaj nyob rau hauv daim ntawv ntawm cov cwjmem yuav muaj 0.5, 0.75 thiab 1.5 ml. Lub qis tshaj koob coj mus rau 22 micrograms ntawm follitropin Alfa (300 IU), medium - 33 mg ntawm active ingredient (450 IU). Qhov loj tshaj plaws nqi ntawm active neeg sawv cev muaj nyob rau hauv 1.5 ml - 66 micrograms ( "Gonal-F 900"). Tus nqi ntawm cov tshuaj nyob rau hauv lub concentration ntawm cov active tshuaj.

Cwj mem muaj ib tug tshwj xeeb dispenser thiab scale, enables koj tswj tau qhov koob. Nyob rau hauv daim ntawv no ntawm cov tshuaj mus yuav qhov feem ntau muaj txiaj ntsim ua tsaug rau ntau yam noj tshuaj npaum cas. Qhov zoo tej zaum yuav tsum tau ntaus nqi, thiab tsis muaj kev xav tau rau kev npaj ntawm ib tug tov ua ntej txhua kev txhaj tshuaj.

Lyophilizate rau kev npaj ntawm cov tshuaj cov kev txhaj tshuaj yog diluted nrog kua ua ntej txhua manipulation. Qhov yuav tsum tau ntau npaum ntawm lub pre-laij ib tug kws rau txhua tus neeg cov ntaub ntawv.

Yuav ua li cas yog cov kev kho mob ntawm "Gonalom-F"?

Nyob rau hauv lub qhaj ntawv ntawm ovulation txoj kev kho pib thaum lub sij hawm thawj lub lim tiam ntawm lub cev ntas, muab kev menses (ib co tau zaus sib txawv). Tus txheej txheem ntawm stimulation yuav tsum muab los siv nyob rau hauv cov kev tswj ntawm lub ultrasound txoj kev tshawb no, uas tso cai rau koj los tswj qhov luaj li cas ntawm lub hauv paus. Pib koob tshuaj - 0,13-0,25 ml tshuaj "Gonal-F 75". Nqe lus teb uas muaj 5.5 mg ntawm follitropin Alfa, yog lub qis tshaj thiab yog nyob ib ncig ntawm 110 rubles. Ua kom cov tshuaj tshaj 1-2 lub lis piam rau 225 IU (nyiaj pab ntau tshaj).

Yog hais tias tsis pub dhau ib lub hlis kev kho mob tsis muab zoo tshwm sim, tshuaj kho yuav tsum tau txiav. thawj zaug ntau npaum yuav muab ntau zog ntxiv kev kho mob.

Thaum qhov yuav tsum tau rau tswj ntawm zes qe menyuam hyperstimulation tshuaj no yog muab nyob rau hauv ib tug ntau npaum ntawm 150-225 IU. Qhov siab tshaj plaws txhua txhua hnub koob tshuaj yuav tsum tsis txhob ntau tshaj 450 IU. Therapy pib nrog 2-3 hnub ntawm lub cev ntas. Nrog kev pab los ntawm ultrasound tshwj xeeb yuav saib xyuas txoj kev loj hlob ntawm hauv paus. Lub caij ntawm kev kho mob tej zaum yuav tsum yog los ntawm 5 mus rau 20 hnub. Tom qab qhov kawg Txoj kev lis ntshav, 48 teev tom qab, ib tug txhaj ntawm tib neeg chorionic gonadotropin.

Tus txiv neej uas muaj teeb meem nrog cov txheej txheem spermotogenez kuj qhia tau hais tias stimulation. "Gonal-F" nyob rau hauv cov ntaub ntawv no yog siv nyob rau hauv ua ke nrog nrog tib neeg chorionic gonadotropin. Li ib txwm kho mob regimen yog lub subcutaneous txhaj tshuaj ntawm cov tshuaj peb lub sij hawm ib lub lim tiam (koob tshuaj 150 IU). Duration ntawm kev kho yuav tsum tau muaj yam tsawg 4 lub hlis, tom qab uas ib tug txiv neej yuav tsum tau soj ntsuam. Nrog me ntsis los yog tsis muaj txoj kev txhim kho nyob rau hauv cov kev tshwm sim ntawm kev kho mob tej zaum yuav ntev li 18 lub hlis.

dosing

Tus thawj txhaj tshuaj ntawm cov tshuaj yuav tsum tau ib tug kws nyob rau hauv ib tug lub tsev kho mob. Thaum qhia, nyob rau hauv lub neej yav tom ntej tus neeg mob siv tau tus cwj mem thiab ua ib tug txhaj koob tshuaj tivthaiv, "Gonal-F." Yuav tsum xub muab cuab kav nrog cov lus qhia mus rau yeeb tshuaj.

Cov nram qab no tswv yim pom zoo rau cov neeg sab nraud siv ntawm cov tshuaj:

1. Ua ntej lub stabbing, "Gonal-F", yuav tsum tau ntxuav lawv ob txhais tes kom huv si uas siv xub npum thiab dej thiab tejzaum nws ntxiv ua antiseptic.
2. Decomposed rau hauv lub huv si nto yuav tsum tau cov khoom: cwj mem koob txhaj, vial ntawm hmoov thiab dej rau txhaj, haus dej haus cawv swabs.
3. Nws yog tsim nyog los npaj tus cwj mem, tshem tawm cov hau, koj muab cov kev kawm ntau npaum thiab muab cov koob.
4. Lyophilisate (hmoov) diluted nrog dej rau txhaj los plaug kua rau hauv lub minyuam lam fwj tshuaj nrog ib tug qhuav tshuaj yeeb dej caw. Cov roj hmab cover yuav tsum tej koob qhib ib lub raj mis nws yog tsis tsim nyog. Cov kua yuav tsum tau ua tswvcuab maj mam.
5. Nws yog los hu mus rau hauv cov huab cua koob txhaj mus txog rau thaum yuav tsum tau txhaj koob tshuaj, inserting ib rab koob mus rau hauv lub minyuam lam fwj tshuaj nrog ib tug daws ntawm (yav tas los muab upside down), yuav ua kom paub huab cua thiab hu cov kev kawm npaum li cas ntawm cov tshuaj.
6. Cov koob txhaj yuav tsum tsis muaj cua bubbles. Nyob rau hauv thiaj li yuav tau tshem ntawm lawv, koj yuav tsum coj mus rhaub koj ntiv tes rau ntawm cov phab ntsa hauv tus xiaslias thiab lub npuas tsiv mus nyob rau lub sab saum toj. Ces nws yog tsim nyog los thawb lub nqus thiab tso ntau heev huab cua.
7. Ntawm daim tawv nqaij yuav tsum tau kho nrog ib tug antiseptic (cawv) ntawm lub qhov koob.
8. Cov kev txhaj tshuaj yuav ua li cas subcutaneously ntawm 45 los yog 90 degrees. Sharply mus nias rau qhov nqus yog tsis tsim nyog. Cov tshuaj yuav tsum tau muab qeeb.
9. Rau kev tswj hwm "Gonal-F" ntawm koob txhaj cwjmem yog txaus mus nias rau qhov pib khawm. Cov koob nyob rau hauv no ntaus ntawv yog nyias thiab me me, yog li cov mob me ntsis los yog yuav luag tsis tuaj.
10. Tom qab txhaj tshuaj mus rau lub site ntawm kev txhaj tshuaj yuav tsum tau nrog los ntawm ib tug paj rwb kua ntswg soaked nyob rau hauv antiseptic.
11. Pov tseg koob txhaj pov tseg tom qab ntawm txoj kev.
12. Nrog koob-koob txhaj leeg yuav tsum tau muab tshem tawm, muab tso rau hauv lub hau. Rau tom ntej no manipulation yog tsim nyog los siv ib tug tshiab koob, uas los nrog cov tshuaj.

phiv

Kev npaj "Gonal-F" tej zaum yuav ua rau kev phiv thaum lub sij hawm kev kho mob. Ib txhia poj niam muab sau rau nram qab no cov tsos mob:

• Me nyuam system - feem ntau tsim ntawm zes qe menyuam hlwv.
• Cov tsis zoo zoo ntawm cov tshuaj yuav ua rau lub nruab nrog cev ntawm lub digestive ib ntsuj av. Nws yog qhia nyob rau hauv cov tsos ntawm xeev siab, ntuav, raws plab, tsis xis nyob thiab mob nyob rau hauv lub plab mog.
• Cov kev txhaj tshuaj qhov chaw yuav tshwm sim o los yog liab ntawm daim tawv nqaij.
• tus neeg mob ntawm kev tsis haum tshuaj yog heev tsawg: pob, khaus, ua pa nyuaj, tawm pob.
• Nyob rau hauv ib feem ntawm lub hauv paus poob siab system - tej zaum yuav ua ntau heev mob taub hau.
• Tsawg kawg yog feem ntau muaj mob ntawm tej yam tsis zoo nyob rau hauv cov hlab plawv system (thromboembolism).

Cov lus qhia "Gonal-F" qhia tias cov txiv neej nrog kev kho mob tej zaum yuav tshwm sim pob txuv, me ntsis nce lub cev hnyav. Muaj tsawg tus neeg mob ntawm varicocele, gynecomastia.

Contraindications

Cov tshuaj muaj ib tug muaj zog tej yam ntawm lub cev thiab yog li ntawd yuav tsis tau muab tsis tau ua ntej kev kho mob. Lub active tshuaj thiab ntxiv Cheebtsam muaj ib co kev txwv thaum siv. Tus kws kho mob yuav tsum noj cov tshuaj no mus rau hauv tus account thiab kho cov kev kho mob regimen.

Cov lus qhia "Gonal-F" ceeb toom hais tias cov tshuaj no yog txwv tsis pub siv rau cov neeg uas intolerance los yog npau taws me ntsis rau tshuaj nyob rau hauv lub formulation. Nyob rau hauv cov ntaub ntawv no, tej zaum yuav tsim tsis haum cov tshuaj tiv thaiv los yog lwm yam teeb meem. Tsis tas li ntawd Contraindications muaj xws li:

• Uterine los ntshav ntawm tsis paub hais tias etiology.
• Oncologic pathology ntawm Internal genitals.
• Thawm ntawm zes qe menyuam hlwv uas tau tsim nyob rau hauv lub keeb kwm yav dhau ntawm polycystic.
• Cev xeeb tub thiab lactation.
• Congenital txawv txav hauv nruab nrog cev, uas yog incompatible nrog cev xeeb tub.

Ib tug specialist yuav siv sij hawm mus rau hauv tus account tag nrho cov comorbidities uas yog muaj nyob rau hauv tus neeg mob lub keeb kwm. Nyob rau hauv tej lub sijhawm, yog tsis muaj yuav tsum tau siv cov cuab yeej, "Gonal-F." Nqe ntawm kev kho mob nyob rau lub caij ntawm kev kho mob thiab ntau npaum ntawm cov tshuaj, tab sis txawm kim kev kho mob coj tsis tau leej twg tshwm sim nyob rau hauv xws pathologies li uterine fibroids, ntxov ntxov lawm, rhuav txhua ntawm txoj hlab qe menyuam.

Nta ntawm daim ntawv thov

Ua ntej koj yuav muab ib tug yeeb tshuaj mus tsim kho ovulation los yog spermatogenesis txheej txheem, ib tug kws kho mob specializing nyob rau hauv cov kev kho mob ntxiv lawm tshob, yuav tsum ua kev cai kuaj mob khub niam txiv, los pab txoj cai tawm hauv lub xub ntiag ntawm contraindications thiab qhov yuav tsum tau rau kev kho mob. Nws tseem yog tsim nyog thiab ntau npaum lub tswvyim yuav muab ntsia tau rau.

Cov neeg mob uas yauv stimulation "Gonalom-F" ua ntej IVF tsub kom tau txoj kev tau txais cev xeeb tub nrog menyuam ntxaib. Tus kws kho mob yog yuam ua hauj lwm mus qhia rau tus poj niam ua ntej pib ntawm kev kho mob.

Tib mus siv ntawm cov tshuaj nrog rau lwm cov neeg uas feem xyuam rau txoj kev loj hlob ntawm hauv paus, yuav ntxias txoj kev loj hlob ntawm hyperstimulation. Thoob plaws hauv lub chav kawm ntawm kev kho yog tsim nyog los ua kev cai ultrasonic mob thiab saib xyuas cov kev loj hlob ntawm hauv paus.

"Gonal-F": tus nqi thiab kev xyuas

Italian tshuaj mus tsim kho ovulation twb rau ib ntev lub sij hawm kws kho rau cov kev kho mob ntxiv lawm tshob nyob rau hauv ob qho tib si cov txiv neej thiab cov poj niam. Qhov no yog ib qho ntawm qhov zoo tshaj cov cuab yeej (ntau cov kws kho mob xa mus rau nws raws li "hnyav artillery"). "Gonal-F" tsom zoo tau txawm nyob rau hauv tus neeg mob qhov uas lwm tus paub txhais tau tias yog powerless. Cov yooj yim txoj cai yuav tsum tau ua raws li los ntawm cov neeg mob, yog nyob rau hauv tag nrho cov kev kho mob tswj cov txheej txheem ntawm kev laus hauv paus thiab spermatogenesis.

Nyob rau hauv cov kev kho mob ntau npaum tej zaum yuav hloov nyob rau hauv me me thiab nyob rau hauv ib txoj kev loj. Tus nqi ntawm cov tshuaj mas nws txawv ntawm 1100 rubles. mus txog 16 000 rubles. ( "Gonal-F" 900 IU). Nyob rau hauv tas li ntawd mus rau lub kev siv ntawm kim cuab yeej, nws yog ib qho tseem ceeb ua raws li tej yam kev cai nyob rau hauv kev noj haus thiab tshem tawm tsis qua ntxi zaub mov noj, semi-tiav lawm cov khoom.

Thaum lub sij hawm txoj kev kho, txwv tsis pub haus dej haus cawv, uas muaj ib tug tsis zoo feem on cov phev ntau lawm, rau qhov pituitary caj pas thiab lub hypothalamus, cuam tshuam cov metabolism hauv pw ua niam txiv steroids. Nce rhiab heev nyob rau hauv cov phev thiab nicotine.